Amino acid dipepetide frequency for Momordica charantia (Bitter gourd) (Balsam pear)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.695AlaAla: 6.695 ± 0.04	1.24AlaCys: 1.24 ± 0.013	3.192AlaAsp: 3.192 ± 0.019	4.323AlaGlu: 4.323 ± 0.024	2.802AlaPhe: 2.802 ± 0.016	4.097AlaGly: 4.097 ± 0.021	1.347AlaHis: 1.347 ± 0.011	3.94AlaIle: 3.94 ± 0.023	3.828AlaLys: 3.828 ± 0.02	6.731AlaLeu: 6.731 ± 0.031	1.793AlaMet: 1.793 ± 0.014	2.608AlaAsn: 2.608 ± 0.014	2.814AlaPro: 2.814 ± 0.019	2.063AlaGln: 2.063 ± 0.016	3.471AlaArg: 3.471 ± 0.019	6.174AlaSer: 6.174 ± 0.027	3.579AlaThr: 3.579 ± 0.02	4.915AlaVal: 4.915 ± 0.027	0.747AlaTrp: 0.747 ± 0.008	1.796AlaTyr: 1.796 ± 0.014	0.018AlaXaa: 0.018 ± 0.002
Cys	1.001CysAla: 1.001 ± 0.011	0.516CysCys: 0.516 ± 0.009	0.869CysAsp: 0.869 ± 0.01	0.918CysGlu: 0.918 ± 0.011	0.889CysPhe: 0.889 ± 0.009	1.418CysGly: 1.418 ± 0.013	0.465CysHis: 0.465 ± 0.007	1.036CysIle: 1.036 ± 0.009	1.112CysLys: 1.112 ± 0.013	1.879CysLeu: 1.879 ± 0.014	0.426CysMet: 0.426 ± 0.006	0.853CysAsn: 0.853 ± 0.01	0.912CysPro: 0.912 ± 0.009	0.595CysGln: 0.595 ± 0.007	1.098CysArg: 1.098 ± 0.011	1.979CysSer: 1.979 ± 0.016	0.832CysThr: 0.832 ± 0.011	1.02CysVal: 1.02 ± 0.011	0.235CysTrp: 0.235 ± 0.005	0.553CysTyr: 0.553 ± 0.008	0.005CysXaa: 0.005 ± 0.001
Asp	3.565AspAla: 3.565 ± 0.02	0.998AspCys: 0.998 ± 0.01	3.62AspAsp: 3.62 ± 0.024	4.018AspGlu: 4.018 ± 0.022	2.401AspPhe: 2.401 ± 0.015	3.919AspGly: 3.919 ± 0.021	1.28AspHis: 1.28 ± 0.011	3.053AspIle: 3.053 ± 0.016	2.662AspLys: 2.662 ± 0.016	5.115AspLeu: 5.115 ± 0.024	1.29AspMet: 1.29 ± 0.01	2.033AspAsn: 2.033 ± 0.013	2.591AspPro: 2.591 ± 0.016	1.815AspGln: 1.815 ± 0.014	2.524AspArg: 2.524 ± 0.018	4.46AspSer: 4.46 ± 0.025	2.087AspThr: 2.087 ± 0.015	3.642AspVal: 3.642 ± 0.021	0.722AspTrp: 0.722 ± 0.008	1.555AspTyr: 1.555 ± 0.013	0.014AspXaa: 0.014 ± 0.001
Glu	4.902GluAla: 4.902 ± 0.024	0.908GluCys: 0.908 ± 0.01	4.037GluAsp: 4.037 ± 0.019	6.175GluGlu: 6.175 ± 0.036	2.43GluPhe: 2.43 ± 0.015	3.693GluGly: 3.693 ± 0.018	1.242GluHis: 1.242 ± 0.01	3.882GluIle: 3.882 ± 0.022	4.829GluLys: 4.829 ± 0.027	6.113GluLeu: 6.113 ± 0.027	1.784GluMet: 1.784 ± 0.015	3.261GluAsn: 3.261 ± 0.021	2.141GluPro: 2.141 ± 0.016	2.16GluGln: 2.16 ± 0.018	3.558GluArg: 3.558 ± 0.021	4.679GluSer: 4.679 ± 0.025	3.095GluThr: 3.095 ± 0.018	4.247GluVal: 4.247 ± 0.02	0.72GluTrp: 0.72 ± 0.008	1.651GluTyr: 1.651 ± 0.012	0.017GluXaa: 0.017 ± 0.001
Phe	2.501PheAla: 2.501 ± 0.017	0.953PheCys: 0.953 ± 0.01	2.441PheAsp: 2.441 ± 0.016	2.367PheGlu: 2.367 ± 0.016	1.979PhePhe: 1.979 ± 0.017	3.1PheGly: 3.1 ± 0.019	1.183PheHis: 1.183 ± 0.011	2.13PheIle: 2.13 ± 0.014	2.131PheLys: 2.131 ± 0.013	4.372PheLeu: 4.372 ± 0.022	0.948PheMet: 0.948 ± 0.009	1.779PheAsn: 1.779 ± 0.012	2.149PhePro: 2.149 ± 0.014	1.639PheGln: 1.639 ± 0.012	2.188PheArg: 2.188 ± 0.016	4.23PheSer: 4.23 ± 0.02	1.934PheThr: 1.934 ± 0.014	2.749PheVal: 2.749 ± 0.017	0.581PheTrp: 0.581 ± 0.008	1.26PheTyr: 1.26 ± 0.011	0.012PheXaa: 0.012 ± 0.001
Gly	3.941GlyAla: 3.941 ± 0.024	1.309GlyCys: 1.309 ± 0.011	3.398GlyAsp: 3.398 ± 0.02	3.714GlyGlu: 3.714 ± 0.019	3.142GlyPhe: 3.142 ± 0.02	5.245GlyGly: 5.245 ± 0.044	1.519GlyHis: 1.519 ± 0.013	3.661GlyIle: 3.661 ± 0.02	4.029GlyLys: 4.029 ± 0.021	5.848GlyLeu: 5.848 ± 0.028	1.476GlyMet: 1.476 ± 0.012	3.096GlyAsn: 3.096 ± 0.018	2.342GlyPro: 2.342 ± 0.014	2.043GlyGln: 2.043 ± 0.015	3.785GlyArg: 3.785 ± 0.02	6.021GlySer: 6.021 ± 0.031	3.105GlyThr: 3.105 ± 0.017	4.048GlyVal: 4.048 ± 0.02	0.883GlyTrp: 0.883 ± 0.01	2.01GlyTyr: 2.01 ± 0.016	0.017GlyXaa: 0.017 ± 0.001
His	1.394HisAla: 1.394 ± 0.012	0.518HisCys: 0.518 ± 0.006	1.171HisAsp: 1.171 ± 0.009	1.321HisGlu: 1.321 ± 0.011	1.101HisPhe: 1.101 ± 0.011	1.748HisGly: 1.748 ± 0.013	0.916HisHis: 0.916 ± 0.012	1.225HisIle: 1.225 ± 0.012	1.171HisLys: 1.171 ± 0.011	2.478HisLeu: 2.478 ± 0.016	0.525HisMet: 0.525 ± 0.007	0.993HisAsn: 0.993 ± 0.01	1.41HisPro: 1.41 ± 0.011	1.031HisGln: 1.031 ± 0.012	1.421HisArg: 1.421 ± 0.011	2.083HisSer: 2.083 ± 0.014	0.948HisThr: 0.948 ± 0.01	1.517HisVal: 1.517 ± 0.012	0.308HisTrp: 0.308 ± 0.005	0.694HisTyr: 0.694 ± 0.008	0.007HisXaa: 0.007 ± 0.001
Ile	3.604IleAla: 3.604 ± 0.02	1.149IleCys: 1.149 ± 0.011	2.986IleAsp: 2.986 ± 0.015	3.359IleGlu: 3.359 ± 0.018	2.391IlePhe: 2.391 ± 0.019	3.438IleGly: 3.438 ± 0.02	1.351IleHis: 1.351 ± 0.011	2.824IleIle: 2.824 ± 0.019	2.911IleLys: 2.911 ± 0.018	5.423IleLeu: 5.423 ± 0.025	1.117IleMet: 1.117 ± 0.01	2.2IleAsn: 2.2 ± 0.017	2.905IlePro: 2.905 ± 0.021	2.042IleGln: 2.042 ± 0.016	2.743IleArg: 2.743 ± 0.016	5.222IleSer: 5.222 ± 0.025	2.545IleThr: 2.545 ± 0.016	3.456IleVal: 3.456 ± 0.02	0.715IleTrp: 0.715 ± 0.009	1.503IleTyr: 1.503 ± 0.014	0.013IleXaa: 0.013 ± 0.001
Lys	3.998LysAla: 3.998 ± 0.02	0.978LysCys: 0.978 ± 0.01	3.223LysAsp: 3.223 ± 0.018	4.572LysGlu: 4.572 ± 0.028	2.348LysPhe: 2.348 ± 0.016	3.452LysGly: 3.452 ± 0.02	1.337LysHis: 1.337 ± 0.013	3.277LysIle: 3.277 ± 0.017	4.566LysLys: 4.566 ± 0.032	6.048LysLeu: 6.048 ± 0.028	1.505LysMet: 1.505 ± 0.012	2.705LysAsn: 2.705 ± 0.016	2.644LysPro: 2.644 ± 0.017	2.28LysGln: 2.28 ± 0.016	3.642LysArg: 3.642 ± 0.021	4.759LysSer: 4.759 ± 0.026	2.768LysThr: 2.768 ± 0.017	3.777LysVal: 3.777 ± 0.019	0.804LysTrp: 0.804 ± 0.01	1.635LysTyr: 1.635 ± 0.013	0.017LysXaa: 0.017 ± 0.002
Leu	6.544LeuAla: 6.544 ± 0.03	1.867LeuCys: 1.867 ± 0.016	5.087LeuAsp: 5.087 ± 0.023	6.502LeuGlu: 6.502 ± 0.027	3.88LeuPhe: 3.88 ± 0.023	5.776LeuGly: 5.776 ± 0.025	2.679LeuHis: 2.679 ± 0.016	4.67LeuIle: 4.67 ± 0.023	6.272LeuLys: 6.272 ± 0.027	10.114LeuLeu: 10.114 ± 0.046	2.103LeuMet: 2.103 ± 0.016	4.053LeuAsn: 4.053 ± 0.02	5.139LeuPro: 5.139 ± 0.024	4.436LeuGln: 4.436 ± 0.024	5.527LeuArg: 5.527 ± 0.025	8.647LeuSer: 8.647 ± 0.039	4.258LeuThr: 4.258 ± 0.023	6.199LeuVal: 6.199 ± 0.031	1.148LeuTrp: 1.148 ± 0.011	2.463LeuTyr: 2.463 ± 0.017	0.024LeuXaa: 0.024 ± 0.001
Met	2.205MetAla: 2.205 ± 0.013	0.307MetCys: 0.307 ± 0.005	1.424MetAsp: 1.424 ± 0.012	2.04MetGlu: 2.04 ± 0.013	0.805MetPhe: 0.805 ± 0.009	1.565MetGly: 1.565 ± 0.013	0.503MetHis: 0.503 ± 0.007	1.186MetIle: 1.186 ± 0.011	1.645MetLys: 1.645 ± 0.012	2.082MetLeu: 2.082 ± 0.015	0.617MetMet: 0.617 ± 0.008	0.975MetAsn: 0.975 ± 0.009	1.019MetPro: 1.019 ± 0.01	0.901MetGln: 0.901 ± 0.009	1.183MetArg: 1.183 ± 0.01	1.696MetSer: 1.696 ± 0.012	1.011MetThr: 1.011 ± 0.01	1.624MetVal: 1.624 ± 0.013	0.25MetTrp: 0.25 ± 0.005	0.559MetTyr: 0.559 ± 0.008	0.006MetXaa: 0.006 ± 0.001
Asn	2.722AsnAla: 2.722 ± 0.017	0.894AsnCys: 0.894 ± 0.009	2.153AsnAsp: 2.153 ± 0.015	2.58AsnGlu: 2.58 ± 0.019	2.087AsnPhe: 2.087 ± 0.013	3.288AsnGly: 3.288 ± 0.021	1.108AsnHis: 1.108 ± 0.01	2.509AsnIle: 2.509 ± 0.017	2.267AsnLys: 2.267 ± 0.014	4.657AsnLeu: 4.657 ± 0.028	1.04AsnMet: 1.04 ± 0.009	2.178AsnAsn: 2.178 ± 0.02	2.309AsnPro: 2.309 ± 0.017	1.732AsnGln: 1.732 ± 0.015	2.114AsnArg: 2.114 ± 0.013	4.162AsnSer: 4.162 ± 0.023	1.826AsnThr: 1.826 ± 0.013	2.827AsnVal: 2.827 ± 0.019	0.578AsnTrp: 0.578 ± 0.007	1.33AsnTyr: 1.33 ± 0.012	0.013AsnXaa: 0.013 ± 0.001
Pro	2.991ProAla: 2.991 ± 0.02	0.785ProCys: 0.785 ± 0.009	2.46ProAsp: 2.46 ± 0.015	3.058ProGlu: 3.058 ± 0.019	2.019ProPhe: 2.019 ± 0.014	2.557ProGly: 2.557 ± 0.017	1.107ProHis: 1.107 ± 0.011	2.416ProIle: 2.416 ± 0.016	2.685ProLys: 2.685 ± 0.016	4.373ProLeu: 4.373 ± 0.02	0.951ProMet: 0.951 ± 0.01	2.301ProAsn: 2.301 ± 0.015	3.826ProPro: 3.826 ± 0.045	1.786ProGln: 1.786 ± 0.015	2.386ProArg: 2.386 ± 0.016	5.186ProSer: 5.186 ± 0.028	2.577ProThr: 2.577 ± 0.016	2.999ProVal: 2.999 ± 0.019	0.595ProTrp: 0.595 ± 0.007	1.272ProTyr: 1.272 ± 0.011	0.017ProXaa: 0.017 ± 0.002
Gln	2.352GlnAla: 2.352 ± 0.015	0.578GlnCys: 0.578 ± 0.007	1.68GlnAsp: 1.68 ± 0.013	2.34GlnGlu: 2.34 ± 0.017	1.452GlnPhe: 1.452 ± 0.012	2.017GlnGly: 2.017 ± 0.016	0.914GlnHis: 0.914 ± 0.01	2.121GlnIle: 2.121 ± 0.014	2.41GlnLys: 2.41 ± 0.016	3.727GlnLeu: 3.727 ± 0.021	0.991GlnMet: 0.991 ± 0.009	1.843GlnAsn: 1.843 ± 0.013	1.728GlnPro: 1.728 ± 0.015	1.945GlnGln: 1.945 ± 0.032	2.146GlnArg: 2.146 ± 0.016	2.978GlnSer: 2.978 ± 0.017	1.681GlnThr: 1.681 ± 0.014	2.314GlnVal: 2.314 ± 0.014	0.466GlnTrp: 0.466 ± 0.007	0.944GlnTyr: 0.944 ± 0.01	0.01GlnXaa: 0.01 ± 0.001
Arg	3.384ArgAla: 3.384 ± 0.02	1.002ArgCys: 1.002 ± 0.011	2.759ArgAsp: 2.759 ± 0.021	3.519ArgGlu: 3.519 ± 0.023	2.294ArgPhe: 2.294 ± 0.017	3.241ArgGly: 3.241 ± 0.022	1.323ArgHis: 1.323 ± 0.012	2.944ArgIle: 2.944 ± 0.017	3.923ArgLys: 3.923 ± 0.023	5.113ArgLeu: 5.113 ± 0.022	1.304ArgMet: 1.304 ± 0.01	2.586ArgAsn: 2.586 ± 0.014	2.405ArgPro: 2.405 ± 0.017	1.919ArgGln: 1.919 ± 0.015	4.218ArgArg: 4.218 ± 0.029	4.654ArgSer: 4.654 ± 0.026	2.575ArgThr: 2.575 ± 0.017	3.257ArgVal: 3.257 ± 0.019	0.743ArgTrp: 0.743 ± 0.008	1.449ArgTyr: 1.449 ± 0.013	0.013ArgXaa: 0.013 ± 0.001
Ser	5.584SerAla: 5.584 ± 0.026	1.783SerCys: 1.783 ± 0.016	4.624SerAsp: 4.624 ± 0.026	5.037SerGlu: 5.037 ± 0.024	4.052SerPhe: 4.052 ± 0.022	6.002SerGly: 6.002 ± 0.029	2.128SerHis: 2.128 ± 0.016	4.769SerIle: 4.769 ± 0.02	5.055SerLys: 5.055 ± 0.023	8.726SerLeu: 8.726 ± 0.032	2.14SerMet: 2.14 ± 0.015	4.262SerAsn: 4.262 ± 0.023	4.661SerPro: 4.661 ± 0.032	3.114SerGln: 3.114 ± 0.02	4.783SerArg: 4.783 ± 0.025	11.606SerSer: 11.606 ± 0.058	4.707SerThr: 4.707 ± 0.024	5.292SerVal: 5.292 ± 0.022	1.183SerTrp: 1.183 ± 0.01	2.33SerTyr: 2.33 ± 0.016	0.025SerXaa: 0.025 ± 0.002
Thr	3.417ThrAla: 3.417 ± 0.019	0.875ThrCys: 0.875 ± 0.008	2.266ThrAsp: 2.266 ± 0.016	2.768ThrGlu: 2.768 ± 0.016	2.034ThrPhe: 2.034 ± 0.014	3.089ThrGly: 3.089 ± 0.019	1.023ThrHis: 1.023 ± 0.009	2.731ThrIle: 2.731 ± 0.015	2.608ThrLys: 2.608 ± 0.017	4.462ThrLeu: 4.462 ± 0.019	1.1ThrMet: 1.1 ± 0.01	2.057ThrAsn: 2.057 ± 0.016	2.483ThrPro: 2.483 ± 0.019	1.47ThrGln: 1.47 ± 0.013	2.32ThrArg: 2.32 ± 0.015	4.556ThrSer: 4.556 ± 0.023	2.733ThrThr: 2.733 ± 0.018	3.237ThrVal: 3.237 ± 0.02	0.601ThrTrp: 0.601 ± 0.007	1.314ThrTyr: 1.314 ± 0.013	0.015ThrXaa: 0.015 ± 0.001
Val	4.803ValAla: 4.803 ± 0.023	1.112ValCys: 1.112 ± 0.012	3.785ValAsp: 3.785 ± 0.019	4.518ValGlu: 4.518 ± 0.022	2.663ValPhe: 2.663 ± 0.018	4.131ValGly: 4.131 ± 0.021	1.547ValHis: 1.547 ± 0.012	3.356ValIle: 3.356 ± 0.018	3.816ValLys: 3.816 ± 0.02	6.207ValLeu: 6.207 ± 0.028	1.456ValMet: 1.456 ± 0.014	2.59ValAsn: 2.59 ± 0.016	3.149ValPro: 3.149 ± 0.019	2.289ValGln: 2.289 ± 0.016	3.162ValArg: 3.162 ± 0.018	5.444ValSer: 5.444 ± 0.024	3.03ValThr: 3.03 ± 0.015	4.834ValVal: 4.834 ± 0.024	0.731ValTrp: 0.731 ± 0.009	1.836ValTyr: 1.836 ± 0.013	0.017ValXaa: 0.017 ± 0.001
Trp	0.777TrpAla: 0.777 ± 0.009	0.224TrpCys: 0.224 ± 0.005	0.674TrpAsp: 0.674 ± 0.008	0.771TrpGlu: 0.771 ± 0.009	0.535TrpPhe: 0.535 ± 0.007	0.736TrpGly: 0.736 ± 0.009	0.287TrpHis: 0.287 ± 0.006	0.719TrpIle: 0.719 ± 0.009	0.936TrpLys: 0.936 ± 0.01	1.201TrpLeu: 1.201 ± 0.013	0.346TrpMet: 0.346 ± 0.006	0.712TrpAsn: 0.712 ± 0.009	0.512TrpPro: 0.512 ± 0.007	0.422TrpGln: 0.422 ± 0.006	0.825TrpArg: 0.825 ± 0.009	0.99TrpSer: 0.99 ± 0.011	0.638TrpThr: 0.638 ± 0.008	0.77TrpVal: 0.77 ± 0.008	0.239TrpTrp: 0.239 ± 0.005	0.325TrpTyr: 0.325 ± 0.005	0.003TrpXaa: 0.003 ± 0.001
Tyr	1.777TyrAla: 1.777 ± 0.014	0.611TyrCys: 0.611 ± 0.008	1.501TyrAsp: 1.501 ± 0.013	1.603TyrGlu: 1.603 ± 0.013	1.307TyrPhe: 1.307 ± 0.011	2.099TyrGly: 2.099 ± 0.018	0.717TyrHis: 0.717 ± 0.009	1.428TyrIle: 1.428 ± 0.014	1.466TyrLys: 1.466 ± 0.012	2.696TyrLeu: 2.696 ± 0.016	0.685TyrMet: 0.685 ± 0.009	1.277TyrAsn: 1.277 ± 0.012	1.197TyrPro: 1.197 ± 0.011	0.944TyrGln: 0.944 ± 0.009	1.515TyrArg: 1.515 ± 0.013	2.313TyrSer: 2.313 ± 0.017	1.219TyrThr: 1.219 ± 0.011	1.733TyrVal: 1.733 ± 0.015	0.391TyrTrp: 0.391 ± 0.006	0.938TyrTyr: 0.938 ± 0.01	0.007TyrXaa: 0.007 ± 0.001
Xaa	0.015XaaAla: 0.015 ± 0.001	0.005XaaCys: 0.005 ± 0.001	0.014XaaAsp: 0.014 ± 0.001	0.022XaaGlu: 0.022 ± 0.001	0.013XaaPhe: 0.013 ± 0.001	0.02XaaGly: 0.02 ± 0.001	0.005XaaHis: 0.005 ± 0.001	0.017XaaIle: 0.017 ± 0.001	0.014XaaLys: 0.014 ± 0.001	0.022XaaLeu: 0.022 ± 0.002	0.007XaaMet: 0.007 ± 0.001	0.014XaaAsn: 0.014 ± 0.001	0.012XaaPro: 0.012 ± 0.001	0.01XaaGln: 0.01 ± 0.001	0.014XaaArg: 0.014 ± 0.001	0.022XaaSer: 0.022 ± 0.002	0.013XaaThr: 0.013 ± 0.001	0.02XaaVal: 0.02 ± 0.001	0.003XaaTrp: 0.003 ± 0.001	0.007XaaTyr: 0.007 ± 0.001	0.043XaaXaa: 0.043 ± 0.01

Statistics based on 24040 proteins (11072412 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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