Amino acid dipepetide frequency for Haliea sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.947AlaAla: 18.947 ± 0.17	1.435AlaCys: 1.435 ± 0.034	6.712AlaAsp: 6.712 ± 0.062	6.04AlaGlu: 6.04 ± 0.066	4.412AlaPhe: 4.412 ± 0.057	12.213AlaGly: 12.213 ± 0.11	2.74AlaHis: 2.74 ± 0.045	5.213AlaIle: 5.213 ± 0.066	3.518AlaLys: 3.518 ± 0.058	15.098AlaLeu: 15.098 ± 0.125	3.761AlaMet: 3.761 ± 0.05	2.881AlaAsn: 2.881 ± 0.049	6.623AlaPro: 6.623 ± 0.076	6.078AlaGln: 6.078 ± 0.072	9.01AlaArg: 9.01 ± 0.089	7.42AlaSer: 7.42 ± 0.087	6.376AlaThr: 6.376 ± 0.074	9.619AlaVal: 9.619 ± 0.089	2.095AlaTrp: 2.095 ± 0.039	2.492AlaTyr: 2.492 ± 0.034	0.001AlaXaa: 0.001 ± 0.001
Cys	1.24CysAla: 1.24 ± 0.031	0.121CysCys: 0.121 ± 0.01	0.51CysAsp: 0.51 ± 0.018	0.517CysGlu: 0.517 ± 0.02	0.323CysPhe: 0.323 ± 0.015	1.032CysGly: 1.032 ± 0.03	0.276CysHis: 0.276 ± 0.014	0.454CysIle: 0.454 ± 0.017	0.227CysLys: 0.227 ± 0.012	0.869CysLeu: 0.869 ± 0.022	0.206CysMet: 0.206 ± 0.011	0.259CysAsn: 0.259 ± 0.013	0.492CysPro: 0.492 ± 0.019	0.265CysGln: 0.265 ± 0.013	0.586CysArg: 0.586 ± 0.023	0.567CysSer: 0.567 ± 0.019	0.523CysThr: 0.523 ± 0.02	0.684CysVal: 0.684 ± 0.021	0.141CysTrp: 0.141 ± 0.01	0.196CysTyr: 0.196 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.188AspAla: 7.188 ± 0.075	0.454AspCys: 0.454 ± 0.014	2.468AspAsp: 2.468 ± 0.051	2.754AspGlu: 2.754 ± 0.044	2.019AspPhe: 2.019 ± 0.036	4.504AspGly: 4.504 ± 0.063	1.098AspHis: 1.098 ± 0.026	2.413AspIle: 2.413 ± 0.038	1.665AspLys: 1.665 ± 0.036	5.157AspLeu: 5.157 ± 0.058	1.278AspMet: 1.278 ± 0.026	1.22AspAsn: 1.22 ± 0.029	2.736AspPro: 2.736 ± 0.045	1.512AspGln: 1.512 ± 0.032	3.139AspArg: 3.139 ± 0.051	2.306AspSer: 2.306 ± 0.043	2.583AspThr: 2.583 ± 0.048	3.877AspVal: 3.877 ± 0.052	0.948AspTrp: 0.948 ± 0.023	1.302AspTyr: 1.302 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.432GluAla: 6.432 ± 0.073	0.337GluCys: 0.337 ± 0.014	2.058GluAsp: 2.058 ± 0.037	2.291GluGlu: 2.291 ± 0.041	1.753GluPhe: 1.753 ± 0.037	3.508GluGly: 3.508 ± 0.048	1.183GluHis: 1.183 ± 0.03	2.385GluIle: 2.385 ± 0.04	1.85GluLys: 1.85 ± 0.037	5.538GluLeu: 5.538 ± 0.07	1.272GluMet: 1.272 ± 0.029	1.111GluAsn: 1.111 ± 0.024	2.404GluPro: 2.404 ± 0.045	2.319GluGln: 2.319 ± 0.042	3.985GluArg: 3.985 ± 0.058	2.362GluSer: 2.362 ± 0.043	2.453GluThr: 2.453 ± 0.039	3.809GluVal: 3.809 ± 0.056	0.65GluTrp: 0.65 ± 0.021	0.862GluTyr: 0.862 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.388PheAla: 4.388 ± 0.05	0.406PheCys: 0.406 ± 0.016	2.392PheAsp: 2.392 ± 0.042	2.025PheGlu: 2.025 ± 0.042	1.421PhePhe: 1.421 ± 0.035	3.528PheGly: 3.528 ± 0.056	0.769PheHis: 0.769 ± 0.022	1.562PheIle: 1.562 ± 0.033	1.14PheLys: 1.14 ± 0.029	3.008PheLeu: 3.008 ± 0.05	0.869PheMet: 0.869 ± 0.022	1.175PheAsn: 1.175 ± 0.026	1.572PhePro: 1.572 ± 0.03	1.003PheGln: 1.003 ± 0.027	1.952PheArg: 1.952 ± 0.032	2.356PheSer: 2.356 ± 0.042	2.101PheThr: 2.101 ± 0.035	2.654PheVal: 2.654 ± 0.042	0.547PheTrp: 0.547 ± 0.021	0.854PheTyr: 0.854 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.014GlyAla: 10.014 ± 0.091	0.944GlyCys: 0.944 ± 0.028	3.963GlyAsp: 3.963 ± 0.057	4.205GlyGlu: 4.205 ± 0.058	3.451GlyPhe: 3.451 ± 0.049	7.336GlyGly: 7.336 ± 0.118	1.939GlyHis: 1.939 ± 0.037	4.126GlyIle: 4.126 ± 0.048	3.397GlyLys: 3.397 ± 0.06	9.574GlyLeu: 9.574 ± 0.09	2.476GlyMet: 2.476 ± 0.039	2.366GlyAsn: 2.366 ± 0.047	3.317GlyPro: 3.317 ± 0.047	3.58GlyGln: 3.58 ± 0.054	5.402GlyArg: 5.402 ± 0.066	4.942GlySer: 4.942 ± 0.058	4.84GlyThr: 4.84 ± 0.079	6.884GlyVal: 6.884 ± 0.069	1.466GlyTrp: 1.466 ± 0.033	2.265GlyTyr: 2.265 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.968HisAla: 2.968 ± 0.053	0.272HisCys: 0.272 ± 0.014	1.151HisAsp: 1.151 ± 0.032	1.117HisGlu: 1.117 ± 0.028	0.857HisPhe: 0.857 ± 0.023	2.144HisGly: 2.144 ± 0.038	0.64HisHis: 0.64 ± 0.023	0.976HisIle: 0.976 ± 0.028	0.535HisLys: 0.535 ± 0.021	2.281HisLeu: 2.281 ± 0.043	0.495HisMet: 0.495 ± 0.019	0.48HisAsn: 0.48 ± 0.017	1.551HisPro: 1.551 ± 0.031	0.762HisGln: 0.762 ± 0.022	1.478HisArg: 1.478 ± 0.032	1.053HisSer: 1.053 ± 0.028	1.111HisThr: 1.111 ± 0.029	1.615HisVal: 1.615 ± 0.034	0.418HisTrp: 0.418 ± 0.017	0.619HisTyr: 0.619 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.153IleAla: 6.153 ± 0.066	0.448IleCys: 0.448 ± 0.017	2.782IleAsp: 2.782 ± 0.039	2.708IleGlu: 2.708 ± 0.049	1.27IlePhe: 1.27 ± 0.035	4.156IleGly: 4.156 ± 0.063	0.925IleHis: 0.925 ± 0.029	1.471IleIle: 1.471 ± 0.031	1.337IleLys: 1.337 ± 0.031	3.226IleLeu: 3.226 ± 0.053	0.76IleMet: 0.76 ± 0.023	1.388IleAsn: 1.388 ± 0.029	2.054IlePro: 2.054 ± 0.038	1.294IleGln: 1.294 ± 0.03	2.563IleArg: 2.563 ± 0.042	2.38IleSer: 2.38 ± 0.043	2.577IleThr: 2.577 ± 0.046	3.353IleVal: 3.353 ± 0.044	0.476IleTrp: 0.476 ± 0.019	1.016IleTyr: 1.016 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.087LysAla: 4.087 ± 0.055	0.168LysCys: 0.168 ± 0.009	1.575LysAsp: 1.575 ± 0.036	1.349LysGlu: 1.349 ± 0.036	0.969LysPhe: 0.969 ± 0.027	2.351LysGly: 2.351 ± 0.045	0.626LysHis: 0.626 ± 0.021	1.36LysIle: 1.36 ± 0.035	1.27LysLys: 1.27 ± 0.035	3.548LysLeu: 3.548 ± 0.051	0.793LysMet: 0.793 ± 0.023	0.883LysAsn: 0.883 ± 0.027	2.124LysPro: 2.124 ± 0.044	1.045LysGln: 1.045 ± 0.026	1.931LysArg: 1.931 ± 0.036	1.729LysSer: 1.729 ± 0.038	1.874LysThr: 1.874 ± 0.036	2.41LysVal: 2.41 ± 0.041	0.338LysTrp: 0.338 ± 0.015	0.629LysTyr: 0.629 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.464LeuAla: 15.464 ± 0.123	1.085LeuCys: 1.085 ± 0.026	5.633LeuAsp: 5.633 ± 0.06	5.111LeuGlu: 5.111 ± 0.067	3.439LeuPhe: 3.439 ± 0.05	8.968LeuGly: 8.968 ± 0.082	2.414LeuHis: 2.414 ± 0.043	4.176LeuIle: 4.176 ± 0.054	3.621LeuLys: 3.621 ± 0.058	11.694LeuLeu: 11.694 ± 0.105	2.771LeuMet: 2.771 ± 0.042	2.742LeuAsn: 2.742 ± 0.039	6.126LeuPro: 6.126 ± 0.07	4.608LeuGln: 4.608 ± 0.059	7.305LeuArg: 7.305 ± 0.079	6.028LeuSer: 6.028 ± 0.073	5.347LeuThr: 5.347 ± 0.063	8.167LeuVal: 8.167 ± 0.077	1.405LeuTrp: 1.405 ± 0.036	2.072LeuTyr: 2.072 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.419MetAla: 3.419 ± 0.052	0.195MetCys: 0.195 ± 0.01	1.182MetAsp: 1.182 ± 0.028	1.013MetGlu: 1.013 ± 0.025	0.744MetPhe: 0.744 ± 0.024	2.035MetGly: 2.035 ± 0.038	0.561MetHis: 0.561 ± 0.017	0.912MetIle: 0.912 ± 0.025	1.053MetLys: 1.053 ± 0.028	2.792MetLeu: 2.792 ± 0.042	0.608MetMet: 0.608 ± 0.021	0.869MetAsn: 0.869 ± 0.024	1.609MetPro: 1.609 ± 0.032	1.163MetGln: 1.163 ± 0.026	1.655MetArg: 1.655 ± 0.035	1.537MetSer: 1.537 ± 0.031	1.621MetThr: 1.621 ± 0.033	1.914MetVal: 1.914 ± 0.038	0.231MetTrp: 0.231 ± 0.013	0.405MetTyr: 0.405 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.341AsnAla: 3.341 ± 0.056	0.243AsnCys: 0.243 ± 0.012	1.229AsnAsp: 1.229 ± 0.033	1.097AsnGlu: 1.097 ± 0.029	0.94AsnPhe: 0.94 ± 0.024	2.225AsnGly: 2.225 ± 0.049	0.541AsnHis: 0.541 ± 0.018	1.233AsnIle: 1.233 ± 0.028	0.744AsnLys: 0.744 ± 0.023	2.64AsnLeu: 2.64 ± 0.044	0.545AsnMet: 0.545 ± 0.018	0.76AsnAsn: 0.76 ± 0.027	1.8AsnPro: 1.8 ± 0.035	0.936AsnGln: 0.936 ± 0.027	1.647AsnArg: 1.647 ± 0.032	1.26AsnSer: 1.26 ± 0.03	1.553AsnThr: 1.553 ± 0.037	1.85AsnVal: 1.85 ± 0.038	0.395AsnTrp: 0.395 ± 0.013	0.65AsnTyr: 0.65 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.03ProAla: 8.03 ± 0.078	0.368ProCys: 0.368 ± 0.016	3.128ProAsp: 3.128 ± 0.048	2.984ProGlu: 2.984 ± 0.045	1.876ProPhe: 1.876 ± 0.035	5.097ProGly: 5.097 ± 0.06	1.172ProHis: 1.172 ± 0.029	1.752ProIle: 1.752 ± 0.033	1.417ProLys: 1.417 ± 0.034	5.395ProLeu: 5.395 ± 0.071	1.306ProMet: 1.306 ± 0.032	1.195ProAsn: 1.195 ± 0.034	2.867ProPro: 2.867 ± 0.049	2.308ProGln: 2.308 ± 0.044	3.002ProArg: 3.002 ± 0.049	2.786ProSer: 2.786 ± 0.041	2.463ProThr: 2.463 ± 0.041	4.636ProVal: 4.636 ± 0.061	0.75ProTrp: 0.75 ± 0.024	1.131ProTyr: 1.131 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	6.133GlnAla: 6.133 ± 0.074	0.299GlnCys: 0.299 ± 0.016	1.717GlnAsp: 1.717 ± 0.032	1.58GlnGlu: 1.58 ± 0.032	1.267GlnPhe: 1.267 ± 0.03	3.206GlnGly: 3.206 ± 0.05	0.948GlnHis: 0.948 ± 0.029	1.606GlnIle: 1.606 ± 0.036	1.118GlnLys: 1.118 ± 0.026	4.463GlnLeu: 4.463 ± 0.062	0.968GlnMet: 0.968 ± 0.027	0.833GlnAsn: 0.833 ± 0.027	2.464GlnPro: 2.464 ± 0.041	2.029GlnGln: 2.029 ± 0.037	3.312GlnArg: 3.312 ± 0.052	1.946GlnSer: 1.946 ± 0.032	1.97GlnThr: 1.97 ± 0.037	3.233GlnVal: 3.233 ± 0.046	0.627GlnTrp: 0.627 ± 0.019	0.728GlnTyr: 0.728 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.667ArgAla: 7.667 ± 0.081	0.587ArgCys: 0.587 ± 0.02	3.361ArgAsp: 3.361 ± 0.049	3.935ArgGlu: 3.935 ± 0.056	2.628ArgPhe: 2.628 ± 0.041	4.71ArgGly: 4.71 ± 0.059	1.797ArgHis: 1.797 ± 0.035	3.344ArgIle: 3.344 ± 0.047	2.055ArgLys: 2.055 ± 0.04	7.609ArgLeu: 7.609 ± 0.083	1.885ArgMet: 1.885 ± 0.039	1.769ArgAsn: 1.769 ± 0.034	3.163ArgPro: 3.163 ± 0.049	2.964ArgGln: 2.964 ± 0.045	4.628ArgArg: 4.628 ± 0.059	3.512ArgSer: 3.512 ± 0.046	3.123ArgThr: 3.123 ± 0.051	4.753ArgVal: 4.753 ± 0.058	1.182ArgTrp: 1.182 ± 0.029	1.702ArgTyr: 1.702 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.807SerAla: 6.807 ± 0.075	0.509SerCys: 0.509 ± 0.021	2.551SerAsp: 2.551 ± 0.039	2.264SerGlu: 2.264 ± 0.041	2.163SerPhe: 2.163 ± 0.036	5.638SerGly: 5.638 ± 0.078	1.25SerHis: 1.25 ± 0.028	2.342SerIle: 2.342 ± 0.039	1.449SerLys: 1.449 ± 0.035	5.771SerLeu: 5.771 ± 0.07	1.377SerMet: 1.377 ± 0.028	1.348SerAsn: 1.348 ± 0.033	3.056SerPro: 3.056 ± 0.045	1.941SerGln: 1.941 ± 0.044	3.663SerArg: 3.663 ± 0.055	3.203SerSer: 3.203 ± 0.055	3.012SerThr: 3.012 ± 0.05	3.944SerVal: 3.944 ± 0.058	0.79SerTrp: 0.79 ± 0.027	1.324SerTyr: 1.324 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.64ThrAla: 6.64 ± 0.075	0.41ThrCys: 0.41 ± 0.018	2.513ThrAsp: 2.513 ± 0.043	2.193ThrGlu: 2.193 ± 0.035	1.775ThrPhe: 1.775 ± 0.037	5.236ThrGly: 5.236 ± 0.08	1.228ThrHis: 1.228 ± 0.029	2.06ThrIle: 2.06 ± 0.04	1.107ThrLys: 1.107 ± 0.028	6.343ThrLeu: 6.343 ± 0.07	1.105ThrMet: 1.105 ± 0.03	1.159ThrAsn: 1.159 ± 0.03	3.731ThrPro: 3.731 ± 0.056	2.022ThrGln: 2.022 ± 0.036	3.272ThrArg: 3.272 ± 0.046	2.833ThrSer: 2.833 ± 0.052	2.908ThrThr: 2.908 ± 0.057	4.498ThrVal: 4.498 ± 0.065	0.683ThrTrp: 0.683 ± 0.023	1.06ThrTyr: 1.06 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	9.74ValAla: 9.74 ± 0.095	0.754ValCys: 0.754 ± 0.022	3.887ValAsp: 3.887 ± 0.051	3.788ValGlu: 3.788 ± 0.05	2.908ValPhe: 2.908 ± 0.049	5.53ValGly: 5.53 ± 0.06	1.67ValHis: 1.67 ± 0.032	3.49ValIle: 3.49 ± 0.055	2.414ValLys: 2.414 ± 0.044	8.683ValLeu: 8.683 ± 0.076	2.123ValMet: 2.123 ± 0.04	2.166ValAsn: 2.166 ± 0.038	4.085ValPro: 4.085 ± 0.06	3.043ValGln: 3.043 ± 0.044	5.115ValArg: 5.115 ± 0.066	4.144ValSer: 4.144 ± 0.054	4.253ValThr: 4.253 ± 0.058	6.477ValVal: 6.477 ± 0.073	1.04ValTrp: 1.04 ± 0.027	1.614ValTyr: 1.614 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.451TrpAla: 1.451 ± 0.035	0.198TrpCys: 0.198 ± 0.011	0.657TrpAsp: 0.657 ± 0.021	0.523TrpGlu: 0.523 ± 0.021	0.575TrpPhe: 0.575 ± 0.023	0.988TrpGly: 0.988 ± 0.03	0.347TrpHis: 0.347 ± 0.015	0.662TrpIle: 0.662 ± 0.022	0.472TrpLys: 0.472 ± 0.019	2.112TrpLeu: 2.112 ± 0.044	0.484TrpMet: 0.484 ± 0.018	0.433TrpAsn: 0.433 ± 0.018	0.766TrpPro: 0.766 ± 0.021	0.752TrpGln: 0.752 ± 0.022	1.176TrpArg: 1.176 ± 0.03	0.807TrpSer: 0.807 ± 0.022	0.793TrpThr: 0.793 ± 0.022	1.023TrpVal: 1.023 ± 0.027	0.274TrpTrp: 0.274 ± 0.014	0.315TrpTyr: 0.315 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.574TyrAla: 2.574 ± 0.042	0.256TyrCys: 0.256 ± 0.012	1.153TyrAsp: 1.153 ± 0.028	1.067TyrGlu: 1.067 ± 0.025	0.93TyrPhe: 0.93 ± 0.025	2.081TyrGly: 2.081 ± 0.037	0.399TyrHis: 0.399 ± 0.017	0.803TyrIle: 0.803 ± 0.025	0.67TyrLys: 0.67 ± 0.021	2.372TyrLeu: 2.372 ± 0.041	0.434TyrMet: 0.434 ± 0.017	0.591TyrAsn: 0.591 ± 0.021	1.125TyrPro: 1.125 ± 0.03	0.823TyrGln: 0.823 ± 0.024	1.553TyrArg: 1.553 ± 0.034	1.23TyrSer: 1.23 ± 0.033	1.299TyrThr: 1.299 ± 0.029	1.526TyrVal: 1.526 ± 0.037	0.352TyrTrp: 0.352 ± 0.017	0.551TyrTyr: 0.551 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 5874 proteins (1496469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---