Amino acid dipepetide frequency for Vibrio metschnikovii CIP 69.14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.876AlaAla: 7.876 ± 0.12	0.995AlaCys: 0.995 ± 0.037	4.672AlaAsp: 4.672 ± 0.076	5.565AlaGlu: 5.565 ± 0.085	3.476AlaPhe: 3.476 ± 0.068	5.924AlaGly: 5.924 ± 0.1	1.909AlaHis: 1.909 ± 0.05	6.35AlaIle: 6.35 ± 0.084	4.729AlaLys: 4.729 ± 0.084	10.674AlaLeu: 10.674 ± 0.125	2.897AlaMet: 2.897 ± 0.056	3.562AlaAsn: 3.562 ± 0.065	2.863AlaPro: 2.863 ± 0.062	5.079AlaGln: 5.079 ± 0.075	4.052AlaArg: 4.052 ± 0.073	5.308AlaSer: 5.308 ± 0.078	4.594AlaThr: 4.594 ± 0.065	5.683AlaVal: 5.683 ± 0.088	1.022AlaTrp: 1.022 ± 0.033	2.399AlaTyr: 2.399 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.901CysAla: 0.901 ± 0.026	0.144CysCys: 0.144 ± 0.011	0.586CysAsp: 0.586 ± 0.026	0.54CysGlu: 0.54 ± 0.025	0.43CysPhe: 0.43 ± 0.024	0.917CysGly: 0.917 ± 0.031	0.364CysHis: 0.364 ± 0.021	0.607CysIle: 0.607 ± 0.023	0.391CysLys: 0.391 ± 0.023	1.056CysLeu: 1.056 ± 0.031	0.224CysMet: 0.224 ± 0.016	0.309CysAsn: 0.309 ± 0.016	0.431CysPro: 0.431 ± 0.019	0.608CysGln: 0.608 ± 0.026	0.502CysArg: 0.502 ± 0.022	0.698CysSer: 0.698 ± 0.03	0.456CysThr: 0.456 ± 0.022	0.642CysVal: 0.642 ± 0.026	0.14CysTrp: 0.14 ± 0.015	0.344CysTyr: 0.344 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.224AspAla: 4.224 ± 0.068	0.548AspCys: 0.548 ± 0.026	2.796AspAsp: 2.796 ± 0.065	3.45AspGlu: 3.45 ± 0.071	2.289AspPhe: 2.289 ± 0.049	3.472AspGly: 3.472 ± 0.075	1.233AspHis: 1.233 ± 0.036	3.839AspIle: 3.839 ± 0.065	2.902AspLys: 2.902 ± 0.053	5.059AspLeu: 5.059 ± 0.072	1.255AspMet: 1.255 ± 0.037	2.366AspAsn: 2.366 ± 0.056	2.147AspPro: 2.147 ± 0.052	2.404AspGln: 2.404 ± 0.052	2.283AspArg: 2.283 ± 0.057	3.049AspSer: 3.049 ± 0.059	2.403AspThr: 2.403 ± 0.049	3.631AspVal: 3.631 ± 0.069	0.893AspTrp: 0.893 ± 0.029	2.163AspTyr: 2.163 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.056GluAla: 5.056 ± 0.083	0.496GluCys: 0.496 ± 0.021	2.277GluAsp: 2.277 ± 0.062	3.217GluGlu: 3.217 ± 0.066	2.255GluPhe: 2.255 ± 0.051	3.115GluGly: 3.115 ± 0.053	1.716GluHis: 1.716 ± 0.038	3.587GluIle: 3.587 ± 0.062	3.371GluLys: 3.371 ± 0.062	6.864GluLeu: 6.864 ± 0.083	1.699GluMet: 1.699 ± 0.04	2.165GluAsn: 2.165 ± 0.048	2.038GluPro: 2.038 ± 0.061	4.709GluGln: 4.709 ± 0.085	3.583GluArg: 3.583 ± 0.064	3.31GluSer: 3.31 ± 0.059	2.898GluThr: 2.898 ± 0.056	4.139GluVal: 4.139 ± 0.066	0.783GluTrp: 0.783 ± 0.028	1.56GluTyr: 1.56 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.876PheAla: 3.876 ± 0.079	0.49PheCys: 0.49 ± 0.026	2.49PheAsp: 2.49 ± 0.051	2.179PheGlu: 2.179 ± 0.047	1.643PhePhe: 1.643 ± 0.044	3.054PheGly: 3.054 ± 0.073	0.898PheHis: 0.898 ± 0.028	2.881PheIle: 2.881 ± 0.051	1.65PheLys: 1.65 ± 0.041	3.412PheLeu: 3.412 ± 0.067	1.022PheMet: 1.022 ± 0.029	1.899PheAsn: 1.899 ± 0.043	1.419PhePro: 1.419 ± 0.035	1.408PheGln: 1.408 ± 0.038	1.54PheArg: 1.54 ± 0.037	3.25PheSer: 3.25 ± 0.054	2.398PheThr: 2.398 ± 0.05	2.623PheVal: 2.623 ± 0.055	0.504PheTrp: 0.504 ± 0.023	1.304PheTyr: 1.304 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.196GlyAla: 5.196 ± 0.086	0.891GlyCys: 0.891 ± 0.027	3.419GlyAsp: 3.419 ± 0.062	4.093GlyGlu: 4.093 ± 0.062	3.214GlyPhe: 3.214 ± 0.059	4.599GlyGly: 4.599 ± 0.084	1.651GlyHis: 1.651 ± 0.043	4.859GlyIle: 4.859 ± 0.085	3.592GlyLys: 3.592 ± 0.057	7.33GlyLeu: 7.33 ± 0.093	1.992GlyMet: 1.992 ± 0.048	2.378GlyAsn: 2.378 ± 0.052	1.73GlyPro: 1.73 ± 0.047	3.33GlyGln: 3.33 ± 0.058	3.336GlyArg: 3.336 ± 0.068	3.793GlySer: 3.793 ± 0.063	3.166GlyThr: 3.166 ± 0.06	5.092GlyVal: 5.092 ± 0.082	0.989GlyTrp: 0.989 ± 0.032	2.646GlyTyr: 2.646 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.875HisAla: 1.875 ± 0.047	0.356HisCys: 0.356 ± 0.02	1.265HisAsp: 1.265 ± 0.039	1.134HisGlu: 1.134 ± 0.033	1.166HisPhe: 1.166 ± 0.032	1.686HisGly: 1.686 ± 0.043	0.957HisHis: 0.957 ± 0.033	1.588HisIle: 1.588 ± 0.042	0.99HisLys: 0.99 ± 0.034	2.608HisLeu: 2.608 ± 0.05	0.517HisMet: 0.517 ± 0.022	0.936HisAsn: 0.936 ± 0.029	1.404HisPro: 1.404 ± 0.036	1.696HisGln: 1.696 ± 0.049	1.248HisArg: 1.248 ± 0.041	1.656HisSer: 1.656 ± 0.047	1.19HisThr: 1.19 ± 0.035	1.351HisVal: 1.351 ± 0.041	0.432HisTrp: 0.432 ± 0.022	1.05HisTyr: 1.05 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.804IleAla: 6.804 ± 0.103	0.672IleCys: 0.672 ± 0.028	4.378IleAsp: 4.378 ± 0.07	4.794IleGlu: 4.794 ± 0.07	2.204IlePhe: 2.204 ± 0.049	4.971IleGly: 4.971 ± 0.082	1.453IleHis: 1.453 ± 0.041	3.969IleIle: 3.969 ± 0.081	2.989IleLys: 2.989 ± 0.061	5.393IleLeu: 5.393 ± 0.086	1.364IleMet: 1.364 ± 0.043	3.047IleAsn: 3.047 ± 0.061	2.771IlePro: 2.771 ± 0.055	2.587IleGln: 2.587 ± 0.047	3.019IleArg: 3.019 ± 0.051	4.337IleSer: 4.337 ± 0.065	3.825IleThr: 3.825 ± 0.067	4.247IleVal: 4.247 ± 0.061	0.633IleTrp: 0.633 ± 0.023	1.714IleTyr: 1.714 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.471LysAla: 4.471 ± 0.067	0.287LysCys: 0.287 ± 0.02	2.181LysAsp: 2.181 ± 0.045	2.816LysGlu: 2.816 ± 0.066	1.329LysPhe: 1.329 ± 0.036	2.975LysGly: 2.975 ± 0.057	1.177LysHis: 1.177 ± 0.031	2.783LysIle: 2.783 ± 0.061	2.517LysLys: 2.517 ± 0.067	4.742LysLeu: 4.742 ± 0.067	1.333LysMet: 1.333 ± 0.037	1.841LysAsn: 1.841 ± 0.047	2.231LysPro: 2.231 ± 0.047	3.044LysGln: 3.044 ± 0.06	2.602LysArg: 2.602 ± 0.052	2.693LysSer: 2.693 ± 0.053	2.614LysThr: 2.614 ± 0.051	3.319LysVal: 3.319 ± 0.061	0.481LysTrp: 0.481 ± 0.022	1.203LysTyr: 1.203 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	11.092LeuAla: 11.092 ± 0.121	1.143LeuCys: 1.143 ± 0.034	5.83LeuAsp: 5.83 ± 0.083	5.807LeuGlu: 5.807 ± 0.079	4.308LeuPhe: 4.308 ± 0.09	7.188LeuGly: 7.188 ± 0.099	2.385LeuHis: 2.385 ± 0.057	6.624LeuIle: 6.624 ± 0.095	4.789LeuLys: 4.789 ± 0.07	11.586LeuLeu: 11.586 ± 0.154	2.875LeuMet: 2.875 ± 0.057	4.571LeuAsn: 4.571 ± 0.069	4.99LeuPro: 4.99 ± 0.084	4.355LeuGln: 4.355 ± 0.07	4.909LeuArg: 4.909 ± 0.072	7.909LeuSer: 7.909 ± 0.106	6.638LeuThr: 6.638 ± 0.081	7.075LeuVal: 7.075 ± 0.071	1.118LeuTrp: 1.118 ± 0.034	2.779LeuTyr: 2.779 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.685MetAla: 2.685 ± 0.054	0.204MetCys: 0.204 ± 0.015	1.237MetAsp: 1.237 ± 0.034	1.202MetGlu: 1.202 ± 0.04	0.878MetPhe: 0.878 ± 0.03	1.79MetGly: 1.79 ± 0.045	0.52MetHis: 0.52 ± 0.022	1.701MetIle: 1.701 ± 0.04	1.334MetLys: 1.334 ± 0.03	2.936MetLeu: 2.936 ± 0.059	0.814MetMet: 0.814 ± 0.034	1.059MetAsn: 1.059 ± 0.029	1.243MetPro: 1.243 ± 0.037	1.226MetGln: 1.226 ± 0.036	1.275MetArg: 1.275 ± 0.035	1.824MetSer: 1.824 ± 0.042	1.7MetThr: 1.7 ± 0.038	1.947MetVal: 1.947 ± 0.046	0.234MetTrp: 0.234 ± 0.016	0.551MetTyr: 0.551 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.308AsnAla: 3.308 ± 0.063	0.356AsnCys: 0.356 ± 0.02	2.1AsnAsp: 2.1 ± 0.051	2.138AsnGlu: 2.138 ± 0.053	1.407AsnPhe: 1.407 ± 0.04	2.743AsnGly: 2.743 ± 0.059	1.109AsnHis: 1.109 ± 0.034	2.646AsnIle: 2.646 ± 0.05	1.88AsnLys: 1.88 ± 0.051	3.767AsnLeu: 3.767 ± 0.069	0.897AsnMet: 0.897 ± 0.031	1.75AsnAsn: 1.75 ± 0.051	2.2AsnPro: 2.2 ± 0.053	2.483AsnGln: 2.483 ± 0.054	2.007AsnArg: 2.007 ± 0.042	2.233AsnSer: 2.233 ± 0.051	2.039AsnThr: 2.039 ± 0.051	2.497AsnVal: 2.497 ± 0.051	0.549AsnTrp: 0.549 ± 0.026	1.275AsnTyr: 1.275 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.261ProAla: 3.261 ± 0.069	0.339ProCys: 0.339 ± 0.017	2.215ProAsp: 2.215 ± 0.047	3.08ProGlu: 3.08 ± 0.068	1.749ProPhe: 1.749 ± 0.04	2.205ProGly: 2.205 ± 0.049	1.043ProHis: 1.043 ± 0.03	2.778ProIle: 2.778 ± 0.048	1.885ProLys: 1.885 ± 0.044	4.539ProLeu: 4.539 ± 0.083	1.052ProMet: 1.052 ± 0.035	1.716ProAsn: 1.716 ± 0.043	1.17ProPro: 1.17 ± 0.035	1.979ProGln: 1.979 ± 0.043	1.566ProArg: 1.566 ± 0.048	2.676ProSer: 2.676 ± 0.05	2.254ProThr: 2.254 ± 0.045	2.923ProVal: 2.923 ± 0.055	0.538ProTrp: 0.538 ± 0.025	1.271ProTyr: 1.271 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.747GlnAla: 5.747 ± 0.098	0.462GlnCys: 0.462 ± 0.022	2.307GlnAsp: 2.307 ± 0.05	2.824GlnGlu: 2.824 ± 0.054	1.916GlnPhe: 1.916 ± 0.041	3.72GlnGly: 3.72 ± 0.063	1.669GlnHis: 1.669 ± 0.041	2.797GlnIle: 2.797 ± 0.05	2.0GlnLys: 2.0 ± 0.047	6.303GlnLeu: 6.303 ± 0.091	1.246GlnMet: 1.246 ± 0.03	1.492GlnAsn: 1.492 ± 0.04	2.205GlnPro: 2.205 ± 0.05	4.581GlnGln: 4.581 ± 0.118	3.327GlnArg: 3.327 ± 0.076	2.986GlnSer: 2.986 ± 0.064	2.769GlnThr: 2.769 ± 0.053	3.779GlnVal: 3.779 ± 0.064	0.884GlnTrp: 0.884 ± 0.034	1.56GlnTyr: 1.56 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.772ArgAla: 3.772 ± 0.059	0.579ArgCys: 0.579 ± 0.027	2.642ArgAsp: 2.642 ± 0.057	3.099ArgGlu: 3.099 ± 0.063	2.362ArgPhe: 2.362 ± 0.051	2.789ArgGly: 2.789 ± 0.056	1.375ArgHis: 1.375 ± 0.041	3.192ArgIle: 3.192 ± 0.059	2.148ArgLys: 2.148 ± 0.054	5.681ArgLeu: 5.681 ± 0.088	1.259ArgMet: 1.259 ± 0.031	1.872ArgAsn: 1.872 ± 0.05	1.73ArgPro: 1.73 ± 0.043	2.924ArgGln: 2.924 ± 0.065	2.622ArgArg: 2.622 ± 0.062	2.829ArgSer: 2.829 ± 0.055	2.254ArgThr: 2.254 ± 0.042	3.207ArgVal: 3.207 ± 0.06	0.706ArgTrp: 0.706 ± 0.028	1.912ArgTyr: 1.912 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.417SerAla: 5.417 ± 0.083	0.557SerCys: 0.557 ± 0.025	3.314SerAsp: 3.314 ± 0.059	3.716SerGlu: 3.716 ± 0.062	2.664SerPhe: 2.664 ± 0.057	4.744SerGly: 4.744 ± 0.084	1.671SerHis: 1.671 ± 0.045	4.131SerIle: 4.131 ± 0.066	2.697SerLys: 2.697 ± 0.055	7.098SerLeu: 7.098 ± 0.09	1.68SerMet: 1.68 ± 0.045	2.247SerAsn: 2.247 ± 0.047	2.438SerPro: 2.438 ± 0.05	3.296SerGln: 3.296 ± 0.059	3.05SerArg: 3.05 ± 0.059	4.22SerSer: 4.22 ± 0.081	3.183SerThr: 3.183 ± 0.067	4.35SerVal: 4.35 ± 0.072	0.766SerTrp: 0.766 ± 0.029	1.857SerTyr: 1.857 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.429ThrAla: 4.429 ± 0.073	0.467ThrCys: 0.467 ± 0.025	2.625ThrAsp: 2.625 ± 0.053	3.066ThrGlu: 3.066 ± 0.058	2.058ThrPhe: 2.058 ± 0.048	3.968ThrGly: 3.968 ± 0.062	1.416ThrHis: 1.416 ± 0.043	3.576ThrIle: 3.576 ± 0.061	1.981ThrLys: 1.981 ± 0.05	6.725ThrLeu: 6.725 ± 0.086	1.255ThrMet: 1.255 ± 0.033	1.927ThrAsn: 1.927 ± 0.05	2.746ThrPro: 2.746 ± 0.049	2.82ThrGln: 2.82 ± 0.059	2.423ThrArg: 2.423 ± 0.048	3.084ThrSer: 3.084 ± 0.054	2.983ThrThr: 2.983 ± 0.057	3.672ThrVal: 3.672 ± 0.058	0.628ThrTrp: 0.628 ± 0.027	1.4ThrTyr: 1.4 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.37ValAla: 6.37 ± 0.089	0.776ValCys: 0.776 ± 0.028	3.922ValAsp: 3.922 ± 0.075	4.355ValGlu: 4.355 ± 0.076	2.624ValPhe: 2.624 ± 0.054	4.611ValGly: 4.611 ± 0.075	1.248ValHis: 1.248 ± 0.038	5.014ValIle: 5.014 ± 0.074	3.245ValLys: 3.245 ± 0.065	6.771ValLeu: 6.771 ± 0.076	2.043ValMet: 2.043 ± 0.046	2.829ValAsn: 2.829 ± 0.047	2.498ValPro: 2.498 ± 0.054	2.478ValGln: 2.478 ± 0.056	3.009ValArg: 3.009 ± 0.056	4.611ValSer: 4.611 ± 0.071	3.932ValThr: 3.932 ± 0.066	5.121ValVal: 5.121 ± 0.084	0.71ValTrp: 0.71 ± 0.027	1.783ValTyr: 1.783 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.814TrpAla: 0.814 ± 0.031	0.158TrpCys: 0.158 ± 0.011	0.579TrpAsp: 0.579 ± 0.024	0.496TrpGlu: 0.496 ± 0.024	0.607TrpPhe: 0.607 ± 0.028	0.762TrpGly: 0.762 ± 0.027	0.377TrpHis: 0.377 ± 0.019	0.733TrpIle: 0.733 ± 0.026	0.466TrpLys: 0.466 ± 0.023	1.861TrpLeu: 1.861 ± 0.053	0.341TrpMet: 0.341 ± 0.021	0.451TrpAsn: 0.451 ± 0.024	0.548TrpPro: 0.548 ± 0.025	1.218TrpGln: 1.218 ± 0.043	0.73TrpArg: 0.73 ± 0.028	0.726TrpSer: 0.726 ± 0.027	0.474TrpThr: 0.474 ± 0.024	0.836TrpVal: 0.836 ± 0.029	0.218TrpTrp: 0.218 ± 0.017	0.381TrpTyr: 0.381 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.455TyrAla: 2.455 ± 0.051	0.371TyrCys: 0.371 ± 0.019	1.571TyrAsp: 1.571 ± 0.04	1.266TyrGlu: 1.266 ± 0.034	1.359TyrPhe: 1.359 ± 0.037	2.061TyrGly: 2.061 ± 0.05	0.935TyrHis: 0.935 ± 0.034	1.519TyrIle: 1.519 ± 0.042	1.083TyrLys: 1.083 ± 0.037	3.565TyrLeu: 3.565 ± 0.066	0.594TyrMet: 0.594 ± 0.024	0.967TyrAsn: 0.967 ± 0.031	1.439TyrPro: 1.439 ± 0.041	2.35TyrGln: 2.35 ± 0.056	1.871TyrArg: 1.871 ± 0.049	1.902TyrSer: 1.902 ± 0.042	1.479TyrThr: 1.479 ± 0.036	1.819TyrVal: 1.819 ± 0.048	0.547TyrTrp: 0.547 ± 0.024	0.98TyrTyr: 0.98 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3034 proteins (1011234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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