Amino acid dipepetide frequency for Alteromonadales bacterium alter-6D02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.11AlaAla: 7.11 ± 0.118	0.852AlaCys: 0.852 ± 0.028	4.238AlaAsp: 4.238 ± 0.066	4.61AlaGlu: 4.61 ± 0.11	3.233AlaPhe: 3.233 ± 0.061	5.405AlaGly: 5.405 ± 0.081	1.636AlaHis: 1.636 ± 0.037	6.239AlaIle: 6.239 ± 0.079	5.148AlaLys: 5.148 ± 0.084	9.41AlaLeu: 9.41 ± 0.109	2.318AlaMet: 2.318 ± 0.043	3.883AlaAsn: 3.883 ± 0.057	2.72AlaPro: 2.72 ± 0.06	4.561AlaGln: 4.561 ± 0.088	3.212AlaArg: 3.212 ± 0.06	5.436AlaSer: 5.436 ± 0.074	4.595AlaThr: 4.595 ± 0.08	5.488AlaVal: 5.488 ± 0.072	0.8AlaTrp: 0.8 ± 0.026	2.317AlaTyr: 2.317 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.741CysAla: 0.741 ± 0.026	0.165CysCys: 0.165 ± 0.011	0.624CysAsp: 0.624 ± 0.024	0.541CysGlu: 0.541 ± 0.026	0.492CysPhe: 0.492 ± 0.024	0.809CysGly: 0.809 ± 0.031	0.351CysHis: 0.351 ± 0.021	0.606CysIle: 0.606 ± 0.026	0.413CysLys: 0.413 ± 0.02	0.964CysLeu: 0.964 ± 0.031	0.194CysMet: 0.194 ± 0.012	0.384CysAsn: 0.384 ± 0.018	0.439CysPro: 0.439 ± 0.02	0.549CysGln: 0.549 ± 0.021	0.388CysArg: 0.388 ± 0.02	0.714CysSer: 0.714 ± 0.028	0.39CysThr: 0.39 ± 0.02	0.63CysVal: 0.63 ± 0.024	0.136CysTrp: 0.136 ± 0.011	0.348CysTyr: 0.348 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.928AspAla: 3.928 ± 0.069	0.545AspCys: 0.545 ± 0.022	3.447AspAsp: 3.447 ± 0.072	3.625AspGlu: 3.625 ± 0.065	2.603AspPhe: 2.603 ± 0.056	3.767AspGly: 3.767 ± 0.069	1.15AspHis: 1.15 ± 0.037	4.33AspIle: 4.33 ± 0.067	3.434AspLys: 3.434 ± 0.053	5.148AspLeu: 5.148 ± 0.066	1.288AspMet: 1.288 ± 0.035	3.029AspAsn: 3.029 ± 0.054	1.795AspPro: 1.795 ± 0.042	2.074AspGln: 2.074 ± 0.047	2.049AspArg: 2.049 ± 0.048	3.849AspSer: 3.849 ± 0.068	2.705AspThr: 2.705 ± 0.061	3.919AspVal: 3.919 ± 0.073	0.727AspTrp: 0.727 ± 0.027	2.167AspTyr: 2.167 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.453GluAla: 4.453 ± 0.076	0.408GluCys: 0.408 ± 0.018	2.497GluAsp: 2.497 ± 0.055	3.152GluGlu: 3.152 ± 0.069	2.51GluPhe: 2.51 ± 0.047	2.957GluGly: 2.957 ± 0.057	1.689GluHis: 1.689 ± 0.039	3.749GluIle: 3.749 ± 0.054	3.407GluLys: 3.407 ± 0.068	7.415GluLeu: 7.415 ± 0.095	1.501GluMet: 1.501 ± 0.036	2.357GluAsn: 2.357 ± 0.043	1.841GluPro: 1.841 ± 0.041	5.349GluGln: 5.349 ± 0.092	3.165GluArg: 3.165 ± 0.059	3.703GluSer: 3.703 ± 0.057	2.883GluThr: 2.883 ± 0.052	4.131GluVal: 4.131 ± 0.073	0.583GluTrp: 0.583 ± 0.025	1.687GluTyr: 1.687 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.331PheAla: 3.331 ± 0.056	0.531PheCys: 0.531 ± 0.022	2.88PheAsp: 2.88 ± 0.051	2.658PheGlu: 2.658 ± 0.05	1.787PhePhe: 1.787 ± 0.043	2.811PheGly: 2.811 ± 0.056	0.78PheHis: 0.78 ± 0.028	3.19PheIle: 3.19 ± 0.055	2.388PheLys: 2.388 ± 0.054	3.344PheLeu: 3.344 ± 0.058	0.929PheMet: 0.929 ± 0.031	2.544PheAsn: 2.544 ± 0.05	1.309PhePro: 1.309 ± 0.032	1.175PheGln: 1.175 ± 0.032	1.362PheArg: 1.362 ± 0.036	3.834PheSer: 3.834 ± 0.054	2.437PheThr: 2.437 ± 0.067	2.617PheVal: 2.617 ± 0.055	0.463PheTrp: 0.463 ± 0.022	1.502PheTyr: 1.502 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.778GlyAla: 4.778 ± 0.076	0.863GlyCys: 0.863 ± 0.03	3.619GlyAsp: 3.619 ± 0.067	4.028GlyGlu: 4.028 ± 0.063	3.07GlyPhe: 3.07 ± 0.051	4.409GlyGly: 4.409 ± 0.072	1.626GlyHis: 1.626 ± 0.039	4.294GlyIle: 4.294 ± 0.064	3.439GlyLys: 3.439 ± 0.06	6.849GlyLeu: 6.849 ± 0.099	1.691GlyMet: 1.691 ± 0.043	2.557GlyAsn: 2.557 ± 0.055	1.463GlyPro: 1.463 ± 0.04	3.128GlyGln: 3.128 ± 0.055	2.761GlyArg: 2.761 ± 0.051	3.934GlySer: 3.934 ± 0.062	3.18GlyThr: 3.18 ± 0.07	4.839GlyVal: 4.839 ± 0.077	0.768GlyTrp: 0.768 ± 0.028	2.447GlyTyr: 2.447 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.54HisAla: 1.54 ± 0.034	0.35HisCys: 0.35 ± 0.018	1.181HisAsp: 1.181 ± 0.034	1.118HisGlu: 1.118 ± 0.032	1.177HisPhe: 1.177 ± 0.037	1.615HisGly: 1.615 ± 0.036	0.775HisHis: 0.775 ± 0.03	1.551HisIle: 1.551 ± 0.036	1.042HisLys: 1.042 ± 0.032	2.355HisLeu: 2.355 ± 0.051	0.425HisMet: 0.425 ± 0.02	1.034HisAsn: 1.034 ± 0.031	1.031HisPro: 1.031 ± 0.03	1.643HisGln: 1.643 ± 0.047	1.048HisArg: 1.048 ± 0.03	1.564HisSer: 1.564 ± 0.037	0.997HisThr: 0.997 ± 0.031	1.224HisVal: 1.224 ± 0.032	0.397HisTrp: 0.397 ± 0.019	0.969HisTyr: 0.969 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.585IleAla: 6.585 ± 0.084	0.674IleCys: 0.674 ± 0.026	4.698IleAsp: 4.698 ± 0.07	5.165IleGlu: 5.165 ± 0.071	2.343IlePhe: 2.343 ± 0.041	4.507IleGly: 4.507 ± 0.083	1.258IleHis: 1.258 ± 0.037	4.397IleIle: 4.397 ± 0.075	4.202IleLys: 4.202 ± 0.062	5.221IleLeu: 5.221 ± 0.081	1.218IleMet: 1.218 ± 0.032	3.849IleAsn: 3.849 ± 0.063	2.432IlePro: 2.432 ± 0.048	2.075IleGln: 2.075 ± 0.046	2.439IleArg: 2.439 ± 0.051	5.129IleSer: 5.129 ± 0.071	4.198IleThr: 4.198 ± 0.065	4.308IleVal: 4.308 ± 0.07	0.558IleTrp: 0.558 ± 0.024	1.811IleTyr: 1.811 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.7LysAla: 4.7 ± 0.091	0.308LysCys: 0.308 ± 0.017	2.663LysAsp: 2.663 ± 0.047	3.333LysGlu: 3.333 ± 0.054	1.733LysPhe: 1.733 ± 0.037	3.005LysGly: 3.005 ± 0.057	1.426LysHis: 1.426 ± 0.032	3.208LysIle: 3.208 ± 0.058	3.34LysLys: 3.34 ± 0.072	5.93LysLeu: 5.93 ± 0.071	1.317LysMet: 1.317 ± 0.031	2.358LysAsn: 2.358 ± 0.048	2.414LysPro: 2.414 ± 0.046	3.735LysGln: 3.735 ± 0.059	2.718LysArg: 2.718 ± 0.047	3.371LysSer: 3.371 ± 0.063	2.972LysThr: 2.972 ± 0.056	3.992LysVal: 3.992 ± 0.061	0.469LysTrp: 0.469 ± 0.021	1.474LysTyr: 1.474 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.271LeuAla: 10.271 ± 0.113	1.072LeuCys: 1.072 ± 0.032	5.705LeuAsp: 5.705 ± 0.076	6.076LeuGlu: 6.076 ± 0.086	4.461LeuPhe: 4.461 ± 0.084	6.533LeuGly: 6.533 ± 0.085	2.05LeuHis: 2.05 ± 0.048	7.049LeuIle: 7.049 ± 0.09	5.576LeuLys: 5.576 ± 0.074	10.954LeuLeu: 10.954 ± 0.14	2.532LeuMet: 2.532 ± 0.052	5.096LeuAsn: 5.096 ± 0.07	4.383LeuPro: 4.383 ± 0.073	3.644LeuGln: 3.644 ± 0.066	4.068LeuArg: 4.068 ± 0.071	8.542LeuSer: 8.542 ± 0.086	6.968LeuThr: 6.968 ± 0.086	7.049LeuVal: 7.049 ± 0.084	0.997LeuTrp: 0.997 ± 0.037	2.677LeuTyr: 2.677 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.307MetAla: 2.307 ± 0.046	0.206MetCys: 0.206 ± 0.013	1.069MetAsp: 1.069 ± 0.03	1.071MetGlu: 1.071 ± 0.03	0.842MetPhe: 0.842 ± 0.027	1.458MetGly: 1.458 ± 0.039	0.454MetHis: 0.454 ± 0.02	1.38MetIle: 1.38 ± 0.035	1.332MetLys: 1.332 ± 0.031	2.6MetLeu: 2.6 ± 0.049	0.685MetMet: 0.685 ± 0.025	1.084MetAsn: 1.084 ± 0.03	1.09MetPro: 1.09 ± 0.036	1.011MetGln: 1.011 ± 0.031	1.074MetArg: 1.074 ± 0.025	1.895MetSer: 1.895 ± 0.046	1.5MetThr: 1.5 ± 0.032	1.606MetVal: 1.606 ± 0.037	0.202MetTrp: 0.202 ± 0.014	0.459MetTyr: 0.459 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.46AsnAla: 3.46 ± 0.059	0.423AsnCys: 0.423 ± 0.021	2.868AsnAsp: 2.868 ± 0.058	2.855AsnGlu: 2.855 ± 0.051	1.66AsnPhe: 1.66 ± 0.039	2.915AsnGly: 2.915 ± 0.055	1.151AsnHis: 1.151 ± 0.032	3.218AsnIle: 3.218 ± 0.06	2.869AsnLys: 2.869 ± 0.051	4.166AsnLeu: 4.166 ± 0.067	0.914AsnMet: 0.914 ± 0.025	2.558AsnAsn: 2.558 ± 0.064	2.016AsnPro: 2.016 ± 0.044	2.614AsnGln: 2.614 ± 0.047	1.996AsnArg: 1.996 ± 0.044	3.008AsnSer: 3.008 ± 0.061	2.48AsnThr: 2.48 ± 0.052	2.921AsnVal: 2.921 ± 0.062	0.53AsnTrp: 0.53 ± 0.02	1.581AsnTyr: 1.581 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.777ProAla: 2.777 ± 0.053	0.292ProCys: 0.292 ± 0.015	2.011ProAsp: 2.011 ± 0.052	2.669ProGlu: 2.669 ± 0.052	1.604ProPhe: 1.604 ± 0.038	2.024ProGly: 2.024 ± 0.054	0.861ProHis: 0.861 ± 0.031	2.387ProIle: 2.387 ± 0.049	1.945ProLys: 1.945 ± 0.036	4.117ProLeu: 4.117 ± 0.069	0.916ProMet: 0.916 ± 0.031	1.67ProAsn: 1.67 ± 0.044	1.008ProPro: 1.008 ± 0.032	2.126ProGln: 2.126 ± 0.049	1.233ProArg: 1.233 ± 0.032	2.556ProSer: 2.556 ± 0.051	2.125ProThr: 2.125 ± 0.044	2.721ProVal: 2.721 ± 0.062	0.473ProTrp: 0.473 ± 0.022	1.141ProTyr: 1.141 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.924GlnAla: 4.924 ± 0.084	0.446GlnCys: 0.446 ± 0.023	2.227GlnAsp: 2.227 ± 0.048	2.561GlnGlu: 2.561 ± 0.048	1.981GlnPhe: 1.981 ± 0.045	3.516GlnGly: 3.516 ± 0.057	1.534GlnHis: 1.534 ± 0.047	2.684GlnIle: 2.684 ± 0.057	2.041GlnLys: 2.041 ± 0.046	6.776GlnLeu: 6.776 ± 0.109	1.097GlnMet: 1.097 ± 0.028	1.479GlnAsn: 1.479 ± 0.035	2.041GlnPro: 2.041 ± 0.045	4.856GlnGln: 4.856 ± 0.116	2.711GlnArg: 2.711 ± 0.051	3.401GlnSer: 3.401 ± 0.059	2.422GlnThr: 2.422 ± 0.053	3.648GlnVal: 3.648 ± 0.062	0.858GlnTrp: 0.858 ± 0.028	1.615GlnTyr: 1.615 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.141ArgAla: 3.141 ± 0.053	0.436ArgCys: 0.436 ± 0.018	2.337ArgAsp: 2.337 ± 0.049	2.593ArgGlu: 2.593 ± 0.051	2.105ArgPhe: 2.105 ± 0.042	2.422ArgGly: 2.422 ± 0.05	1.093ArgHis: 1.093 ± 0.03	2.808ArgIle: 2.808 ± 0.055	2.066ArgLys: 2.066 ± 0.047	4.759ArgLeu: 4.759 ± 0.067	0.968ArgMet: 0.968 ± 0.031	1.7ArgAsn: 1.7 ± 0.041	1.419ArgPro: 1.419 ± 0.039	2.252ArgGln: 2.252 ± 0.042	1.981ArgArg: 1.981 ± 0.044	2.592ArgSer: 2.592 ± 0.053	1.951ArgThr: 1.951 ± 0.047	2.973ArgVal: 2.973 ± 0.062	0.58ArgTrp: 0.58 ± 0.021	1.626ArgTyr: 1.626 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.468SerAla: 5.468 ± 0.067	0.652SerCys: 0.652 ± 0.024	3.973SerAsp: 3.973 ± 0.067	4.066SerGlu: 4.066 ± 0.064	3.298SerPhe: 3.298 ± 0.064	4.845SerGly: 4.845 ± 0.072	1.699SerHis: 1.699 ± 0.038	4.57SerIle: 4.57 ± 0.069	3.552SerLys: 3.552 ± 0.056	7.815SerLeu: 7.815 ± 0.09	1.637SerMet: 1.637 ± 0.039	3.043SerAsn: 3.043 ± 0.056	2.569SerPro: 2.569 ± 0.05	3.694SerGln: 3.694 ± 0.063	2.773SerArg: 2.773 ± 0.047	4.878SerSer: 4.878 ± 0.075	3.712SerThr: 3.712 ± 0.069	4.67SerVal: 4.67 ± 0.079	0.801SerTrp: 0.801 ± 0.03	2.315SerTyr: 2.315 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.439ThrAla: 4.439 ± 0.073	0.448ThrCys: 0.448 ± 0.018	3.072ThrAsp: 3.072 ± 0.076	3.057ThrGlu: 3.057 ± 0.063	2.224ThrPhe: 2.224 ± 0.051	3.848ThrGly: 3.848 ± 0.079	1.142ThrHis: 1.142 ± 0.031	3.83ThrIle: 3.83 ± 0.065	2.723ThrLys: 2.723 ± 0.049	6.388ThrLeu: 6.388 ± 0.073	1.155ThrMet: 1.155 ± 0.03	2.402ThrAsn: 2.402 ± 0.044	2.687ThrPro: 2.687 ± 0.046	2.763ThrGln: 2.763 ± 0.051	2.032ThrArg: 2.032 ± 0.047	3.609ThrSer: 3.609 ± 0.069	3.409ThrThr: 3.409 ± 0.062	3.897ThrVal: 3.897 ± 0.077	0.548ThrTrp: 0.548 ± 0.025	1.478ThrTyr: 1.478 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.363ValAla: 6.363 ± 0.096	0.683ValCys: 0.683 ± 0.027	4.277ValAsp: 4.277 ± 0.068	4.492ValGlu: 4.492 ± 0.077	2.694ValPhe: 2.694 ± 0.051	4.207ValGly: 4.207 ± 0.071	1.138ValHis: 1.138 ± 0.032	5.143ValIle: 5.143 ± 0.066	3.739ValLys: 3.739 ± 0.067	6.439ValLeu: 6.439 ± 0.073	1.746ValMet: 1.746 ± 0.04	3.464ValAsn: 3.464 ± 0.055	2.251ValPro: 2.251 ± 0.049	2.094ValGln: 2.094 ± 0.043	2.521ValArg: 2.521 ± 0.045	5.164ValSer: 5.164 ± 0.063	4.276ValThr: 4.276 ± 0.082	4.979ValVal: 4.979 ± 0.088	0.604ValTrp: 0.604 ± 0.024	1.793ValTyr: 1.793 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.718TrpAla: 0.718 ± 0.024	0.125TrpCys: 0.125 ± 0.009	0.534TrpAsp: 0.534 ± 0.019	0.409TrpGlu: 0.409 ± 0.02	0.529TrpPhe: 0.529 ± 0.022	0.676TrpGly: 0.676 ± 0.029	0.351TrpHis: 0.351 ± 0.019	0.532TrpIle: 0.532 ± 0.024	0.363TrpLys: 0.363 ± 0.018	1.653TrpLeu: 1.653 ± 0.04	0.245TrpMet: 0.245 ± 0.016	0.395TrpAsn: 0.395 ± 0.02	0.437TrpPro: 0.437 ± 0.022	1.115TrpGln: 1.115 ± 0.034	0.612TrpArg: 0.612 ± 0.021	0.728TrpSer: 0.728 ± 0.028	0.442TrpThr: 0.442 ± 0.023	0.753TrpVal: 0.753 ± 0.028	0.16TrpTrp: 0.16 ± 0.014	0.341TrpTyr: 0.341 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.177TyrAla: 2.177 ± 0.047	0.399TyrCys: 0.399 ± 0.021	1.66TyrAsp: 1.66 ± 0.039	1.361TyrGlu: 1.361 ± 0.04	1.528TyrPhe: 1.528 ± 0.038	2.013TyrGly: 2.013 ± 0.041	0.871TyrHis: 0.871 ± 0.029	1.902TyrIle: 1.902 ± 0.037	1.444TyrLys: 1.444 ± 0.035	3.4TyrLeu: 3.4 ± 0.06	0.549TyrMet: 0.549 ± 0.022	1.315TyrAsn: 1.315 ± 0.035	1.314TyrPro: 1.314 ± 0.033	2.36TyrGln: 2.36 ± 0.051	1.658TyrArg: 1.658 ± 0.043	2.125TyrSer: 2.125 ± 0.048	1.509TyrThr: 1.509 ± 0.037	1.703TyrVal: 1.703 ± 0.039	0.464TyrTrp: 0.464 ± 0.021	1.084TyrTyr: 1.084 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3415 proteins (1160949 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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