Amino acid dipepetide frequency for Oribacterium sp. oral taxon 078 str. F0262

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.621AlaAla: 8.621 ± 0.127	1.092AlaCys: 1.092 ± 0.04	3.932AlaAsp: 3.932 ± 0.074	7.497AlaGlu: 7.497 ± 0.118	3.421AlaPhe: 3.421 ± 0.086	6.788AlaGly: 6.788 ± 0.09	1.024AlaHis: 1.024 ± 0.036	4.065AlaIle: 4.065 ± 0.071	4.267AlaLys: 4.267 ± 0.071	9.08AlaLeu: 9.08 ± 0.117	2.26AlaMet: 2.26 ± 0.059	1.933AlaAsn: 1.933 ± 0.053	2.526AlaPro: 2.526 ± 0.058	1.801AlaGln: 1.801 ± 0.051	3.994AlaArg: 3.994 ± 0.069	4.771AlaSer: 4.771 ± 0.082	2.147AlaThr: 2.147 ± 0.068	5.993AlaVal: 5.993 ± 0.1	0.695AlaTrp: 0.695 ± 0.029	2.454AlaTyr: 2.454 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.051CysAla: 1.051 ± 0.044	0.291CysCys: 0.291 ± 0.021	0.658CysAsp: 0.658 ± 0.027	0.909CysGlu: 0.909 ± 0.032	0.877CysPhe: 0.877 ± 0.032	1.523CysGly: 1.523 ± 0.055	0.324CysHis: 0.324 ± 0.019	0.966CysIle: 0.966 ± 0.036	0.525CysLys: 0.525 ± 0.026	1.366CysLeu: 1.366 ± 0.049	0.316CysMet: 0.316 ± 0.023	0.369CysAsn: 0.369 ± 0.02	0.726CysPro: 0.726 ± 0.036	0.303CysGln: 0.303 ± 0.021	1.126CysArg: 1.126 ± 0.041	0.949CysSer: 0.949 ± 0.034	0.609CysThr: 0.609 ± 0.03	0.7CysVal: 0.7 ± 0.03	0.096CysTrp: 0.096 ± 0.011	0.553CysTyr: 0.553 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.131AspAla: 4.131 ± 0.076	0.856AspCys: 0.856 ± 0.035	1.939AspAsp: 1.939 ± 0.057	3.588AspGlu: 3.588 ± 0.065	3.037AspPhe: 3.037 ± 0.069	4.436AspGly: 4.436 ± 0.091	0.834AspHis: 0.834 ± 0.033	3.384AspIle: 3.384 ± 0.073	2.35AspLys: 2.35 ± 0.059	4.598AspLeu: 4.598 ± 0.085	1.323AspMet: 1.323 ± 0.04	1.296AspAsn: 1.296 ± 0.036	2.454AspPro: 2.454 ± 0.057	1.324AspGln: 1.324 ± 0.042	3.564AspArg: 3.564 ± 0.066	3.33AspSer: 3.33 ± 0.07	2.119AspThr: 2.119 ± 0.056	2.626AspVal: 2.626 ± 0.065	0.588AspTrp: 0.588 ± 0.032	2.437AspTyr: 2.437 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.578GluAla: 6.578 ± 0.097	0.714GluCys: 0.714 ± 0.032	4.336GluAsp: 4.336 ± 0.078	9.957GluGlu: 9.957 ± 0.165	2.076GluPhe: 2.076 ± 0.045	6.298GluGly: 6.298 ± 0.102	1.288GluHis: 1.288 ± 0.039	5.7GluIle: 5.7 ± 0.089	7.55GluLys: 7.55 ± 0.128	9.326GluLeu: 9.326 ± 0.146	2.042GluMet: 2.042 ± 0.056	3.414GluAsn: 3.414 ± 0.063	1.981GluPro: 1.981 ± 0.053	2.444GluGln: 2.444 ± 0.059	7.184GluArg: 7.184 ± 0.121	5.017GluSer: 5.017 ± 0.102	3.078GluThr: 3.078 ± 0.063	3.361GluVal: 3.361 ± 0.073	0.572GluTrp: 0.572 ± 0.025	2.37GluTyr: 2.37 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.708PheAla: 2.708 ± 0.064	0.825PheCys: 0.825 ± 0.033	2.186PheAsp: 2.186 ± 0.045	2.243PheGlu: 2.243 ± 0.046	2.481PhePhe: 2.481 ± 0.079	3.163PheGly: 3.163 ± 0.067	0.895PheHis: 0.895 ± 0.033	2.282PheIle: 2.282 ± 0.063	1.315PheLys: 1.315 ± 0.042	5.644PheLeu: 5.644 ± 0.123	1.11PheMet: 1.11 ± 0.041	1.094PheAsn: 1.094 ± 0.037	2.038PhePro: 2.038 ± 0.051	1.455PheGln: 1.455 ± 0.043	3.375PheArg: 3.375 ± 0.079	4.297PheSer: 4.297 ± 0.085	1.854PheThr: 1.854 ± 0.052	2.252PheVal: 2.252 ± 0.059	0.468PheTrp: 0.468 ± 0.026	1.746PheTyr: 1.746 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	6.065GlyAla: 6.065 ± 0.087	1.134GlyCys: 1.134 ± 0.038	3.513GlyAsp: 3.513 ± 0.063	7.145GlyGlu: 7.145 ± 0.106	3.204GlyPhe: 3.204 ± 0.067	6.463GlyGly: 6.463 ± 0.121	1.176GlyHis: 1.176 ± 0.044	6.242GlyIle: 6.242 ± 0.094	5.813GlyLys: 5.813 ± 0.104	6.558GlyLeu: 6.558 ± 0.098	2.448GlyMet: 2.448 ± 0.057	2.712GlyAsn: 2.712 ± 0.082	1.677GlyPro: 1.677 ± 0.049	1.939GlyGln: 1.939 ± 0.052	6.086GlyArg: 6.086 ± 0.099	5.437GlySer: 5.437 ± 0.101	3.479GlyThr: 3.479 ± 0.073	4.136GlyVal: 4.136 ± 0.075	0.767GlyTrp: 0.767 ± 0.038	2.757GlyTyr: 2.757 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.209HisAla: 1.209 ± 0.039	0.341HisCys: 0.341 ± 0.02	0.747HisAsp: 0.747 ± 0.032	1.014HisGlu: 1.014 ± 0.036	1.023HisPhe: 1.023 ± 0.037	1.359HisGly: 1.359 ± 0.046	0.42HisHis: 0.42 ± 0.037	1.134HisIle: 1.134 ± 0.038	0.7HisLys: 0.7 ± 0.028	1.36HisLeu: 1.36 ± 0.039	0.426HisMet: 0.426 ± 0.021	0.473HisAsn: 0.473 ± 0.027	0.972HisPro: 0.972 ± 0.038	0.44HisGln: 0.44 ± 0.023	1.141HisArg: 1.141 ± 0.041	1.156HisSer: 1.156 ± 0.042	0.657HisThr: 0.657 ± 0.031	0.928HisVal: 0.928 ± 0.032	0.22HisTrp: 0.22 ± 0.017	0.777HisTyr: 0.777 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.169IleAla: 5.169 ± 0.09	1.029IleCys: 1.029 ± 0.037	3.222IleAsp: 3.222 ± 0.063	4.183IleGlu: 4.183 ± 0.072	2.828IlePhe: 2.828 ± 0.071	4.703IleGly: 4.703 ± 0.091	1.207IleHis: 1.207 ± 0.04	3.356IleIle: 3.356 ± 0.078	2.24IleLys: 2.24 ± 0.063	7.404IleLeu: 7.404 ± 0.111	1.541IleMet: 1.541 ± 0.046	1.832IleAsn: 1.832 ± 0.047	3.299IlePro: 3.299 ± 0.071	1.672IleGln: 1.672 ± 0.054	5.222IleArg: 5.222 ± 0.084	4.859IleSer: 4.859 ± 0.07	2.816IleThr: 2.816 ± 0.065	3.553IleVal: 3.553 ± 0.071	0.51IleTrp: 0.51 ± 0.03	2.308IleTyr: 2.308 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.777LysAla: 4.777 ± 0.095	0.519LysCys: 0.519 ± 0.025	3.196LysAsp: 3.196 ± 0.074	5.785LysGlu: 5.785 ± 0.109	1.324LysPhe: 1.324 ± 0.045	4.105LysGly: 4.105 ± 0.08	0.832LysHis: 0.832 ± 0.036	3.399LysIle: 3.399 ± 0.065	4.817LysLys: 4.817 ± 0.103	5.718LysLeu: 5.718 ± 0.081	1.383LysMet: 1.383 ± 0.044	2.417LysAsn: 2.417 ± 0.059	1.888LysPro: 1.888 ± 0.054	1.561LysGln: 1.561 ± 0.047	4.552LysArg: 4.552 ± 0.073	3.538LysSer: 3.538 ± 0.072	2.907LysThr: 2.907 ± 0.065	2.608LysVal: 2.608 ± 0.06	0.509LysTrp: 0.509 ± 0.027	1.893LysTyr: 1.893 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	6.532LeuAla: 6.532 ± 0.103	2.043LeuCys: 2.043 ± 0.06	4.777LeuAsp: 4.777 ± 0.076	6.188LeuGlu: 6.188 ± 0.103	5.29LeuPhe: 5.29 ± 0.127	6.663LeuGly: 6.663 ± 0.113	1.862LeuHis: 1.862 ± 0.05	6.415LeuIle: 6.415 ± 0.108	5.516LeuLys: 5.516 ± 0.081	13.404LeuLeu: 13.404 ± 0.239	2.744LeuMet: 2.744 ± 0.072	3.048LeuAsn: 3.048 ± 0.069	5.384LeuPro: 5.384 ± 0.091	2.706LeuGln: 2.706 ± 0.067	8.079LeuArg: 8.079 ± 0.13	11.463LeuSer: 11.463 ± 0.177	4.135LeuThr: 4.135 ± 0.073	4.862LeuVal: 4.862 ± 0.087	0.958LeuTrp: 0.958 ± 0.041	3.676LeuTyr: 3.676 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	2.065MetAla: 2.065 ± 0.049	0.222MetCys: 0.222 ± 0.015	1.623MetAsp: 1.623 ± 0.044	2.41MetGlu: 2.41 ± 0.059	0.672MetPhe: 0.672 ± 0.029	1.955MetGly: 1.955 ± 0.052	0.42MetHis: 0.42 ± 0.024	1.764MetIle: 1.764 ± 0.048	2.14MetLys: 2.14 ± 0.051	2.706MetLeu: 2.706 ± 0.074	0.755MetMet: 0.755 ± 0.029	1.136MetAsn: 1.136 ± 0.038	1.05MetPro: 1.05 ± 0.034	0.968MetGln: 0.968 ± 0.036	1.843MetArg: 1.843 ± 0.045	1.64MetSer: 1.64 ± 0.047	1.317MetThr: 1.317 ± 0.041	1.284MetVal: 1.284 ± 0.039	0.162MetTrp: 0.162 ± 0.012	0.59MetTyr: 0.59 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.868AsnAla: 2.868 ± 0.063	0.487AsnCys: 0.487 ± 0.025	1.346AsnAsp: 1.346 ± 0.045	2.058AsnGlu: 2.058 ± 0.055	1.386AsnPhe: 1.386 ± 0.039	2.869AsnGly: 2.869 ± 0.072	0.597AsnHis: 0.597 ± 0.031	2.187AsnIle: 2.187 ± 0.055	1.304AsnLys: 1.304 ± 0.043	2.954AsnLeu: 2.954 ± 0.068	0.918AsnMet: 0.918 ± 0.035	0.961AsnAsn: 0.961 ± 0.044	1.802AsnPro: 1.802 ± 0.054	1.096AsnGln: 1.096 ± 0.036	2.03AsnArg: 2.03 ± 0.048	1.788AsnSer: 1.788 ± 0.049	1.545AsnThr: 1.545 ± 0.044	2.022AsnVal: 2.022 ± 0.058	0.359AsnTrp: 0.359 ± 0.022	1.288AsnTyr: 1.288 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.014ProAla: 3.014 ± 0.069	0.514ProCys: 0.514 ± 0.027	2.499ProAsp: 2.499 ± 0.054	4.499ProGlu: 4.499 ± 0.072	1.759ProPhe: 1.759 ± 0.048	3.347ProGly: 3.347 ± 0.068	0.634ProHis: 0.634 ± 0.029	2.211ProIle: 2.211 ± 0.054	2.118ProLys: 2.118 ± 0.06	3.921ProLeu: 3.921 ± 0.081	0.934ProMet: 0.934 ± 0.03	1.094ProAsn: 1.094 ± 0.036	1.284ProPro: 1.284 ± 0.042	0.826ProGln: 0.826 ± 0.038	1.802ProArg: 1.802 ± 0.05	2.61ProSer: 2.61 ± 0.058	1.249ProThr: 1.249 ± 0.042	2.442ProVal: 2.442 ± 0.053	0.354ProTrp: 0.354 ± 0.021	1.46ProTyr: 1.46 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	1.971GlnAla: 1.971 ± 0.049	0.289GlnCys: 0.289 ± 0.017	1.37GlnAsp: 1.37 ± 0.045	2.245GlnGlu: 2.245 ± 0.057	0.926GlnPhe: 0.926 ± 0.03	1.912GlnGly: 1.912 ± 0.053	0.398GlnHis: 0.398 ± 0.023	1.723GlnIle: 1.723 ± 0.051	2.312GlnLys: 2.312 ± 0.061	2.563GlnLeu: 2.563 ± 0.06	0.742GlnMet: 0.742 ± 0.032	1.289GlnAsn: 1.289 ± 0.04	0.788GlnPro: 0.788 ± 0.03	0.826GlnGln: 0.826 ± 0.041	2.133GlnArg: 2.133 ± 0.052	1.942GlnSer: 1.942 ± 0.053	1.181GlnThr: 1.181 ± 0.041	1.21GlnVal: 1.21 ± 0.035	0.254GlnTrp: 0.254 ± 0.017	1.003GlnTyr: 1.003 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.15ArgAla: 5.15 ± 0.092	0.877ArgCys: 0.877 ± 0.037	3.543ArgAsp: 3.543 ± 0.07	8.344ArgGlu: 8.344 ± 0.13	2.996ArgPhe: 2.996 ± 0.065	5.292ArgGly: 5.292 ± 0.091	1.012ArgHis: 1.012 ± 0.033	5.272ArgIle: 5.272 ± 0.071	4.685ArgLys: 4.685 ± 0.09	6.558ArgLeu: 6.558 ± 0.112	2.122ArgMet: 2.122 ± 0.057	2.312ArgAsn: 2.312 ± 0.052	2.222ArgPro: 2.222 ± 0.052	1.918ArgGln: 1.918 ± 0.044	5.881ArgArg: 5.881 ± 0.109	4.439ArgSer: 4.439 ± 0.08	2.667ArgThr: 2.667 ± 0.059	3.23ArgVal: 3.23 ± 0.059	0.587ArgTrp: 0.587 ± 0.025	2.48ArgTyr: 2.48 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.251SerAla: 6.251 ± 0.103	1.145SerCys: 1.145 ± 0.041	3.579SerAsp: 3.579 ± 0.078	6.104SerGlu: 6.104 ± 0.091	4.032SerPhe: 4.032 ± 0.066	7.197SerGly: 7.197 ± 0.116	1.098SerHis: 1.098 ± 0.042	3.847SerIle: 3.847 ± 0.085	2.696SerLys: 2.696 ± 0.063	7.523SerLeu: 7.523 ± 0.128	1.953SerMet: 1.953 ± 0.051	1.618SerAsn: 1.618 ± 0.05	2.88SerPro: 2.88 ± 0.067	1.632SerGln: 1.632 ± 0.049	4.346SerArg: 4.346 ± 0.085	5.117SerSer: 5.117 ± 0.12	2.461SerThr: 2.461 ± 0.059	4.402SerVal: 4.402 ± 0.081	0.705SerTrp: 0.705 ± 0.028	2.936SerTyr: 2.936 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.973ThrAla: 3.973 ± 0.078	0.348ThrCys: 0.348 ± 0.023	2.433ThrAsp: 2.433 ± 0.059	4.202ThrGlu: 4.202 ± 0.083	1.275ThrPhe: 1.275 ± 0.042	3.714ThrGly: 3.714 ± 0.073	0.603ThrHis: 0.603 ± 0.028	2.692ThrIle: 2.692 ± 0.064	2.172ThrLys: 2.172 ± 0.053	3.971ThrLeu: 3.971 ± 0.066	1.066ThrMet: 1.066 ± 0.039	1.215ThrAsn: 1.215 ± 0.042	1.654ThrPro: 1.654 ± 0.046	0.992ThrGln: 0.992 ± 0.042	1.996ThrArg: 1.996 ± 0.052	1.944ThrSer: 1.944 ± 0.044	1.695ThrThr: 1.695 ± 0.056	3.269ThrVal: 3.269 ± 0.057	0.309ThrTrp: 0.309 ± 0.022	1.023ThrTyr: 1.023 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	3.148ValAla: 3.148 ± 0.07	0.824ValCys: 0.824 ± 0.032	2.888ValAsp: 2.888 ± 0.068	3.378ValGlu: 3.378 ± 0.078	2.648ValPhe: 2.648 ± 0.061	3.573ValGly: 3.573 ± 0.079	0.936ValHis: 0.936 ± 0.034	3.619ValIle: 3.619 ± 0.078	3.18ValLys: 3.18 ± 0.066	6.295ValLeu: 6.295 ± 0.08	1.514ValMet: 1.514 ± 0.043	2.118ValAsn: 2.118 ± 0.058	2.291ValPro: 2.291 ± 0.062	1.545ValGln: 1.545 ± 0.047	3.571ValArg: 3.571 ± 0.069	4.396ValSer: 4.396 ± 0.076	2.701ValThr: 2.701 ± 0.053	3.028ValVal: 3.028 ± 0.071	0.473ValTrp: 0.473 ± 0.024	2.06ValTyr: 2.06 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.536TrpAla: 0.536 ± 0.029	0.122TrpCys: 0.122 ± 0.014	0.469TrpAsp: 0.469 ± 0.029	0.782TrpGlu: 0.782 ± 0.034	0.363TrpPhe: 0.363 ± 0.022	0.622TrpGly: 0.622 ± 0.031	0.178TrpHis: 0.178 ± 0.015	0.668TrpIle: 0.668 ± 0.031	0.678TrpLys: 0.678 ± 0.029	0.921TrpLeu: 0.921 ± 0.034	0.3TrpMet: 0.3 ± 0.021	0.435TrpAsn: 0.435 ± 0.024	0.207TrpPro: 0.207 ± 0.017	0.363TrpGln: 0.363 ± 0.022	0.616TrpArg: 0.616 ± 0.025	0.541TrpSer: 0.541 ± 0.028	0.356TrpThr: 0.356 ± 0.019	0.421TrpVal: 0.421 ± 0.022	0.099TrpTrp: 0.099 ± 0.01	0.367TrpTyr: 0.367 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.542TyrAla: 2.542 ± 0.061	0.567TyrCys: 0.567 ± 0.029	1.956TyrAsp: 1.956 ± 0.054	2.755TyrGlu: 2.755 ± 0.062	1.816TyrPhe: 1.816 ± 0.048	2.769TyrGly: 2.769 ± 0.061	0.76TyrHis: 0.76 ± 0.033	2.029TyrIle: 2.029 ± 0.047	1.351TyrLys: 1.351 ± 0.04	3.873TyrLeu: 3.873 ± 0.077	0.824TyrMet: 0.824 ± 0.035	1.098TyrAsn: 1.098 ± 0.037	1.446TyrPro: 1.446 ± 0.042	1.267TyrGln: 1.267 ± 0.044	3.043TyrArg: 3.043 ± 0.078	2.29TyrSer: 2.29 ± 0.054	1.573TyrThr: 1.573 ± 0.049	1.859TyrVal: 1.859 ± 0.053	0.359TyrTrp: 0.359 ± 0.021	1.497TyrTyr: 1.497 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2936 proteins (809676 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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