Amino acid dipepetide frequency for Ferrimonas lipolytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.408AlaAla: 10.408 ± 0.134	1.067AlaCys: 1.067 ± 0.034	5.656AlaAsp: 5.656 ± 0.087	6.426AlaGlu: 6.426 ± 0.092	3.081AlaPhe: 3.081 ± 0.055	7.007AlaGly: 7.007 ± 0.087	1.748AlaHis: 1.748 ± 0.041	6.035AlaIle: 6.035 ± 0.081	4.878AlaLys: 4.878 ± 0.084	10.908AlaLeu: 10.908 ± 0.143	2.961AlaMet: 2.961 ± 0.053	3.974AlaAsn: 3.974 ± 0.079	3.638AlaPro: 3.638 ± 0.077	5.01AlaGln: 5.01 ± 0.084	4.096AlaArg: 4.096 ± 0.066	5.464AlaSer: 5.464 ± 0.076	5.363AlaThr: 5.363 ± 0.076	6.784AlaVal: 6.784 ± 0.092	1.031AlaTrp: 1.031 ± 0.036	2.249AlaTyr: 2.249 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.955CysAla: 0.955 ± 0.031	0.215CysCys: 0.215 ± 0.015	0.645CysAsp: 0.645 ± 0.028	0.569CysGlu: 0.569 ± 0.026	0.389CysPhe: 0.389 ± 0.019	1.044CysGly: 1.044 ± 0.034	0.621CysHis: 0.621 ± 0.033	0.576CysIle: 0.576 ± 0.022	0.376CysLys: 0.376 ± 0.021	0.966CysLeu: 0.966 ± 0.029	0.244CysMet: 0.244 ± 0.015	0.434CysAsn: 0.434 ± 0.021	0.563CysPro: 0.563 ± 0.03	0.591CysGln: 0.591 ± 0.022	0.555CysArg: 0.555 ± 0.021	0.772CysSer: 0.772 ± 0.023	0.503CysThr: 0.503 ± 0.021	0.672CysVal: 0.672 ± 0.027	0.159CysTrp: 0.159 ± 0.014	0.326CysTyr: 0.326 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.173AspAla: 5.173 ± 0.098	0.594AspCys: 0.594 ± 0.023	3.476AspAsp: 3.476 ± 0.091	3.579AspGlu: 3.579 ± 0.062	2.243AspPhe: 2.243 ± 0.042	4.694AspGly: 4.694 ± 0.116	1.164AspHis: 1.164 ± 0.036	3.316AspIle: 3.316 ± 0.069	2.787AspLys: 2.787 ± 0.053	5.202AspLeu: 5.202 ± 0.071	1.42AspMet: 1.42 ± 0.04	2.714AspAsn: 2.714 ± 0.056	2.334AspPro: 2.334 ± 0.046	2.301AspGln: 2.301 ± 0.051	2.438AspArg: 2.438 ± 0.051	3.732AspSer: 3.732 ± 0.105	2.679AspThr: 2.679 ± 0.116	3.627AspVal: 3.627 ± 0.063	0.876AspTrp: 0.876 ± 0.03	2.025AspTyr: 2.025 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.284GluAla: 5.284 ± 0.084	0.494GluCys: 0.494 ± 0.021	2.473GluAsp: 2.473 ± 0.06	2.706GluGlu: 2.706 ± 0.063	2.142GluPhe: 2.142 ± 0.04	3.322GluGly: 3.322 ± 0.059	1.556GluHis: 1.556 ± 0.039	3.218GluIle: 3.218 ± 0.059	2.191GluLys: 2.191 ± 0.048	7.738GluLeu: 7.738 ± 0.107	1.552GluMet: 1.552 ± 0.037	1.746GluAsn: 1.746 ± 0.037	2.307GluPro: 2.307 ± 0.056	5.106GluGln: 5.106 ± 0.09	3.639GluArg: 3.639 ± 0.067	2.998GluSer: 2.998 ± 0.054	2.62GluThr: 2.62 ± 0.05	4.281GluVal: 4.281 ± 0.068	0.621GluTrp: 0.621 ± 0.02	1.466GluTyr: 1.466 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.767PheAla: 3.767 ± 0.06	0.449PheCys: 0.449 ± 0.02	2.75PheAsp: 2.75 ± 0.052	2.426PheGlu: 2.426 ± 0.051	1.37PhePhe: 1.37 ± 0.046	3.37PheGly: 3.37 ± 0.066	0.759PheHis: 0.759 ± 0.025	2.169PheIle: 2.169 ± 0.045	1.473PheLys: 1.473 ± 0.038	2.742PheLeu: 2.742 ± 0.061	0.897PheMet: 0.897 ± 0.031	1.878PheAsn: 1.878 ± 0.065	1.258PhePro: 1.258 ± 0.039	1.187PheGln: 1.187 ± 0.033	1.511PheArg: 1.511 ± 0.035	2.923PheSer: 2.923 ± 0.052	2.122PheThr: 2.122 ± 0.051	2.535PheVal: 2.535 ± 0.053	0.484PheTrp: 0.484 ± 0.022	1.119PheTyr: 1.119 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.211GlyAla: 6.211 ± 0.089	1.077GlyCys: 1.077 ± 0.032	4.185GlyAsp: 4.185 ± 0.087	4.374GlyGlu: 4.374 ± 0.058	3.277GlyPhe: 3.277 ± 0.063	5.196GlyGly: 5.196 ± 0.085	1.733GlyHis: 1.733 ± 0.042	4.468GlyIle: 4.468 ± 0.074	3.772GlyLys: 3.772 ± 0.061	7.421GlyLeu: 7.421 ± 0.104	2.081GlyMet: 2.081 ± 0.048	2.864GlyAsn: 2.864 ± 0.065	1.875GlyPro: 1.875 ± 0.039	3.332GlyGln: 3.332 ± 0.063	3.445GlyArg: 3.445 ± 0.063	4.484GlySer: 4.484 ± 0.076	3.594GlyThr: 3.594 ± 0.115	5.343GlyVal: 5.343 ± 0.08	1.05GlyTrp: 1.05 ± 0.032	2.555GlyTyr: 2.555 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.709HisAla: 1.709 ± 0.042	0.395HisCys: 0.395 ± 0.019	1.162HisAsp: 1.162 ± 0.036	0.949HisGlu: 0.949 ± 0.03	1.068HisPhe: 1.068 ± 0.03	1.921HisGly: 1.921 ± 0.041	0.856HisHis: 0.856 ± 0.033	1.273HisIle: 1.273 ± 0.034	0.922HisLys: 0.922 ± 0.031	2.238HisLeu: 2.238 ± 0.051	0.468HisMet: 0.468 ± 0.022	1.05HisAsn: 1.05 ± 0.03	1.177HisPro: 1.177 ± 0.031	1.648HisGln: 1.648 ± 0.044	1.262HisArg: 1.262 ± 0.04	1.572HisSer: 1.572 ± 0.039	1.057HisThr: 1.057 ± 0.031	1.16HisVal: 1.16 ± 0.032	0.417HisTrp: 0.417 ± 0.017	0.893HisTyr: 0.893 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.369IleAla: 6.369 ± 0.082	0.661IleCys: 0.661 ± 0.027	4.302IleAsp: 4.302 ± 0.067	4.332IleGlu: 4.332 ± 0.067	1.635IlePhe: 1.635 ± 0.039	4.705IleGly: 4.705 ± 0.075	1.159IleHis: 1.159 ± 0.032	2.88IleIle: 2.88 ± 0.066	2.433IleLys: 2.433 ± 0.057	4.322IleLeu: 4.322 ± 0.061	1.117IleMet: 1.117 ± 0.035	2.829IleAsn: 2.829 ± 0.057	2.176IlePro: 2.176 ± 0.044	1.77IleGln: 1.77 ± 0.034	2.557IleArg: 2.557 ± 0.053	3.963IleSer: 3.963 ± 0.061	3.353IleThr: 3.353 ± 0.057	3.613IleVal: 3.613 ± 0.066	0.565IleTrp: 0.565 ± 0.023	1.461IleTyr: 1.461 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.201LysAla: 4.201 ± 0.074	0.308LysCys: 0.308 ± 0.02	1.941LysAsp: 1.941 ± 0.051	2.149LysGlu: 2.149 ± 0.046	1.239LysPhe: 1.239 ± 0.035	2.668LysGly: 2.668 ± 0.055	1.025LysHis: 1.025 ± 0.033	2.158LysIle: 2.158 ± 0.051	1.875LysLys: 1.875 ± 0.051	4.829LysLeu: 4.829 ± 0.072	1.248LysMet: 1.248 ± 0.037	1.33LysAsn: 1.33 ± 0.037	2.227LysPro: 2.227 ± 0.046	2.813LysGln: 2.813 ± 0.053	2.569LysArg: 2.569 ± 0.049	2.459LysSer: 2.459 ± 0.05	2.178LysThr: 2.178 ± 0.048	3.425LysVal: 3.425 ± 0.061	0.532LysTrp: 0.532 ± 0.022	1.063LysTyr: 1.063 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.974LeuAla: 11.974 ± 0.152	1.175LeuCys: 1.175 ± 0.036	5.883LeuAsp: 5.883 ± 0.08	5.907LeuGlu: 5.907 ± 0.089	3.966LeuPhe: 3.966 ± 0.082	7.244LeuGly: 7.244 ± 0.099	2.21LeuHis: 2.21 ± 0.049	5.556LeuIle: 5.556 ± 0.076	4.355LeuLys: 4.355 ± 0.065	12.333LeuLeu: 12.333 ± 0.197	2.814LeuMet: 2.814 ± 0.058	4.2LeuAsn: 4.2 ± 0.064	5.272LeuPro: 5.272 ± 0.079	5.169LeuGln: 5.169 ± 0.104	5.005LeuArg: 5.005 ± 0.077	7.448LeuSer: 7.448 ± 0.088	6.471LeuThr: 6.471 ± 0.104	7.439LeuVal: 7.439 ± 0.093	1.28LeuTrp: 1.28 ± 0.038	2.566LeuTyr: 2.566 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.061MetAla: 3.061 ± 0.067	0.206MetCys: 0.206 ± 0.014	1.328MetAsp: 1.328 ± 0.037	1.31MetGlu: 1.31 ± 0.036	0.84MetPhe: 0.84 ± 0.025	1.853MetGly: 1.853 ± 0.044	0.484MetHis: 0.484 ± 0.022	1.298MetIle: 1.298 ± 0.034	1.28MetLys: 1.28 ± 0.031	2.95MetLeu: 2.95 ± 0.059	0.907MetMet: 0.907 ± 0.03	0.98MetAsn: 0.98 ± 0.029	1.296MetPro: 1.296 ± 0.036	1.165MetGln: 1.165 ± 0.031	1.237MetArg: 1.237 ± 0.036	1.855MetSer: 1.855 ± 0.04	1.601MetThr: 1.601 ± 0.037	2.098MetVal: 2.098 ± 0.049	0.256MetTrp: 0.256 ± 0.014	0.446MetTyr: 0.446 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.469AsnAla: 3.469 ± 0.065	0.494AsnCys: 0.494 ± 0.022	2.439AsnAsp: 2.439 ± 0.101	2.08AsnGlu: 2.08 ± 0.05	1.403AsnPhe: 1.403 ± 0.047	3.292AsnGly: 3.292 ± 0.071	0.974AsnHis: 0.974 ± 0.027	2.218AsnIle: 2.218 ± 0.047	1.65AsnLys: 1.65 ± 0.039	3.799AsnLeu: 3.799 ± 0.062	0.914AsnMet: 0.914 ± 0.033	1.855AsnAsn: 1.855 ± 0.041	2.078AsnPro: 2.078 ± 0.048	2.132AsnGln: 2.132 ± 0.041	2.059AsnArg: 2.059 ± 0.045	2.481AsnSer: 2.481 ± 0.061	1.934AsnThr: 1.934 ± 0.048	2.45AsnVal: 2.45 ± 0.047	0.596AsnTrp: 0.596 ± 0.027	1.337AsnTyr: 1.337 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.912ProAla: 3.912 ± 0.07	0.337ProCys: 0.337 ± 0.015	2.159ProAsp: 2.159 ± 0.049	3.039ProGlu: 3.039 ± 0.058	1.626ProPhe: 1.626 ± 0.037	2.406ProGly: 2.406 ± 0.046	0.91ProHis: 0.91 ± 0.03	2.348ProIle: 2.348 ± 0.051	1.92ProLys: 1.92 ± 0.044	4.912ProLeu: 4.912 ± 0.079	1.176ProMet: 1.176 ± 0.034	1.679ProAsn: 1.679 ± 0.045	1.241ProPro: 1.241 ± 0.044	2.26ProGln: 2.26 ± 0.058	1.568ProArg: 1.568 ± 0.046	2.551ProSer: 2.551 ± 0.051	2.403ProThr: 2.403 ± 0.05	3.169ProVal: 3.169 ± 0.066	0.602ProTrp: 0.602 ± 0.023	1.205ProTyr: 1.205 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.15GlnAla: 5.15 ± 0.084	0.501GlnCys: 0.501 ± 0.022	1.974GlnAsp: 1.974 ± 0.042	2.052GlnGlu: 2.052 ± 0.044	2.161GlnPhe: 2.161 ± 0.051	3.435GlnGly: 3.435 ± 0.056	1.649GlnHis: 1.649 ± 0.046	2.746GlnIle: 2.746 ± 0.051	1.483GlnLys: 1.483 ± 0.04	7.709GlnLeu: 7.709 ± 0.155	1.393GlnMet: 1.393 ± 0.04	1.297GlnAsn: 1.297 ± 0.037	2.522GlnPro: 2.522 ± 0.053	6.01GlnGln: 6.01 ± 0.171	3.522GlnArg: 3.522 ± 0.066	2.809GlnSer: 2.809 ± 0.058	2.352GlnThr: 2.352 ± 0.044	3.477GlnVal: 3.477 ± 0.063	1.014GlnTrp: 1.014 ± 0.032	1.385GlnTyr: 1.385 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	4.102ArgAla: 4.102 ± 0.066	0.615ArgCys: 0.615 ± 0.022	2.627ArgAsp: 2.627 ± 0.052	2.57ArgGlu: 2.57 ± 0.049	2.332ArgPhe: 2.332 ± 0.044	3.02ArgGly: 3.02 ± 0.056	1.348ArgHis: 1.348 ± 0.039	2.914ArgIle: 2.914 ± 0.047	1.951ArgLys: 1.951 ± 0.044	5.669ArgLeu: 5.669 ± 0.083	1.292ArgMet: 1.292 ± 0.035	1.963ArgAsn: 1.963 ± 0.043	1.823ArgPro: 1.823 ± 0.042	2.992ArgGln: 2.992 ± 0.061	2.907ArgArg: 2.907 ± 0.066	2.852ArgSer: 2.852 ± 0.047	2.295ArgThr: 2.295 ± 0.045	3.215ArgVal: 3.215 ± 0.055	0.76ArgTrp: 0.76 ± 0.028	1.904ArgTyr: 1.904 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.864SerAla: 5.864 ± 0.084	0.776SerCys: 0.776 ± 0.032	3.667SerAsp: 3.667 ± 0.093	3.376SerGlu: 3.376 ± 0.058	2.519SerPhe: 2.519 ± 0.06	5.156SerGly: 5.156 ± 0.072	1.548SerHis: 1.548 ± 0.039	3.498SerIle: 3.498 ± 0.061	2.613SerLys: 2.613 ± 0.051	6.513SerLeu: 6.513 ± 0.079	1.702SerMet: 1.702 ± 0.032	2.647SerAsn: 2.647 ± 0.06	2.303SerPro: 2.303 ± 0.045	2.914SerGln: 2.914 ± 0.053	2.894SerArg: 2.894 ± 0.05	4.115SerSer: 4.115 ± 0.072	3.086SerThr: 3.086 ± 0.056	4.391SerVal: 4.391 ± 0.102	0.928SerTrp: 0.928 ± 0.025	2.008SerTyr: 2.008 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	5.172ThrAla: 5.172 ± 0.075	0.495ThrCys: 0.495 ± 0.022	3.055ThrAsp: 3.055 ± 0.088	3.212ThrGlu: 3.212 ± 0.051	1.825ThrPhe: 1.825 ± 0.049	4.013ThrGly: 4.013 ± 0.069	0.977ThrHis: 0.977 ± 0.03	3.323ThrIle: 3.323 ± 0.069	2.07ThrLys: 2.07 ± 0.047	6.032ThrLeu: 6.032 ± 0.091	1.283ThrMet: 1.283 ± 0.031	1.915ThrAsn: 1.915 ± 0.043	2.644ThrPro: 2.644 ± 0.049	2.307ThrGln: 2.307 ± 0.063	2.104ThrArg: 2.104 ± 0.045	3.009ThrSer: 3.009 ± 0.062	3.095ThrThr: 3.095 ± 0.066	4.259ThrVal: 4.259 ± 0.076	0.536ThrTrp: 0.536 ± 0.024	1.21ThrTyr: 1.21 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.839ValAla: 7.839 ± 0.102	0.754ValCys: 0.754 ± 0.03	4.384ValAsp: 4.384 ± 0.064	4.672ValGlu: 4.672 ± 0.074	2.321ValPhe: 2.321 ± 0.053	4.898ValGly: 4.898 ± 0.076	1.253ValHis: 1.253 ± 0.029	4.377ValIle: 4.377 ± 0.07	2.923ValLys: 2.923 ± 0.066	6.839ValLeu: 6.839 ± 0.084	2.066ValMet: 2.066 ± 0.045	2.866ValAsn: 2.866 ± 0.066	2.777ValPro: 2.777 ± 0.044	2.443ValGln: 2.443 ± 0.048	3.097ValArg: 3.097 ± 0.056	4.475ValSer: 4.475 ± 0.075	4.103ValThr: 4.103 ± 0.064	5.811ValVal: 5.811 ± 0.092	0.752ValTrp: 0.752 ± 0.028	1.569ValTyr: 1.569 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.927TrpAla: 0.927 ± 0.033	0.184TrpCys: 0.184 ± 0.011	0.618TrpAsp: 0.618 ± 0.026	0.479TrpGlu: 0.479 ± 0.02	0.598TrpPhe: 0.598 ± 0.024	0.836TrpGly: 0.836 ± 0.03	0.423TrpHis: 0.423 ± 0.018	0.573TrpIle: 0.573 ± 0.023	0.339TrpLys: 0.339 ± 0.02	1.998TrpLeu: 1.998 ± 0.05	0.332TrpMet: 0.332 ± 0.018	0.425TrpAsn: 0.425 ± 0.021	0.594TrpPro: 0.594 ± 0.023	1.335TrpGln: 1.335 ± 0.044	0.793TrpArg: 0.793 ± 0.027	0.73TrpSer: 0.73 ± 0.026	0.488TrpThr: 0.488 ± 0.023	0.795TrpVal: 0.795 ± 0.028	0.24TrpTrp: 0.24 ± 0.016	0.386TrpTyr: 0.386 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.237TyrAla: 2.237 ± 0.047	0.379TyrCys: 0.379 ± 0.017	1.648TyrAsp: 1.648 ± 0.046	1.254TyrGlu: 1.254 ± 0.035	1.154TyrPhe: 1.154 ± 0.031	2.257TyrGly: 2.257 ± 0.046	0.801TyrHis: 0.801 ± 0.026	1.26TyrIle: 1.26 ± 0.033	0.946TyrLys: 0.946 ± 0.031	3.147TyrLeu: 3.147 ± 0.067	0.584TyrMet: 0.584 ± 0.022	1.007TyrAsn: 1.007 ± 0.034	1.316TyrPro: 1.316 ± 0.039	2.154TyrGln: 2.154 ± 0.055	1.894TyrArg: 1.894 ± 0.042	1.827TyrSer: 1.827 ± 0.046	1.237TyrThr: 1.237 ± 0.063	1.676TyrVal: 1.676 ± 0.039	0.395TyrTrp: 0.395 ± 0.021	0.92TyrTyr: 0.92 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3539 proteins (1156617 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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