Amino acid dipepetide frequency for Oleomonas sp. K1W22B-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.478AlaAla: 20.478 ± 0.188
1.191AlaCys: 1.191 ± 0.034
7.523AlaAsp: 7.523 ± 0.09
7.124AlaGlu: 7.124 ± 0.089
4.476AlaPhe: 4.476 ± 0.059
12.917AlaGly: 12.917 ± 0.129
2.248AlaHis: 2.248 ± 0.046
6.344AlaIle: 6.344 ± 0.075
3.967AlaLys: 3.967 ± 0.068
14.247AlaLeu: 14.247 ± 0.126
3.452AlaMet: 3.452 ± 0.052
2.874AlaAsn: 2.874 ± 0.052
6.311AlaPro: 6.311 ± 0.09
4.458AlaGln: 4.458 ± 0.062
9.735AlaArg: 9.735 ± 0.093
5.781AlaSer: 5.781 ± 0.061
6.526AlaThr: 6.526 ± 0.064
9.804AlaVal: 9.804 ± 0.082
1.738AlaTrp: 1.738 ± 0.04
2.686AlaTyr: 2.686 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.971CysAla: 0.971 ± 0.027
0.132CysCys: 0.132 ± 0.009
0.482CysAsp: 0.482 ± 0.02
0.36CysGlu: 0.36 ± 0.015
0.324CysPhe: 0.324 ± 0.016
0.865CysGly: 0.865 ± 0.024
0.245CysHis: 0.245 ± 0.014
0.325CysIle: 0.325 ± 0.013
0.188CysLys: 0.188 ± 0.011
0.841CysLeu: 0.841 ± 0.023
0.135CysMet: 0.135 ± 0.01
0.182CysAsn: 0.182 ± 0.011
0.521CysPro: 0.521 ± 0.018
0.211CysGln: 0.211 ± 0.01
0.692CysArg: 0.692 ± 0.024
0.449CysSer: 0.449 ± 0.017
0.405CysThr: 0.405 ± 0.018
0.556CysVal: 0.556 ± 0.02
0.133CysTrp: 0.133 ± 0.01
0.191CysTyr: 0.191 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.849AspAla: 6.849 ± 0.079
0.438AspCys: 0.438 ± 0.018
3.569AspAsp: 3.569 ± 0.09
3.302AspGlu: 3.302 ± 0.048
2.304AspPhe: 2.304 ± 0.041
6.084AspGly: 6.084 ± 0.092
1.26AspHis: 1.26 ± 0.03
2.846AspIle: 2.846 ± 0.045
1.672AspLys: 1.672 ± 0.036
6.596AspLeu: 6.596 ± 0.068
1.163AspMet: 1.163 ± 0.032
1.283AspAsn: 1.283 ± 0.034
3.608AspPro: 3.608 ± 0.045
1.797AspGln: 1.797 ± 0.04
4.543AspArg: 4.543 ± 0.064
2.255AspSer: 2.255 ± 0.049
3.049AspThr: 3.049 ± 0.093
4.066AspVal: 4.066 ± 0.054
1.016AspTrp: 1.016 ± 0.025
1.55AspTyr: 1.55 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
7.831GluAla: 7.831 ± 0.084
0.301GluCys: 0.301 ± 0.014
2.346GluAsp: 2.346 ± 0.043
2.421GluGlu: 2.421 ± 0.05
1.624GluPhe: 1.624 ± 0.029
4.092GluGly: 4.092 ± 0.062
1.033GluHis: 1.033 ± 0.029
3.352GluIle: 3.352 ± 0.051
1.694GluLys: 1.694 ± 0.036
4.948GluLeu: 4.948 ± 0.064
1.281GluMet: 1.281 ± 0.029
1.33GluAsn: 1.33 ± 0.037
2.435GluPro: 2.435 ± 0.045
1.819GluGln: 1.819 ± 0.039
4.387GluArg: 4.387 ± 0.064
1.995GluSer: 1.995 ± 0.031
3.045GluThr: 3.045 ± 0.041
3.821GluVal: 3.821 ± 0.051
0.59GluTrp: 0.59 ± 0.022
0.91GluTyr: 0.91 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
4.738PheAla: 4.738 ± 0.059
0.385PheCys: 0.385 ± 0.017
2.707PheAsp: 2.707 ± 0.041
2.123PheGlu: 2.123 ± 0.036
1.35PhePhe: 1.35 ± 0.032
3.778PheGly: 3.778 ± 0.057
0.756PheHis: 0.756 ± 0.022
1.572PheIle: 1.572 ± 0.036
1.048PheLys: 1.048 ± 0.028
3.339PheLeu: 3.339 ± 0.051
0.759PheMet: 0.759 ± 0.021
1.0PheAsn: 1.0 ± 0.026
1.552PhePro: 1.552 ± 0.032
0.986PheGln: 0.986 ± 0.027
2.145PheArg: 2.145 ± 0.037
1.912PheSer: 1.912 ± 0.036
2.101PheThr: 2.101 ± 0.041
2.797PheVal: 2.797 ± 0.046
0.522PheTrp: 0.522 ± 0.02
0.901PheTyr: 0.901 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.597GlyAla: 10.597 ± 0.095
0.845GlyCys: 0.845 ± 0.029
5.828GlyAsp: 5.828 ± 0.143
4.686GlyGlu: 4.686 ± 0.053
3.825GlyPhe: 3.825 ± 0.055
9.06GlyGly: 9.06 ± 0.171
1.953GlyHis: 1.953 ± 0.035
4.714GlyIle: 4.714 ± 0.064
2.98GlyLys: 2.98 ± 0.05
9.989GlyLeu: 9.989 ± 0.105
2.074GlyMet: 2.074 ± 0.037
2.706GlyAsn: 2.706 ± 0.093
4.012GlyPro: 4.012 ± 0.062
3.036GlyGln: 3.036 ± 0.043
6.798GlyArg: 6.798 ± 0.079
4.657GlySer: 4.657 ± 0.064
5.224GlyThr: 5.224 ± 0.073
6.299GlyVal: 6.299 ± 0.068
1.398GlyTrp: 1.398 ± 0.032
2.164GlyTyr: 2.164 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.221HisAla: 2.221 ± 0.045
0.223HisCys: 0.223 ± 0.012
1.197HisAsp: 1.197 ± 0.029
0.943HisGlu: 0.943 ± 0.026
0.882HisPhe: 0.882 ± 0.026
2.108HisGly: 2.108 ± 0.043
0.624HisHis: 0.624 ± 0.022
0.816HisIle: 0.816 ± 0.021
0.478HisLys: 0.478 ± 0.02
2.194HisLeu: 2.194 ± 0.037
0.444HisMet: 0.444 ± 0.017
0.395HisAsn: 0.395 ± 0.015
1.298HisPro: 1.298 ± 0.034
0.547HisGln: 0.547 ± 0.019
1.562HisArg: 1.562 ± 0.034
0.784HisSer: 0.784 ± 0.025
0.76HisThr: 0.76 ± 0.021
1.47HisVal: 1.47 ± 0.036
0.352HisTrp: 0.352 ± 0.015
0.543HisTyr: 0.543 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.246IleAla: 7.246 ± 0.071
0.421IleCys: 0.421 ± 0.017
3.785IleAsp: 3.785 ± 0.051
3.695IleGlu: 3.695 ± 0.049
1.535IlePhe: 1.535 ± 0.036
4.913IleGly: 4.913 ± 0.064
0.929IleHis: 0.929 ± 0.023
1.972IleIle: 1.972 ± 0.042
1.315IleLys: 1.315 ± 0.03
4.314IleLeu: 4.314 ± 0.057
0.912IleMet: 0.912 ± 0.025
1.323IleAsn: 1.323 ± 0.035
2.177IlePro: 2.177 ± 0.036
1.166IleGln: 1.166 ± 0.028
2.987IleArg: 2.987 ± 0.049
2.432IleSer: 2.432 ± 0.045
2.742IleThr: 2.742 ± 0.045
4.027IleVal: 4.027 ± 0.059
0.543IleTrp: 0.543 ± 0.02
1.043IleTyr: 1.043 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
4.333LysAla: 4.333 ± 0.059
0.147LysCys: 0.147 ± 0.01
1.439LysAsp: 1.439 ± 0.035
1.232LysGlu: 1.232 ± 0.032
0.858LysPhe: 0.858 ± 0.024
2.531LysGly: 2.531 ± 0.047
0.507LysHis: 0.507 ± 0.018
1.516LysIle: 1.516 ± 0.037
0.924LysLys: 0.924 ± 0.029
3.0LysLeu: 3.0 ± 0.057
0.631LysMet: 0.631 ± 0.019
0.601LysAsn: 0.601 ± 0.02
1.925LysPro: 1.925 ± 0.041
0.787LysGln: 0.787 ± 0.024
2.134LysArg: 2.134 ± 0.038
1.453LysSer: 1.453 ± 0.034
1.63LysThr: 1.63 ± 0.036
2.482LysVal: 2.482 ± 0.05
0.354LysTrp: 0.354 ± 0.016
0.574LysTyr: 0.574 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
15.022LeuAla: 15.022 ± 0.128
0.859LeuCys: 0.859 ± 0.024
6.66LeuAsp: 6.66 ± 0.072
4.975LeuGlu: 4.975 ± 0.055
3.52LeuPhe: 3.52 ± 0.05
9.495LeuGly: 9.495 ± 0.094
1.928LeuHis: 1.928 ± 0.04
5.13LeuIle: 5.13 ± 0.066
3.367LeuLys: 3.367 ± 0.05
9.563LeuLeu: 9.563 ± 0.106
2.236LeuMet: 2.236 ± 0.04
2.498LeuAsn: 2.498 ± 0.043
5.941LeuPro: 5.941 ± 0.069
2.412LeuGln: 2.412 ± 0.04
7.012LeuArg: 7.012 ± 0.085
5.951LeuSer: 5.951 ± 0.067
5.748LeuThr: 5.748 ± 0.075
8.001LeuVal: 8.001 ± 0.076
1.261LeuTrp: 1.261 ± 0.033
2.105LeuTyr: 2.105 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.29MetAla: 3.29 ± 0.048
0.135MetCys: 0.135 ± 0.009
1.008MetAsp: 1.008 ± 0.025
0.91MetGlu: 0.91 ± 0.026
0.637MetPhe: 0.637 ± 0.021
1.761MetGly: 1.761 ± 0.035
0.372MetHis: 0.372 ± 0.016
1.213MetIle: 1.213 ± 0.026
0.792MetLys: 0.792 ± 0.023
2.241MetLeu: 2.241 ± 0.041
0.575MetMet: 0.575 ± 0.027
0.622MetAsn: 0.622 ± 0.019
1.468MetPro: 1.468 ± 0.027
0.632MetGln: 0.632 ± 0.021
1.584MetArg: 1.584 ± 0.032
1.436MetSer: 1.436 ± 0.031
1.727MetThr: 1.727 ± 0.033
1.717MetVal: 1.717 ± 0.034
0.202MetTrp: 0.202 ± 0.013
0.279MetTyr: 0.279 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.836AsnAla: 2.836 ± 0.042
0.207AsnCys: 0.207 ± 0.011
1.59AsnAsp: 1.59 ± 0.068
1.076AsnGlu: 1.076 ± 0.026
0.942AsnPhe: 0.942 ± 0.029
2.447AsnGly: 2.447 ± 0.063
0.461AsnHis: 0.461 ± 0.018
1.133AsnIle: 1.133 ± 0.03
0.611AsnLys: 0.611 ± 0.02
2.619AsnLeu: 2.619 ± 0.051
0.498AsnMet: 0.498 ± 0.017
0.64AsnAsn: 0.64 ± 0.025
1.731AsnPro: 1.731 ± 0.036
0.717AsnGln: 0.717 ± 0.022
1.677AsnArg: 1.677 ± 0.034
1.026AsnSer: 1.026 ± 0.026
1.225AsnThr: 1.225 ± 0.032
1.767AsnVal: 1.767 ± 0.039
0.391AsnTrp: 0.391 ± 0.017
0.615AsnTyr: 0.615 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
7.707ProAla: 7.707 ± 0.095
0.385ProCys: 0.385 ± 0.017
3.623ProAsp: 3.623 ± 0.045
3.106ProGlu: 3.106 ± 0.045
1.989ProPhe: 1.989 ± 0.038
5.221ProGly: 5.221 ± 0.073
0.997ProHis: 0.997 ± 0.027
2.298ProIle: 2.298 ± 0.039
1.537ProLys: 1.537 ± 0.033
5.096ProLeu: 5.096 ± 0.06
1.316ProMet: 1.316 ± 0.031
1.15ProAsn: 1.15 ± 0.028
3.407ProPro: 3.407 ± 0.092
1.582ProGln: 1.582 ± 0.034
3.373ProArg: 3.373 ± 0.055
2.67ProSer: 2.67 ± 0.043
2.592ProThr: 2.592 ± 0.043
4.371ProVal: 4.371 ± 0.059
0.772ProTrp: 0.772 ± 0.024
1.179ProTyr: 1.179 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.65GlnAla: 4.65 ± 0.072
0.206GlnCys: 0.206 ± 0.012
1.398GlnAsp: 1.398 ± 0.029
1.221GlnGlu: 1.221 ± 0.029
1.08GlnPhe: 1.08 ± 0.028
2.731GlnGly: 2.731 ± 0.037
0.545GlnHis: 0.545 ± 0.02
1.684GlnIle: 1.684 ± 0.033
0.801GlnLys: 0.801 ± 0.023
2.663GlnLeu: 2.663 ± 0.045
0.73GlnMet: 0.73 ± 0.023
0.703GlnAsn: 0.703 ± 0.023
1.62GlnPro: 1.62 ± 0.032
1.001GlnGln: 1.001 ± 0.029
2.337GlnArg: 2.337 ± 0.037
1.445GlnSer: 1.445 ± 0.035
1.451GlnThr: 1.451 ± 0.03
2.481GlnVal: 2.481 ± 0.043
0.426GlnTrp: 0.426 ± 0.017
0.579GlnTyr: 0.579 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
8.426ArgAla: 8.426 ± 0.101
0.548ArgCys: 0.548 ± 0.019
4.018ArgAsp: 4.018 ± 0.052
3.647ArgGlu: 3.647 ± 0.05
2.923ArgPhe: 2.923 ± 0.042
5.183ArgGly: 5.183 ± 0.062
1.943ArgHis: 1.943 ± 0.037
3.669ArgIle: 3.669 ± 0.047
1.884ArgLys: 1.884 ± 0.033
9.165ArgLeu: 9.165 ± 0.093
1.624ArgMet: 1.624 ± 0.033
1.666ArgAsn: 1.666 ± 0.033
4.169ArgPro: 4.169 ± 0.071
2.582ArgGln: 2.582 ± 0.043
6.755ArgArg: 6.755 ± 0.088
3.287ArgSer: 3.287 ± 0.048
3.039ArgThr: 3.039 ± 0.047
4.723ArgVal: 4.723 ± 0.056
1.074ArgTrp: 1.074 ± 0.03
1.739ArgTyr: 1.739 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
5.726SerAla: 5.726 ± 0.075
0.401SerCys: 0.401 ± 0.017
2.501SerAsp: 2.501 ± 0.041
1.964SerGlu: 1.964 ± 0.035
2.159SerPhe: 2.159 ± 0.042
4.936SerGly: 4.936 ± 0.07
0.993SerHis: 0.993 ± 0.029
2.517SerIle: 2.517 ± 0.046
1.255SerLys: 1.255 ± 0.028
5.318SerLeu: 5.318 ± 0.049
1.089SerMet: 1.089 ± 0.028
1.132SerAsn: 1.132 ± 0.027
2.898SerPro: 2.898 ± 0.051
1.304SerGln: 1.304 ± 0.035
3.41SerArg: 3.41 ± 0.046
2.536SerSer: 2.536 ± 0.046
2.616SerThr: 2.616 ± 0.052
3.699SerVal: 3.699 ± 0.058
0.673SerTrp: 0.673 ± 0.021
1.231SerTyr: 1.231 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.677ThrAla: 6.677 ± 0.075
0.431ThrCys: 0.431 ± 0.019
2.867ThrAsp: 2.867 ± 0.046
2.217ThrGlu: 2.217 ± 0.042
1.863ThrPhe: 1.863 ± 0.031
5.578ThrGly: 5.578 ± 0.075
0.884ThrHis: 0.884 ± 0.027
2.889ThrIle: 2.889 ± 0.043
1.387ThrLys: 1.387 ± 0.031
6.118ThrLeu: 6.118 ± 0.086
1.174ThrMet: 1.174 ± 0.025
1.174ThrAsn: 1.174 ± 0.027
3.318ThrPro: 3.318 ± 0.052
1.527ThrGln: 1.527 ± 0.038
3.384ThrArg: 3.384 ± 0.053
2.522ThrSer: 2.522 ± 0.042
2.906ThrThr: 2.906 ± 0.047
4.654ThrVal: 4.654 ± 0.06
0.688ThrTrp: 0.688 ± 0.02
1.3ThrTyr: 1.3 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
10.282ValAla: 10.282 ± 0.092
0.594ValCys: 0.594 ± 0.019
4.531ValAsp: 4.531 ± 0.062
4.633ValGlu: 4.633 ± 0.058
2.709ValPhe: 2.709 ± 0.047
6.079ValGly: 6.079 ± 0.079
1.33ValHis: 1.33 ± 0.029
4.01ValIle: 4.01 ± 0.051
2.155ValLys: 2.155 ± 0.046
7.407ValLeu: 7.407 ± 0.077
1.78ValMet: 1.78 ± 0.036
1.927ValAsn: 1.927 ± 0.045
4.138ValPro: 4.138 ± 0.053
1.973ValGln: 1.973 ± 0.034
4.558ValArg: 4.558 ± 0.062
3.904ValSer: 3.904 ± 0.057
4.932ValThr: 4.932 ± 0.06
6.401ValVal: 6.401 ± 0.074
0.856ValTrp: 0.856 ± 0.026
1.402ValTyr: 1.402 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.473TrpAla: 1.473 ± 0.033
0.147TrpCys: 0.147 ± 0.01
0.638TrpAsp: 0.638 ± 0.023
0.507TrpGlu: 0.507 ± 0.018
0.508TrpPhe: 0.508 ± 0.017
1.016TrpGly: 1.016 ± 0.027
0.332TrpHis: 0.332 ± 0.016
0.617TrpIle: 0.617 ± 0.021
0.406TrpLys: 0.406 ± 0.016
1.674TrpLeu: 1.674 ± 0.037
0.327TrpMet: 0.327 ± 0.014
0.422TrpAsn: 0.422 ± 0.017
0.753TrpPro: 0.753 ± 0.025
0.554TrpGln: 0.554 ± 0.018
1.23TrpArg: 1.23 ± 0.031
0.792TrpSer: 0.792 ± 0.023
0.754TrpThr: 0.754 ± 0.022
0.86TrpVal: 0.86 ± 0.024
0.249TrpTrp: 0.249 ± 0.014
0.311TrpTyr: 0.311 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.526TyrAla: 2.526 ± 0.045
0.209TyrCys: 0.209 ± 0.013
1.539TyrAsp: 1.539 ± 0.034
1.116TyrGlu: 1.116 ± 0.033
0.962TyrPhe: 0.962 ± 0.027
2.048TyrGly: 2.048 ± 0.044
0.5TyrHis: 0.5 ± 0.018
0.863TyrIle: 0.863 ± 0.024
0.596TyrLys: 0.596 ± 0.022
2.354TyrLeu: 2.354 ± 0.039
0.404TyrMet: 0.404 ± 0.018
0.585TyrAsn: 0.585 ± 0.023
1.086TyrPro: 1.086 ± 0.027
0.658TyrGln: 0.658 ± 0.021
1.761TyrArg: 1.761 ± 0.033
1.074TyrSer: 1.074 ± 0.027
1.084TyrThr: 1.084 ± 0.027
1.603TyrVal: 1.603 ± 0.037
0.332TyrTrp: 0.332 ± 0.015
0.637TyrTyr: 0.637 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5024 proteins (1531126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski