Amino acid dipepetide frequency for Grimontia hollisae CIP 101886

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.799AlaAla: 8.799 ± 0.127	0.998AlaCys: 0.998 ± 0.03	4.901AlaAsp: 4.901 ± 0.079	5.978AlaGlu: 5.978 ± 0.083	3.757AlaPhe: 3.757 ± 0.065	6.717AlaGly: 6.717 ± 0.104	1.723AlaHis: 1.723 ± 0.04	5.962AlaIle: 5.962 ± 0.079	4.787AlaLys: 4.787 ± 0.068	10.722AlaLeu: 10.722 ± 0.136	3.153AlaMet: 3.153 ± 0.061	3.518AlaAsn: 3.518 ± 0.059	3.185AlaPro: 3.185 ± 0.07	3.613AlaGln: 3.613 ± 0.063	4.553AlaArg: 4.553 ± 0.077	5.584AlaSer: 5.584 ± 0.08	4.662AlaThr: 4.662 ± 0.081	6.591AlaVal: 6.591 ± 0.075	1.044AlaTrp: 1.044 ± 0.03	2.421AlaTyr: 2.421 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.839CysAla: 0.839 ± 0.026	0.165CysCys: 0.165 ± 0.013	0.611CysAsp: 0.611 ± 0.025	0.615CysGlu: 0.615 ± 0.024	0.458CysPhe: 0.458 ± 0.021	1.009CysGly: 1.009 ± 0.031	0.368CysHis: 0.368 ± 0.023	0.587CysIle: 0.587 ± 0.022	0.414CysLys: 0.414 ± 0.018	0.93CysLeu: 0.93 ± 0.029	0.241CysMet: 0.241 ± 0.015	0.353CysAsn: 0.353 ± 0.016	0.484CysPro: 0.484 ± 0.023	0.457CysGln: 0.457 ± 0.02	0.573CysArg: 0.573 ± 0.023	0.619CysSer: 0.619 ± 0.026	0.478CysThr: 0.478 ± 0.02	0.65CysVal: 0.65 ± 0.025	0.15CysTrp: 0.15 ± 0.011	0.323CysTyr: 0.323 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.426AspAla: 5.426 ± 0.084	0.58AspCys: 0.58 ± 0.024	3.307AspAsp: 3.307 ± 0.083	3.808AspGlu: 3.808 ± 0.069	2.366AspPhe: 2.366 ± 0.051	4.154AspGly: 4.154 ± 0.077	1.112AspHis: 1.112 ± 0.033	4.294AspIle: 4.294 ± 0.069	2.973AspLys: 2.973 ± 0.062	5.132AspLeu: 5.132 ± 0.07	1.555AspMet: 1.555 ± 0.038	2.498AspAsn: 2.498 ± 0.047	2.232AspPro: 2.232 ± 0.048	1.701AspGln: 1.701 ± 0.045	2.471AspArg: 2.471 ± 0.048	2.923AspSer: 2.923 ± 0.056	3.108AspThr: 3.108 ± 0.07	4.559AspVal: 4.559 ± 0.065	0.824AspTrp: 0.824 ± 0.027	1.862AspTyr: 1.862 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.858GluAla: 5.858 ± 0.089	0.522GluCys: 0.522 ± 0.023	2.988GluAsp: 2.988 ± 0.058	4.007GluGlu: 4.007 ± 0.068	2.216GluPhe: 2.216 ± 0.044	4.136GluGly: 4.136 ± 0.072	1.583GluHis: 1.583 ± 0.04	3.643GluIle: 3.643 ± 0.068	4.164GluLys: 4.164 ± 0.065	6.384GluLeu: 6.384 ± 0.089	1.864GluMet: 1.864 ± 0.044	2.857GluAsn: 2.857 ± 0.05	2.163GluPro: 2.163 ± 0.054	3.386GluGln: 3.386 ± 0.069	3.67GluArg: 3.67 ± 0.06	3.586GluSer: 3.586 ± 0.059	3.294GluThr: 3.294 ± 0.056	4.163GluVal: 4.163 ± 0.064	0.796GluTrp: 0.796 ± 0.029	1.674GluTyr: 1.674 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.472PheAla: 3.472 ± 0.061	0.475PheCys: 0.475 ± 0.023	2.816PheAsp: 2.816 ± 0.056	2.404PheGlu: 2.404 ± 0.051	1.72PhePhe: 1.72 ± 0.043	3.298PheGly: 3.298 ± 0.055	0.828PheHis: 0.828 ± 0.029	2.475PheIle: 2.475 ± 0.049	1.652PheLys: 1.652 ± 0.045	3.327PheLeu: 3.327 ± 0.067	0.994PheMet: 0.994 ± 0.032	1.896PheAsn: 1.896 ± 0.039	1.496PhePro: 1.496 ± 0.04	1.171PheGln: 1.171 ± 0.029	1.747PheArg: 1.747 ± 0.037	3.187PheSer: 3.187 ± 0.06	2.487PheThr: 2.487 ± 0.054	2.821PheVal: 2.821 ± 0.051	0.519PheTrp: 0.519 ± 0.025	1.272PheTyr: 1.272 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.872GlyAla: 5.872 ± 0.092	0.91GlyCys: 0.91 ± 0.028	4.02GlyAsp: 4.02 ± 0.092	4.879GlyGlu: 4.879 ± 0.078	3.366GlyPhe: 3.366 ± 0.057	5.19GlyGly: 5.19 ± 0.102	1.633GlyHis: 1.633 ± 0.042	4.979GlyIle: 4.979 ± 0.07	4.31GlyLys: 4.31 ± 0.072	7.16GlyLeu: 7.16 ± 0.095	2.29GlyMet: 2.29 ± 0.05	2.857GlyAsn: 2.857 ± 0.083	1.813GlyPro: 1.813 ± 0.042	2.79GlyGln: 2.79 ± 0.05	3.489GlyArg: 3.489 ± 0.063	4.036GlySer: 4.036 ± 0.061	3.737GlyThr: 3.737 ± 0.079	5.523GlyVal: 5.523 ± 0.066	1.047GlyTrp: 1.047 ± 0.035	2.53GlyTyr: 2.53 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.876HisAla: 1.876 ± 0.042	0.339HisCys: 0.339 ± 0.019	1.166HisAsp: 1.166 ± 0.032	1.169HisGlu: 1.169 ± 0.034	1.048HisPhe: 1.048 ± 0.032	1.63HisGly: 1.63 ± 0.043	0.757HisHis: 0.757 ± 0.028	1.378HisIle: 1.378 ± 0.033	0.934HisLys: 0.934 ± 0.023	2.164HisLeu: 2.164 ± 0.046	0.533HisMet: 0.533 ± 0.023	0.839HisAsn: 0.839 ± 0.028	1.305HisPro: 1.305 ± 0.038	1.094HisGln: 1.094 ± 0.033	1.115HisArg: 1.115 ± 0.034	1.219HisSer: 1.219 ± 0.03	1.127HisThr: 1.127 ± 0.035	1.407HisVal: 1.407 ± 0.036	0.378HisTrp: 0.378 ± 0.019	0.842HisTyr: 0.842 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.415IleAla: 6.415 ± 0.08	0.666IleCys: 0.666 ± 0.025	4.141IleAsp: 4.141 ± 0.061	4.289IleGlu: 4.289 ± 0.078	2.016IlePhe: 2.016 ± 0.051	4.634IleGly: 4.634 ± 0.073	1.276IleHis: 1.276 ± 0.037	3.222IleIle: 3.222 ± 0.076	2.79IleLys: 2.79 ± 0.059	4.985IleLeu: 4.985 ± 0.079	1.228IleMet: 1.228 ± 0.036	2.796IleAsn: 2.796 ± 0.05	2.674IlePro: 2.674 ± 0.05	2.048IleGln: 2.048 ± 0.041	3.064IleArg: 3.064 ± 0.053	4.143IleSer: 4.143 ± 0.06	3.611IleThr: 3.611 ± 0.078	3.982IleVal: 3.982 ± 0.073	0.566IleTrp: 0.566 ± 0.025	1.55IleTyr: 1.55 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	5.125LysAla: 5.125 ± 0.071	0.344LysCys: 0.344 ± 0.02	2.579LysAsp: 2.579 ± 0.057	3.229LysGlu: 3.229 ± 0.056	1.386LysPhe: 1.386 ± 0.035	3.542LysGly: 3.542 ± 0.066	1.205LysHis: 1.205 ± 0.033	2.635LysIle: 2.635 ± 0.064	2.814LysLys: 2.814 ± 0.069	4.829LysLeu: 4.829 ± 0.077	1.382LysMet: 1.382 ± 0.041	2.047LysAsn: 2.047 ± 0.049	2.391LysPro: 2.391 ± 0.054	2.339LysGln: 2.339 ± 0.051	2.965LysArg: 2.965 ± 0.056	2.684LysSer: 2.684 ± 0.054	2.799LysThr: 2.799 ± 0.052	3.662LysVal: 3.662 ± 0.071	0.534LysTrp: 0.534 ± 0.023	1.317LysTyr: 1.317 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	10.074LeuAla: 10.074 ± 0.136	1.105LeuCys: 1.105 ± 0.032	6.01LeuAsp: 6.01 ± 0.088	6.076LeuGlu: 6.076 ± 0.083	4.163LeuPhe: 4.163 ± 0.073	7.092LeuGly: 7.092 ± 0.104	2.007LeuHis: 2.007 ± 0.046	5.685LeuIle: 5.685 ± 0.087	5.133LeuLys: 5.133 ± 0.072	10.367LeuLeu: 10.367 ± 0.157	2.874LeuMet: 2.874 ± 0.056	4.283LeuAsn: 4.283 ± 0.065	4.934LeuPro: 4.934 ± 0.076	3.36LeuGln: 3.36 ± 0.056	4.878LeuArg: 4.878 ± 0.072	7.686LeuSer: 7.686 ± 0.092	6.026LeuThr: 6.026 ± 0.073	7.358LeuVal: 7.358 ± 0.087	1.023LeuTrp: 1.023 ± 0.035	2.494LeuTyr: 2.494 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	3.014MetAla: 3.014 ± 0.059	0.216MetCys: 0.216 ± 0.013	1.382MetAsp: 1.382 ± 0.038	1.48MetGlu: 1.48 ± 0.043	0.949MetPhe: 0.949 ± 0.026	1.92MetGly: 1.92 ± 0.046	0.46MetHis: 0.46 ± 0.019	1.516MetIle: 1.516 ± 0.042	1.535MetLys: 1.535 ± 0.035	3.014MetLeu: 3.014 ± 0.056	0.878MetMet: 0.878 ± 0.031	1.046MetAsn: 1.046 ± 0.028	1.377MetPro: 1.377 ± 0.034	1.159MetGln: 1.159 ± 0.029	1.31MetArg: 1.31 ± 0.033	1.86MetSer: 1.86 ± 0.046	1.777MetThr: 1.777 ± 0.043	2.102MetVal: 2.102 ± 0.042	0.216MetTrp: 0.216 ± 0.014	0.568MetTyr: 0.568 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.847AsnAla: 3.847 ± 0.064	0.353AsnCys: 0.353 ± 0.017	2.32AsnAsp: 2.32 ± 0.063	2.262AsnGlu: 2.262 ± 0.047	1.353AsnPhe: 1.353 ± 0.037	3.202AsnGly: 3.202 ± 0.072	0.964AsnHis: 0.964 ± 0.03	2.613AsnIle: 2.613 ± 0.047	1.94AsnLys: 1.94 ± 0.051	3.753AsnLeu: 3.753 ± 0.06	1.012AsnMet: 1.012 ± 0.03	1.75AsnAsn: 1.75 ± 0.049	2.205AsnPro: 2.205 ± 0.046	1.705AsnGln: 1.705 ± 0.044	2.13AsnArg: 2.13 ± 0.042	1.916AsnSer: 1.916 ± 0.045	2.27AsnThr: 2.27 ± 0.047	2.918AsnVal: 2.918 ± 0.052	0.543AsnTrp: 0.543 ± 0.024	1.128AsnTyr: 1.128 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.665ProAla: 3.665 ± 0.065	0.354ProCys: 0.354 ± 0.017	2.749ProAsp: 2.749 ± 0.059	3.356ProGlu: 3.356 ± 0.06	1.816ProPhe: 1.816 ± 0.042	2.779ProGly: 2.779 ± 0.05	0.917ProHis: 0.917 ± 0.031	2.22ProIle: 2.22 ± 0.047	1.819ProLys: 1.819 ± 0.046	4.36ProLeu: 4.36 ± 0.067	1.104ProMet: 1.104 ± 0.033	1.556ProAsn: 1.556 ± 0.038	1.439ProPro: 1.439 ± 0.044	1.572ProGln: 1.572 ± 0.042	1.587ProArg: 1.587 ± 0.034	2.509ProSer: 2.509 ± 0.049	2.215ProThr: 2.215 ± 0.045	3.687ProVal: 3.687 ± 0.061	0.547ProTrp: 0.547 ± 0.023	1.254ProTyr: 1.254 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.002GlnAla: 4.002 ± 0.063	0.358GlnCys: 0.358 ± 0.019	1.902GlnAsp: 1.902 ± 0.046	2.248GlnGlu: 2.248 ± 0.049	1.576GlnPhe: 1.576 ± 0.037	2.867GlnGly: 2.867 ± 0.055	1.063GlnHis: 1.063 ± 0.033	2.234GlnIle: 2.234 ± 0.046	1.926GlnLys: 1.926 ± 0.042	4.297GlnLeu: 4.297 ± 0.071	1.128GlnMet: 1.128 ± 0.034	1.352GlnAsn: 1.352 ± 0.038	1.726GlnPro: 1.726 ± 0.035	2.449GlnGln: 2.449 ± 0.059	2.429GlnArg: 2.429 ± 0.052	2.425GlnSer: 2.425 ± 0.051	2.198GlnThr: 2.198 ± 0.044	2.743GlnVal: 2.743 ± 0.053	0.568GlnTrp: 0.568 ± 0.027	1.172GlnTyr: 1.172 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.038ArgAla: 4.038 ± 0.069	0.545ArgCys: 0.545 ± 0.021	2.839ArgAsp: 2.839 ± 0.058	3.597ArgGlu: 3.597 ± 0.062	2.426ArgPhe: 2.426 ± 0.047	2.939ArgGly: 2.939 ± 0.052	1.321ArgHis: 1.321 ± 0.037	3.168ArgIle: 3.168 ± 0.06	2.522ArgLys: 2.522 ± 0.053	5.373ArgLeu: 5.373 ± 0.085	1.381ArgMet: 1.381 ± 0.036	1.996ArgAsn: 1.996 ± 0.046	1.819ArgPro: 1.819 ± 0.041	2.441ArgGln: 2.441 ± 0.054	2.886ArgArg: 2.886 ± 0.059	2.517ArgSer: 2.517 ± 0.051	2.252ArgThr: 2.252 ± 0.048	3.613ArgVal: 3.613 ± 0.068	0.691ArgTrp: 0.691 ± 0.028	1.842ArgTyr: 1.842 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.389SerAla: 5.389 ± 0.079	0.535SerCys: 0.535 ± 0.021	3.593SerAsp: 3.593 ± 0.063	3.726SerGlu: 3.726 ± 0.057	2.525SerPhe: 2.525 ± 0.05	5.025SerGly: 5.025 ± 0.071	1.487SerHis: 1.487 ± 0.038	3.434SerIle: 3.434 ± 0.049	2.666SerLys: 2.666 ± 0.05	6.86SerLeu: 6.86 ± 0.091	1.637SerMet: 1.637 ± 0.039	2.201SerAsn: 2.201 ± 0.049	2.656SerPro: 2.656 ± 0.049	2.576SerGln: 2.576 ± 0.051	3.057SerArg: 3.057 ± 0.056	3.523SerSer: 3.523 ± 0.062	3.004SerThr: 3.004 ± 0.053	4.653SerVal: 4.653 ± 0.072	0.769SerTrp: 0.769 ± 0.03	1.705SerTyr: 1.705 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.795ThrAla: 4.795 ± 0.077	0.521ThrCys: 0.521 ± 0.023	3.01ThrAsp: 3.01 ± 0.069	3.151ThrGlu: 3.151 ± 0.055	2.233ThrPhe: 2.233 ± 0.047	4.392ThrGly: 4.392 ± 0.076	1.249ThrHis: 1.249 ± 0.036	3.153ThrIle: 3.153 ± 0.07	2.101ThrLys: 2.101 ± 0.047	6.951ThrLeu: 6.951 ± 0.097	1.236ThrMet: 1.236 ± 0.036	1.856ThrAsn: 1.856 ± 0.05	2.814ThrPro: 2.814 ± 0.051	2.13ThrGln: 2.13 ± 0.05	2.495ThrArg: 2.495 ± 0.059	3.052ThrSer: 3.052 ± 0.061	2.857ThrThr: 2.857 ± 0.062	4.347ThrVal: 4.347 ± 0.083	0.585ThrTrp: 0.585 ± 0.024	1.398ThrTyr: 1.398 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	6.975ValAla: 6.975 ± 0.087	0.824ValCys: 0.824 ± 0.025	4.347ValAsp: 4.347 ± 0.067	4.697ValGlu: 4.697 ± 0.067	2.89ValPhe: 2.89 ± 0.049	5.006ValGly: 5.006 ± 0.08	1.242ValHis: 1.242 ± 0.033	4.782ValIle: 4.782 ± 0.066	3.598ValLys: 3.598 ± 0.067	7.15ValLeu: 7.15 ± 0.101	2.282ValMet: 2.282 ± 0.05	3.002ValAsn: 3.002 ± 0.054	2.971ValPro: 2.971 ± 0.047	2.226ValGln: 2.226 ± 0.041	3.284ValArg: 3.284 ± 0.059	5.134ValSer: 5.134 ± 0.076	4.408ValThr: 4.408 ± 0.072	5.834ValVal: 5.834 ± 0.084	0.838ValTrp: 0.838 ± 0.029	1.887ValTyr: 1.887 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.881TrpAla: 0.881 ± 0.033	0.144TrpCys: 0.144 ± 0.011	0.582TrpAsp: 0.582 ± 0.023	0.614TrpGlu: 0.614 ± 0.027	0.558TrpPhe: 0.558 ± 0.023	0.825TrpGly: 0.825 ± 0.029	0.37TrpHis: 0.37 ± 0.019	0.603TrpIle: 0.603 ± 0.024	0.528TrpLys: 0.528 ± 0.025	1.708TrpLeu: 1.708 ± 0.044	0.367TrpMet: 0.367 ± 0.018	0.412TrpAsn: 0.412 ± 0.02	0.495TrpPro: 0.495 ± 0.022	0.853TrpGln: 0.853 ± 0.029	0.707TrpArg: 0.707 ± 0.025	0.647TrpSer: 0.647 ± 0.031	0.513TrpThr: 0.513 ± 0.027	0.913TrpVal: 0.913 ± 0.032	0.192TrpTrp: 0.192 ± 0.014	0.364TrpTyr: 0.364 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.306TyrAla: 2.306 ± 0.042	0.371TyrCys: 0.371 ± 0.02	1.621TyrAsp: 1.621 ± 0.037	1.368TyrGlu: 1.368 ± 0.036	1.235TyrPhe: 1.235 ± 0.035	2.074TyrGly: 2.074 ± 0.046	0.755TyrHis: 0.755 ± 0.025	1.515TyrIle: 1.515 ± 0.04	1.203TyrLys: 1.203 ± 0.032	3.162TyrLeu: 3.162 ± 0.056	0.64TyrMet: 0.64 ± 0.022	1.067TyrAsn: 1.067 ± 0.036	1.327TyrPro: 1.327 ± 0.038	1.593TyrGln: 1.593 ± 0.036	1.797TyrArg: 1.797 ± 0.042	1.771TyrSer: 1.771 ± 0.043	1.502TyrThr: 1.502 ± 0.047	1.853TyrVal: 1.853 ± 0.036	0.444TyrTrp: 0.444 ± 0.017	0.882TyrTyr: 0.882 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3553 proteins (1131702 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---