Amino acid dipepetide frequency for Flavivirga rizhaonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.602AlaAla: 3.602 ± 0.075
0.552AlaCys: 0.552 ± 0.022
2.958AlaAsp: 2.958 ± 0.059
3.328AlaGlu: 3.328 ± 0.058
3.199AlaPhe: 3.199 ± 0.05
3.678AlaGly: 3.678 ± 0.069
1.012AlaHis: 1.012 ± 0.027
5.319AlaIle: 5.319 ± 0.067
4.36AlaLys: 4.36 ± 0.07
5.811AlaLeu: 5.811 ± 0.076
1.315AlaMet: 1.315 ± 0.031
3.442AlaAsn: 3.442 ± 0.055
1.8AlaPro: 1.8 ± 0.045
1.978AlaGln: 1.978 ± 0.043
1.781AlaArg: 1.781 ± 0.045
4.154AlaSer: 4.154 ± 0.056
3.398AlaThr: 3.398 ± 0.061
3.548AlaVal: 3.548 ± 0.057
0.589AlaTrp: 0.589 ± 0.019
2.465AlaTyr: 2.465 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.428CysAla: 0.428 ± 0.02
0.098CysCys: 0.098 ± 0.008
0.474CysAsp: 0.474 ± 0.028
0.488CysGlu: 0.488 ± 0.02
0.471CysPhe: 0.471 ± 0.019
0.576CysGly: 0.576 ± 0.024
0.204CysHis: 0.204 ± 0.017
0.656CysIle: 0.656 ± 0.025
0.556CysLys: 0.556 ± 0.021
0.665CysLeu: 0.665 ± 0.021
0.159CysMet: 0.159 ± 0.011
0.439CysAsn: 0.439 ± 0.019
0.313CysPro: 0.313 ± 0.017
0.192CysGln: 0.192 ± 0.013
0.204CysArg: 0.204 ± 0.013
0.609CysSer: 0.609 ± 0.025
0.424CysThr: 0.424 ± 0.025
0.438CysVal: 0.438 ± 0.019
0.07CysTrp: 0.07 ± 0.008
0.32CysTyr: 0.32 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.59AspAla: 3.59 ± 0.053
0.435AspCys: 0.435 ± 0.023
3.196AspAsp: 3.196 ± 0.055
3.55AspGlu: 3.55 ± 0.054
3.711AspPhe: 3.711 ± 0.061
3.725AspGly: 3.725 ± 0.075
0.918AspHis: 0.918 ± 0.024
5.167AspIle: 5.167 ± 0.063
4.258AspLys: 4.258 ± 0.066
5.316AspLeu: 5.316 ± 0.068
1.163AspMet: 1.163 ± 0.031
3.53AspAsn: 3.53 ± 0.055
1.646AspPro: 1.646 ± 0.044
1.333AspGln: 1.333 ± 0.034
1.777AspArg: 1.777 ± 0.036
3.362AspSer: 3.362 ± 0.058
3.048AspThr: 3.048 ± 0.055
3.779AspVal: 3.779 ± 0.051
0.769AspTrp: 0.769 ± 0.024
3.051AspTyr: 3.051 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
4.308GluAla: 4.308 ± 0.072
0.353GluCys: 0.353 ± 0.018
3.701GluAsp: 3.701 ± 0.056
4.273GluGlu: 4.273 ± 0.067
2.939GluPhe: 2.939 ± 0.05
3.555GluGly: 3.555 ± 0.046
1.145GluHis: 1.145 ± 0.028
5.239GluIle: 5.239 ± 0.067
5.47GluLys: 5.47 ± 0.077
5.971GluLeu: 5.971 ± 0.079
1.293GluMet: 1.293 ± 0.033
4.653GluAsn: 4.653 ± 0.068
1.542GluPro: 1.542 ± 0.039
1.997GluGln: 1.997 ± 0.037
2.338GluArg: 2.338 ± 0.045
3.555GluSer: 3.555 ± 0.054
3.843GluThr: 3.843 ± 0.052
4.034GluVal: 4.034 ± 0.06
0.633GluTrp: 0.633 ± 0.024
2.258GluTyr: 2.258 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
2.661PheAla: 2.661 ± 0.041
0.476PheCys: 0.476 ± 0.021
3.231PheAsp: 3.231 ± 0.056
3.37PheGlu: 3.37 ± 0.054
2.785PhePhe: 2.785 ± 0.05
3.439PheGly: 3.439 ± 0.052
0.847PheHis: 0.847 ± 0.025
4.194PheIle: 4.194 ± 0.064
4.365PheLys: 4.365 ± 0.062
4.575PheLeu: 4.575 ± 0.066
1.034PheMet: 1.034 ± 0.026
3.98PheAsn: 3.98 ± 0.063
1.677PhePro: 1.677 ± 0.034
1.459PheGln: 1.459 ± 0.033
1.587PheArg: 1.587 ± 0.035
4.174PheSer: 4.174 ± 0.061
3.073PheThr: 3.073 ± 0.049
2.893PheVal: 2.893 ± 0.048
0.582PheTrp: 0.582 ± 0.02
2.16PheTyr: 2.16 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
3.874GlyAla: 3.874 ± 0.061
0.639GlyCys: 0.639 ± 0.033
3.495GlyAsp: 3.495 ± 0.059
3.435GlyGlu: 3.435 ± 0.058
3.651GlyPhe: 3.651 ± 0.059
4.407GlyGly: 4.407 ± 0.092
1.171GlyHis: 1.171 ± 0.032
5.293GlyIle: 5.293 ± 0.072
4.822GlyLys: 4.822 ± 0.071
5.68GlyLeu: 5.68 ± 0.081
1.395GlyMet: 1.395 ± 0.03
3.885GlyAsn: 3.885 ± 0.075
1.303GlyPro: 1.303 ± 0.041
1.758GlyGln: 1.758 ± 0.042
2.04GlyArg: 2.04 ± 0.044
3.954GlySer: 3.954 ± 0.07
3.994GlyThr: 3.994 ± 0.088
4.229GlyVal: 4.229 ± 0.068
0.769GlyTrp: 0.769 ± 0.025
2.865GlyTyr: 2.865 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
0.947HisAla: 0.947 ± 0.026
0.167HisCys: 0.167 ± 0.011
0.936HisAsp: 0.936 ± 0.028
0.933HisGlu: 0.933 ± 0.027
1.147HisPhe: 1.147 ± 0.029
1.097HisGly: 1.097 ± 0.03
0.493HisHis: 0.493 ± 0.024
1.602HisIle: 1.602 ± 0.039
1.293HisLys: 1.293 ± 0.036
1.792HisLeu: 1.792 ± 0.042
0.308HisMet: 0.308 ± 0.015
1.034HisAsn: 1.034 ± 0.027
0.823HisPro: 0.823 ± 0.022
0.642HisGln: 0.642 ± 0.024
0.622HisArg: 0.622 ± 0.022
1.044HisSer: 1.044 ± 0.028
0.96HisThr: 0.96 ± 0.029
1.034HisVal: 1.034 ± 0.027
0.249HisTrp: 0.249 ± 0.014
0.876HisTyr: 0.876 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.182IleAla: 5.182 ± 0.072
0.637IleCys: 0.637 ± 0.02
5.48IleAsp: 5.48 ± 0.065
5.815IleGlu: 5.815 ± 0.074
3.647IlePhe: 3.647 ± 0.054
5.213IleGly: 5.213 ± 0.079
1.368IleHis: 1.368 ± 0.032
6.875IleIle: 6.875 ± 0.098
6.867IleLys: 6.867 ± 0.083
7.29IleLeu: 7.29 ± 0.096
1.459IleMet: 1.459 ± 0.037
5.62IleAsn: 5.62 ± 0.073
3.269IlePro: 3.269 ± 0.06
2.497IleGln: 2.497 ± 0.045
2.542IleArg: 2.542 ± 0.037
6.102IleSer: 6.102 ± 0.064
5.166IleThr: 5.166 ± 0.074
4.906IleVal: 4.906 ± 0.071
0.729IleTrp: 0.729 ± 0.025
3.105IleTyr: 3.105 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.838LysAla: 4.838 ± 0.062
0.374LysCys: 0.374 ± 0.018
4.926LysAsp: 4.926 ± 0.058
6.222LysGlu: 6.222 ± 0.087
3.037LysPhe: 3.037 ± 0.054
4.708LysGly: 4.708 ± 0.057
1.665LysHis: 1.665 ± 0.041
6.525LysIle: 6.525 ± 0.078
7.429LysLys: 7.429 ± 0.096
6.956LysLeu: 6.956 ± 0.077
1.883LysMet: 1.883 ± 0.04
5.846LysAsn: 5.846 ± 0.081
2.59LysPro: 2.59 ± 0.049
2.911LysGln: 2.911 ± 0.056
3.191LysArg: 3.191 ± 0.057
4.961LysSer: 4.961 ± 0.064
5.14LysThr: 5.14 ± 0.065
4.638LysVal: 4.638 ± 0.057
0.85LysTrp: 0.85 ± 0.024
3.266LysTyr: 3.266 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
5.088LeuAla: 5.088 ± 0.077
0.693LeuCys: 0.693 ± 0.026
5.1LeuAsp: 5.1 ± 0.063
6.041LeuGlu: 6.041 ± 0.07
5.018LeuPhe: 5.018 ± 0.069
5.638LeuGly: 5.638 ± 0.08
1.485LeuHis: 1.485 ± 0.038
7.304LeuIle: 7.304 ± 0.094
8.387LeuLys: 8.387 ± 0.096
8.557LeuLeu: 8.557 ± 0.101
1.88LeuMet: 1.88 ± 0.047
6.262LeuAsn: 6.262 ± 0.073
3.32LeuPro: 3.32 ± 0.053
2.842LeuGln: 2.842 ± 0.052
2.968LeuArg: 2.968 ± 0.049
6.829LeuSer: 6.829 ± 0.08
4.953LeuThr: 4.953 ± 0.07
5.171LeuVal: 5.171 ± 0.071
0.822LeuTrp: 0.822 ± 0.025
3.322LeuTyr: 3.322 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
1.371MetAla: 1.371 ± 0.037
0.15MetCys: 0.15 ± 0.011
1.001MetAsp: 1.001 ± 0.029
1.135MetGlu: 1.135 ± 0.03
0.871MetPhe: 0.871 ± 0.03
1.253MetGly: 1.253 ± 0.031
0.418MetHis: 0.418 ± 0.017
1.475MetIle: 1.475 ± 0.036
2.066MetLys: 2.066 ± 0.043
1.78MetLeu: 1.78 ± 0.035
0.49MetMet: 0.49 ± 0.02
1.236MetAsn: 1.236 ± 0.029
0.77MetPro: 0.77 ± 0.027
0.707MetGln: 0.707 ± 0.023
0.716MetArg: 0.716 ± 0.023
1.402MetSer: 1.402 ± 0.032
1.102MetThr: 1.102 ± 0.031
1.221MetVal: 1.221 ± 0.03
0.158MetTrp: 0.158 ± 0.011
0.731MetTyr: 0.731 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.761AsnAla: 3.761 ± 0.055
0.495AsnCys: 0.495 ± 0.02
3.874AsnAsp: 3.874 ± 0.05
3.954AsnGlu: 3.954 ± 0.058
3.174AsnPhe: 3.174 ± 0.055
4.335AsnGly: 4.335 ± 0.07
1.175AsnHis: 1.175 ± 0.027
5.766AsnIle: 5.766 ± 0.074
5.384AsnLys: 5.384 ± 0.071
5.766AsnLeu: 5.766 ± 0.079
1.334AsnMet: 1.334 ± 0.033
4.955AsnAsn: 4.955 ± 0.091
2.738AsnPro: 2.738 ± 0.054
2.255AsnGln: 2.255 ± 0.048
2.314AsnArg: 2.314 ± 0.042
4.301AsnSer: 4.301 ± 0.069
4.274AsnThr: 4.274 ± 0.079
3.684AsnVal: 3.684 ± 0.063
0.843AsnTrp: 0.843 ± 0.023
3.153AsnTyr: 3.153 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
1.677ProAla: 1.677 ± 0.047
0.239ProCys: 0.239 ± 0.013
2.001ProAsp: 2.001 ± 0.036
2.645ProGlu: 2.645 ± 0.052
1.855ProPhe: 1.855 ± 0.032
1.796ProGly: 1.796 ± 0.048
0.613ProHis: 0.613 ± 0.018
2.805ProIle: 2.805 ± 0.049
2.64ProLys: 2.64 ± 0.044
2.862ProLeu: 2.862 ± 0.049
0.618ProMet: 0.618 ± 0.022
2.455ProAsn: 2.455 ± 0.047
0.808ProPro: 0.808 ± 0.032
1.01ProGln: 1.01 ± 0.027
0.922ProArg: 0.922 ± 0.026
2.143ProSer: 2.143 ± 0.046
1.914ProThr: 1.914 ± 0.049
2.14ProVal: 2.14 ± 0.046
0.369ProTrp: 0.369 ± 0.017
1.38ProTyr: 1.38 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
1.777GlnAla: 1.777 ± 0.037
0.176GlnCys: 0.176 ± 0.012
1.657GlnAsp: 1.657 ± 0.035
2.101GlnGlu: 2.101 ± 0.048
1.588GlnPhe: 1.588 ± 0.037
1.721GlnGly: 1.721 ± 0.038
0.545GlnHis: 0.545 ± 0.02
2.593GlnIle: 2.593 ± 0.041
2.556GlnLys: 2.556 ± 0.05
3.21GlnLeu: 3.21 ± 0.05
0.659GlnMet: 0.659 ± 0.02
2.129GlnAsn: 2.129 ± 0.04
0.993GlnPro: 0.993 ± 0.028
1.204GlnGln: 1.204 ± 0.037
1.09GlnArg: 1.09 ± 0.029
1.832GlnSer: 1.832 ± 0.033
1.811GlnThr: 1.811 ± 0.039
1.792GlnVal: 1.792 ± 0.044
0.344GlnTrp: 0.344 ± 0.018
1.265GlnTyr: 1.265 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.005ArgAla: 2.005 ± 0.046
0.2ArgCys: 0.2 ± 0.013
1.813ArgAsp: 1.813 ± 0.038
1.936ArgGlu: 1.936 ± 0.044
1.909ArgPhe: 1.909 ± 0.038
1.992ArgGly: 1.992 ± 0.044
0.63ArgHis: 0.63 ± 0.02
2.826ArgIle: 2.826 ± 0.041
2.698ArgLys: 2.698 ± 0.051
3.198ArgLeu: 3.198 ± 0.05
0.729ArgMet: 0.729 ± 0.023
2.095ArgAsn: 2.095 ± 0.039
1.05ArgPro: 1.05 ± 0.026
1.031ArgGln: 1.031 ± 0.029
1.297ArgArg: 1.297 ± 0.034
1.907ArgSer: 1.907 ± 0.043
1.733ArgThr: 1.733 ± 0.04
2.07ArgVal: 2.07 ± 0.041
0.415ArgTrp: 0.415 ± 0.015
1.501ArgTyr: 1.501 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
3.432SerAla: 3.432 ± 0.054
0.686SerCys: 0.686 ± 0.021
3.673SerAsp: 3.673 ± 0.061
4.013SerGlu: 4.013 ± 0.061
3.927SerPhe: 3.927 ± 0.054
4.693SerGly: 4.693 ± 0.075
1.204SerHis: 1.204 ± 0.029
5.959SerIle: 5.959 ± 0.069
5.579SerLys: 5.579 ± 0.068
6.033SerLeu: 6.033 ± 0.077
1.206SerMet: 1.206 ± 0.033
4.541SerAsn: 4.541 ± 0.068
2.084SerPro: 2.084 ± 0.046
2.091SerGln: 2.091 ± 0.041
2.131SerArg: 2.131 ± 0.046
4.556SerSer: 4.556 ± 0.075
3.678SerThr: 3.678 ± 0.068
3.942SerVal: 3.942 ± 0.053
0.736SerTrp: 0.736 ± 0.023
2.843SerTyr: 2.843 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
3.325ThrAla: 3.325 ± 0.074
0.412ThrCys: 0.412 ± 0.021
3.338ThrAsp: 3.338 ± 0.066
3.222ThrGlu: 3.222 ± 0.049
3.145ThrPhe: 3.145 ± 0.055
3.932ThrGly: 3.932 ± 0.083
1.055ThrHis: 1.055 ± 0.03
5.418ThrIle: 5.418 ± 0.075
4.171ThrLys: 4.171 ± 0.055
5.529ThrLeu: 5.529 ± 0.068
0.945ThrMet: 0.945 ± 0.025
3.779ThrAsn: 3.779 ± 0.072
2.46ThrPro: 2.46 ± 0.055
1.779ThrGln: 1.779 ± 0.039
1.639ThrArg: 1.639 ± 0.036
4.154ThrSer: 4.154 ± 0.069
3.678ThrThr: 3.678 ± 0.074
3.661ThrVal: 3.661 ± 0.069
0.589ThrTrp: 0.589 ± 0.025
2.581ThrTyr: 2.581 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
3.561ValAla: 3.561 ± 0.059
0.521ValCys: 0.521 ± 0.022
3.452ValAsp: 3.452 ± 0.055
3.658ValGlu: 3.658 ± 0.059
3.434ValPhe: 3.434 ± 0.055
3.546ValGly: 3.546 ± 0.06
0.951ValHis: 0.951 ± 0.025
4.998ValIle: 4.998 ± 0.068
4.501ValLys: 4.501 ± 0.062
5.817ValLeu: 5.817 ± 0.07
1.175ValMet: 1.175 ± 0.029
3.784ValAsn: 3.784 ± 0.056
1.983ValPro: 1.983 ± 0.039
1.551ValGln: 1.551 ± 0.033
1.851ValArg: 1.851 ± 0.041
4.561ValSer: 4.561 ± 0.056
3.561ValThr: 3.561 ± 0.075
3.678ValVal: 3.678 ± 0.062
0.645ValTrp: 0.645 ± 0.024
2.444ValTyr: 2.444 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.566TrpAla: 0.566 ± 0.021
0.126TrpCys: 0.126 ± 0.009
0.649TrpAsp: 0.649 ± 0.022
0.668TrpGlu: 0.668 ± 0.021
0.589TrpPhe: 0.589 ± 0.023
0.734TrpGly: 0.734 ± 0.028
0.252TrpHis: 0.252 ± 0.014
0.748TrpIle: 0.748 ± 0.028
0.875TrpLys: 0.875 ± 0.028
0.988TrpLeu: 0.988 ± 0.026
0.279TrpMet: 0.279 ± 0.016
0.774TrpAsn: 0.774 ± 0.028
0.245TrpPro: 0.245 ± 0.014
0.419TrpGln: 0.419 ± 0.018
0.396TrpArg: 0.396 ± 0.018
0.653TrpSer: 0.653 ± 0.022
0.585TrpThr: 0.585 ± 0.025
0.663TrpVal: 0.663 ± 0.023
0.157TrpTrp: 0.157 ± 0.01
0.467TrpTyr: 0.467 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.298TyrAla: 2.298 ± 0.038
0.353TyrCys: 0.353 ± 0.016
2.371TyrAsp: 2.371 ± 0.049
2.312TyrGlu: 2.312 ± 0.044
2.468TyrPhe: 2.468 ± 0.047
2.62TyrGly: 2.62 ± 0.051
0.849TyrHis: 0.849 ± 0.024
3.007TyrIle: 3.007 ± 0.049
3.677TyrLys: 3.677 ± 0.06
3.885TyrLeu: 3.885 ± 0.061
0.731TyrMet: 0.731 ± 0.022
3.096TyrAsn: 3.096 ± 0.053
1.476TyrPro: 1.476 ± 0.034
1.389TyrGln: 1.389 ± 0.035
1.628TyrArg: 1.628 ± 0.037
2.754TyrSer: 2.754 ± 0.055
2.477TyrThr: 2.477 ± 0.054
2.152TyrVal: 2.152 ± 0.039
0.512TyrTrp: 0.512 ± 0.022
1.95TyrTyr: 1.95 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4045 proteins (1423285 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski