Amino acid dipepetide frequency for Zhizhongheella caldifontis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.505AlaAla: 17.505 ± 0.192	1.315AlaCys: 1.315 ± 0.037	6.204AlaAsp: 6.204 ± 0.077	7.015AlaGlu: 7.015 ± 0.082	3.957AlaPhe: 3.957 ± 0.066	10.537AlaGly: 10.537 ± 0.124	2.951AlaHis: 2.951 ± 0.052	4.626AlaIle: 4.626 ± 0.07	3.174AlaLys: 3.174 ± 0.068	15.947AlaLeu: 15.947 ± 0.153	3.32AlaMet: 3.32 ± 0.058	2.305AlaAsn: 2.305 ± 0.048	6.528AlaPro: 6.528 ± 0.102	6.266AlaGln: 6.266 ± 0.093	10.129AlaArg: 10.129 ± 0.111	6.362AlaSer: 6.362 ± 0.088	5.807AlaThr: 5.807 ± 0.086	9.524AlaVal: 9.524 ± 0.112	2.358AlaTrp: 2.358 ± 0.054	2.573AlaTyr: 2.573 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.035	0.111CysCys: 0.111 ± 0.011	0.525CysAsp: 0.525 ± 0.021	0.56CysGlu: 0.56 ± 0.024	0.308CysPhe: 0.308 ± 0.018	0.957CysGly: 0.957 ± 0.035	0.275CysHis: 0.275 ± 0.017	0.348CysIle: 0.348 ± 0.021	0.21CysLys: 0.21 ± 0.013	0.828CysLeu: 0.828 ± 0.027	0.173CysMet: 0.173 ± 0.011	0.216CysAsn: 0.216 ± 0.015	0.518CysPro: 0.518 ± 0.024	0.261CysGln: 0.261 ± 0.014	0.623CysArg: 0.623 ± 0.021	0.471CysSer: 0.471 ± 0.024	0.449CysThr: 0.449 ± 0.021	0.726CysVal: 0.726 ± 0.028	0.12CysTrp: 0.12 ± 0.012	0.182CysTyr: 0.182 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.839AspAla: 6.839 ± 0.09	0.411AspCys: 0.411 ± 0.02	2.759AspAsp: 2.759 ± 0.052	3.593AspGlu: 3.593 ± 0.057	1.949AspPhe: 1.949 ± 0.046	4.328AspGly: 4.328 ± 0.068	1.284AspHis: 1.284 ± 0.037	2.084AspIle: 2.084 ± 0.045	1.486AspLys: 1.486 ± 0.043	5.656AspLeu: 5.656 ± 0.081	1.015AspMet: 1.015 ± 0.031	1.073AspAsn: 1.073 ± 0.031	3.168AspPro: 3.168 ± 0.062	1.612AspGln: 1.612 ± 0.04	3.86AspArg: 3.86 ± 0.058	1.85AspSer: 1.85 ± 0.04	2.718AspThr: 2.718 ± 0.052	4.094AspVal: 4.094 ± 0.065	0.964AspTrp: 0.964 ± 0.033	1.262AspTyr: 1.262 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.206GluAla: 8.206 ± 0.097	0.394GluCys: 0.394 ± 0.021	2.477GluAsp: 2.477 ± 0.047	2.696GluGlu: 2.696 ± 0.059	1.801GluPhe: 1.801 ± 0.045	4.256GluGly: 4.256 ± 0.066	1.574GluHis: 1.574 ± 0.033	2.503GluIle: 2.503 ± 0.057	1.57GluLys: 1.57 ± 0.054	6.198GluLeu: 6.198 ± 0.079	1.274GluMet: 1.274 ± 0.032	1.03GluAsn: 1.03 ± 0.027	2.854GluPro: 2.854 ± 0.05	2.603GluGln: 2.603 ± 0.057	5.587GluArg: 5.587 ± 0.081	2.275GluSer: 2.275 ± 0.051	2.474GluThr: 2.474 ± 0.047	4.672GluVal: 4.672 ± 0.074	0.736GluTrp: 0.736 ± 0.024	1.003GluTyr: 1.003 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.925PheAla: 3.925 ± 0.067	0.336PheCys: 0.336 ± 0.018	2.367PheAsp: 2.367 ± 0.045	2.275PheGlu: 2.275 ± 0.05	1.327PhePhe: 1.327 ± 0.044	3.267PheGly: 3.267 ± 0.06	0.774PheHis: 0.774 ± 0.028	1.437PheIle: 1.437 ± 0.037	1.012PheLys: 1.012 ± 0.034	3.004PheLeu: 3.004 ± 0.057	0.718PheMet: 0.718 ± 0.027	0.984PheAsn: 0.984 ± 0.033	1.494PhePro: 1.494 ± 0.034	1.014PheGln: 1.014 ± 0.026	2.059PheArg: 2.059 ± 0.043	1.817PheSer: 1.817 ± 0.042	1.839PheThr: 1.839 ± 0.041	2.712PheVal: 2.712 ± 0.051	0.544PheTrp: 0.544 ± 0.022	0.819PheTyr: 0.819 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.0GlyAla: 9.0 ± 0.11	0.9GlyCys: 0.9 ± 0.035	3.866GlyAsp: 3.866 ± 0.062	4.77GlyGlu: 4.77 ± 0.072	3.161GlyPhe: 3.161 ± 0.062	6.753GlyGly: 6.753 ± 0.106	2.156GlyHis: 2.156 ± 0.046	3.46GlyIle: 3.46 ± 0.061	2.576GlyLys: 2.576 ± 0.061	10.027GlyLeu: 10.027 ± 0.104	2.099GlyMet: 2.099 ± 0.051	1.682GlyAsn: 1.682 ± 0.045	3.507GlyPro: 3.507 ± 0.062	3.557GlyGln: 3.557 ± 0.071	6.419GlyArg: 6.419 ± 0.081	4.197GlySer: 4.197 ± 0.072	4.125GlyThr: 4.125 ± 0.065	6.776GlyVal: 6.776 ± 0.086	1.646GlyTrp: 1.646 ± 0.04	2.131GlyTyr: 2.131 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.939HisAla: 2.939 ± 0.052	0.31HisCys: 0.31 ± 0.02	1.313HisAsp: 1.313 ± 0.033	1.355HisGlu: 1.355 ± 0.036	0.951HisPhe: 0.951 ± 0.031	2.244HisGly: 2.244 ± 0.051	0.769HisHis: 0.769 ± 0.036	0.882HisIle: 0.882 ± 0.026	0.559HisLys: 0.559 ± 0.022	2.761HisLeu: 2.761 ± 0.061	0.446HisMet: 0.446 ± 0.021	0.471HisAsn: 0.471 ± 0.02	1.795HisPro: 1.795 ± 0.041	0.809HisGln: 0.809 ± 0.03	1.918HisArg: 1.918 ± 0.046	0.982HisSer: 0.982 ± 0.029	1.199HisThr: 1.199 ± 0.035	1.735HisVal: 1.735 ± 0.037	0.489HisTrp: 0.489 ± 0.022	0.649HisTyr: 0.649 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.404IleAla: 5.404 ± 0.079	0.354IleCys: 0.354 ± 0.016	3.094IleAsp: 3.094 ± 0.047	3.213IleGlu: 3.213 ± 0.06	1.179IlePhe: 1.179 ± 0.04	3.719IleGly: 3.719 ± 0.062	0.824IleHis: 0.824 ± 0.029	1.337IleIle: 1.337 ± 0.042	1.176IleLys: 1.176 ± 0.047	3.144IleLeu: 3.144 ± 0.06	0.632IleMet: 0.632 ± 0.025	1.148IleAsn: 1.148 ± 0.039	1.829IlePro: 1.829 ± 0.044	1.186IleGln: 1.186 ± 0.03	2.623IleArg: 2.623 ± 0.053	1.906IleSer: 1.906 ± 0.052	2.297IleThr: 2.297 ± 0.051	3.413IleVal: 3.413 ± 0.053	0.427IleTrp: 0.427 ± 0.02	0.861IleTyr: 0.861 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.579LysAla: 3.579 ± 0.077	0.144LysCys: 0.144 ± 0.013	1.491LysAsp: 1.491 ± 0.039	1.342LysGlu: 1.342 ± 0.042	0.748LysPhe: 0.748 ± 0.028	2.142LysGly: 2.142 ± 0.056	0.613LysHis: 0.613 ± 0.022	1.188LysIle: 1.188 ± 0.042	1.106LysLys: 1.106 ± 0.05	3.067LysLeu: 3.067 ± 0.059	0.628LysMet: 0.628 ± 0.029	0.687LysAsn: 0.687 ± 0.029	1.749LysPro: 1.749 ± 0.046	0.98LysGln: 0.98 ± 0.032	2.071LysArg: 2.071 ± 0.052	1.418LysSer: 1.418 ± 0.039	1.558LysThr: 1.558 ± 0.044	2.239LysVal: 2.239 ± 0.053	0.273LysTrp: 0.273 ± 0.018	0.539LysTyr: 0.539 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.801LeuAla: 15.801 ± 0.164	0.94LeuCys: 0.94 ± 0.033	6.161LeuAsp: 6.161 ± 0.087	5.517LeuGlu: 5.517 ± 0.083	3.321LeuPhe: 3.321 ± 0.063	9.318LeuGly: 9.318 ± 0.115	2.6LeuHis: 2.6 ± 0.054	4.277LeuIle: 4.277 ± 0.076	3.499LeuLys: 3.499 ± 0.062	11.478LeuLeu: 11.478 ± 0.153	2.755LeuMet: 2.755 ± 0.051	2.531LeuAsn: 2.531 ± 0.047	6.531LeuPro: 6.531 ± 0.073	4.42LeuGln: 4.42 ± 0.065	8.888LeuArg: 8.888 ± 0.11	6.315LeuSer: 6.315 ± 0.089	5.433LeuThr: 5.433 ± 0.083	8.406LeuVal: 8.406 ± 0.119	1.594LeuTrp: 1.594 ± 0.042	2.117LeuTyr: 2.117 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.955MetAla: 2.955 ± 0.057	0.163MetCys: 0.163 ± 0.013	1.165MetAsp: 1.165 ± 0.031	1.024MetGlu: 1.024 ± 0.027	0.627MetPhe: 0.627 ± 0.026	1.86MetGly: 1.86 ± 0.05	0.539MetHis: 0.539 ± 0.024	0.913MetIle: 0.913 ± 0.031	0.922MetLys: 0.922 ± 0.033	2.589MetLeu: 2.589 ± 0.053	0.57MetMet: 0.57 ± 0.023	0.781MetAsn: 0.781 ± 0.025	1.393MetPro: 1.393 ± 0.037	0.953MetGln: 0.953 ± 0.033	1.709MetArg: 1.709 ± 0.039	1.612MetSer: 1.612 ± 0.041	1.378MetThr: 1.378 ± 0.037	1.728MetVal: 1.728 ± 0.044	0.214MetTrp: 0.214 ± 0.015	0.345MetTyr: 0.345 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.67AsnAla: 2.67 ± 0.05	0.216AsnCys: 0.216 ± 0.015	1.182AsnAsp: 1.182 ± 0.035	1.164AsnGlu: 1.164 ± 0.033	0.828AsnPhe: 0.828 ± 0.027	1.846AsnGly: 1.846 ± 0.05	0.483AsnHis: 0.483 ± 0.023	0.979AsnIle: 0.979 ± 0.032	0.628AsnLys: 0.628 ± 0.025	2.402AsnLeu: 2.402 ± 0.049	0.441AsnMet: 0.441 ± 0.023	0.564AsnAsn: 0.564 ± 0.026	1.692AsnPro: 1.692 ± 0.046	0.754AsnGln: 0.754 ± 0.029	1.56AsnArg: 1.56 ± 0.042	0.829AsnSer: 0.829 ± 0.029	1.225AsnThr: 1.225 ± 0.031	1.713AsnVal: 1.713 ± 0.041	0.361AsnTrp: 0.361 ± 0.014	0.555AsnTyr: 0.555 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.563ProAla: 7.563 ± 0.109	0.379ProCys: 0.379 ± 0.018	3.271ProAsp: 3.271 ± 0.059	3.656ProGlu: 3.656 ± 0.062	1.679ProPhe: 1.679 ± 0.041	4.978ProGly: 4.978 ± 0.068	1.306ProHis: 1.306 ± 0.033	1.716ProIle: 1.716 ± 0.044	1.394ProLys: 1.394 ± 0.041	5.58ProLeu: 5.58 ± 0.083	1.287ProMet: 1.287 ± 0.033	1.187ProAsn: 1.187 ± 0.028	3.105ProPro: 3.105 ± 0.079	2.304ProGln: 2.304 ± 0.046	3.527ProArg: 3.527 ± 0.065	2.878ProSer: 2.878 ± 0.059	2.67ProThr: 2.67 ± 0.056	4.687ProVal: 4.687 ± 0.072	0.937ProTrp: 0.937 ± 0.033	1.164ProTyr: 1.164 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	6.526GlnAla: 6.526 ± 0.111	0.289GlnCys: 0.289 ± 0.017	1.587GlnAsp: 1.587 ± 0.04	1.649GlnGlu: 1.649 ± 0.039	1.134GlnPhe: 1.134 ± 0.031	3.578GlnGly: 3.578 ± 0.06	1.002GlnHis: 1.002 ± 0.029	1.619GlnIle: 1.619 ± 0.039	0.784GlnLys: 0.784 ± 0.031	3.99GlnLeu: 3.99 ± 0.059	0.945GlnMet: 0.945 ± 0.029	0.611GlnAsn: 0.611 ± 0.023	2.402GlnPro: 2.402 ± 0.051	1.787GlnGln: 1.787 ± 0.045	3.939GlnArg: 3.939 ± 0.065	1.713GlnSer: 1.713 ± 0.041	1.765GlnThr: 1.765 ± 0.046	3.276GlnVal: 3.276 ± 0.062	0.704GlnTrp: 0.704 ± 0.026	0.682GlnTyr: 0.682 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.718ArgAla: 8.718 ± 0.112	0.695ArgCys: 0.695 ± 0.029	3.944ArgAsp: 3.944 ± 0.071	5.174ArgGlu: 5.174 ± 0.081	3.015ArgPhe: 3.015 ± 0.055	5.118ArgGly: 5.118 ± 0.073	2.354ArgHis: 2.354 ± 0.053	3.549ArgIle: 3.549 ± 0.061	1.985ArgLys: 1.985 ± 0.05	9.403ArgLeu: 9.403 ± 0.119	1.966ArgMet: 1.966 ± 0.043	1.757ArgAsn: 1.757 ± 0.042	3.933ArgPro: 3.933 ± 0.074	3.277ArgGln: 3.277 ± 0.059	6.427ArgArg: 6.427 ± 0.086	3.774ArgSer: 3.774 ± 0.06	3.446ArgThr: 3.446 ± 0.052	5.844ArgVal: 5.844 ± 0.087	1.497ArgTrp: 1.497 ± 0.042	1.939ArgTyr: 1.939 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.827SerAla: 5.827 ± 0.076	0.373SerCys: 0.373 ± 0.019	2.317SerAsp: 2.317 ± 0.05	2.443SerGlu: 2.443 ± 0.048	1.962SerPhe: 1.962 ± 0.045	4.664SerGly: 4.664 ± 0.075	1.113SerHis: 1.113 ± 0.034	2.08SerIle: 2.08 ± 0.044	1.208SerLys: 1.208 ± 0.037	5.793SerLeu: 5.793 ± 0.076	1.263SerMet: 1.263 ± 0.033	1.119SerAsn: 1.119 ± 0.036	3.003SerPro: 3.003 ± 0.053	1.783SerGln: 1.783 ± 0.042	3.677SerArg: 3.677 ± 0.058	2.527SerSer: 2.527 ± 0.057	2.581SerThr: 2.581 ± 0.049	3.693SerVal: 3.693 ± 0.06	0.695SerTrp: 0.695 ± 0.028	1.062SerTyr: 1.062 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.782ThrAla: 5.782 ± 0.077	0.394ThrCys: 0.394 ± 0.021	2.472ThrAsp: 2.472 ± 0.05	2.456ThrGlu: 2.456 ± 0.053	1.475ThrPhe: 1.475 ± 0.039	4.461ThrGly: 4.461 ± 0.074	1.199ThrHis: 1.199 ± 0.032	1.8ThrIle: 1.8 ± 0.046	1.08ThrLys: 1.08 ± 0.036	6.313ThrLeu: 6.313 ± 0.08	1.006ThrMet: 1.006 ± 0.035	1.009ThrAsn: 1.009 ± 0.033	3.671ThrPro: 3.671 ± 0.068	1.834ThrGln: 1.834 ± 0.045	3.574ThrArg: 3.574 ± 0.07	2.34ThrSer: 2.34 ± 0.048	2.622ThrThr: 2.622 ± 0.059	4.291ThrVal: 4.291 ± 0.066	0.735ThrTrp: 0.735 ± 0.026	1.003ThrTyr: 1.003 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.811ValAla: 9.811 ± 0.106	0.793ValCys: 0.793 ± 0.029	4.006ValAsp: 4.006 ± 0.068	4.486ValGlu: 4.486 ± 0.067	2.798ValPhe: 2.798 ± 0.054	5.843ValGly: 5.843 ± 0.08	1.852ValHis: 1.852 ± 0.041	3.479ValIle: 3.479 ± 0.062	2.229ValLys: 2.229 ± 0.05	9.103ValLeu: 9.103 ± 0.116	1.991ValMet: 1.991 ± 0.044	2.027ValAsn: 2.027 ± 0.047	4.175ValPro: 4.175 ± 0.067	3.026ValGln: 3.026 ± 0.059	5.895ValArg: 5.895 ± 0.083	4.187ValSer: 4.187 ± 0.063	3.971ValThr: 3.971 ± 0.065	6.844ValVal: 6.844 ± 0.094	1.185ValTrp: 1.185 ± 0.031	1.578ValTyr: 1.578 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.718TrpAla: 1.718 ± 0.043	0.19TrpCys: 0.19 ± 0.014	0.658TrpAsp: 0.658 ± 0.026	0.6TrpGlu: 0.6 ± 0.02	0.582TrpPhe: 0.582 ± 0.025	1.043TrpGly: 1.043 ± 0.03	0.414TrpHis: 0.414 ± 0.019	0.696TrpIle: 0.696 ± 0.027	0.419TrpLys: 0.419 ± 0.023	2.318TrpLeu: 2.318 ± 0.054	0.522TrpMet: 0.522 ± 0.025	0.37TrpAsn: 0.37 ± 0.018	0.86TrpPro: 0.86 ± 0.032	0.79TrpGln: 0.79 ± 0.028	1.538TrpArg: 1.538 ± 0.043	0.781TrpSer: 0.781 ± 0.025	0.777TrpThr: 0.777 ± 0.028	1.267TrpVal: 1.267 ± 0.039	0.378TrpTrp: 0.378 ± 0.018	0.324TrpTyr: 0.324 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.562TyrAla: 2.562 ± 0.047	0.227TyrCys: 0.227 ± 0.015	1.145TyrAsp: 1.145 ± 0.034	1.196TyrGlu: 1.196 ± 0.03	0.923TyrPhe: 0.923 ± 0.029	1.901TyrGly: 1.901 ± 0.043	0.495TyrHis: 0.495 ± 0.022	0.794TyrIle: 0.794 ± 0.03	0.542TyrLys: 0.542 ± 0.023	2.302TyrLeu: 2.302 ± 0.048	0.388TyrMet: 0.388 ± 0.021	0.543TyrAsn: 0.543 ± 0.022	1.06TyrPro: 1.06 ± 0.036	0.763TyrGln: 0.763 ± 0.027	1.793TyrArg: 1.793 ± 0.04	0.948TyrSer: 0.948 ± 0.032	1.18TyrThr: 1.18 ± 0.037	1.639TyrVal: 1.639 ± 0.038	0.387TyrTrp: 0.387 ± 0.019	0.536TyrTyr: 0.536 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3372 proteins (1112190 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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