Amino acid dipepetide frequency for Streptococcus satellite phage Javan285

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.733AlaAla: 0.733 ± 0.422
0.366AlaCys: 0.366 ± 0.321
4.396AlaAsp: 4.396 ± 1.61
2.564AlaGlu: 2.564 ± 0.666
2.564AlaPhe: 2.564 ± 1.117
3.297AlaGly: 3.297 ± 1.263
1.099AlaHis: 1.099 ± 0.664
4.029AlaIle: 4.029 ± 1.011
4.396AlaLys: 4.396 ± 1.317
2.93AlaLeu: 2.93 ± 0.893
2.198AlaMet: 2.198 ± 0.755
2.564AlaAsn: 2.564 ± 0.454
2.198AlaPro: 2.198 ± 1.039
2.198AlaGln: 2.198 ± 0.927
3.663AlaArg: 3.663 ± 0.874
1.832AlaSer: 1.832 ± 0.71
3.663AlaThr: 3.663 ± 0.985
2.564AlaVal: 2.564 ± 0.881
0.366AlaTrp: 0.366 ± 0.351
3.663AlaTyr: 3.663 ± 0.745
0.0AlaXaa: 0.0 ± 0.0
Cys
0.366CysAla: 0.366 ± 0.329
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.366CysGlu: 0.366 ± 0.309
0.733CysPhe: 0.733 ± 0.618
0.733CysGly: 0.733 ± 0.377
0.0CysHis: 0.0 ± 0.0
0.366CysIle: 0.366 ± 0.309
0.366CysLys: 0.366 ± 0.324
1.832CysLeu: 1.832 ± 0.89
0.0CysMet: 0.0 ± 0.0
0.366CysAsn: 0.366 ± 0.386
0.0CysPro: 0.0 ± 0.0
0.366CysGln: 0.366 ± 0.321
0.733CysArg: 0.733 ± 0.401
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.366CysVal: 0.366 ± 0.329
0.366CysTrp: 0.366 ± 0.31
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.198AspAla: 2.198 ± 0.997
0.733AspCys: 0.733 ± 0.444
4.762AspAsp: 4.762 ± 1.672
6.227AspGlu: 6.227 ± 1.28
2.93AspPhe: 2.93 ± 1.166
2.93AspGly: 2.93 ± 0.799
0.733AspHis: 0.733 ± 0.385
3.297AspIle: 3.297 ± 1.028
5.861AspLys: 5.861 ± 1.565
7.692AspLeu: 7.692 ± 1.335
3.297AspMet: 3.297 ± 1.257
4.396AspAsn: 4.396 ± 1.445
1.465AspPro: 1.465 ± 0.745
0.0AspGln: 0.0 ± 0.0
3.297AspArg: 3.297 ± 1.015
1.465AspSer: 1.465 ± 0.827
4.029AspThr: 4.029 ± 0.991
3.297AspVal: 3.297 ± 1.421
0.366AspTrp: 0.366 ± 0.321
3.297AspTyr: 3.297 ± 0.754
0.0AspXaa: 0.0 ± 0.0
Glu
5.861GluAla: 5.861 ± 1.448
0.733GluCys: 0.733 ± 0.382
4.762GluAsp: 4.762 ± 1.136
4.762GluGlu: 4.762 ± 1.4
1.832GluPhe: 1.832 ± 0.705
1.832GluGly: 1.832 ± 0.567
1.099GluHis: 1.099 ± 0.538
7.692GluIle: 7.692 ± 1.991
6.593GluLys: 6.593 ± 1.331
10.256GluLeu: 10.256 ± 2.256
2.198GluMet: 2.198 ± 1.285
3.663GluAsn: 3.663 ± 0.682
1.465GluPro: 1.465 ± 0.747
2.198GluGln: 2.198 ± 0.973
5.128GluArg: 5.128 ± 1.695
3.297GluSer: 3.297 ± 1.101
4.396GluThr: 4.396 ± 1.49
8.059GluVal: 8.059 ± 1.278
1.832GluTrp: 1.832 ± 0.613
5.128GluTyr: 5.128 ± 1.873
0.0GluXaa: 0.0 ± 0.0
Phe
1.832PheAla: 1.832 ± 0.84
0.0PheCys: 0.0 ± 0.0
2.93PheAsp: 2.93 ± 0.777
1.832PheGlu: 1.832 ± 0.822
1.099PhePhe: 1.099 ± 0.52
1.465PheGly: 1.465 ± 0.597
2.198PheHis: 2.198 ± 0.966
2.564PheIle: 2.564 ± 0.919
3.663PheLys: 3.663 ± 1.007
6.227PheLeu: 6.227 ± 1.27
0.733PheMet: 0.733 ± 0.401
2.198PheAsn: 2.198 ± 1.135
1.832PhePro: 1.832 ± 0.716
0.733PheGln: 0.733 ± 0.499
1.465PheArg: 1.465 ± 0.653
2.198PheSer: 2.198 ± 0.707
2.198PheThr: 2.198 ± 0.59
1.465PheVal: 1.465 ± 0.593
0.0PheTrp: 0.0 ± 0.0
2.198PheTyr: 2.198 ± 0.673
0.0PheXaa: 0.0 ± 0.0
Gly
1.832GlyAla: 1.832 ± 0.738
0.366GlyCys: 0.366 ± 0.324
2.93GlyAsp: 2.93 ± 0.743
3.297GlyGlu: 3.297 ± 0.807
2.93GlyPhe: 2.93 ± 0.974
0.733GlyGly: 0.733 ± 0.486
2.198GlyHis: 2.198 ± 0.687
3.663GlyIle: 3.663 ± 0.973
6.227GlyLys: 6.227 ± 1.826
4.396GlyLeu: 4.396 ± 1.609
1.465GlyMet: 1.465 ± 0.646
2.198GlyAsn: 2.198 ± 0.712
0.0GlyPro: 0.0 ± 0.0
0.0GlyGln: 0.0 ± 0.0
2.93GlyArg: 2.93 ± 0.926
1.832GlySer: 1.832 ± 0.61
3.663GlyThr: 3.663 ± 1.019
4.029GlyVal: 4.029 ± 1.147
1.099GlyTrp: 1.099 ± 0.56
1.832GlyTyr: 1.832 ± 0.784
0.0GlyXaa: 0.0 ± 0.0
His
1.832HisAla: 1.832 ± 0.922
0.733HisCys: 0.733 ± 0.377
0.733HisAsp: 0.733 ± 0.44
0.733HisGlu: 0.733 ± 0.429
1.099HisPhe: 1.099 ± 0.735
1.832HisGly: 1.832 ± 0.787
1.099HisHis: 1.099 ± 0.735
2.93HisIle: 2.93 ± 1.145
0.366HisLys: 0.366 ± 0.31
3.297HisLeu: 3.297 ± 1.128
0.366HisMet: 0.366 ± 0.309
1.099HisAsn: 1.099 ± 0.514
0.733HisPro: 0.733 ± 0.642
0.366HisGln: 0.366 ± 0.351
1.099HisArg: 1.099 ± 0.68
1.832HisSer: 1.832 ± 1.202
1.832HisThr: 1.832 ± 0.683
1.465HisVal: 1.465 ± 0.746
0.366HisTrp: 0.366 ± 0.37
0.366HisTyr: 0.366 ± 0.31
0.0HisXaa: 0.0 ± 0.0
Ile
6.96IleAla: 6.96 ± 1.91
0.366IleCys: 0.366 ± 0.309
7.692IleAsp: 7.692 ± 2.213
6.227IleGlu: 6.227 ± 1.66
2.198IlePhe: 2.198 ± 0.736
2.564IleGly: 2.564 ± 0.749
1.099IleHis: 1.099 ± 0.506
5.495IleIle: 5.495 ± 1.653
8.425IleLys: 8.425 ± 2.604
5.495IleLeu: 5.495 ± 1.717
1.099IleMet: 1.099 ± 0.519
4.396IleAsn: 4.396 ± 1.188
2.198IlePro: 2.198 ± 0.665
4.029IleGln: 4.029 ± 1.036
2.564IleArg: 2.564 ± 0.89
4.396IleSer: 4.396 ± 1.137
4.029IleThr: 4.029 ± 0.719
2.564IleVal: 2.564 ± 1.206
0.733IleTrp: 0.733 ± 0.446
4.029IleTyr: 4.029 ± 1.188
0.0IleXaa: 0.0 ± 0.0
Lys
5.495LysAla: 5.495 ± 1.307
0.733LysCys: 0.733 ± 0.47
2.564LysAsp: 2.564 ± 0.965
11.355LysGlu: 11.355 ± 2.959
0.733LysPhe: 0.733 ± 0.516
5.128LysGly: 5.128 ± 1.249
1.832LysHis: 1.832 ± 0.941
8.059LysIle: 8.059 ± 1.854
4.762LysLys: 4.762 ± 1.337
8.425LysLeu: 8.425 ± 1.373
1.832LysMet: 1.832 ± 0.812
3.297LysAsn: 3.297 ± 1.059
2.564LysPro: 2.564 ± 1.092
5.861LysGln: 5.861 ± 1.285
6.227LysArg: 6.227 ± 1.267
4.396LysSer: 4.396 ± 0.865
8.059LysThr: 8.059 ± 1.748
3.663LysVal: 3.663 ± 0.672
0.0LysTrp: 0.0 ± 0.0
3.297LysTyr: 3.297 ± 1.25
0.0LysXaa: 0.0 ± 0.0
Leu
4.396LeuAla: 4.396 ± 1.404
0.733LeuCys: 0.733 ± 0.486
6.227LeuAsp: 6.227 ± 1.473
8.425LeuGlu: 8.425 ± 1.454
3.663LeuPhe: 3.663 ± 1.192
4.762LeuGly: 4.762 ± 1.551
1.832LeuHis: 1.832 ± 0.727
6.593LeuIle: 6.593 ± 1.621
9.89LeuLys: 9.89 ± 1.875
8.425LeuLeu: 8.425 ± 1.395
2.93LeuMet: 2.93 ± 0.842
7.326LeuAsn: 7.326 ± 1.719
3.297LeuPro: 3.297 ± 0.825
3.297LeuGln: 3.297 ± 1.14
2.93LeuArg: 2.93 ± 0.992
6.593LeuSer: 6.593 ± 1.25
5.861LeuThr: 5.861 ± 1.735
5.861LeuVal: 5.861 ± 1.623
1.099LeuTrp: 1.099 ± 0.623
2.564LeuTyr: 2.564 ± 0.731
0.0LeuXaa: 0.0 ± 0.0
Met
1.099MetAla: 1.099 ± 0.779
0.0MetCys: 0.0 ± 0.0
1.099MetAsp: 1.099 ± 0.922
3.297MetGlu: 3.297 ± 0.973
1.832MetPhe: 1.832 ± 0.696
0.366MetGly: 0.366 ± 0.323
0.0MetHis: 0.0 ± 0.0
1.465MetIle: 1.465 ± 0.72
1.465MetLys: 1.465 ± 0.742
2.93MetLeu: 2.93 ± 0.798
0.366MetMet: 0.366 ± 0.37
1.465MetAsn: 1.465 ± 0.48
1.099MetPro: 1.099 ± 0.663
1.099MetGln: 1.099 ± 0.684
0.733MetArg: 0.733 ± 0.449
0.733MetSer: 0.733 ± 0.382
2.93MetThr: 2.93 ± 0.821
1.099MetVal: 1.099 ± 0.569
0.0MetTrp: 0.0 ± 0.0
1.099MetTyr: 1.099 ± 0.587
0.0MetXaa: 0.0 ± 0.0
Asn
1.465AsnAla: 1.465 ± 0.687
0.366AsnCys: 0.366 ± 0.351
5.495AsnAsp: 5.495 ± 1.69
6.227AsnGlu: 6.227 ± 2.188
2.198AsnPhe: 2.198 ± 0.931
3.663AsnGly: 3.663 ± 1.016
1.832AsnHis: 1.832 ± 0.645
2.93AsnIle: 2.93 ± 0.701
4.762AsnLys: 4.762 ± 1.123
3.297AsnLeu: 3.297 ± 1.044
1.099AsnMet: 1.099 ± 0.577
2.93AsnAsn: 2.93 ± 0.779
1.465AsnPro: 1.465 ± 0.506
2.198AsnGln: 2.198 ± 1.242
5.128AsnArg: 5.128 ± 0.957
3.297AsnSer: 3.297 ± 1.278
2.93AsnThr: 2.93 ± 1.037
2.93AsnVal: 2.93 ± 1.009
0.733AsnTrp: 0.733 ± 0.466
2.93AsnTyr: 2.93 ± 1.03
0.0AsnXaa: 0.0 ± 0.0
Pro
2.198ProAla: 2.198 ± 0.882
0.366ProCys: 0.366 ± 0.329
1.465ProAsp: 1.465 ± 0.704
1.099ProGlu: 1.099 ± 0.635
1.099ProPhe: 1.099 ± 0.452
0.0ProGly: 0.0 ± 0.0
0.366ProHis: 0.366 ± 0.321
1.832ProIle: 1.832 ± 0.64
3.297ProLys: 3.297 ± 1.006
1.832ProLeu: 1.832 ± 0.812
0.0ProMet: 0.0 ± 0.0
2.198ProAsn: 2.198 ± 0.73
0.733ProPro: 0.733 ± 0.619
1.832ProGln: 1.832 ± 0.986
1.099ProArg: 1.099 ± 0.494
1.099ProSer: 1.099 ± 0.773
1.465ProThr: 1.465 ± 0.503
2.93ProVal: 2.93 ± 0.777
0.366ProTrp: 0.366 ± 0.321
1.465ProTyr: 1.465 ± 0.563
0.0ProXaa: 0.0 ± 0.0
Gln
2.93GlnAla: 2.93 ± 1.474
0.0GlnCys: 0.0 ± 0.0
2.198GlnAsp: 2.198 ± 0.788
3.663GlnGlu: 3.663 ± 1.268
1.465GlnPhe: 1.465 ± 0.672
1.465GlnGly: 1.465 ± 0.562
0.733GlnHis: 0.733 ± 0.401
3.663GlnIle: 3.663 ± 1.638
2.93GlnLys: 2.93 ± 0.661
6.227GlnLeu: 6.227 ± 1.264
0.366GlnMet: 0.366 ± 0.324
0.733GlnAsn: 0.733 ± 0.421
0.366GlnPro: 0.366 ± 0.37
1.099GlnGln: 1.099 ± 0.468
1.832GlnArg: 1.832 ± 0.675
2.198GlnSer: 2.198 ± 1.069
1.832GlnThr: 1.832 ± 0.92
1.832GlnVal: 1.832 ± 0.586
0.366GlnTrp: 0.366 ± 0.321
2.93GlnTyr: 2.93 ± 1.008
0.0GlnXaa: 0.0 ± 0.0
Arg
2.198ArgAla: 2.198 ± 0.809
0.366ArgCys: 0.366 ± 0.324
2.93ArgAsp: 2.93 ± 1.109
4.029ArgGlu: 4.029 ± 1.4
1.832ArgPhe: 1.832 ± 0.735
4.396ArgGly: 4.396 ± 1.882
2.93ArgHis: 2.93 ± 1.944
6.227ArgIle: 6.227 ± 1.139
4.762ArgLys: 4.762 ± 1.737
3.663ArgLeu: 3.663 ± 0.777
0.366ArgMet: 0.366 ± 0.288
2.93ArgAsn: 2.93 ± 0.858
1.832ArgPro: 1.832 ± 0.687
1.832ArgGln: 1.832 ± 0.925
2.198ArgArg: 2.198 ± 1.217
0.733ArgSer: 0.733 ± 0.422
2.93ArgThr: 2.93 ± 0.929
2.564ArgVal: 2.564 ± 0.955
0.366ArgTrp: 0.366 ± 0.471
2.198ArgTyr: 2.198 ± 1.046
0.0ArgXaa: 0.0 ± 0.0
Ser
0.733SerAla: 0.733 ± 0.556
0.366SerCys: 0.366 ± 0.309
3.663SerAsp: 3.663 ± 0.992
2.564SerGlu: 2.564 ± 1.103
1.099SerPhe: 1.099 ± 0.719
1.832SerGly: 1.832 ± 0.73
1.832SerHis: 1.832 ± 1.279
4.396SerIle: 4.396 ± 1.098
4.396SerLys: 4.396 ± 0.998
3.663SerLeu: 3.663 ± 0.909
0.366SerMet: 0.366 ± 0.324
1.832SerAsn: 1.832 ± 0.711
1.099SerPro: 1.099 ± 0.661
4.396SerGln: 4.396 ± 1.018
2.198SerArg: 2.198 ± 1.18
3.297SerSer: 3.297 ± 1.09
3.297SerThr: 3.297 ± 1.393
1.099SerVal: 1.099 ± 0.653
0.366SerTrp: 0.366 ± 0.324
4.029SerTyr: 4.029 ± 1.443
0.0SerXaa: 0.0 ± 0.0
Thr
4.029ThrAla: 4.029 ± 0.833
0.0ThrCys: 0.0 ± 0.0
4.029ThrAsp: 4.029 ± 0.799
3.663ThrGlu: 3.663 ± 1.129
4.762ThrPhe: 4.762 ± 0.962
4.762ThrGly: 4.762 ± 1.097
0.733ThrHis: 0.733 ± 0.401
5.495ThrIle: 5.495 ± 1.119
5.128ThrLys: 5.128 ± 1.237
6.227ThrLeu: 6.227 ± 1.829
1.465ThrMet: 1.465 ± 0.48
5.861ThrAsn: 5.861 ± 1.397
1.832ThrPro: 1.832 ± 0.994
0.366ThrGln: 0.366 ± 0.471
2.93ThrArg: 2.93 ± 0.624
2.198ThrSer: 2.198 ± 0.931
4.029ThrThr: 4.029 ± 0.961
5.128ThrVal: 5.128 ± 1.302
0.0ThrTrp: 0.0 ± 0.0
2.564ThrTyr: 2.564 ± 1.304
0.0ThrXaa: 0.0 ± 0.0
Val
3.663ValAla: 3.663 ± 0.731
0.366ValCys: 0.366 ± 0.329
1.832ValAsp: 1.832 ± 0.644
5.861ValGlu: 5.861 ± 1.191
3.663ValPhe: 3.663 ± 1.065
0.733ValGly: 0.733 ± 0.388
0.366ValHis: 0.366 ± 0.321
3.663ValIle: 3.663 ± 0.803
5.861ValLys: 5.861 ± 1.45
5.128ValLeu: 5.128 ± 1.576
1.099ValMet: 1.099 ± 0.717
4.029ValAsn: 4.029 ± 0.888
2.198ValPro: 2.198 ± 0.754
1.099ValGln: 1.099 ± 0.594
1.832ValArg: 1.832 ± 0.785
2.93ValSer: 2.93 ± 1.175
5.128ValThr: 5.128 ± 1.228
1.465ValVal: 1.465 ± 0.557
1.099ValTrp: 1.099 ± 0.599
2.198ValTyr: 2.198 ± 0.683
0.0ValXaa: 0.0 ± 0.0
Trp
1.099TrpAla: 1.099 ± 0.676
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.832TrpGlu: 1.832 ± 0.68
0.0TrpPhe: 0.0 ± 0.0
1.099TrpGly: 1.099 ± 0.674
0.0TrpHis: 0.0 ± 0.0
0.733TrpIle: 0.733 ± 0.439
0.366TrpLys: 0.366 ± 0.321
0.733TrpLeu: 0.733 ± 0.49
0.0TrpMet: 0.0 ± 0.0
0.366TrpAsn: 0.366 ± 0.329
0.0TrpPro: 0.0 ± 0.0
0.733TrpGln: 0.733 ± 0.429
0.0TrpArg: 0.0 ± 0.0
0.733TrpSer: 0.733 ± 0.422
0.366TrpThr: 0.366 ± 0.351
1.099TrpVal: 1.099 ± 0.519
0.0TrpTrp: 0.0 ± 0.0
0.366TrpTyr: 0.366 ± 0.31
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.733TyrAla: 0.733 ± 0.465
0.366TyrCys: 0.366 ± 0.31
2.564TyrAsp: 2.564 ± 0.581
4.762TyrGlu: 4.762 ± 1.191
1.099TyrPhe: 1.099 ± 0.635
4.029TyrGly: 4.029 ± 0.871
2.198TyrHis: 2.198 ± 0.722
1.465TyrIle: 1.465 ± 0.711
4.762TyrLys: 4.762 ± 1.131
4.029TyrLeu: 4.029 ± 1.19
2.564TyrMet: 2.564 ± 0.769
4.029TyrAsn: 4.029 ± 1.122
0.366TyrPro: 0.366 ± 0.324
5.128TyrGln: 5.128 ± 1.246
3.297TyrArg: 3.297 ± 1.15
1.465TyrSer: 1.465 ± 0.52
2.564TyrThr: 2.564 ± 1.012
0.733TyrVal: 0.733 ± 0.477
0.0TyrTrp: 0.0 ± 0.0
4.029TyrTyr: 4.029 ± 1.103
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 16 proteins (2731 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski