Amino acid dipepetide frequency for Streptococcus varani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.761AlaAla: 5.761 ± 0.125
0.54AlaCys: 0.54 ± 0.031
4.482AlaAsp: 4.482 ± 0.095
4.915AlaGlu: 4.915 ± 0.104
3.379AlaPhe: 3.379 ± 0.07
5.737AlaGly: 5.737 ± 0.117
1.38AlaHis: 1.38 ± 0.047
6.015AlaIle: 6.015 ± 0.094
5.173AlaLys: 5.173 ± 0.105
7.477AlaLeu: 7.477 ± 0.123
1.98AlaMet: 1.98 ± 0.052
3.155AlaAsn: 3.155 ± 0.073
2.062AlaPro: 2.062 ± 0.056
3.107AlaGln: 3.107 ± 0.084
2.951AlaArg: 2.951 ± 0.077
4.759AlaSer: 4.759 ± 0.089
4.139AlaThr: 4.139 ± 0.09
5.188AlaVal: 5.188 ± 0.101
0.713AlaTrp: 0.713 ± 0.037
2.942AlaTyr: 2.942 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.353CysAla: 0.353 ± 0.021
0.073CysCys: 0.073 ± 0.012
0.322CysAsp: 0.322 ± 0.022
0.306CysGlu: 0.306 ± 0.022
0.263CysPhe: 0.263 ± 0.022
0.523CysGly: 0.523 ± 0.03
0.225CysHis: 0.225 ± 0.021
0.33CysIle: 0.33 ± 0.021
0.264CysLys: 0.264 ± 0.022
0.722CysLeu: 0.722 ± 0.034
0.111CysMet: 0.111 ± 0.014
0.2CysAsn: 0.2 ± 0.018
0.292CysPro: 0.292 ± 0.024
0.391CysGln: 0.391 ± 0.024
0.245CysArg: 0.245 ± 0.02
0.358CysSer: 0.358 ± 0.024
0.225CysThr: 0.225 ± 0.019
0.325CysVal: 0.325 ± 0.021
0.046CysTrp: 0.046 ± 0.009
0.207CysTyr: 0.207 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.941AspAla: 3.941 ± 0.11
0.402AspCys: 0.402 ± 0.024
2.795AspAsp: 2.795 ± 0.062
3.918AspGlu: 3.918 ± 0.085
3.449AspPhe: 3.449 ± 0.069
4.001AspGly: 4.001 ± 0.096
1.034AspHis: 1.034 ± 0.039
4.282AspIle: 4.282 ± 0.09
4.074AspLys: 4.074 ± 0.089
6.055AspLeu: 6.055 ± 0.104
1.688AspMet: 1.688 ± 0.046
2.27AspAsn: 2.27 ± 0.057
1.689AspPro: 1.689 ± 0.056
2.257AspGln: 2.257 ± 0.065
2.247AspArg: 2.247 ± 0.059
3.2AspSer: 3.2 ± 0.068
2.703AspThr: 2.703 ± 0.061
3.584AspVal: 3.584 ± 0.08
0.706AspTrp: 0.706 ± 0.036
2.835AspTyr: 2.835 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
5.355GluAla: 5.355 ± 0.1
0.323GluCys: 0.323 ± 0.023
3.893GluAsp: 3.893 ± 0.074
6.032GluGlu: 6.032 ± 0.127
2.63GluPhe: 2.63 ± 0.066
3.651GluGly: 3.651 ± 0.071
1.237GluHis: 1.237 ± 0.039
5.152GluIle: 5.152 ± 0.092
5.854GluLys: 5.854 ± 0.098
6.836GluLeu: 6.836 ± 0.126
1.99GluMet: 1.99 ± 0.053
3.835GluAsn: 3.835 ± 0.077
1.611GluPro: 1.611 ± 0.054
2.542GluGln: 2.542 ± 0.059
3.091GluArg: 3.091 ± 0.067
3.439GluSer: 3.439 ± 0.079
3.724GluThr: 3.724 ± 0.084
4.739GluVal: 4.739 ± 0.096
0.613GluTrp: 0.613 ± 0.034
2.1GluTyr: 2.1 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
3.476PheAla: 3.476 ± 0.074
0.268PheCys: 0.268 ± 0.02
3.127PheAsp: 3.127 ± 0.075
2.947PheGlu: 2.947 ± 0.065
2.236PhePhe: 2.236 ± 0.072
3.391PheGly: 3.391 ± 0.076
0.932PheHis: 0.932 ± 0.032
3.3PheIle: 3.3 ± 0.082
2.646PheLys: 2.646 ± 0.064
4.756PheLeu: 4.756 ± 0.101
1.093PheMet: 1.093 ± 0.045
1.865PheAsn: 1.865 ± 0.051
1.574PhePro: 1.574 ± 0.049
1.689PheGln: 1.689 ± 0.05
1.635PheArg: 1.635 ± 0.049
3.304PheSer: 3.304 ± 0.079
2.365PheThr: 2.365 ± 0.063
3.043PheVal: 3.043 ± 0.076
0.481PheTrp: 0.481 ± 0.029
1.893PheTyr: 1.893 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.464GlyAla: 4.464 ± 0.099
0.409GlyCys: 0.409 ± 0.027
3.233GlyAsp: 3.233 ± 0.088
3.478GlyGlu: 3.478 ± 0.086
3.466GlyPhe: 3.466 ± 0.065
4.309GlyGly: 4.309 ± 0.102
1.383GlyHis: 1.383 ± 0.046
5.48GlyIle: 5.48 ± 0.093
4.642GlyLys: 4.642 ± 0.092
6.972GlyLeu: 6.972 ± 0.111
1.952GlyMet: 1.952 ± 0.048
3.029GlyAsn: 3.029 ± 0.101
1.443GlyPro: 1.443 ± 0.052
3.505GlyGln: 3.505 ± 0.071
2.85GlyArg: 2.85 ± 0.072
3.911GlySer: 3.911 ± 0.075
3.672GlyThr: 3.672 ± 0.08
4.659GlyVal: 4.659 ± 0.087
0.77GlyTrp: 0.77 ± 0.041
2.779GlyTyr: 2.779 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.269HisAla: 1.269 ± 0.044
0.145HisCys: 0.145 ± 0.014
1.04HisAsp: 1.04 ± 0.042
1.12HisGlu: 1.12 ± 0.042
1.268HisPhe: 1.268 ± 0.045
1.325HisGly: 1.325 ± 0.044
0.59HisHis: 0.59 ± 0.026
1.325HisIle: 1.325 ± 0.039
0.995HisLys: 0.995 ± 0.039
2.299HisLeu: 2.299 ± 0.064
0.505HisMet: 0.505 ± 0.03
0.706HisAsn: 0.706 ± 0.033
0.926HisPro: 0.926 ± 0.038
1.032HisGln: 1.032 ± 0.04
0.814HisArg: 0.814 ± 0.037
1.131HisSer: 1.131 ± 0.043
0.94HisThr: 0.94 ± 0.039
1.182HisVal: 1.182 ± 0.043
0.183HisTrp: 0.183 ± 0.016
0.971HisTyr: 0.971 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.194IleAla: 6.194 ± 0.106
0.6IleCys: 0.6 ± 0.032
4.43IleAsp: 4.43 ± 0.081
4.963IleGlu: 4.963 ± 0.103
3.335IlePhe: 3.335 ± 0.088
4.991IleGly: 4.991 ± 0.085
1.412IleHis: 1.412 ± 0.041
4.902IleIle: 4.902 ± 0.107
4.566IleLys: 4.566 ± 0.083
7.574IleLeu: 7.574 ± 0.123
1.667IleMet: 1.667 ± 0.051
3.151IleAsn: 3.151 ± 0.067
2.928IlePro: 2.928 ± 0.066
2.878IleGln: 2.878 ± 0.075
3.037IleArg: 3.037 ± 0.074
5.065IleSer: 5.065 ± 0.091
3.747IleThr: 3.747 ± 0.075
4.611IleVal: 4.611 ± 0.086
0.652IleTrp: 0.652 ± 0.038
2.561IleTyr: 2.561 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
5.01LysAla: 5.01 ± 0.101
0.226LysCys: 0.226 ± 0.021
3.885LysAsp: 3.885 ± 0.099
6.015LysGlu: 6.015 ± 0.095
2.027LysPhe: 2.027 ± 0.057
3.82LysGly: 3.82 ± 0.065
1.148LysHis: 1.148 ± 0.051
4.929LysIle: 4.929 ± 0.088
5.553LysLys: 5.553 ± 0.094
5.951LysLeu: 5.951 ± 0.115
2.094LysMet: 2.094 ± 0.055
3.391LysAsn: 3.391 ± 0.074
2.01LysPro: 2.01 ± 0.054
2.521LysGln: 2.521 ± 0.065
3.006LysArg: 3.006 ± 0.07
3.963LysSer: 3.963 ± 0.071
4.013LysThr: 4.013 ± 0.079
4.458LysVal: 4.458 ± 0.079
0.691LysTrp: 0.691 ± 0.037
2.115LysTyr: 2.115 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
8.791LeuAla: 8.791 ± 0.125
0.523LeuCys: 0.523 ± 0.029
5.889LeuAsp: 5.889 ± 0.106
7.15LeuGlu: 7.15 ± 0.119
4.423LeuPhe: 4.423 ± 0.105
6.61LeuGly: 6.61 ± 0.094
1.727LeuHis: 1.727 ± 0.05
6.801LeuIle: 6.801 ± 0.111
6.192LeuLys: 6.192 ± 0.108
9.911LeuLeu: 9.911 ± 0.168
2.557LeuMet: 2.557 ± 0.065
3.965LeuAsn: 3.965 ± 0.071
4.074LeuPro: 4.074 ± 0.083
3.575LeuGln: 3.575 ± 0.078
3.737LeuArg: 3.737 ± 0.077
7.415LeuSer: 7.415 ± 0.111
6.176LeuThr: 6.176 ± 0.101
7.068LeuVal: 7.068 ± 0.115
0.721LeuTrp: 0.721 ± 0.035
3.314LeuTyr: 3.314 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.228MetAla: 2.228 ± 0.057
0.101MetCys: 0.101 ± 0.012
1.564MetAsp: 1.564 ± 0.042
1.661MetGlu: 1.661 ± 0.049
0.839MetPhe: 0.839 ± 0.034
1.803MetGly: 1.803 ± 0.057
0.406MetHis: 0.406 ± 0.021
1.973MetIle: 1.973 ± 0.051
2.098MetLys: 2.098 ± 0.052
2.232MetLeu: 2.232 ± 0.054
0.749MetMet: 0.749 ± 0.034
1.301MetAsn: 1.301 ± 0.04
0.801MetPro: 0.801 ± 0.038
0.895MetGln: 0.895 ± 0.037
1.026MetArg: 1.026 ± 0.037
1.781MetSer: 1.781 ± 0.053
2.058MetThr: 2.058 ± 0.057
1.837MetVal: 1.837 ± 0.055
0.163MetTrp: 0.163 ± 0.016
0.651MetTyr: 0.651 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.968AsnAla: 2.968 ± 0.061
0.273AsnCys: 0.273 ± 0.019
2.128AsnAsp: 2.128 ± 0.061
2.499AsnGlu: 2.499 ± 0.065
2.069AsnPhe: 2.069 ± 0.06
3.306AsnGly: 3.306 ± 0.091
1.204AsnHis: 1.204 ± 0.044
3.197AsnIle: 3.197 ± 0.07
2.575AsnLys: 2.575 ± 0.072
4.673AsnLeu: 4.673 ± 0.085
1.242AsnMet: 1.242 ± 0.041
1.768AsnAsn: 1.768 ± 0.056
2.223AsnPro: 2.223 ± 0.056
2.448AsnGln: 2.448 ± 0.066
2.039AsnArg: 2.039 ± 0.053
2.458AsnSer: 2.458 ± 0.071
2.063AsnThr: 2.063 ± 0.06
2.49AsnVal: 2.49 ± 0.08
0.52AsnTrp: 0.52 ± 0.027
1.925AsnTyr: 1.925 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.587ProAla: 2.587 ± 0.07
0.149ProCys: 0.149 ± 0.015
1.97ProAsp: 1.97 ± 0.053
2.627ProGlu: 2.627 ± 0.064
1.632ProPhe: 1.632 ± 0.055
1.893ProGly: 1.893 ± 0.055
0.745ProHis: 0.745 ± 0.036
2.436ProIle: 2.436 ± 0.062
2.096ProLys: 2.096 ± 0.045
3.025ProLeu: 3.025 ± 0.064
0.8ProMet: 0.8 ± 0.038
1.653ProAsn: 1.653 ± 0.055
0.54ProPro: 0.54 ± 0.032
1.304ProGln: 1.304 ± 0.046
1.058ProArg: 1.058 ± 0.044
2.214ProSer: 2.214 ± 0.06
2.029ProThr: 2.029 ± 0.056
2.558ProVal: 2.558 ± 0.064
0.267ProTrp: 0.267 ± 0.021
1.344ProTyr: 1.344 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.878GlnAla: 3.878 ± 0.083
0.178GlnCys: 0.178 ± 0.016
2.256GlnAsp: 2.256 ± 0.055
3.501GlnGlu: 3.501 ± 0.086
1.684GlnPhe: 1.684 ± 0.055
2.384GlnGly: 2.384 ± 0.066
0.749GlnHis: 0.749 ± 0.035
3.032GlnIle: 3.032 ± 0.066
2.877GlnLys: 2.877 ± 0.072
4.266GlnLeu: 4.266 ± 0.088
1.137GlnMet: 1.137 ± 0.04
1.743GlnAsn: 1.743 ± 0.057
1.196GlnPro: 1.196 ± 0.042
1.524GlnGln: 1.524 ± 0.049
1.435GlnArg: 1.435 ± 0.045
2.405GlnSer: 2.405 ± 0.063
2.455GlnThr: 2.455 ± 0.063
3.49GlnVal: 3.49 ± 0.071
0.347GlnTrp: 0.347 ± 0.023
1.337GlnTyr: 1.337 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.509ArgAla: 2.509 ± 0.067
0.195ArgCys: 0.195 ± 0.018
2.205ArgAsp: 2.205 ± 0.059
2.928ArgGlu: 2.928 ± 0.071
2.062ArgPhe: 2.062 ± 0.06
2.423ArgGly: 2.423 ± 0.064
0.873ArgHis: 0.873 ± 0.039
3.003ArgIle: 3.003 ± 0.069
2.93ArgLys: 2.93 ± 0.069
4.152ArgLeu: 4.152 ± 0.08
1.089ArgMet: 1.089 ± 0.041
1.862ArgAsn: 1.862 ± 0.056
1.389ArgPro: 1.389 ± 0.041
2.125ArgGln: 2.125 ± 0.051
1.944ArgArg: 1.944 ± 0.066
2.157ArgSer: 2.157 ± 0.055
1.994ArgThr: 1.994 ± 0.056
2.646ArgVal: 2.646 ± 0.063
0.349ArgTrp: 0.349 ± 0.025
1.734ArgTyr: 1.734 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
4.142SerAla: 4.142 ± 0.102
0.356SerCys: 0.356 ± 0.021
3.668SerAsp: 3.668 ± 0.074
3.653SerGlu: 3.653 ± 0.087
3.155SerPhe: 3.155 ± 0.066
4.524SerGly: 4.524 ± 0.078
1.414SerHis: 1.414 ± 0.046
4.684SerIle: 4.684 ± 0.076
3.924SerLys: 3.924 ± 0.074
6.704SerLeu: 6.704 ± 0.119
1.511SerMet: 1.511 ± 0.048
2.662SerAsn: 2.662 ± 0.06
2.081SerPro: 2.081 ± 0.058
3.248SerGln: 3.248 ± 0.075
2.656SerArg: 2.656 ± 0.06
4.264SerSer: 4.264 ± 0.095
3.285SerThr: 3.285 ± 0.088
3.979SerVal: 3.979 ± 0.081
0.638SerTrp: 0.638 ± 0.025
2.69SerTyr: 2.69 ± 0.108
0.0SerXaa: 0.0 ± 0.0
Thr
4.133ThrAla: 4.133 ± 0.071
0.309ThrCys: 0.309 ± 0.019
3.244ThrAsp: 3.244 ± 0.084
3.372ThrGlu: 3.372 ± 0.075
2.585ThrPhe: 2.585 ± 0.06
4.199ThrGly: 4.199 ± 0.09
1.016ThrHis: 1.016 ± 0.041
4.613ThrIle: 4.613 ± 0.085
3.311ThrLys: 3.311 ± 0.07
5.093ThrLeu: 5.093 ± 0.086
1.231ThrMet: 1.231 ± 0.048
2.478ThrAsn: 2.478 ± 0.065
2.187ThrPro: 2.187 ± 0.068
1.809ThrGln: 1.809 ± 0.054
2.028ThrArg: 2.028 ± 0.052
3.736ThrSer: 3.736 ± 0.094
3.148ThrThr: 3.148 ± 0.112
4.285ThrVal: 4.285 ± 0.079
0.547ThrTrp: 0.547 ± 0.024
2.391ThrTyr: 2.391 ± 0.117
0.0ThrXaa: 0.0 ± 0.0
Val
5.653ValAla: 5.653 ± 0.094
0.401ValCys: 0.401 ± 0.027
4.104ValAsp: 4.104 ± 0.082
4.683ValGlu: 4.683 ± 0.09
3.065ValPhe: 3.065 ± 0.059
4.37ValGly: 4.37 ± 0.084
1.219ValHis: 1.219 ± 0.044
4.863ValIle: 4.863 ± 0.092
4.19ValLys: 4.19 ± 0.082
6.614ValLeu: 6.614 ± 0.107
1.657ValMet: 1.657 ± 0.053
2.815ValAsn: 2.815 ± 0.074
2.287ValPro: 2.287 ± 0.062
2.354ValGln: 2.354 ± 0.069
2.6ValArg: 2.6 ± 0.066
4.583ValSer: 4.583 ± 0.078
4.416ValThr: 4.416 ± 0.102
4.735ValVal: 4.735 ± 0.109
0.568ValTrp: 0.568 ± 0.03
2.363ValTyr: 2.363 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.583TrpAla: 0.583 ± 0.03
0.065TrpCys: 0.065 ± 0.009
0.481TrpAsp: 0.481 ± 0.024
0.578TrpGlu: 0.578 ± 0.034
0.461TrpPhe: 0.461 ± 0.029
0.645TrpGly: 0.645 ± 0.036
0.178TrpHis: 0.178 ± 0.017
0.679TrpIle: 0.679 ± 0.034
0.665TrpLys: 0.665 ± 0.032
1.077TrpLeu: 1.077 ± 0.044
0.284TrpMet: 0.284 ± 0.016
0.52TrpAsn: 0.52 ± 0.026
0.193TrpPro: 0.193 ± 0.018
0.492TrpGln: 0.492 ± 0.026
0.379TrpArg: 0.379 ± 0.026
0.627TrpSer: 0.627 ± 0.031
0.595TrpThr: 0.595 ± 0.034
0.534TrpVal: 0.534 ± 0.032
0.112TrpTrp: 0.112 ± 0.012
0.327TrpTyr: 0.327 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.561TyrAla: 2.561 ± 0.06
0.245TyrCys: 0.245 ± 0.022
2.416TyrAsp: 2.416 ± 0.131
2.302TyrGlu: 2.302 ± 0.057
1.997TyrPhe: 1.997 ± 0.052
2.502TyrGly: 2.502 ± 0.064
0.892TyrHis: 0.892 ± 0.041
2.267TyrIle: 2.267 ± 0.06
2.201TyrLys: 2.201 ± 0.06
4.23TyrLeu: 4.23 ± 0.1
0.829TyrMet: 0.829 ± 0.034
1.702TyrAsn: 1.702 ± 0.065
1.42TyrPro: 1.42 ± 0.041
2.173TyrGln: 2.173 ± 0.061
1.791TyrArg: 1.791 ± 0.055
2.468TyrSer: 2.468 ± 0.067
1.968TyrThr: 1.968 ± 0.081
2.126TyrVal: 2.126 ± 0.056
0.388TyrTrp: 0.388 ± 0.024
1.632TyrTyr: 1.632 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2422 proteins (711518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski