Amino acid dipepetide frequency for Streptococcus phage DCC1738

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.357AlaAla: 2.357 ± 0.839
0.272AlaCys: 0.272 ± 0.16
5.438AlaAsp: 5.438 ± 0.779
6.163AlaGlu: 6.163 ± 0.968
2.81AlaPhe: 2.81 ± 0.809
5.982AlaGly: 5.982 ± 1.202
0.363AlaHis: 0.363 ± 0.189
5.076AlaIle: 5.076 ± 1.039
5.891AlaLys: 5.891 ± 0.797
6.345AlaLeu: 6.345 ± 0.95
2.175AlaMet: 2.175 ± 0.397
3.716AlaAsn: 3.716 ± 0.667
1.722AlaPro: 1.722 ± 0.359
2.9AlaGln: 2.9 ± 0.556
2.9AlaArg: 2.9 ± 0.574
2.81AlaSer: 2.81 ± 0.728
4.985AlaThr: 4.985 ± 0.801
4.985AlaVal: 4.985 ± 0.88
1.36AlaTrp: 1.36 ± 0.445
2.085AlaTyr: 2.085 ± 0.425
0.0AlaXaa: 0.0 ± 0.0
Cys
0.363CysAla: 0.363 ± 0.173
0.272CysCys: 0.272 ± 0.177
0.453CysAsp: 0.453 ± 0.226
0.453CysGlu: 0.453 ± 0.192
0.272CysPhe: 0.272 ± 0.149
0.544CysGly: 0.544 ± 0.325
0.181CysHis: 0.181 ± 0.102
0.363CysIle: 0.363 ± 0.241
0.725CysLys: 0.725 ± 0.234
0.272CysLeu: 0.272 ± 0.127
0.181CysMet: 0.181 ± 0.147
0.181CysAsn: 0.181 ± 0.183
0.181CysPro: 0.181 ± 0.127
0.272CysGln: 0.272 ± 0.137
0.363CysArg: 0.363 ± 0.155
0.363CysSer: 0.363 ± 0.194
0.181CysThr: 0.181 ± 0.118
0.0CysVal: 0.0 ± 0.0
0.181CysTrp: 0.181 ± 0.106
0.181CysTyr: 0.181 ± 0.106
0.0CysXaa: 0.0 ± 0.0
Asp
3.897AspAla: 3.897 ± 0.745
0.634AspCys: 0.634 ± 0.262
3.354AspAsp: 3.354 ± 0.749
5.076AspGlu: 5.076 ± 1.197
3.625AspPhe: 3.625 ± 0.533
4.622AspGly: 4.622 ± 0.47
0.272AspHis: 0.272 ± 0.193
4.985AspIle: 4.985 ± 0.542
4.804AspLys: 4.804 ± 0.898
5.529AspLeu: 5.529 ± 0.646
2.175AspMet: 2.175 ± 0.377
2.538AspAsn: 2.538 ± 0.417
1.903AspPro: 1.903 ± 0.526
1.722AspGln: 1.722 ± 0.401
2.447AspArg: 2.447 ± 0.459
3.535AspSer: 3.535 ± 0.534
3.444AspThr: 3.444 ± 0.431
3.897AspVal: 3.897 ± 0.51
1.541AspTrp: 1.541 ± 0.403
2.719AspTyr: 2.719 ± 0.7
0.0AspXaa: 0.0 ± 0.0
Glu
6.707GluAla: 6.707 ± 0.967
0.363GluCys: 0.363 ± 0.194
4.351GluAsp: 4.351 ± 0.885
6.345GluGlu: 6.345 ± 1.15
3.807GluPhe: 3.807 ± 0.721
3.807GluGly: 3.807 ± 0.578
0.906GluHis: 0.906 ± 0.266
6.617GluIle: 6.617 ± 0.678
6.254GluLys: 6.254 ± 1.214
9.426GluLeu: 9.426 ± 1.222
2.085GluMet: 2.085 ± 0.763
4.441GluAsn: 4.441 ± 0.625
1.541GluPro: 1.541 ± 0.432
3.988GluGln: 3.988 ± 0.873
4.894GluArg: 4.894 ± 0.808
4.894GluSer: 4.894 ± 0.783
3.897GluThr: 3.897 ± 0.607
5.257GluVal: 5.257 ± 0.605
1.269GluTrp: 1.269 ± 0.287
2.628GluTyr: 2.628 ± 0.529
0.0GluXaa: 0.0 ± 0.0
Phe
2.447PheAla: 2.447 ± 0.57
0.272PheCys: 0.272 ± 0.142
3.988PheAsp: 3.988 ± 0.581
4.079PheGlu: 4.079 ± 0.715
1.178PhePhe: 1.178 ± 0.317
2.085PheGly: 2.085 ± 0.786
0.181PheHis: 0.181 ± 0.136
1.903PheIle: 1.903 ± 0.433
3.807PheLys: 3.807 ± 0.625
2.538PheLeu: 2.538 ± 0.46
1.178PheMet: 1.178 ± 0.373
3.082PheAsn: 3.082 ± 0.531
0.634PhePro: 0.634 ± 0.288
2.175PheGln: 2.175 ± 0.43
0.997PheArg: 0.997 ± 0.259
3.444PheSer: 3.444 ± 0.642
2.538PheThr: 2.538 ± 0.426
1.813PheVal: 1.813 ± 0.394
0.634PheTrp: 0.634 ± 0.265
1.722PheTyr: 1.722 ± 0.354
0.0PheXaa: 0.0 ± 0.0
Gly
3.716GlyAla: 3.716 ± 0.527
0.0GlyCys: 0.0 ± 0.0
3.988GlyAsp: 3.988 ± 0.704
4.713GlyGlu: 4.713 ± 0.873
2.719GlyPhe: 2.719 ± 0.588
5.257GlyGly: 5.257 ± 1.273
0.906GlyHis: 0.906 ± 0.275
3.354GlyIle: 3.354 ± 0.701
4.985GlyLys: 4.985 ± 0.703
5.529GlyLeu: 5.529 ± 1.164
2.175GlyMet: 2.175 ± 0.349
3.172GlyAsn: 3.172 ± 0.412
0.725GlyPro: 0.725 ± 0.287
4.622GlyGln: 4.622 ± 0.554
3.535GlyArg: 3.535 ± 0.611
4.26GlySer: 4.26 ± 0.864
2.628GlyThr: 2.628 ± 0.512
4.894GlyVal: 4.894 ± 0.721
0.725GlyTrp: 0.725 ± 0.203
3.535GlyTyr: 3.535 ± 0.694
0.0GlyXaa: 0.0 ± 0.0
His
0.725HisAla: 0.725 ± 0.276
0.0HisCys: 0.0 ± 0.0
0.816HisAsp: 0.816 ± 0.275
1.088HisGlu: 1.088 ± 0.392
0.725HisPhe: 0.725 ± 0.243
0.725HisGly: 0.725 ± 0.28
0.272HisHis: 0.272 ± 0.21
0.816HisIle: 0.816 ± 0.32
0.816HisLys: 0.816 ± 0.297
1.088HisLeu: 1.088 ± 0.347
0.272HisMet: 0.272 ± 0.144
0.906HisAsn: 0.906 ± 0.386
0.725HisPro: 0.725 ± 0.199
0.544HisGln: 0.544 ± 0.249
0.725HisArg: 0.725 ± 0.286
0.725HisSer: 0.725 ± 0.296
0.453HisThr: 0.453 ± 0.197
0.544HisVal: 0.544 ± 0.198
0.272HisTrp: 0.272 ± 0.177
0.725HisTyr: 0.725 ± 0.269
0.0HisXaa: 0.0 ± 0.0
Ile
5.529IleAla: 5.529 ± 0.856
0.634IleCys: 0.634 ± 0.252
3.354IleAsp: 3.354 ± 0.455
5.801IleGlu: 5.801 ± 0.632
3.082IlePhe: 3.082 ± 0.497
4.532IleGly: 4.532 ± 0.824
0.725IleHis: 0.725 ± 0.291
2.991IleIle: 2.991 ± 0.377
6.073IleLys: 6.073 ± 0.672
3.535IleLeu: 3.535 ± 0.474
1.903IleMet: 1.903 ± 0.533
4.441IleAsn: 4.441 ± 0.589
1.36IlePro: 1.36 ± 0.309
2.447IleGln: 2.447 ± 0.404
3.172IleArg: 3.172 ± 0.579
5.076IleSer: 5.076 ± 0.616
4.169IleThr: 4.169 ± 0.576
2.991IleVal: 2.991 ± 0.637
0.453IleTrp: 0.453 ± 0.194
1.541IleTyr: 1.541 ± 0.455
0.0IleXaa: 0.0 ± 0.0
Lys
5.438LysAla: 5.438 ± 0.762
0.453LysCys: 0.453 ± 0.2
5.529LysAsp: 5.529 ± 0.614
7.16LysGlu: 7.16 ± 0.9
2.538LysPhe: 2.538 ± 0.528
4.894LysGly: 4.894 ± 0.753
1.178LysHis: 1.178 ± 0.273
6.163LysIle: 6.163 ± 0.864
7.251LysLys: 7.251 ± 1.041
8.52LysLeu: 8.52 ± 0.927
2.266LysMet: 2.266 ± 0.451
4.622LysAsn: 4.622 ± 0.581
2.266LysPro: 2.266 ± 0.515
4.169LysGln: 4.169 ± 0.934
3.807LysArg: 3.807 ± 0.451
4.713LysSer: 4.713 ± 0.595
4.532LysThr: 4.532 ± 0.683
6.617LysVal: 6.617 ± 0.745
1.269LysTrp: 1.269 ± 0.38
2.991LysTyr: 2.991 ± 0.506
0.0LysXaa: 0.0 ± 0.0
Leu
6.617LeuAla: 6.617 ± 0.974
0.634LeuCys: 0.634 ± 0.285
6.435LeuAsp: 6.435 ± 0.795
8.339LeuGlu: 8.339 ± 1.061
2.719LeuPhe: 2.719 ± 0.49
6.073LeuGly: 6.073 ± 1.455
0.997LeuHis: 0.997 ± 0.262
4.26LeuIle: 4.26 ± 0.629
6.888LeuLys: 6.888 ± 0.843
7.432LeuLeu: 7.432 ± 1.182
1.813LeuMet: 1.813 ± 0.358
3.988LeuAsn: 3.988 ± 0.613
2.357LeuPro: 2.357 ± 0.514
2.991LeuGln: 2.991 ± 0.603
4.804LeuArg: 4.804 ± 0.7
5.348LeuSer: 5.348 ± 0.963
4.532LeuThr: 4.532 ± 0.528
3.535LeuVal: 3.535 ± 0.493
0.544LeuTrp: 0.544 ± 0.199
2.9LeuTyr: 2.9 ± 0.521
0.0LeuXaa: 0.0 ± 0.0
Met
1.994MetAla: 1.994 ± 0.495
0.0MetCys: 0.0 ± 0.0
1.45MetAsp: 1.45 ± 0.317
1.722MetGlu: 1.722 ± 0.376
1.088MetPhe: 1.088 ± 0.333
1.36MetGly: 1.36 ± 0.422
0.363MetHis: 0.363 ± 0.203
1.994MetIle: 1.994 ± 0.518
2.538MetLys: 2.538 ± 0.518
1.903MetLeu: 1.903 ± 0.383
0.544MetMet: 0.544 ± 0.263
1.36MetAsn: 1.36 ± 0.406
0.725MetPro: 0.725 ± 0.226
1.088MetGln: 1.088 ± 0.381
1.269MetArg: 1.269 ± 0.331
1.994MetSer: 1.994 ± 0.847
1.722MetThr: 1.722 ± 0.466
1.36MetVal: 1.36 ± 0.351
0.363MetTrp: 0.363 ± 0.214
0.725MetTyr: 0.725 ± 0.213
0.0MetXaa: 0.0 ± 0.0
Asn
4.079AsnAla: 4.079 ± 0.89
0.453AsnCys: 0.453 ± 0.196
3.082AsnAsp: 3.082 ± 0.369
3.535AsnGlu: 3.535 ± 0.715
2.085AsnPhe: 2.085 ± 0.428
3.625AsnGly: 3.625 ± 0.592
1.269AsnHis: 1.269 ± 0.411
2.9AsnIle: 2.9 ± 0.467
4.351AsnLys: 4.351 ± 0.512
3.988AsnLeu: 3.988 ± 0.761
1.088AsnMet: 1.088 ± 0.354
1.36AsnAsn: 1.36 ± 0.444
2.266AsnPro: 2.266 ± 0.438
2.991AsnGln: 2.991 ± 0.566
2.175AsnArg: 2.175 ± 0.481
2.9AsnSer: 2.9 ± 0.666
2.628AsnThr: 2.628 ± 0.475
3.716AsnVal: 3.716 ± 0.562
0.544AsnTrp: 0.544 ± 0.176
1.541AsnTyr: 1.541 ± 0.358
0.0AsnXaa: 0.0 ± 0.0
Pro
2.357ProAla: 2.357 ± 0.438
0.0ProCys: 0.0 ± 0.0
2.175ProAsp: 2.175 ± 0.547
3.172ProGlu: 3.172 ± 0.497
1.36ProPhe: 1.36 ± 0.504
0.906ProGly: 0.906 ± 0.217
0.272ProHis: 0.272 ± 0.13
1.088ProIle: 1.088 ± 0.441
2.991ProLys: 2.991 ± 0.419
1.36ProLeu: 1.36 ± 0.386
0.363ProMet: 0.363 ± 0.189
1.269ProAsn: 1.269 ± 0.471
0.816ProPro: 0.816 ± 0.312
0.906ProGln: 0.906 ± 0.325
1.269ProArg: 1.269 ± 0.275
0.906ProSer: 0.906 ± 0.325
0.997ProThr: 0.997 ± 0.294
1.813ProVal: 1.813 ± 0.421
0.544ProTrp: 0.544 ± 0.238
0.725ProTyr: 0.725 ± 0.255
0.0ProXaa: 0.0 ± 0.0
Gln
3.625GlnAla: 3.625 ± 0.53
0.363GlnCys: 0.363 ± 0.192
2.085GlnAsp: 2.085 ± 0.372
4.713GlnGlu: 4.713 ± 0.852
1.269GlnPhe: 1.269 ± 0.361
2.266GlnGly: 2.266 ± 0.384
0.363GlnHis: 0.363 ± 0.219
3.807GlnIle: 3.807 ± 0.513
3.807GlnLys: 3.807 ± 0.711
3.082GlnLeu: 3.082 ± 0.486
0.906GlnMet: 0.906 ± 0.234
1.722GlnAsn: 1.722 ± 0.494
0.906GlnPro: 0.906 ± 0.368
2.266GlnGln: 2.266 ± 0.53
2.719GlnArg: 2.719 ± 0.523
2.628GlnSer: 2.628 ± 0.445
3.354GlnThr: 3.354 ± 0.561
3.988GlnVal: 3.988 ± 0.543
0.453GlnTrp: 0.453 ± 0.186
1.088GlnTyr: 1.088 ± 0.402
0.0GlnXaa: 0.0 ± 0.0
Arg
2.991ArgAla: 2.991 ± 0.481
0.363ArgCys: 0.363 ± 0.159
2.447ArgAsp: 2.447 ± 0.464
3.444ArgGlu: 3.444 ± 0.666
1.45ArgPhe: 1.45 ± 0.359
2.175ArgGly: 2.175 ± 0.576
0.725ArgHis: 0.725 ± 0.202
3.263ArgIle: 3.263 ± 0.498
4.351ArgLys: 4.351 ± 0.926
5.257ArgLeu: 5.257 ± 0.678
1.722ArgMet: 1.722 ± 0.4
2.175ArgAsn: 2.175 ± 0.579
1.088ArgPro: 1.088 ± 0.252
2.628ArgGln: 2.628 ± 0.47
1.813ArgArg: 1.813 ± 0.452
2.266ArgSer: 2.266 ± 0.464
2.81ArgThr: 2.81 ± 0.687
2.538ArgVal: 2.538 ± 0.493
0.272ArgTrp: 0.272 ± 0.166
2.085ArgTyr: 2.085 ± 0.392
0.0ArgXaa: 0.0 ± 0.0
Ser
4.713SerAla: 4.713 ± 1.011
0.091SerCys: 0.091 ± 0.061
3.897SerAsp: 3.897 ± 0.781
5.348SerGlu: 5.348 ± 1.447
1.813SerPhe: 1.813 ± 0.383
5.166SerGly: 5.166 ± 0.796
1.36SerHis: 1.36 ± 0.435
3.716SerIle: 3.716 ± 0.742
5.348SerLys: 5.348 ± 0.683
4.713SerLeu: 4.713 ± 0.451
1.45SerMet: 1.45 ± 0.519
2.719SerAsn: 2.719 ± 0.524
1.45SerPro: 1.45 ± 0.304
2.9SerGln: 2.9 ± 0.502
2.991SerArg: 2.991 ± 0.631
3.263SerSer: 3.263 ± 0.696
3.807SerThr: 3.807 ± 0.609
3.263SerVal: 3.263 ± 0.762
0.906SerTrp: 0.906 ± 0.458
2.628SerTyr: 2.628 ± 0.598
0.0SerXaa: 0.0 ± 0.0
Thr
4.713ThrAla: 4.713 ± 1.071
0.181ThrCys: 0.181 ± 0.122
3.625ThrAsp: 3.625 ± 0.6
3.625ThrGlu: 3.625 ± 0.51
3.082ThrPhe: 3.082 ± 0.542
3.625ThrGly: 3.625 ± 0.496
0.725ThrHis: 0.725 ± 0.333
4.26ThrIle: 4.26 ± 0.765
4.622ThrLys: 4.622 ± 0.736
5.166ThrLeu: 5.166 ± 0.636
1.088ThrMet: 1.088 ± 0.317
2.81ThrAsn: 2.81 ± 0.483
1.45ThrPro: 1.45 ± 0.443
2.9ThrGln: 2.9 ± 0.597
1.178ThrArg: 1.178 ± 0.285
3.625ThrSer: 3.625 ± 0.653
3.897ThrThr: 3.897 ± 0.941
4.351ThrVal: 4.351 ± 0.729
0.725ThrTrp: 0.725 ± 0.233
2.085ThrTyr: 2.085 ± 0.552
0.0ThrXaa: 0.0 ± 0.0
Val
5.166ValAla: 5.166 ± 0.719
0.181ValCys: 0.181 ± 0.135
3.354ValAsp: 3.354 ± 0.582
5.166ValGlu: 5.166 ± 0.655
2.628ValPhe: 2.628 ± 0.507
4.804ValGly: 4.804 ± 0.799
0.906ValHis: 0.906 ± 0.317
2.991ValIle: 2.991 ± 0.507
6.163ValLys: 6.163 ± 0.597
3.897ValLeu: 3.897 ± 0.596
1.088ValMet: 1.088 ± 0.334
3.535ValAsn: 3.535 ± 0.825
1.994ValPro: 1.994 ± 0.32
1.45ValGln: 1.45 ± 0.454
2.81ValArg: 2.81 ± 0.408
5.348ValSer: 5.348 ± 0.668
4.713ValThr: 4.713 ± 0.613
4.804ValVal: 4.804 ± 0.992
0.816ValTrp: 0.816 ± 0.25
2.447ValTyr: 2.447 ± 0.589
0.0ValXaa: 0.0 ± 0.0
Trp
0.997TrpAla: 0.997 ± 0.329
0.181TrpCys: 0.181 ± 0.108
0.634TrpAsp: 0.634 ± 0.34
0.816TrpGlu: 0.816 ± 0.312
1.178TrpPhe: 1.178 ± 0.464
0.634TrpGly: 0.634 ± 0.26
0.091TrpHis: 0.091 ± 0.1
0.816TrpIle: 0.816 ± 0.247
0.906TrpLys: 0.906 ± 0.274
0.725TrpLeu: 0.725 ± 0.343
0.544TrpMet: 0.544 ± 0.193
1.269TrpAsn: 1.269 ± 0.286
0.091TrpPro: 0.091 ± 0.09
0.544TrpGln: 0.544 ± 0.267
0.453TrpArg: 0.453 ± 0.223
0.816TrpSer: 0.816 ± 0.299
0.906TrpThr: 0.906 ± 0.282
1.178TrpVal: 1.178 ± 0.404
0.181TrpTrp: 0.181 ± 0.116
0.181TrpTyr: 0.181 ± 0.127
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.903TyrAla: 1.903 ± 0.3
0.634TyrCys: 0.634 ± 0.328
2.266TyrAsp: 2.266 ± 0.426
2.719TyrGlu: 2.719 ± 0.483
1.269TyrPhe: 1.269 ± 0.363
2.357TyrGly: 2.357 ± 0.528
0.906TyrHis: 0.906 ± 0.267
2.447TyrIle: 2.447 ± 0.492
3.807TyrLys: 3.807 ± 0.705
2.9TyrLeu: 2.9 ± 0.589
0.453TyrMet: 0.453 ± 0.307
1.269TyrAsn: 1.269 ± 0.322
1.088TyrPro: 1.088 ± 0.296
1.903TyrGln: 1.903 ± 0.547
1.541TyrArg: 1.541 ± 0.402
2.628TyrSer: 2.628 ± 0.522
1.541TyrThr: 1.541 ± 0.32
2.719TyrVal: 2.719 ± 0.558
0.091TyrTrp: 0.091 ± 0.061
1.178TyrTyr: 1.178 ± 0.442
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (11034 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski