Amino acid dipepetide frequency for Candidatus Tokpelaia sp. JSC161

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.367AlaAla: 6.367 ± 0.177
1.064AlaCys: 1.064 ± 0.072
3.549AlaAsp: 3.549 ± 0.112
4.481AlaGlu: 4.481 ± 0.137
3.611AlaPhe: 3.611 ± 0.128
4.943AlaGly: 4.943 ± 0.142
1.883AlaHis: 1.883 ± 0.087
6.653AlaIle: 6.653 ± 0.154
3.886AlaLys: 3.886 ± 0.144
8.846AlaLeu: 8.846 ± 0.199
2.093AlaMet: 2.093 ± 0.087
2.564AlaAsn: 2.564 ± 0.104
2.041AlaPro: 2.041 ± 0.084
2.533AlaGln: 2.533 ± 0.09
4.709AlaArg: 4.709 ± 0.141
4.65AlaSer: 4.65 ± 0.143
3.201AlaThr: 3.201 ± 0.112
5.005AlaVal: 5.005 ± 0.156
0.681AlaTrp: 0.681 ± 0.052
2.358AlaTyr: 2.358 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
0.874CysAla: 0.874 ± 0.057
0.169CysCys: 0.169 ± 0.025
0.685CysAsp: 0.685 ± 0.051
0.578CysGlu: 0.578 ± 0.044
0.716CysPhe: 0.716 ± 0.05
1.008CysGly: 1.008 ± 0.057
0.275CysHis: 0.275 ± 0.032
0.96CysIle: 0.96 ± 0.061
0.537CysLys: 0.537 ± 0.041
1.249CysLeu: 1.249 ± 0.069
0.317CysMet: 0.317 ± 0.029
0.406CysAsn: 0.406 ± 0.035
0.461CysPro: 0.461 ± 0.044
0.379CysGln: 0.379 ± 0.038
0.675CysArg: 0.675 ± 0.049
0.909CysSer: 0.909 ± 0.064
0.523CysThr: 0.523 ± 0.045
0.661CysVal: 0.661 ± 0.055
0.107CysTrp: 0.107 ± 0.017
0.368CysTyr: 0.368 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
3.549AspAla: 3.549 ± 0.118
0.585AspCys: 0.585 ± 0.048
2.22AspAsp: 2.22 ± 0.104
2.802AspGlu: 2.802 ± 0.098
2.619AspPhe: 2.619 ± 0.086
3.177AspGly: 3.177 ± 0.133
1.287AspHis: 1.287 ± 0.073
5.091AspIle: 5.091 ± 0.135
2.643AspLys: 2.643 ± 0.095
5.232AspLeu: 5.232 ± 0.135
1.466AspMet: 1.466 ± 0.063
1.645AspAsn: 1.645 ± 0.078
2.0AspPro: 2.0 ± 0.096
1.704AspGln: 1.704 ± 0.082
2.685AspArg: 2.685 ± 0.103
3.191AspSer: 3.191 ± 0.104
2.223AspThr: 2.223 ± 0.092
3.297AspVal: 3.297 ± 0.111
0.582AspTrp: 0.582 ± 0.04
1.542AspTyr: 1.542 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
4.595GluAla: 4.595 ± 0.15
0.516GluCys: 0.516 ± 0.045
2.692GluAsp: 2.692 ± 0.1
4.172GluGlu: 4.172 ± 0.134
1.907GluPhe: 1.907 ± 0.081
3.703GluGly: 3.703 ± 0.129
1.322GluHis: 1.322 ± 0.065
5.376GluIle: 5.376 ± 0.166
5.235GluLys: 5.235 ± 0.156
4.64GluLeu: 4.64 ± 0.135
1.583GluMet: 1.583 ± 0.074
3.17GluAsn: 3.17 ± 0.121
1.597GluPro: 1.597 ± 0.073
1.969GluGln: 1.969 ± 0.105
4.086GluArg: 4.086 ± 0.136
3.631GluSer: 3.631 ± 0.137
3.201GluThr: 3.201 ± 0.122
3.542GluVal: 3.542 ± 0.116
0.592GluTrp: 0.592 ± 0.045
1.425GluTyr: 1.425 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
2.647PheAla: 2.647 ± 0.1
0.826PheCys: 0.826 ± 0.06
2.643PheAsp: 2.643 ± 0.103
2.464PheGlu: 2.464 ± 0.098
2.919PhePhe: 2.919 ± 0.127
3.142PheGly: 3.142 ± 0.135
1.215PheHis: 1.215 ± 0.078
3.679PheIle: 3.679 ± 0.119
1.9PheLys: 1.9 ± 0.081
5.486PheLeu: 5.486 ± 0.206
1.156PheMet: 1.156 ± 0.06
1.752PheAsn: 1.752 ± 0.085
1.89PhePro: 1.89 ± 0.092
1.563PheGln: 1.563 ± 0.088
2.213PheArg: 2.213 ± 0.096
4.64PheSer: 4.64 ± 0.144
2.055PheThr: 2.055 ± 0.087
2.702PheVal: 2.702 ± 0.111
0.499PheTrp: 0.499 ± 0.05
1.583PheTyr: 1.583 ± 0.091
0.0PheXaa: 0.0 ± 0.0
Gly
5.066GlyAla: 5.066 ± 0.147
0.929GlyCys: 0.929 ± 0.061
3.28GlyAsp: 3.28 ± 0.123
3.559GlyGlu: 3.559 ± 0.103
3.511GlyPhe: 3.511 ± 0.125
4.826GlyGly: 4.826 ± 0.183
1.735GlyHis: 1.735 ± 0.075
6.216GlyIle: 6.216 ± 0.153
4.45GlyLys: 4.45 ± 0.131
7.001GlyLeu: 7.001 ± 0.18
1.945GlyMet: 1.945 ± 0.093
2.471GlyAsn: 2.471 ± 0.109
2.055GlyPro: 2.055 ± 0.079
2.027GlyGln: 2.027 ± 0.092
3.972GlyArg: 3.972 ± 0.119
4.103GlySer: 4.103 ± 0.124
3.335GlyThr: 3.335 ± 0.113
4.209GlyVal: 4.209 ± 0.13
0.802GlyTrp: 0.802 ± 0.063
2.189GlyTyr: 2.189 ± 0.103
0.0GlyXaa: 0.0 ± 0.0
His
1.886HisAla: 1.886 ± 0.087
0.341HisCys: 0.341 ± 0.034
1.012HisAsp: 1.012 ± 0.062
1.342HisGlu: 1.342 ± 0.065
1.253HisPhe: 1.253 ± 0.062
1.714HisGly: 1.714 ± 0.077
0.647HisHis: 0.647 ± 0.047
2.093HisIle: 2.093 ± 0.096
1.208HisLys: 1.208 ± 0.068
2.468HisLeu: 2.468 ± 0.121
0.633HisMet: 0.633 ± 0.047
0.984HisAsn: 0.984 ± 0.062
1.273HisPro: 1.273 ± 0.075
0.812HisGln: 0.812 ± 0.069
1.298HisArg: 1.298 ± 0.076
1.566HisSer: 1.566 ± 0.076
1.153HisThr: 1.153 ± 0.079
1.59HisVal: 1.59 ± 0.065
0.248HisTrp: 0.248 ± 0.028
0.733HisTyr: 0.733 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
7.724IleAla: 7.724 ± 0.163
0.977IleCys: 0.977 ± 0.06
4.612IleAsp: 4.612 ± 0.136
5.318IleGlu: 5.318 ± 0.161
4.024IlePhe: 4.024 ± 0.129
6.309IleGly: 6.309 ± 0.155
2.213IleHis: 2.213 ± 0.101
6.715IleIle: 6.715 ± 0.199
4.454IleLys: 4.454 ± 0.148
9.069IleLeu: 9.069 ± 0.185
1.638IleMet: 1.638 ± 0.08
3.373IleAsn: 3.373 ± 0.132
3.783IlePro: 3.783 ± 0.129
2.884IleGln: 2.884 ± 0.105
4.994IleArg: 4.994 ± 0.125
6.491IleSer: 6.491 ± 0.178
4.313IleThr: 4.313 ± 0.131
4.688IleVal: 4.688 ± 0.134
0.757IleTrp: 0.757 ± 0.052
2.254IleTyr: 2.254 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
4.375LysAla: 4.375 ± 0.125
0.416LysCys: 0.416 ± 0.039
2.936LysAsp: 2.936 ± 0.107
4.203LysGlu: 4.203 ± 0.127
1.621LysPhe: 1.621 ± 0.083
3.92LysGly: 3.92 ± 0.115
1.129LysHis: 1.129 ± 0.063
5.714LysIle: 5.714 ± 0.141
5.714LysLys: 5.714 ± 0.173
4.681LysLeu: 4.681 ± 0.144
1.463LysMet: 1.463 ± 0.082
3.889LysAsn: 3.889 ± 0.13
1.938LysPro: 1.938 ± 0.092
1.872LysGln: 1.872 ± 0.077
4.01LysArg: 4.01 ± 0.114
3.693LysSer: 3.693 ± 0.128
3.425LysThr: 3.425 ± 0.148
3.222LysVal: 3.222 ± 0.116
0.447LysTrp: 0.447 ± 0.038
1.349LysTyr: 1.349 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
8.02LeuAla: 8.02 ± 0.193
1.287LeuCys: 1.287 ± 0.064
5.445LeuAsp: 5.445 ± 0.138
6.25LeuGlu: 6.25 ± 0.167
4.643LeuPhe: 4.643 ± 0.188
6.454LeuGly: 6.454 ± 0.174
2.361LeuHis: 2.361 ± 0.1
8.405LeuIle: 8.405 ± 0.234
6.378LeuLys: 6.378 ± 0.163
10.061LeuLeu: 10.061 ± 0.231
2.592LeuMet: 2.592 ± 0.094
4.127LeuAsn: 4.127 ± 0.159
4.175LeuPro: 4.175 ± 0.12
3.686LeuGln: 3.686 ± 0.126
6.047LeuArg: 6.047 ± 0.148
9.001LeuSer: 9.001 ± 0.203
4.884LeuThr: 4.884 ± 0.126
5.903LeuVal: 5.903 ± 0.16
0.967LeuTrp: 0.967 ± 0.069
2.833LeuTyr: 2.833 ± 0.116
0.0LeuXaa: 0.0 ± 0.0
Met
1.804MetAla: 1.804 ± 0.077
0.255MetCys: 0.255 ± 0.03
1.156MetAsp: 1.156 ± 0.061
1.291MetGlu: 1.291 ± 0.068
0.833MetPhe: 0.833 ± 0.052
1.576MetGly: 1.576 ± 0.073
0.561MetHis: 0.561 ± 0.047
2.475MetIle: 2.475 ± 0.073
1.848MetLys: 1.848 ± 0.083
2.55MetLeu: 2.55 ± 0.108
0.761MetMet: 0.761 ± 0.055
1.483MetAsn: 1.483 ± 0.07
1.095MetPro: 1.095 ± 0.06
1.015MetGln: 1.015 ± 0.055
1.828MetArg: 1.828 ± 0.085
1.766MetSer: 1.766 ± 0.078
1.487MetThr: 1.487 ± 0.066
1.37MetVal: 1.37 ± 0.065
0.182MetTrp: 0.182 ± 0.026
0.351MetTyr: 0.351 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.07AsnAla: 3.07 ± 0.098
0.461AsnCys: 0.461 ± 0.042
1.752AsnAsp: 1.752 ± 0.081
2.027AsnGlu: 2.027 ± 0.094
1.938AsnPhe: 1.938 ± 0.075
2.791AsnGly: 2.791 ± 0.11
1.112AsnHis: 1.112 ± 0.065
4.048AsnIle: 4.048 ± 0.152
2.506AsnLys: 2.506 ± 0.102
4.209AsnLeu: 4.209 ± 0.14
1.07AsnMet: 1.07 ± 0.058
1.838AsnAsn: 1.838 ± 0.103
2.389AsnPro: 2.389 ± 0.08
1.718AsnGln: 1.718 ± 0.107
2.471AsnArg: 2.471 ± 0.093
2.485AsnSer: 2.485 ± 0.095
2.065AsnThr: 2.065 ± 0.118
2.275AsnVal: 2.275 ± 0.092
0.492AsnTrp: 0.492 ± 0.04
1.28AsnTyr: 1.28 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
2.072ProAla: 2.072 ± 0.083
0.485ProCys: 0.485 ± 0.039
2.172ProAsp: 2.172 ± 0.097
2.454ProGlu: 2.454 ± 0.101
2.12ProPhe: 2.12 ± 0.089
2.733ProGly: 2.733 ± 0.096
1.05ProHis: 1.05 ± 0.049
3.125ProIle: 3.125 ± 0.108
1.845ProLys: 1.845 ± 0.08
4.189ProLeu: 4.189 ± 0.132
0.895ProMet: 0.895 ± 0.055
1.435ProAsn: 1.435 ± 0.077
1.222ProPro: 1.222 ± 0.076
1.304ProGln: 1.304 ± 0.069
1.597ProArg: 1.597 ± 0.076
2.595ProSer: 2.595 ± 0.096
1.759ProThr: 1.759 ± 0.067
2.695ProVal: 2.695 ± 0.133
0.434ProTrp: 0.434 ± 0.041
1.27ProTyr: 1.27 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
2.977GlnAla: 2.977 ± 0.096
0.296GlnCys: 0.296 ± 0.033
1.446GlnAsp: 1.446 ± 0.065
2.354GlnGlu: 2.354 ± 0.112
1.294GlnPhe: 1.294 ± 0.069
2.02GlnGly: 2.02 ± 0.083
0.716GlnHis: 0.716 ± 0.062
2.853GlnIle: 2.853 ± 0.136
2.729GlnLys: 2.729 ± 0.111
3.012GlnLeu: 3.012 ± 0.118
0.829GlnMet: 0.829 ± 0.057
1.69GlnAsn: 1.69 ± 0.099
1.046GlnPro: 1.046 ± 0.067
1.088GlnGln: 1.088 ± 0.103
2.254GlnArg: 2.254 ± 0.09
2.117GlnSer: 2.117 ± 0.099
1.652GlnThr: 1.652 ± 0.086
1.866GlnVal: 1.866 ± 0.075
0.372GlnTrp: 0.372 ± 0.038
0.898GlnTyr: 0.898 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
4.048ArgAla: 4.048 ± 0.124
0.606ArgCys: 0.606 ± 0.046
2.977ArgAsp: 2.977 ± 0.113
3.679ArgGlu: 3.679 ± 0.133
3.098ArgPhe: 3.098 ± 0.106
3.438ArgGly: 3.438 ± 0.115
1.311ArgHis: 1.311 ± 0.067
5.576ArgIle: 5.576 ± 0.133
3.738ArgLys: 3.738 ± 0.113
6.257ArgLeu: 6.257 ± 0.155
1.656ArgMet: 1.656 ± 0.076
2.564ArgAsn: 2.564 ± 0.116
1.821ArgPro: 1.821 ± 0.077
1.883ArgGln: 1.883 ± 0.088
3.666ArgArg: 3.666 ± 0.135
3.8ArgSer: 3.8 ± 0.129
2.633ArgThr: 2.633 ± 0.099
3.851ArgVal: 3.851 ± 0.14
0.53ArgTrp: 0.53 ± 0.036
1.952ArgTyr: 1.952 ± 0.096
0.0ArgXaa: 0.0 ± 0.0
Ser
4.791SerAla: 4.791 ± 0.151
0.919SerCys: 0.919 ± 0.058
3.614SerAsp: 3.614 ± 0.119
3.721SerGlu: 3.721 ± 0.115
4.006SerPhe: 4.006 ± 0.135
5.696SerGly: 5.696 ± 0.146
1.762SerHis: 1.762 ± 0.087
5.683SerIle: 5.683 ± 0.15
3.376SerLys: 3.376 ± 0.109
8.147SerLeu: 8.147 ± 0.177
1.824SerMet: 1.824 ± 0.068
2.592SerAsn: 2.592 ± 0.106
2.458SerPro: 2.458 ± 0.111
2.213SerGln: 2.213 ± 0.094
3.755SerArg: 3.755 ± 0.12
5.294SerSer: 5.294 ± 0.165
2.902SerThr: 2.902 ± 0.11
4.502SerVal: 4.502 ± 0.156
0.764SerTrp: 0.764 ± 0.049
2.43SerTyr: 2.43 ± 0.107
0.0SerXaa: 0.0 ± 0.0
Thr
3.886ThrAla: 3.886 ± 0.11
0.547ThrCys: 0.547 ± 0.046
2.206ThrAsp: 2.206 ± 0.098
2.513ThrGlu: 2.513 ± 0.098
2.175ThrPhe: 2.175 ± 0.087
3.752ThrGly: 3.752 ± 0.124
1.287ThrHis: 1.287 ± 0.075
3.896ThrIle: 3.896 ± 0.143
2.217ThrLys: 2.217 ± 0.097
5.617ThrLeu: 5.617 ± 0.162
1.146ThrMet: 1.146 ± 0.066
1.824ThrAsn: 1.824 ± 0.101
2.113ThrPro: 2.113 ± 0.083
1.6ThrGln: 1.6 ± 0.092
2.726ThrArg: 2.726 ± 0.107
3.098ThrSer: 3.098 ± 0.112
2.444ThrThr: 2.444 ± 0.101
3.098ThrVal: 3.098 ± 0.107
0.41ThrTrp: 0.41 ± 0.043
1.387ThrTyr: 1.387 ± 0.078
0.0ThrXaa: 0.0 ± 0.0
Val
4.53ValAla: 4.53 ± 0.122
0.716ValCys: 0.716 ± 0.058
3.204ValAsp: 3.204 ± 0.119
3.628ValGlu: 3.628 ± 0.138
2.967ValPhe: 2.967 ± 0.118
3.765ValGly: 3.765 ± 0.129
1.356ValHis: 1.356 ± 0.065
4.98ValIle: 4.98 ± 0.148
3.015ValLys: 3.015 ± 0.112
6.619ValLeu: 6.619 ± 0.162
1.594ValMet: 1.594 ± 0.069
2.34ValAsn: 2.34 ± 0.085
2.399ValPro: 2.399 ± 0.092
1.776ValGln: 1.776 ± 0.076
3.597ValArg: 3.597 ± 0.147
4.853ValSer: 4.853 ± 0.131
2.836ValThr: 2.836 ± 0.094
4.086ValVal: 4.086 ± 0.154
0.613ValTrp: 0.613 ± 0.049
1.611ValTyr: 1.611 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.558TrpAla: 0.558 ± 0.041
0.155TrpCys: 0.155 ± 0.025
0.372TrpAsp: 0.372 ± 0.033
0.42TrpGlu: 0.42 ± 0.038
0.437TrpPhe: 0.437 ± 0.051
0.516TrpGly: 0.516 ± 0.046
0.258TrpHis: 0.258 ± 0.029
0.878TrpIle: 0.878 ± 0.052
0.764TrpLys: 0.764 ± 0.061
1.153TrpLeu: 1.153 ± 0.072
0.348TrpMet: 0.348 ± 0.032
0.578TrpAsn: 0.578 ± 0.049
0.43TrpPro: 0.43 ± 0.043
0.406TrpGln: 0.406 ± 0.038
0.695TrpArg: 0.695 ± 0.044
0.63TrpSer: 0.63 ± 0.046
0.399TrpThr: 0.399 ± 0.039
0.537TrpVal: 0.537 ± 0.048
0.182TrpTrp: 0.182 ± 0.024
0.282TrpTyr: 0.282 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.279TyrAla: 2.279 ± 0.092
0.306TyrCys: 0.306 ± 0.032
1.566TyrAsp: 1.566 ± 0.076
1.697TyrGlu: 1.697 ± 0.073
1.284TyrPhe: 1.284 ± 0.071
2.196TyrGly: 2.196 ± 0.094
0.774TyrHis: 0.774 ± 0.056
2.175TyrIle: 2.175 ± 0.087
1.573TyrLys: 1.573 ± 0.072
3.032TyrLeu: 3.032 ± 0.097
0.675TyrMet: 0.675 ± 0.047
1.27TyrAsn: 1.27 ± 0.067
1.267TyrPro: 1.267 ± 0.066
1.077TyrGln: 1.077 ± 0.061
1.81TyrArg: 1.81 ± 0.09
1.938TyrSer: 1.938 ± 0.092
1.452TyrThr: 1.452 ± 0.081
1.387TyrVal: 1.387 ± 0.072
0.337TyrTrp: 0.337 ± 0.037
0.799TyrTyr: 0.799 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 891 proteins (290539 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski