Amino acid dipepetide frequency for Rhizobium smilacinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.835AlaAla: 14.835 ± 0.138
0.891AlaCys: 0.891 ± 0.023
6.568AlaAsp: 6.568 ± 0.065
7.042AlaGlu: 7.042 ± 0.076
4.498AlaPhe: 4.498 ± 0.056
9.795AlaGly: 9.795 ± 0.082
1.971AlaHis: 1.971 ± 0.029
7.138AlaIle: 7.138 ± 0.064
4.493AlaLys: 4.493 ± 0.068
12.027AlaLeu: 12.027 ± 0.12
3.399AlaMet: 3.399 ± 0.047
3.019AlaAsn: 3.019 ± 0.044
4.469AlaPro: 4.469 ± 0.067
3.555AlaGln: 3.555 ± 0.054
7.044AlaArg: 7.044 ± 0.08
6.76AlaSer: 6.76 ± 0.063
5.745AlaThr: 5.745 ± 0.062
8.231AlaVal: 8.231 ± 0.068
1.239AlaTrp: 1.239 ± 0.024
2.55AlaTyr: 2.55 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.806CysAla: 0.806 ± 0.022
0.1CysCys: 0.1 ± 0.007
0.478CysAsp: 0.478 ± 0.018
0.402CysGlu: 0.402 ± 0.013
0.297CysPhe: 0.297 ± 0.013
0.847CysGly: 0.847 ± 0.026
0.229CysHis: 0.229 ± 0.012
0.415CysIle: 0.415 ± 0.015
0.177CysLys: 0.177 ± 0.011
0.8CysLeu: 0.8 ± 0.024
0.17CysMet: 0.17 ± 0.01
0.214CysAsn: 0.214 ± 0.012
0.353CysPro: 0.353 ± 0.014
0.214CysGln: 0.214 ± 0.012
0.538CysArg: 0.538 ± 0.02
0.424CysSer: 0.424 ± 0.015
0.346CysThr: 0.346 ± 0.015
0.553CysVal: 0.553 ± 0.018
0.111CysTrp: 0.111 ± 0.008
0.18CysTyr: 0.18 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.398AspAla: 6.398 ± 0.068
0.476AspCys: 0.476 ± 0.018
3.249AspAsp: 3.249 ± 0.055
3.567AspGlu: 3.567 ± 0.048
2.32AspPhe: 2.32 ± 0.043
5.019AspGly: 5.019 ± 0.068
1.248AspHis: 1.248 ± 0.03
3.611AspIle: 3.611 ± 0.043
2.021AspLys: 2.021 ± 0.035
5.984AspLeu: 5.984 ± 0.065
1.458AspMet: 1.458 ± 0.032
1.524AspAsn: 1.524 ± 0.032
3.144AspPro: 3.144 ± 0.048
1.774AspGln: 1.774 ± 0.032
4.045AspArg: 4.045 ± 0.057
2.103AspSer: 2.103 ± 0.04
2.667AspThr: 2.667 ± 0.034
4.177AspVal: 4.177 ± 0.054
0.898AspTrp: 0.898 ± 0.022
1.559AspTyr: 1.559 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
6.942GluAla: 6.942 ± 0.07
0.323GluCys: 0.323 ± 0.014
2.816GluAsp: 2.816 ± 0.047
3.471GluGlu: 3.471 ± 0.057
1.931GluPhe: 1.931 ± 0.034
4.115GluGly: 4.115 ± 0.053
1.155GluHis: 1.155 ± 0.028
3.98GluIle: 3.98 ± 0.055
2.957GluLys: 2.957 ± 0.042
5.319GluLeu: 5.319 ± 0.057
1.559GluMet: 1.559 ± 0.031
1.964GluAsn: 1.964 ± 0.039
2.585GluPro: 2.585 ± 0.043
2.156GluGln: 2.156 ± 0.042
4.411GluArg: 4.411 ± 0.06
2.318GluSer: 2.318 ± 0.038
3.733GluThr: 3.733 ± 0.05
3.725GluVal: 3.725 ± 0.043
0.696GluTrp: 0.696 ± 0.02
1.073GluTyr: 1.073 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.495PheAla: 4.495 ± 0.058
0.382PheCys: 0.382 ± 0.014
2.835PheAsp: 2.835 ± 0.038
2.198PheGlu: 2.198 ± 0.033
1.668PhePhe: 1.668 ± 0.037
3.865PheGly: 3.865 ± 0.055
0.753PheHis: 0.753 ± 0.02
2.068PheIle: 2.068 ± 0.039
1.205PheLys: 1.205 ± 0.031
3.655PheLeu: 3.655 ± 0.056
0.88PheMet: 0.88 ± 0.023
1.167PheAsn: 1.167 ± 0.024
1.643PhePro: 1.643 ± 0.036
1.144PheGln: 1.144 ± 0.022
2.309PheArg: 2.309 ± 0.034
2.779PheSer: 2.779 ± 0.036
1.993PheThr: 1.993 ± 0.031
3.009PheVal: 3.009 ± 0.042
0.615PheTrp: 0.615 ± 0.022
0.979PheTyr: 0.979 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
8.182GlyAla: 8.182 ± 0.069
0.762GlyCys: 0.762 ± 0.023
4.2GlyAsp: 4.2 ± 0.058
4.788GlyGlu: 4.788 ± 0.053
3.751GlyPhe: 3.751 ± 0.052
6.845GlyGly: 6.845 ± 0.068
1.845GlyHis: 1.845 ± 0.032
5.149GlyIle: 5.149 ± 0.055
3.717GlyLys: 3.717 ± 0.045
8.573GlyLeu: 8.573 ± 0.087
2.364GlyMet: 2.364 ± 0.04
2.453GlyAsn: 2.453 ± 0.041
3.079GlyPro: 3.079 ± 0.042
2.857GlyGln: 2.857 ± 0.048
5.487GlyArg: 5.487 ± 0.055
4.986GlySer: 4.986 ± 0.054
4.605GlyThr: 4.605 ± 0.083
5.758GlyVal: 5.758 ± 0.062
1.224GlyTrp: 1.224 ± 0.024
2.394GlyTyr: 2.394 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.098HisAla: 2.098 ± 0.038
0.204HisCys: 0.204 ± 0.011
1.219HisAsp: 1.219 ± 0.026
1.048HisGlu: 1.048 ± 0.025
0.875HisPhe: 0.875 ± 0.028
1.848HisGly: 1.848 ± 0.033
0.564HisHis: 0.564 ± 0.02
1.047HisIle: 1.047 ± 0.026
0.523HisLys: 0.523 ± 0.017
2.039HisLeu: 2.039 ± 0.033
0.554HisMet: 0.554 ± 0.019
0.455HisAsn: 0.455 ± 0.014
1.213HisPro: 1.213 ± 0.028
0.62HisGln: 0.62 ± 0.02
1.295HisArg: 1.295 ± 0.029
1.029HisSer: 1.029 ± 0.025
0.779HisThr: 0.779 ± 0.021
1.49HisVal: 1.49 ± 0.027
0.279HisTrp: 0.279 ± 0.013
0.534HisTyr: 0.534 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
7.89IleAla: 7.89 ± 0.083
0.565IleCys: 0.565 ± 0.018
3.99IleAsp: 3.99 ± 0.052
3.916IleGlu: 3.916 ± 0.054
2.188IlePhe: 2.188 ± 0.038
5.618IleGly: 5.618 ± 0.066
0.978IleHis: 0.978 ± 0.025
2.935IleIle: 2.935 ± 0.049
1.803IleLys: 1.803 ± 0.04
5.187IleLeu: 5.187 ± 0.053
1.221IleMet: 1.221 ± 0.03
1.674IleAsn: 1.674 ± 0.032
2.63IlePro: 2.63 ± 0.038
1.395IleGln: 1.395 ± 0.03
3.619IleArg: 3.619 ± 0.053
3.776IleSer: 3.776 ± 0.048
3.09IleThr: 3.09 ± 0.039
4.777IleVal: 4.777 ± 0.049
0.677IleTrp: 0.677 ± 0.022
1.34IleTyr: 1.34 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.808LysAla: 4.808 ± 0.064
0.155LysCys: 0.155 ± 0.01
2.134LysAsp: 2.134 ± 0.035
1.873LysGlu: 1.873 ± 0.037
1.12LysPhe: 1.12 ± 0.025
2.938LysGly: 2.938 ± 0.045
0.646LysHis: 0.646 ± 0.019
2.264LysIle: 2.264 ± 0.038
1.617LysLys: 1.617 ± 0.038
3.876LysLeu: 3.876 ± 0.048
0.944LysMet: 0.944 ± 0.025
1.193LysAsn: 1.193 ± 0.025
2.322LysPro: 2.322 ± 0.045
1.2LysGln: 1.2 ± 0.026
2.501LysArg: 2.501 ± 0.04
2.371LysSer: 2.371 ± 0.048
2.435LysThr: 2.435 ± 0.037
2.75LysVal: 2.75 ± 0.051
0.423LysTrp: 0.423 ± 0.016
0.691LysTyr: 0.691 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
12.206LeuAla: 12.206 ± 0.099
0.842LeuCys: 0.842 ± 0.024
5.893LeuAsp: 5.893 ± 0.068
5.146LeuGlu: 5.146 ± 0.054
3.754LeuPhe: 3.754 ± 0.057
7.914LeuGly: 7.914 ± 0.084
1.747LeuHis: 1.747 ± 0.036
5.595LeuIle: 5.595 ± 0.063
4.294LeuLys: 4.294 ± 0.047
9.192LeuLeu: 9.192 ± 0.108
2.462LeuMet: 2.462 ± 0.041
2.792LeuAsn: 2.792 ± 0.042
5.2LeuPro: 5.2 ± 0.051
2.838LeuGln: 2.838 ± 0.045
5.921LeuArg: 5.921 ± 0.068
7.399LeuSer: 7.399 ± 0.091
5.76LeuThr: 5.76 ± 0.074
7.341LeuVal: 7.341 ± 0.065
1.051LeuTrp: 1.051 ± 0.026
2.099LeuTyr: 2.099 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
3.154MetAla: 3.154 ± 0.045
0.141MetCys: 0.141 ± 0.009
1.251MetAsp: 1.251 ± 0.026
1.197MetGlu: 1.197 ± 0.026
0.793MetPhe: 0.793 ± 0.024
1.759MetGly: 1.759 ± 0.034
0.409MetHis: 0.409 ± 0.015
1.631MetIle: 1.631 ± 0.033
1.163MetLys: 1.163 ± 0.026
2.657MetLeu: 2.657 ± 0.044
0.751MetMet: 0.751 ± 0.023
0.856MetAsn: 0.856 ± 0.023
1.5MetPro: 1.5 ± 0.03
0.916MetGln: 0.916 ± 0.022
1.757MetArg: 1.757 ± 0.031
1.852MetSer: 1.852 ± 0.029
2.013MetThr: 2.013 ± 0.036
1.846MetVal: 1.846 ± 0.036
0.206MetTrp: 0.206 ± 0.012
0.312MetTyr: 0.312 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.354AsnAla: 3.354 ± 0.049
0.244AsnCys: 0.244 ± 0.012
1.613AsnAsp: 1.613 ± 0.032
1.459AsnGlu: 1.459 ± 0.032
1.144AsnPhe: 1.144 ± 0.029
2.667AsnGly: 2.667 ± 0.042
0.565AsnHis: 0.565 ± 0.017
1.634AsnIle: 1.634 ± 0.032
0.868AsnLys: 0.868 ± 0.024
2.891AsnLeu: 2.891 ± 0.047
0.711AsnMet: 0.711 ± 0.02
0.828AsnAsn: 0.828 ± 0.026
1.881AsnPro: 1.881 ± 0.036
0.854AsnGln: 0.854 ± 0.021
1.933AsnArg: 1.933 ± 0.031
1.591AsnSer: 1.591 ± 0.036
1.422AsnThr: 1.422 ± 0.03
2.11AsnVal: 2.11 ± 0.035
0.457AsnTrp: 0.457 ± 0.016
0.768AsnTyr: 0.768 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
5.341ProAla: 5.341 ± 0.071
0.244ProCys: 0.244 ± 0.012
3.299ProAsp: 3.299 ± 0.056
3.411ProGlu: 3.411 ± 0.047
2.009ProPhe: 2.009 ± 0.037
3.877ProGly: 3.877 ± 0.049
1.048ProHis: 1.048 ± 0.026
2.521ProIle: 2.521 ± 0.036
1.915ProLys: 1.915 ± 0.039
4.482ProLeu: 4.482 ± 0.052
1.144ProMet: 1.144 ± 0.026
1.444ProAsn: 1.444 ± 0.03
1.957ProPro: 1.957 ± 0.05
1.608ProGln: 1.608 ± 0.036
2.408ProArg: 2.408 ± 0.036
2.801ProSer: 2.801 ± 0.043
2.44ProThr: 2.44 ± 0.039
4.042ProVal: 4.042 ± 0.054
0.554ProTrp: 0.554 ± 0.018
1.221ProTyr: 1.221 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.795GlnAla: 3.795 ± 0.053
0.147GlnCys: 0.147 ± 0.009
1.548GlnAsp: 1.548 ± 0.028
1.583GlnGlu: 1.583 ± 0.031
1.185GlnPhe: 1.185 ± 0.027
2.224GlnGly: 2.224 ± 0.034
0.628GlnHis: 0.628 ± 0.019
1.997GlnIle: 1.997 ± 0.047
1.314GlnLys: 1.314 ± 0.028
2.855GlnLeu: 2.855 ± 0.04
0.979GlnMet: 0.979 ± 0.021
0.98GlnAsn: 0.98 ± 0.027
1.723GlnPro: 1.723 ± 0.04
1.359GlnGln: 1.359 ± 0.039
2.239GlnArg: 2.239 ± 0.042
2.059GlnSer: 2.059 ± 0.038
1.846GlnThr: 1.846 ± 0.033
2.215GlnVal: 2.215 ± 0.043
0.39GlnTrp: 0.39 ± 0.016
0.665GlnTyr: 0.665 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
6.157ArgAla: 6.157 ± 0.063
0.419ArgCys: 0.419 ± 0.018
3.719ArgAsp: 3.719 ± 0.045
3.826ArgGlu: 3.826 ± 0.046
2.709ArgPhe: 2.709 ± 0.042
4.255ArgGly: 4.255 ± 0.048
1.604ArgHis: 1.604 ± 0.028
4.029ArgIle: 4.029 ± 0.047
2.531ArgLys: 2.531 ± 0.04
6.986ArgLeu: 6.986 ± 0.071
1.889ArgMet: 1.889 ± 0.038
2.073ArgAsn: 2.073 ± 0.035
2.964ArgPro: 2.964 ± 0.046
2.604ArgGln: 2.604 ± 0.04
4.785ArgArg: 4.785 ± 0.061
3.797ArgSer: 3.797 ± 0.039
3.13ArgThr: 3.13 ± 0.043
4.109ArgVal: 4.109 ± 0.053
0.864ArgTrp: 0.864 ± 0.022
1.768ArgTyr: 1.768 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
6.484SerAla: 6.484 ± 0.063
0.419SerCys: 0.419 ± 0.019
3.334SerAsp: 3.334 ± 0.047
3.223SerGlu: 3.223 ± 0.044
2.667SerPhe: 2.667 ± 0.039
5.932SerGly: 5.932 ± 0.065
1.24SerHis: 1.24 ± 0.028
3.533SerIle: 3.533 ± 0.051
2.072SerLys: 2.072 ± 0.035
6.046SerLeu: 6.046 ± 0.067
1.551SerMet: 1.551 ± 0.031
1.634SerAsn: 1.634 ± 0.034
2.843SerPro: 2.843 ± 0.042
1.863SerGln: 1.863 ± 0.038
3.769SerArg: 3.769 ± 0.046
3.8SerSer: 3.8 ± 0.055
3.159SerThr: 3.159 ± 0.062
4.494SerVal: 4.494 ± 0.058
0.785SerTrp: 0.785 ± 0.024
1.493SerTyr: 1.493 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.198ThrAla: 6.198 ± 0.076
0.399ThrCys: 0.399 ± 0.015
2.994ThrAsp: 2.994 ± 0.047
2.839ThrGlu: 2.839 ± 0.04
2.19ThrPhe: 2.19 ± 0.038
5.046ThrGly: 5.046 ± 0.065
1.002ThrHis: 1.002 ± 0.022
3.414ThrIle: 3.414 ± 0.044
1.765ThrLys: 1.765 ± 0.033
5.702ThrLeu: 5.702 ± 0.061
1.291ThrMet: 1.291 ± 0.027
1.508ThrAsn: 1.508 ± 0.034
2.969ThrPro: 2.969 ± 0.046
1.436ThrGln: 1.436 ± 0.031
3.075ThrArg: 3.075 ± 0.044
3.308ThrSer: 3.308 ± 0.049
3.038ThrThr: 3.038 ± 0.057
4.578ThrVal: 4.578 ± 0.065
0.648ThrTrp: 0.648 ± 0.019
1.318ThrTyr: 1.318 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
8.574ValAla: 8.574 ± 0.078
0.593ValCys: 0.593 ± 0.019
4.047ValAsp: 4.047 ± 0.048
4.444ValGlu: 4.444 ± 0.056
2.966ValPhe: 2.966 ± 0.044
5.445ValGly: 5.445 ± 0.063
1.328ValHis: 1.328 ± 0.026
4.545ValIle: 4.545 ± 0.059
2.609ValLys: 2.609 ± 0.039
7.225ValLeu: 7.225 ± 0.072
1.983ValMet: 1.983 ± 0.039
2.078ValAsn: 2.078 ± 0.036
3.45ValPro: 3.45 ± 0.043
1.958ValGln: 1.958 ± 0.039
4.365ValArg: 4.365 ± 0.049
4.985ValSer: 4.985 ± 0.065
4.644ValThr: 4.644 ± 0.053
5.75ValVal: 5.75 ± 0.072
0.836ValTrp: 0.836 ± 0.023
1.519ValTyr: 1.519 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.088TrpAla: 1.088 ± 0.028
0.122TrpCys: 0.122 ± 0.008
0.611TrpAsp: 0.611 ± 0.019
0.541TrpGlu: 0.541 ± 0.02
0.545TrpPhe: 0.545 ± 0.022
0.81TrpGly: 0.81 ± 0.024
0.292TrpHis: 0.292 ± 0.015
0.677TrpIle: 0.677 ± 0.02
0.521TrpLys: 0.521 ± 0.018
1.539TrpLeu: 1.539 ± 0.032
0.355TrpMet: 0.355 ± 0.013
0.473TrpAsn: 0.473 ± 0.017
0.666TrpPro: 0.666 ± 0.018
0.558TrpGln: 0.558 ± 0.018
0.975TrpArg: 0.975 ± 0.026
0.836TrpSer: 0.836 ± 0.022
0.714TrpThr: 0.714 ± 0.022
0.728TrpVal: 0.728 ± 0.02
0.225TrpTrp: 0.225 ± 0.012
0.295TrpTyr: 0.295 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.464TyrAla: 2.464 ± 0.039
0.226TyrCys: 0.226 ± 0.011
1.439TyrAsp: 1.439 ± 0.033
1.256TyrGlu: 1.256 ± 0.026
1.034TyrPhe: 1.034 ± 0.027
2.201TyrGly: 2.201 ± 0.035
0.46TyrHis: 0.46 ± 0.017
1.086TyrIle: 1.086 ± 0.029
0.697TyrLys: 0.697 ± 0.022
2.413TyrLeu: 2.413 ± 0.038
0.497TyrMet: 0.497 ± 0.015
0.668TyrAsn: 0.668 ± 0.022
1.176TyrPro: 1.176 ± 0.027
0.821TyrGln: 0.821 ± 0.025
1.742TyrArg: 1.742 ± 0.036
1.368TyrSer: 1.368 ± 0.029
1.157TyrThr: 1.157 ± 0.028
1.661TyrVal: 1.661 ± 0.033
0.392TyrTrp: 0.392 ± 0.015
0.658TyrTyr: 0.658 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5526 proteins (1739106 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski