Amino acid dipepetide frequency for Aliicoccus persicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.454AlaAla: 4.454 ± 0.115
0.418AlaCys: 0.418 ± 0.027
4.026AlaAsp: 4.026 ± 0.365
4.344AlaGlu: 4.344 ± 0.122
2.975AlaPhe: 2.975 ± 0.08
4.227AlaGly: 4.227 ± 0.099
1.435AlaHis: 1.435 ± 0.054
5.389AlaIle: 5.389 ± 0.108
3.375AlaLys: 3.375 ± 0.084
6.882AlaLeu: 6.882 ± 0.122
1.92AlaMet: 1.92 ± 0.065
2.549AlaAsn: 2.549 ± 0.06
1.883AlaPro: 1.883 ± 0.054
2.074AlaGln: 2.074 ± 0.067
2.734AlaArg: 2.734 ± 0.07
3.808AlaSer: 3.808 ± 0.093
3.321AlaThr: 3.321 ± 0.077
4.706AlaVal: 4.706 ± 0.099
0.383AlaTrp: 0.383 ± 0.028
2.206AlaTyr: 2.206 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.301CysAla: 0.301 ± 0.027
0.054CysCys: 0.054 ± 0.011
0.32CysAsp: 0.32 ± 0.023
0.378CysGlu: 0.378 ± 0.028
0.172CysPhe: 0.172 ± 0.018
0.511CysGly: 0.511 ± 0.035
0.144CysHis: 0.144 ± 0.016
0.331CysIle: 0.331 ± 0.023
0.254CysLys: 0.254 ± 0.021
0.373CysLeu: 0.373 ± 0.027
0.105CysMet: 0.105 ± 0.015
0.276CysAsn: 0.276 ± 0.026
0.258CysPro: 0.258 ± 0.02
0.132CysGln: 0.132 ± 0.017
0.177CysArg: 0.177 ± 0.016
0.308CysSer: 0.308 ± 0.021
0.315CysThr: 0.315 ± 0.021
0.316CysVal: 0.316 ± 0.021
0.023CysTrp: 0.023 ± 0.006
0.182CysTyr: 0.182 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.104AspAla: 5.104 ± 0.358
0.273AspCys: 0.273 ± 0.02
4.552AspAsp: 4.552 ± 0.123
6.482AspGlu: 6.482 ± 0.139
2.923AspPhe: 2.923 ± 0.073
4.18AspGly: 4.18 ± 0.116
1.234AspHis: 1.234 ± 0.048
5.241AspIle: 5.241 ± 0.107
3.961AspLys: 3.961 ± 0.077
5.147AspLeu: 5.147 ± 0.09
1.729AspMet: 1.729 ± 0.053
2.941AspAsn: 2.941 ± 0.079
1.853AspPro: 1.853 ± 0.059
1.788AspGln: 1.788 ± 0.054
2.357AspArg: 2.357 ± 0.067
3.386AspSer: 3.386 ± 0.083
3.5AspThr: 3.5 ± 0.087
5.338AspVal: 5.338 ± 0.095
0.524AspTrp: 0.524 ± 0.033
2.898AspTyr: 2.898 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
5.4GluAla: 5.4 ± 0.12
0.295GluCys: 0.295 ± 0.024
5.598GluAsp: 5.598 ± 0.148
7.876GluGlu: 7.876 ± 0.217
3.0GluPhe: 3.0 ± 0.071
4.198GluGly: 4.198 ± 0.097
1.651GluHis: 1.651 ± 0.054
6.346GluIle: 6.346 ± 0.112
4.86GluLys: 4.86 ± 0.104
7.35GluLeu: 7.35 ± 0.123
2.63GluMet: 2.63 ± 0.07
4.418GluAsn: 4.418 ± 0.08
1.974GluPro: 1.974 ± 0.064
2.968GluGln: 2.968 ± 0.083
3.889GluArg: 3.889 ± 0.08
4.878GluSer: 4.878 ± 0.095
4.669GluThr: 4.669 ± 0.112
6.068GluVal: 6.068 ± 0.127
0.711GluTrp: 0.711 ± 0.039
2.804GluTyr: 2.804 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
2.541PheAla: 2.541 ± 0.074
0.182PheCys: 0.182 ± 0.018
3.104PheAsp: 3.104 ± 0.075
3.51PheGlu: 3.51 ± 0.091
2.109PhePhe: 2.109 ± 0.066
3.179PheGly: 3.179 ± 0.076
0.825PheHis: 0.825 ± 0.038
4.304PheIle: 4.304 ± 0.09
3.006PheLys: 3.006 ± 0.076
4.019PheLeu: 4.019 ± 0.095
1.266PheMet: 1.266 ± 0.052
2.732PheAsn: 2.732 ± 0.074
1.297PhePro: 1.297 ± 0.042
1.239PheGln: 1.239 ± 0.049
1.498PheArg: 1.498 ± 0.051
2.906PheSer: 2.906 ± 0.077
2.752PheThr: 2.752 ± 0.075
3.398PheVal: 3.398 ± 0.093
0.37PheTrp: 0.37 ± 0.03
1.779PheTyr: 1.779 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.145GlyAla: 4.145 ± 0.103
0.393GlyCys: 0.393 ± 0.033
3.711GlyAsp: 3.711 ± 0.088
4.592GlyGlu: 4.592 ± 0.104
3.155GlyPhe: 3.155 ± 0.071
4.177GlyGly: 4.177 ± 0.106
1.522GlyHis: 1.522 ± 0.063
5.191GlyIle: 5.191 ± 0.115
3.855GlyLys: 3.855 ± 0.095
5.943GlyLeu: 5.943 ± 0.111
1.93GlyMet: 1.93 ± 0.058
2.496GlyAsn: 2.496 ± 0.081
1.497GlyPro: 1.497 ± 0.059
1.948GlyGln: 1.948 ± 0.056
2.477GlyArg: 2.477 ± 0.073
3.435GlySer: 3.435 ± 0.078
3.864GlyThr: 3.864 ± 0.079
5.159GlyVal: 5.159 ± 0.098
0.557GlyTrp: 0.557 ± 0.029
2.665GlyTyr: 2.665 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.455HisAla: 1.455 ± 0.054
0.146HisCys: 0.146 ± 0.016
1.512HisAsp: 1.512 ± 0.061
1.657HisGlu: 1.657 ± 0.061
1.041HisPhe: 1.041 ± 0.038
1.468HisGly: 1.468 ± 0.051
0.696HisHis: 0.696 ± 0.038
1.731HisIle: 1.731 ± 0.06
1.053HisLys: 1.053 ± 0.044
2.097HisLeu: 2.097 ± 0.059
0.594HisMet: 0.594 ± 0.034
1.018HisAsn: 1.018 ± 0.044
1.036HisPro: 1.036 ± 0.039
0.763HisGln: 0.763 ± 0.038
0.912HisArg: 0.912 ± 0.039
1.214HisSer: 1.214 ± 0.045
1.095HisThr: 1.095 ± 0.041
1.644HisVal: 1.644 ± 0.058
0.159HisTrp: 0.159 ± 0.016
0.889HisTyr: 0.889 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.417IleAla: 5.417 ± 0.116
0.42IleCys: 0.42 ± 0.027
5.802IleAsp: 5.802 ± 0.098
7.017IleGlu: 7.017 ± 0.127
3.552IlePhe: 3.552 ± 0.095
5.643IleGly: 5.643 ± 0.105
1.667IleHis: 1.667 ± 0.054
6.883IleIle: 6.883 ± 0.167
4.536IleLys: 4.536 ± 0.108
6.902IleLeu: 6.902 ± 0.151
1.972IleMet: 1.972 ± 0.061
4.084IleAsn: 4.084 ± 0.088
2.943IlePro: 2.943 ± 0.087
2.59IleGln: 2.59 ± 0.068
2.983IleArg: 2.983 ± 0.072
4.898IleSer: 4.898 ± 0.103
4.55IleThr: 4.55 ± 0.093
6.361IleVal: 6.361 ± 0.123
0.49IleTrp: 0.49 ± 0.027
2.806IleTyr: 2.806 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
3.304LysAla: 3.304 ± 0.084
0.281LysCys: 0.281 ± 0.022
4.016LysAsp: 4.016 ± 0.101
5.583LysGlu: 5.583 ± 0.112
2.183LysPhe: 2.183 ± 0.067
3.045LysGly: 3.045 ± 0.079
1.547LysHis: 1.547 ± 0.06
4.361LysIle: 4.361 ± 0.106
4.491LysLys: 4.491 ± 0.114
4.983LysLeu: 4.983 ± 0.091
1.868LysMet: 1.868 ± 0.056
3.33LysAsn: 3.33 ± 0.092
1.756LysPro: 1.756 ± 0.062
2.28LysGln: 2.28 ± 0.07
3.219LysArg: 3.219 ± 0.081
3.571LysSer: 3.571 ± 0.091
3.251LysThr: 3.251 ± 0.07
4.126LysVal: 4.126 ± 0.084
0.454LysTrp: 0.454 ± 0.031
2.568LysTyr: 2.568 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
5.747LeuAla: 5.747 ± 0.107
0.393LeuCys: 0.393 ± 0.026
5.725LeuAsp: 5.725 ± 0.098
7.206LeuGlu: 7.206 ± 0.116
4.436LeuPhe: 4.436 ± 0.103
5.67LeuGly: 5.67 ± 0.127
1.744LeuHis: 1.744 ± 0.053
7.481LeuIle: 7.481 ± 0.165
5.922LeuLys: 5.922 ± 0.123
8.616LeuLeu: 8.616 ± 0.155
2.737LeuMet: 2.737 ± 0.071
5.223LeuAsn: 5.223 ± 0.092
3.201LeuPro: 3.201 ± 0.078
2.626LeuGln: 2.626 ± 0.076
3.46LeuArg: 3.46 ± 0.087
6.647LeuSer: 6.647 ± 0.111
5.397LeuThr: 5.397 ± 0.105
6.09LeuVal: 6.09 ± 0.114
0.579LeuTrp: 0.579 ± 0.03
3.256LeuTyr: 3.256 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
1.743MetAla: 1.743 ± 0.057
0.142MetCys: 0.142 ± 0.016
1.717MetAsp: 1.717 ± 0.056
1.605MetGlu: 1.605 ± 0.05
1.326MetPhe: 1.326 ± 0.053
1.589MetGly: 1.589 ± 0.056
0.593MetHis: 0.593 ± 0.033
2.347MetIle: 2.347 ± 0.068
2.263MetLys: 2.263 ± 0.064
2.677MetLeu: 2.677 ± 0.072
1.071MetMet: 1.071 ± 0.045
1.898MetAsn: 1.898 ± 0.066
0.979MetPro: 0.979 ± 0.041
0.894MetGln: 0.894 ± 0.044
1.378MetArg: 1.378 ± 0.052
2.066MetSer: 2.066 ± 0.056
1.853MetThr: 1.853 ± 0.059
1.704MetVal: 1.704 ± 0.05
0.206MetTrp: 0.206 ± 0.018
0.947MetTyr: 0.947 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.057AsnAla: 3.057 ± 0.073
0.263AsnCys: 0.263 ± 0.02
3.333AsnAsp: 3.333 ± 0.082
4.18AsnGlu: 4.18 ± 0.088
2.106AsnPhe: 2.106 ± 0.055
2.955AsnGly: 2.955 ± 0.077
1.356AsnHis: 1.356 ± 0.052
4.302AsnIle: 4.302 ± 0.084
3.12AsnLys: 3.12 ± 0.086
3.932AsnLeu: 3.932 ± 0.103
1.383AsnMet: 1.383 ± 0.051
2.759AsnAsn: 2.759 ± 0.091
1.9AsnPro: 1.9 ± 0.052
2.02AsnGln: 2.02 ± 0.056
2.221AsnArg: 2.221 ± 0.065
2.554AsnSer: 2.554 ± 0.07
2.541AsnThr: 2.541 ± 0.067
3.746AsnVal: 3.746 ± 0.083
0.385AsnTrp: 0.385 ± 0.027
2.01AsnTyr: 2.01 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
1.726ProAla: 1.726 ± 0.056
0.162ProCys: 0.162 ± 0.018
2.096ProAsp: 2.096 ± 0.059
2.958ProGlu: 2.958 ± 0.08
1.746ProPhe: 1.746 ± 0.052
2.042ProGly: 2.042 ± 0.061
0.787ProHis: 0.787 ± 0.038
2.533ProIle: 2.533 ± 0.07
1.823ProLys: 1.823 ± 0.06
2.948ProLeu: 2.948 ± 0.068
0.862ProMet: 0.862 ± 0.039
1.625ProAsn: 1.625 ± 0.048
0.758ProPro: 0.758 ± 0.036
0.812ProGln: 0.812 ± 0.035
1.018ProArg: 1.018 ± 0.04
2.02ProSer: 2.02 ± 0.067
1.838ProThr: 1.838 ± 0.061
2.561ProVal: 2.561 ± 0.063
0.253ProTrp: 0.253 ± 0.021
1.25ProTyr: 1.25 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.037GlnAla: 2.037 ± 0.07
0.119GlnCys: 0.119 ± 0.013
2.01GlnAsp: 2.01 ± 0.058
2.362GlnGlu: 2.362 ± 0.063
1.615GlnPhe: 1.615 ± 0.054
1.654GlnGly: 1.654 ± 0.058
0.787GlnHis: 0.787 ± 0.037
2.342GlnIle: 2.342 ± 0.061
1.87GlnLys: 1.87 ± 0.066
3.576GlnLeu: 3.576 ± 0.081
1.063GlnMet: 1.063 ± 0.042
1.55GlnAsn: 1.55 ± 0.053
0.949GlnPro: 0.949 ± 0.04
1.143GlnGln: 1.143 ± 0.046
1.279GlnArg: 1.279 ± 0.049
2.042GlnSer: 2.042 ± 0.063
1.778GlnThr: 1.778 ± 0.054
2.226GlnVal: 2.226 ± 0.059
0.258GlnTrp: 0.258 ± 0.023
1.411GlnTyr: 1.411 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
2.648ArgAla: 2.648 ± 0.07
0.162ArgCys: 0.162 ± 0.017
2.566ArgAsp: 2.566 ± 0.081
3.308ArgGlu: 3.308 ± 0.087
2.029ArgPhe: 2.029 ± 0.061
2.526ArgGly: 2.526 ± 0.065
0.921ArgHis: 0.921 ± 0.048
3.102ArgIle: 3.102 ± 0.072
2.6ArgLys: 2.6 ± 0.064
3.992ArgLeu: 3.992 ± 0.103
1.393ArgMet: 1.393 ± 0.048
2.052ArgAsn: 2.052 ± 0.059
1.217ArgPro: 1.217 ± 0.046
1.525ArgGln: 1.525 ± 0.061
1.965ArgArg: 1.965 ± 0.063
2.186ArgSer: 2.186 ± 0.065
2.198ArgThr: 2.198 ± 0.064
3.048ArgVal: 3.048 ± 0.072
0.29ArgTrp: 0.29 ± 0.024
1.53ArgTyr: 1.53 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.355SerAla: 3.355 ± 0.083
0.261SerCys: 0.261 ± 0.027
3.939SerAsp: 3.939 ± 0.081
4.588SerGlu: 4.588 ± 0.092
2.923SerPhe: 2.923 ± 0.082
4.334SerGly: 4.334 ± 0.096
1.409SerHis: 1.409 ± 0.046
5.062SerIle: 5.062 ± 0.093
3.639SerLys: 3.639 ± 0.085
5.586SerLeu: 5.586 ± 0.097
1.711SerMet: 1.711 ± 0.05
2.888SerAsn: 2.888 ± 0.078
1.871SerPro: 1.871 ± 0.055
1.93SerGln: 1.93 ± 0.06
2.719SerArg: 2.719 ± 0.072
3.566SerSer: 3.566 ± 0.09
3.351SerThr: 3.351 ± 0.085
4.213SerVal: 4.213 ± 0.092
0.415SerTrp: 0.415 ± 0.027
2.449SerTyr: 2.449 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
3.38ThrAla: 3.38 ± 0.076
0.259ThrCys: 0.259 ± 0.024
3.495ThrAsp: 3.495 ± 0.077
4.411ThrGlu: 4.411 ± 0.116
2.866ThrPhe: 2.866 ± 0.076
3.701ThrGly: 3.701 ± 0.082
1.394ThrHis: 1.394 ± 0.049
4.809ThrIle: 4.809 ± 0.089
2.822ThrLys: 2.822 ± 0.079
5.77ThrLeu: 5.77 ± 0.099
1.455ThrMet: 1.455 ± 0.056
2.385ThrAsn: 2.385 ± 0.072
2.367ThrPro: 2.367 ± 0.077
1.594ThrGln: 1.594 ± 0.053
2.248ThrArg: 2.248 ± 0.061
3.258ThrSer: 3.258 ± 0.066
3.112ThrThr: 3.112 ± 0.079
4.443ThrVal: 4.443 ± 0.104
0.403ThrTrp: 0.403 ± 0.028
2.215ThrTyr: 2.215 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
4.709ValAla: 4.709 ± 0.094
0.413ValCys: 0.413 ± 0.029
4.868ValAsp: 4.868 ± 0.102
5.931ValGlu: 5.931 ± 0.135
3.355ValPhe: 3.355 ± 0.084
4.722ValGly: 4.722 ± 0.099
1.409ValHis: 1.409 ± 0.051
6.157ValIle: 6.157 ± 0.111
4.173ValLys: 4.173 ± 0.097
6.96ValLeu: 6.96 ± 0.12
2.02ValMet: 2.02 ± 0.058
3.582ValAsn: 3.582 ± 0.091
2.513ValPro: 2.513 ± 0.063
2.026ValGln: 2.026 ± 0.059
2.775ValArg: 2.775 ± 0.075
4.839ValSer: 4.839 ± 0.096
4.513ValThr: 4.513 ± 0.084
5.507ValVal: 5.507 ± 0.103
0.531ValTrp: 0.531 ± 0.034
2.504ValTyr: 2.504 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.429TrpAla: 0.429 ± 0.031
0.05TrpCys: 0.05 ± 0.008
0.422TrpAsp: 0.422 ± 0.031
0.449TrpGlu: 0.449 ± 0.034
0.367TrpPhe: 0.367 ± 0.028
0.452TrpGly: 0.452 ± 0.032
0.189TrpHis: 0.189 ± 0.019
0.646TrpIle: 0.646 ± 0.035
0.365TrpLys: 0.365 ± 0.027
0.857TrpLeu: 0.857 ± 0.045
0.306TrpMet: 0.306 ± 0.022
0.38TrpAsn: 0.38 ± 0.028
0.211TrpPro: 0.211 ± 0.021
0.28TrpGln: 0.28 ± 0.025
0.27TrpArg: 0.27 ± 0.018
0.362TrpSer: 0.362 ± 0.026
0.388TrpThr: 0.388 ± 0.03
0.497TrpVal: 0.497 ± 0.034
0.077TrpTrp: 0.077 ± 0.011
0.326TrpTyr: 0.326 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.159TyrAla: 2.159 ± 0.058
0.244TyrCys: 0.244 ± 0.021
2.6TyrAsp: 2.6 ± 0.071
3.144TyrGlu: 3.144 ± 0.073
2.139TyrPhe: 2.139 ± 0.067
2.441TyrGly: 2.441 ± 0.063
0.87TyrHis: 0.87 ± 0.044
2.96TyrIle: 2.96 ± 0.074
2.226TyrLys: 2.226 ± 0.069
3.545TyrLeu: 3.545 ± 0.077
0.981TyrMet: 0.981 ± 0.042
1.937TyrAsn: 1.937 ± 0.062
1.356TyrPro: 1.356 ± 0.049
1.44TyrGln: 1.44 ± 0.05
1.679TyrArg: 1.679 ± 0.055
2.265TyrSer: 2.265 ± 0.064
2.103TyrThr: 2.103 ± 0.076
2.355TyrVal: 2.355 ± 0.071
0.253TyrTrp: 0.253 ± 0.021
1.773TyrTyr: 1.773 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1983 proteins (597384 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski