Amino acid dipepetide frequency for Neoasaia chiangmaiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.866AlaAla: 15.866 ± 0.185	1.319AlaCys: 1.319 ± 0.036	6.657AlaAsp: 6.657 ± 0.08	6.322AlaGlu: 6.322 ± 0.088	4.112AlaPhe: 4.112 ± 0.073	9.935AlaGly: 9.935 ± 0.138	2.788AlaHis: 2.788 ± 0.052	6.298AlaIle: 6.298 ± 0.088	2.749AlaLys: 2.749 ± 0.07	13.746AlaLeu: 13.746 ± 0.164	3.543AlaMet: 3.543 ± 0.06	2.904AlaAsn: 2.904 ± 0.056	6.218AlaPro: 6.218 ± 0.098	4.712AlaGln: 4.712 ± 0.094	9.761AlaArg: 9.761 ± 0.103	6.496AlaSer: 6.496 ± 0.079	6.769AlaThr: 6.769 ± 0.084	8.093AlaVal: 8.093 ± 0.113	1.746AlaTrp: 1.746 ± 0.041	2.532AlaTyr: 2.532 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.215CysAla: 1.215 ± 0.04	0.145CysCys: 0.145 ± 0.012	0.603CysAsp: 0.603 ± 0.029	0.38CysGlu: 0.38 ± 0.022	0.32CysPhe: 0.32 ± 0.018	1.019CysGly: 1.019 ± 0.033	0.273CysHis: 0.273 ± 0.021	0.419CysIle: 0.419 ± 0.021	0.133CysLys: 0.133 ± 0.012	0.906CysLeu: 0.906 ± 0.032	0.168CysMet: 0.168 ± 0.012	0.213CysAsn: 0.213 ± 0.014	0.466CysPro: 0.466 ± 0.024	0.253CysGln: 0.253 ± 0.018	0.679CysArg: 0.679 ± 0.028	0.464CysSer: 0.464 ± 0.022	0.445CysThr: 0.445 ± 0.023	0.764CysVal: 0.764 ± 0.027	0.158CysTrp: 0.158 ± 0.011	0.189CysTyr: 0.189 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.504AspAla: 7.504 ± 0.094	0.505AspCys: 0.505 ± 0.022	3.57AspAsp: 3.57 ± 0.076	3.073AspGlu: 3.073 ± 0.066	2.053AspPhe: 2.053 ± 0.047	5.315AspGly: 5.315 ± 0.088	1.468AspHis: 1.468 ± 0.035	3.412AspIle: 3.412 ± 0.062	1.236AspLys: 1.236 ± 0.039	5.94AspLeu: 5.94 ± 0.079	1.509AspMet: 1.509 ± 0.043	1.402AspAsn: 1.402 ± 0.046	3.572AspPro: 3.572 ± 0.063	1.702AspGln: 1.702 ± 0.046	4.601AspArg: 4.601 ± 0.067	2.304AspSer: 2.304 ± 0.054	2.865AspThr: 2.865 ± 0.049	4.361AspVal: 4.361 ± 0.069	1.064AspTrp: 1.064 ± 0.034	1.424AspTyr: 1.424 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.402GluAla: 6.402 ± 0.1	0.35GluCys: 0.35 ± 0.018	2.399GluAsp: 2.399 ± 0.055	2.489GluGlu: 2.489 ± 0.071	1.37GluPhe: 1.37 ± 0.04	3.683GluGly: 3.683 ± 0.069	1.283GluHis: 1.283 ± 0.036	2.924GluIle: 2.924 ± 0.061	1.759GluLys: 1.759 ± 0.049	4.296GluLeu: 4.296 ± 0.071	1.304GluMet: 1.304 ± 0.032	1.633GluAsn: 1.633 ± 0.043	2.142GluPro: 2.142 ± 0.056	1.891GluGln: 1.891 ± 0.044	4.574GluArg: 4.574 ± 0.083	2.286GluSer: 2.286 ± 0.05	3.553GluThr: 3.553 ± 0.063	2.839GluVal: 2.839 ± 0.059	0.672GluTrp: 0.672 ± 0.024	0.869GluTyr: 0.869 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.067PheAla: 4.067 ± 0.071	0.42PheCys: 0.42 ± 0.024	2.54PheAsp: 2.54 ± 0.05	1.746PheGlu: 1.746 ± 0.049	1.294PhePhe: 1.294 ± 0.04	3.575PheGly: 3.575 ± 0.055	0.859PheHis: 0.859 ± 0.031	1.435PheIle: 1.435 ± 0.043	0.666PheLys: 0.666 ± 0.027	3.427PheLeu: 3.427 ± 0.071	0.802PheMet: 0.802 ± 0.031	0.978PheAsn: 0.978 ± 0.034	1.574PhePro: 1.574 ± 0.038	1.019PheGln: 1.019 ± 0.035	2.429PheArg: 2.429 ± 0.05	2.282PheSer: 2.282 ± 0.048	1.897PheThr: 1.897 ± 0.049	2.607PheVal: 2.607 ± 0.053	0.535PheTrp: 0.535 ± 0.024	0.921PheTyr: 0.921 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.231GlyAla: 9.231 ± 0.118	0.887GlyCys: 0.887 ± 0.032	4.311GlyAsp: 4.311 ± 0.082	3.961GlyGlu: 3.961 ± 0.065	3.396GlyPhe: 3.396 ± 0.062	7.436GlyGly: 7.436 ± 0.132	2.383GlyHis: 2.383 ± 0.044	4.701GlyIle: 4.701 ± 0.063	2.601GlyLys: 2.601 ± 0.062	8.79GlyLeu: 8.79 ± 0.104	2.431GlyMet: 2.431 ± 0.055	2.327GlyAsn: 2.327 ± 0.067	3.524GlyPro: 3.524 ± 0.064	3.208GlyGln: 3.208 ± 0.068	6.31GlyArg: 6.31 ± 0.088	4.569GlySer: 4.569 ± 0.079	4.879GlyThr: 4.879 ± 0.082	6.033GlyVal: 6.033 ± 0.079	1.534GlyTrp: 1.534 ± 0.04	2.199GlyTyr: 2.199 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	3.23HisAla: 3.23 ± 0.053	0.241HisCys: 0.241 ± 0.015	1.731HisAsp: 1.731 ± 0.045	1.157HisGlu: 1.157 ± 0.04	0.936HisPhe: 0.936 ± 0.032	2.357HisGly: 2.357 ± 0.05	0.8HisHis: 0.8 ± 0.03	1.209HisIle: 1.209 ± 0.038	0.483HisLys: 0.483 ± 0.024	2.33HisLeu: 2.33 ± 0.048	0.554HisMet: 0.554 ± 0.026	0.634HisAsn: 0.634 ± 0.026	1.564HisPro: 1.564 ± 0.048	0.759HisGln: 0.759 ± 0.026	1.929HisArg: 1.929 ± 0.054	1.03HisSer: 1.03 ± 0.037	1.032HisThr: 1.032 ± 0.032	1.99HisVal: 1.99 ± 0.046	0.437HisTrp: 0.437 ± 0.02	0.687HisTyr: 0.687 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	7.155IleAla: 7.155 ± 0.101	0.548IleCys: 0.548 ± 0.025	3.744IleAsp: 3.744 ± 0.064	3.052IleGlu: 3.052 ± 0.061	1.527IlePhe: 1.527 ± 0.036	5.101IleGly: 5.101 ± 0.072	1.03IleHis: 1.03 ± 0.032	1.938IleIle: 1.938 ± 0.054	1.002IleLys: 1.002 ± 0.036	4.568IleLeu: 4.568 ± 0.072	1.082IleMet: 1.082 ± 0.037	1.339IleAsn: 1.339 ± 0.039	2.366IlePro: 2.366 ± 0.05	1.325IleGln: 1.325 ± 0.04	3.489IleArg: 3.489 ± 0.058	2.795IleSer: 2.795 ± 0.057	2.566IleThr: 2.566 ± 0.055	4.449IleVal: 4.449 ± 0.083	0.617IleTrp: 0.617 ± 0.026	1.04IleTyr: 1.04 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.035LysAla: 3.035 ± 0.066	0.119LysCys: 0.119 ± 0.011	1.25LysAsp: 1.25 ± 0.04	1.067LysGlu: 1.067 ± 0.039	0.638LysPhe: 0.638 ± 0.029	1.93LysGly: 1.93 ± 0.046	0.527LysHis: 0.527 ± 0.025	1.364LysIle: 1.364 ± 0.037	0.786LysLys: 0.786 ± 0.028	2.642LysLeu: 2.642 ± 0.059	0.587LysMet: 0.587 ± 0.026	0.665LysAsn: 0.665 ± 0.03	1.657LysPro: 1.657 ± 0.045	0.898LysGln: 0.898 ± 0.027	1.951LysArg: 1.951 ± 0.048	1.419LysSer: 1.419 ± 0.041	1.581LysThr: 1.581 ± 0.042	1.614LysVal: 1.614 ± 0.048	0.278LysTrp: 0.278 ± 0.016	0.453LysTyr: 0.453 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.195LeuAla: 13.195 ± 0.146	1.103LeuCys: 1.103 ± 0.036	6.249LeuAsp: 6.249 ± 0.077	4.396LeuGlu: 4.396 ± 0.072	3.47LeuPhe: 3.47 ± 0.063	8.298LeuGly: 8.298 ± 0.101	2.683LeuHis: 2.683 ± 0.056	4.612LeuIle: 4.612 ± 0.073	2.62LeuLys: 2.62 ± 0.055	10.158LeuLeu: 10.158 ± 0.146	2.331LeuMet: 2.331 ± 0.054	2.811LeuAsn: 2.811 ± 0.051	6.516LeuPro: 6.516 ± 0.082	3.069LeuGln: 3.069 ± 0.063	8.335LeuArg: 8.335 ± 0.12	6.939LeuSer: 6.939 ± 0.087	6.088LeuThr: 6.088 ± 0.082	6.695LeuVal: 6.695 ± 0.088	1.204LeuTrp: 1.204 ± 0.036	2.094LeuTyr: 2.094 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.204MetAla: 3.204 ± 0.05	0.149MetCys: 0.149 ± 0.012	1.097MetAsp: 1.097 ± 0.031	0.94MetGlu: 0.94 ± 0.03	0.738MetPhe: 0.738 ± 0.026	1.765MetGly: 1.765 ± 0.048	0.53MetHis: 0.53 ± 0.022	1.316MetIle: 1.316 ± 0.037	0.772MetLys: 0.772 ± 0.026	2.655MetLeu: 2.655 ± 0.061	0.629MetMet: 0.629 ± 0.025	0.788MetAsn: 0.788 ± 0.029	1.763MetPro: 1.763 ± 0.04	0.928MetGln: 0.928 ± 0.031	1.973MetArg: 1.973 ± 0.045	1.778MetSer: 1.778 ± 0.04	2.038MetThr: 2.038 ± 0.05	1.517MetVal: 1.517 ± 0.045	0.219MetTrp: 0.219 ± 0.015	0.258MetTyr: 0.258 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.48AsnAla: 3.48 ± 0.063	0.223AsnCys: 0.223 ± 0.015	1.65AsnAsp: 1.65 ± 0.046	1.18AsnGlu: 1.18 ± 0.033	1.003AsnPhe: 1.003 ± 0.036	2.696AsnGly: 2.696 ± 0.064	0.587AsnHis: 0.587 ± 0.026	1.483AsnIle: 1.483 ± 0.042	0.578AsnLys: 0.578 ± 0.026	2.542AsnLeu: 2.542 ± 0.057	0.605AsnMet: 0.605 ± 0.025	0.823AsnAsn: 0.823 ± 0.034	1.765AsnPro: 1.765 ± 0.047	0.852AsnGln: 0.852 ± 0.032	1.791AsnArg: 1.791 ± 0.046	1.229AsnSer: 1.229 ± 0.045	1.423AsnThr: 1.423 ± 0.042	2.136AsnVal: 2.136 ± 0.047	0.458AsnTrp: 0.458 ± 0.024	0.75AsnTyr: 0.75 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.218ProAla: 6.218 ± 0.097	0.396ProCys: 0.396 ± 0.018	4.252ProAsp: 4.252 ± 0.071	3.375ProGlu: 3.375 ± 0.066	2.076ProPhe: 2.076 ± 0.042	4.809ProGly: 4.809 ± 0.078	1.378ProHis: 1.378 ± 0.041	2.378ProIle: 2.378 ± 0.051	1.294ProLys: 1.294 ± 0.037	5.097ProLeu: 5.097 ± 0.08	1.294ProMet: 1.294 ± 0.04	1.593ProAsn: 1.593 ± 0.049	3.134ProPro: 3.134 ± 0.085	1.947ProGln: 1.947 ± 0.043	3.177ProArg: 3.177 ± 0.061	3.157ProSer: 3.157 ± 0.061	2.951ProThr: 2.951 ± 0.058	4.447ProVal: 4.447 ± 0.073	0.781ProTrp: 0.781 ± 0.033	1.28ProTyr: 1.28 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.734GlnAla: 4.734 ± 0.073	0.215GlnCys: 0.215 ± 0.013	1.917GlnAsp: 1.917 ± 0.043	1.589GlnGlu: 1.589 ± 0.043	1.141GlnPhe: 1.141 ± 0.033	2.662GlnGly: 2.662 ± 0.058	0.865GlnHis: 0.865 ± 0.034	2.023GlnIle: 2.023 ± 0.05	0.983GlnLys: 0.983 ± 0.032	2.872GlnLeu: 2.872 ± 0.053	0.835GlnMet: 0.835 ± 0.036	1.131GlnAsn: 1.131 ± 0.041	1.949GlnPro: 1.949 ± 0.046	1.439GlnGln: 1.439 ± 0.05	2.657GlnArg: 2.657 ± 0.06	2.034GlnSer: 2.034 ± 0.049	2.072GlnThr: 2.072 ± 0.048	2.267GlnVal: 2.267 ± 0.044	0.472GlnTrp: 0.472 ± 0.027	0.77GlnTyr: 0.77 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.627ArgAla: 8.627 ± 0.108	0.571ArgCys: 0.571 ± 0.026	4.721ArgAsp: 4.721 ± 0.072	3.973ArgGlu: 3.973 ± 0.076	2.972ArgPhe: 2.972 ± 0.05	5.002ArgGly: 5.002 ± 0.067	2.459ArgHis: 2.459 ± 0.063	4.204ArgIle: 4.204 ± 0.073	1.998ArgLys: 1.998 ± 0.052	8.803ArgLeu: 8.803 ± 0.131	1.931ArgMet: 1.931 ± 0.047	2.178ArgAsn: 2.178 ± 0.047	3.861ArgPro: 3.861 ± 0.063	3.273ArgGln: 3.273 ± 0.065	6.695ArgArg: 6.695 ± 0.108	3.679ArgSer: 3.679 ± 0.06	3.626ArgThr: 3.626 ± 0.07	4.883ArgVal: 4.883 ± 0.074	1.076ArgTrp: 1.076 ± 0.037	1.949ArgTyr: 1.949 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.486SerAla: 6.486 ± 0.097	0.493SerCys: 0.493 ± 0.024	3.048SerAsp: 3.048 ± 0.059	2.434SerGlu: 2.434 ± 0.048	2.29SerPhe: 2.29 ± 0.054	5.572SerGly: 5.572 ± 0.088	1.287SerHis: 1.287 ± 0.036	2.658SerIle: 2.658 ± 0.059	1.15SerLys: 1.15 ± 0.039	5.828SerLeu: 5.828 ± 0.072	1.412SerMet: 1.412 ± 0.041	1.398SerAsn: 1.398 ± 0.039	3.153SerPro: 3.153 ± 0.06	1.714SerGln: 1.714 ± 0.044	3.923SerArg: 3.923 ± 0.069	3.156SerSer: 3.156 ± 0.069	2.898SerThr: 2.898 ± 0.062	4.115SerVal: 4.115 ± 0.068	0.816SerTrp: 0.816 ± 0.027	1.304SerTyr: 1.304 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.448ThrAla: 6.448 ± 0.091	0.485ThrCys: 0.485 ± 0.024	3.093ThrAsp: 3.093 ± 0.057	2.349ThrGlu: 2.349 ± 0.054	1.829ThrPhe: 1.829 ± 0.047	5.116ThrGly: 5.116 ± 0.077	1.343ThrHis: 1.343 ± 0.038	3.072ThrIle: 3.072 ± 0.053	1.205ThrLys: 1.205 ± 0.038	6.779ThrLeu: 6.779 ± 0.082	1.346ThrMet: 1.346 ± 0.039	1.429ThrAsn: 1.429 ± 0.045	3.85ThrPro: 3.85 ± 0.069	1.94ThrGln: 1.94 ± 0.045	3.786ThrArg: 3.786 ± 0.067	2.877ThrSer: 2.877 ± 0.061	3.287ThrThr: 3.287 ± 0.067	4.25ThrVal: 4.25 ± 0.072	0.692ThrTrp: 0.692 ± 0.026	1.281ThrTyr: 1.281 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	8.597ValAla: 8.597 ± 0.109	0.648ValCys: 0.648 ± 0.025	3.856ValAsp: 3.856 ± 0.065	3.644ValGlu: 3.644 ± 0.07	2.555ValPhe: 2.555 ± 0.053	5.321ValGly: 5.321 ± 0.086	1.515ValHis: 1.515 ± 0.041	3.614ValIle: 3.614 ± 0.074	1.579ValLys: 1.579 ± 0.045	7.49ValLeu: 7.49 ± 0.095	1.936ValMet: 1.936 ± 0.049	1.827ValAsn: 1.827 ± 0.049	4.071ValPro: 4.071 ± 0.064	2.262ValGln: 2.262 ± 0.05	4.979ValArg: 4.979 ± 0.078	4.613ValSer: 4.613 ± 0.07	4.57ValThr: 4.57 ± 0.068	5.675ValVal: 5.675 ± 0.099	0.954ValTrp: 0.954 ± 0.035	1.344ValTyr: 1.344 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.242TrpAla: 1.242 ± 0.038	0.14TrpCys: 0.14 ± 0.012	0.677TrpAsp: 0.677 ± 0.034	0.5TrpGlu: 0.5 ± 0.027	0.526TrpPhe: 0.526 ± 0.024	0.933TrpGly: 0.933 ± 0.035	0.483TrpHis: 0.483 ± 0.022	0.729TrpIle: 0.729 ± 0.028	0.399TrpLys: 0.399 ± 0.023	1.851TrpLeu: 1.851 ± 0.048	0.368TrpMet: 0.368 ± 0.018	0.497TrpAsn: 0.497 ± 0.023	0.756TrpPro: 0.756 ± 0.03	0.663TrpGln: 0.663 ± 0.028	1.482TrpArg: 1.482 ± 0.04	0.921TrpSer: 0.921 ± 0.032	0.8TrpThr: 0.8 ± 0.031	0.783TrpVal: 0.783 ± 0.033	0.258TrpTrp: 0.258 ± 0.018	0.306TrpTyr: 0.306 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.629TyrAla: 2.629 ± 0.049	0.254TyrCys: 0.254 ± 0.019	1.518TyrAsp: 1.518 ± 0.044	1.091TyrGlu: 1.091 ± 0.036	0.829TyrPhe: 0.829 ± 0.027	2.188TyrGly: 2.188 ± 0.06	0.549TyrHis: 0.549 ± 0.026	0.943TyrIle: 0.943 ± 0.033	0.467TyrLys: 0.467 ± 0.027	2.146TyrLeu: 2.146 ± 0.051	0.39TyrMet: 0.39 ± 0.021	0.682TyrAsn: 0.682 ± 0.039	1.131TyrPro: 1.131 ± 0.036	0.775TyrGln: 0.775 ± 0.029	1.958TyrArg: 1.958 ± 0.047	1.107TyrSer: 1.107 ± 0.035	1.118TyrThr: 1.118 ± 0.041	1.533TyrVal: 1.533 ± 0.043	0.346TyrTrp: 0.346 ± 0.019	0.63TyrTyr: 0.63 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2999 proteins (985694 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---