Amino acid dipepetide frequency for Vicugna pacos (Alpaca) (Lama pacos)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.791AlaAla: 6.791 ± 0.031	1.354AlaCys: 1.354 ± 0.01	3.016AlaAsp: 3.016 ± 0.012	4.868AlaGlu: 4.868 ± 0.022	2.511AlaPhe: 2.511 ± 0.014	4.686AlaGly: 4.686 ± 0.022	1.548AlaHis: 1.548 ± 0.009	2.66AlaIle: 2.66 ± 0.014	3.654AlaLys: 3.654 ± 0.032	7.143AlaLeu: 7.143 ± 0.028	1.446AlaMet: 1.446 ± 0.009	2.002AlaAsn: 2.002 ± 0.011	4.295AlaPro: 4.295 ± 0.025	3.464AlaGln: 3.464 ± 0.018	3.759AlaArg: 3.759 ± 0.017	6.053AlaSer: 6.053 ± 0.02	3.627AlaThr: 3.627 ± 0.017	4.654AlaVal: 4.654 ± 0.017	0.79AlaTrp: 0.79 ± 0.007	1.473AlaTyr: 1.473 ± 0.01	0.007AlaXaa: 0.007 ± 0.001
Cys	1.199CysAla: 1.199 ± 0.009	0.575CysCys: 0.575 ± 0.009	0.966CysAsp: 0.966 ± 0.009	1.216CysGlu: 1.216 ± 0.011	0.799CysPhe: 0.799 ± 0.006	1.633CysGly: 1.633 ± 0.016	0.639CysHis: 0.639 ± 0.007	0.859CysIle: 0.859 ± 0.007	1.085CysLys: 1.085 ± 0.009	2.063CysLeu: 2.063 ± 0.013	0.385CysMet: 0.385 ± 0.004	0.73CysAsn: 0.73 ± 0.007	1.33CysPro: 1.33 ± 0.012	1.039CysGln: 1.039 ± 0.01	1.248CysArg: 1.248 ± 0.009	1.948CysSer: 1.948 ± 0.014	1.016CysThr: 1.016 ± 0.01	1.271CysVal: 1.271 ± 0.012	0.272CysTrp: 0.272 ± 0.004	0.536CysTyr: 0.536 ± 0.005	0.002CysXaa: 0.002 ± 0.0
Asp	2.958AspAla: 2.958 ± 0.014	1.02AspCys: 1.02 ± 0.01	2.684AspAsp: 2.684 ± 0.015	3.461AspGlu: 3.461 ± 0.019	2.09AspPhe: 2.09 ± 0.01	3.24AspGly: 3.24 ± 0.018	1.147AspHis: 1.147 ± 0.007	2.493AspIle: 2.493 ± 0.013	2.541AspLys: 2.541 ± 0.013	5.118AspLeu: 5.118 ± 0.021	1.123AspMet: 1.123 ± 0.009	1.597AspAsn: 1.597 ± 0.01	2.975AspPro: 2.975 ± 0.013	1.925AspGln: 1.925 ± 0.01	2.505AspArg: 2.505 ± 0.014	4.303AspSer: 4.303 ± 0.017	2.541AspThr: 2.541 ± 0.013	3.139AspVal: 3.139 ± 0.014	0.622AspTrp: 0.622 ± 0.006	1.496AspTyr: 1.496 ± 0.013	0.005AspXaa: 0.005 ± 0.0
Glu	5.38GluAla: 5.38 ± 0.022	1.375GluCys: 1.375 ± 0.016	4.501GluAsp: 4.501 ± 0.021	8.162GluGlu: 8.162 ± 0.047	1.963GluPhe: 1.963 ± 0.011	4.269GluGly: 4.269 ± 0.018	1.508GluHis: 1.508 ± 0.008	3.133GluIle: 3.133 ± 0.014	5.607GluLys: 5.607 ± 0.031	6.57GluLeu: 6.57 ± 0.029	1.703GluMet: 1.703 ± 0.009	3.102GluAsn: 3.102 ± 0.017	3.404GluPro: 3.404 ± 0.021	3.348GluGln: 3.348 ± 0.021	4.244GluArg: 4.244 ± 0.023	4.572GluSer: 4.572 ± 0.022	3.543GluThr: 3.543 ± 0.016	4.245GluVal: 4.245 ± 0.016	0.688GluTrp: 0.688 ± 0.006	1.572GluTyr: 1.572 ± 0.013	0.004GluXaa: 0.004 ± 0.0
Phe	1.857PheAla: 1.857 ± 0.011	0.884PheCys: 0.884 ± 0.007	1.57PheAsp: 1.57 ± 0.01	1.973PheGlu: 1.973 ± 0.01	1.488PhePhe: 1.488 ± 0.011	2.066PheGly: 2.066 ± 0.014	0.983PheHis: 0.983 ± 0.006	1.662PheIle: 1.662 ± 0.012	1.697PheLys: 1.697 ± 0.012	3.862PheLeu: 3.862 ± 0.019	0.724PheMet: 0.724 ± 0.005	1.242PheAsn: 1.242 ± 0.008	1.989PhePro: 1.989 ± 0.013	1.739PheGln: 1.739 ± 0.009	1.886PheArg: 1.886 ± 0.012	3.398PheSer: 3.398 ± 0.014	1.959PheThr: 1.959 ± 0.011	2.003PheVal: 2.003 ± 0.01	0.44PheTrp: 0.44 ± 0.005	1.088PheTyr: 1.088 ± 0.009	0.003PheXaa: 0.003 ± 0.0
Gly	4.455GlyAla: 4.455 ± 0.024	1.229GlyCys: 1.229 ± 0.01	3.101GlyAsp: 3.101 ± 0.015	4.121GlyGlu: 4.121 ± 0.023	2.29GlyPhe: 2.29 ± 0.015	4.806GlyGly: 4.806 ± 0.026	1.707GlyHis: 1.707 ± 0.011	2.571GlyIle: 2.571 ± 0.012	3.698GlyLys: 3.698 ± 0.018	5.791GlyLeu: 5.791 ± 0.026	1.265GlyMet: 1.265 ± 0.009	2.274GlyAsn: 2.274 ± 0.011	4.305GlyPro: 4.305 ± 0.036	2.847GlyGln: 2.847 ± 0.015	3.842GlyArg: 3.842 ± 0.019	5.948GlySer: 5.948 ± 0.024	3.545GlyThr: 3.545 ± 0.018	3.5GlyVal: 3.5 ± 0.017	0.802GlyTrp: 0.802 ± 0.008	1.663GlyTyr: 1.663 ± 0.012	0.01GlyXaa: 0.01 ± 0.001
His	1.382HisAla: 1.382 ± 0.009	0.695HisCys: 0.695 ± 0.007	0.878HisAsp: 0.878 ± 0.006	1.306HisGlu: 1.306 ± 0.007	1.04HisPhe: 1.04 ± 0.008	1.491HisGly: 1.491 ± 0.009	0.929HisHis: 0.929 ± 0.01	1.22HisIle: 1.22 ± 0.01	1.247HisLys: 1.247 ± 0.009	2.934HisLeu: 2.934 ± 0.012	0.575HisMet: 0.575 ± 0.006	0.801HisAsn: 0.801 ± 0.005	1.703HisPro: 1.703 ± 0.011	1.395HisGln: 1.395 ± 0.01	1.611HisArg: 1.611 ± 0.009	2.324HisSer: 2.324 ± 0.012	1.532HisThr: 1.532 ± 0.012	1.533HisVal: 1.533 ± 0.011	0.343HisTrp: 0.343 ± 0.004	0.803HisTyr: 0.803 ± 0.008	0.002HisXaa: 0.002 ± 0.0
Ile	2.418IleAla: 2.418 ± 0.011	0.972IleCys: 0.972 ± 0.007	1.928IleAsp: 1.928 ± 0.01	2.48IleGlu: 2.48 ± 0.013	1.726IlePhe: 1.726 ± 0.011	2.058IleGly: 2.058 ± 0.013	1.307IleHis: 1.307 ± 0.01	2.143IleIle: 2.143 ± 0.015	2.555IleLys: 2.555 ± 0.015	4.344IleLeu: 4.344 ± 0.016	0.943IleMet: 0.943 ± 0.008	1.726IleAsn: 1.726 ± 0.012	2.579IlePro: 2.579 ± 0.013	2.299IleGln: 2.299 ± 0.013	2.326IleArg: 2.326 ± 0.01	3.599IleSer: 3.599 ± 0.014	2.478IleThr: 2.478 ± 0.013	2.347IleVal: 2.347 ± 0.012	0.46IleTrp: 0.46 ± 0.003	1.279IleTyr: 1.279 ± 0.009	0.003IleXaa: 0.003 ± 0.0
Lys	4.177LysAla: 4.177 ± 0.027	1.063LysCys: 1.063 ± 0.01	3.208LysAsp: 3.208 ± 0.019	5.318LysGlu: 5.318 ± 0.025	1.687LysPhe: 1.687 ± 0.011	3.28LysGly: 3.28 ± 0.023	1.409LysHis: 1.409 ± 0.01	2.683LysIle: 2.683 ± 0.016	4.726LysLys: 4.726 ± 0.033	5.157LysLeu: 5.157 ± 0.024	1.43LysMet: 1.43 ± 0.01	2.364LysAsn: 2.364 ± 0.015	3.158LysPro: 3.158 ± 0.02	2.723LysGln: 2.723 ± 0.018	3.322LysArg: 3.322 ± 0.015	4.015LysSer: 4.015 ± 0.016	3.19LysThr: 3.19 ± 0.02	3.48LysVal: 3.48 ± 0.015	0.593LysTrp: 0.593 ± 0.005	1.567LysTyr: 1.567 ± 0.022	0.005LysXaa: 0.005 ± 0.0
Leu	6.803LeuAla: 6.803 ± 0.025	2.106LeuCys: 2.106 ± 0.013	4.774LeuAsp: 4.774 ± 0.018	7.452LeuGlu: 7.452 ± 0.035	3.157LeuPhe: 3.157 ± 0.018	5.862LeuGly: 5.862 ± 0.022	2.784LeuHis: 2.784 ± 0.014	3.658LeuIle: 3.658 ± 0.016	5.786LeuLys: 5.786 ± 0.025	10.665LeuLeu: 10.665 ± 0.047	1.948LeuMet: 1.948 ± 0.01	3.43LeuAsn: 3.43 ± 0.015	6.122LeuPro: 6.122 ± 0.023	5.988LeuGln: 5.988 ± 0.028	5.969LeuArg: 5.969 ± 0.022	8.113LeuSer: 8.113 ± 0.027	5.058LeuThr: 5.058 ± 0.02	5.396LeuVal: 5.396 ± 0.021	1.077LeuTrp: 1.077 ± 0.008	2.479LeuTyr: 2.479 ± 0.017	0.009LeuXaa: 0.009 ± 0.001
Met	1.834MetAla: 1.834 ± 0.01	0.377MetCys: 0.377 ± 0.004	1.212MetAsp: 1.212 ± 0.007	1.837MetGlu: 1.837 ± 0.01	0.692MetPhe: 0.692 ± 0.006	1.258MetGly: 1.258 ± 0.01	0.467MetHis: 0.467 ± 0.004	0.789MetIle: 0.789 ± 0.007	1.429MetLys: 1.429 ± 0.008	1.954MetLeu: 1.954 ± 0.011	0.555MetMet: 0.555 ± 0.006	0.884MetAsn: 0.884 ± 0.008	1.104MetPro: 1.104 ± 0.008	0.965MetGln: 0.965 ± 0.008	1.046MetArg: 1.046 ± 0.007	1.549MetSer: 1.549 ± 0.01	1.1MetThr: 1.1 ± 0.008	1.367MetVal: 1.367 ± 0.009	0.235MetTrp: 0.235 ± 0.003	0.547MetTyr: 0.547 ± 0.005	0.001MetXaa: 0.001 ± 0.0
Asn	2.054AsnAla: 2.054 ± 0.013	0.744AsnCys: 0.744 ± 0.007	1.468AsnAsp: 1.468 ± 0.01	2.168AsnGlu: 2.168 ± 0.012	1.381AsnPhe: 1.381 ± 0.009	2.349AsnGly: 2.349 ± 0.017	0.928AsnHis: 0.928 ± 0.007	1.966AsnIle: 1.966 ± 0.012	2.146AsnLys: 2.146 ± 0.013	3.634AsnLeu: 3.634 ± 0.015	0.863AsnMet: 0.863 ± 0.006	1.41AsnAsn: 1.41 ± 0.011	2.099AsnPro: 2.099 ± 0.012	1.704AsnGln: 1.704 ± 0.01	1.779AsnArg: 1.779 ± 0.009	3.123AsnSer: 3.123 ± 0.016	1.937AsnThr: 1.937 ± 0.012	2.148AsnVal: 2.148 ± 0.011	0.409AsnTrp: 0.409 ± 0.005	1.072AsnTyr: 1.072 ± 0.011	0.003AsnXaa: 0.003 ± 0.0
Pro	5.128ProAla: 5.128 ± 0.027	1.11ProCys: 1.11 ± 0.011	2.917ProAsp: 2.917 ± 0.021	4.647ProGlu: 4.647 ± 0.021	1.888ProPhe: 1.888 ± 0.012	5.416ProGly: 5.416 ± 0.053	1.465ProHis: 1.465 ± 0.009	1.838ProIle: 1.838 ± 0.011	2.853ProLys: 2.853 ± 0.018	5.443ProLeu: 5.443 ± 0.022	1.048ProMet: 1.048 ± 0.008	1.768ProAsn: 1.768 ± 0.011	6.309ProPro: 6.309 ± 0.045	2.963ProGln: 2.963 ± 0.018	3.524ProArg: 3.524 ± 0.021	6.106ProSer: 6.106 ± 0.031	3.221ProThr: 3.221 ± 0.018	3.974ProVal: 3.974 ± 0.017	0.674ProTrp: 0.674 ± 0.007	1.455ProTyr: 1.455 ± 0.01	0.012ProXaa: 0.012 ± 0.001
Gln	3.699GlnAla: 3.699 ± 0.018	0.886GlnCys: 0.886 ± 0.008	2.426GlnAsp: 2.426 ± 0.013	4.169GlnGlu: 4.169 ± 0.023	1.32GlnPhe: 1.32 ± 0.008	2.932GlnGly: 2.932 ± 0.015	1.36GlnHis: 1.36 ± 0.009	1.977GlnIle: 1.977 ± 0.012	3.042GlnLys: 3.042 ± 0.015	4.94GlnLeu: 4.94 ± 0.025	1.145GlnMet: 1.145 ± 0.009	1.862GlnAsn: 1.862 ± 0.011	2.918GlnPro: 2.918 ± 0.017	3.343GlnGln: 3.343 ± 0.033	3.085GlnArg: 3.085 ± 0.015	3.373GlnSer: 3.373 ± 0.017	2.405GlnThr: 2.405 ± 0.014	2.892GlnVal: 2.892 ± 0.012	0.555GlnTrp: 0.555 ± 0.006	1.12GlnTyr: 1.12 ± 0.008	0.004GlnXaa: 0.004 ± 0.0
Arg	3.935ArgAla: 3.935 ± 0.016	1.175ArgCys: 1.175 ± 0.01	2.821ArgAsp: 2.821 ± 0.013	4.208ArgGlu: 4.208 ± 0.021	1.757ArgPhe: 1.757 ± 0.01	3.675ArgGly: 3.675 ± 0.02	1.529ArgHis: 1.529 ± 0.01	2.328ArgIle: 2.328 ± 0.011	3.737ArgLys: 3.737 ± 0.017	5.525ArgLeu: 5.525 ± 0.021	1.195ArgMet: 1.195 ± 0.009	2.111ArgAsn: 2.111 ± 0.012	3.426ArgPro: 3.426 ± 0.019	2.74ArgGln: 2.74 ± 0.013	4.515ArgArg: 4.515 ± 0.026	4.535ArgSer: 4.535 ± 0.031	2.898ArgThr: 2.898 ± 0.014	3.196ArgVal: 3.196 ± 0.014	0.68ArgTrp: 0.68 ± 0.005	1.395ArgTyr: 1.395 ± 0.008	0.007ArgXaa: 0.007 ± 0.001
Ser	5.536SerAla: 5.536 ± 0.02	1.756SerCys: 1.756 ± 0.013	4.17SerAsp: 4.17 ± 0.029	5.48SerGlu: 5.48 ± 0.019	2.951SerPhe: 2.951 ± 0.014	5.676SerGly: 5.676 ± 0.024	2.162SerHis: 2.162 ± 0.013	3.148SerIle: 3.148 ± 0.013	4.161SerLys: 4.161 ± 0.016	8.386SerLeu: 8.386 ± 0.028	1.601SerMet: 1.601 ± 0.01	2.648SerAsn: 2.648 ± 0.014	6.615SerPro: 6.615 ± 0.042	4.093SerGln: 4.093 ± 0.016	4.781SerArg: 4.781 ± 0.025	9.955SerSer: 9.955 ± 0.051	4.561SerThr: 4.561 ± 0.021	5.004SerVal: 5.004 ± 0.016	1.061SerTrp: 1.061 ± 0.008	2.036SerTyr: 2.036 ± 0.01	0.007SerXaa: 0.007 ± 0.001
Thr	3.838ThrAla: 3.838 ± 0.016	1.248ThrCys: 1.248 ± 0.01	2.477ThrAsp: 2.477 ± 0.011	3.669ThrGlu: 3.669 ± 0.017	1.987ThrPhe: 1.987 ± 0.011	3.526ThrGly: 3.526 ± 0.019	1.278ThrHis: 1.278 ± 0.008	2.275ThrIle: 2.275 ± 0.014	2.722ThrLys: 2.722 ± 0.017	5.275ThrLeu: 5.275 ± 0.019	1.092ThrMet: 1.092 ± 0.007	1.666ThrAsn: 1.666 ± 0.009	3.906ThrPro: 3.906 ± 0.025	2.357ThrGln: 2.357 ± 0.012	2.519ThrArg: 2.519 ± 0.012	4.851ThrSer: 4.851 ± 0.021	3.14ThrThr: 3.14 ± 0.03	3.848ThrVal: 3.848 ± 0.021	0.664ThrTrp: 0.664 ± 0.007	1.374ThrTyr: 1.374 ± 0.009	0.005ThrXaa: 0.005 ± 0.001
Val	4.286ValAla: 4.286 ± 0.016	1.38ValCys: 1.38 ± 0.01	2.972ValAsp: 2.972 ± 0.013	3.829ValGlu: 3.829 ± 0.017	2.265ValPhe: 2.265 ± 0.014	3.273ValGly: 3.273 ± 0.015	1.575ValHis: 1.575 ± 0.009	2.762ValIle: 2.762 ± 0.012	3.448ValLys: 3.448 ± 0.017	6.139ValLeu: 6.139 ± 0.019	1.284ValMet: 1.284 ± 0.009	2.219ValAsn: 2.219 ± 0.013	3.789ValPro: 3.789 ± 0.016	2.781ValGln: 2.781 ± 0.012	3.06ValArg: 3.06 ± 0.014	5.028ValSer: 5.028 ± 0.018	3.862ValThr: 3.862 ± 0.019	3.927ValVal: 3.927 ± 0.017	0.688ValTrp: 0.688 ± 0.006	1.548ValTyr: 1.548 ± 0.008	0.005ValXaa: 0.005 ± 0.001
Trp	0.762TrpAla: 0.762 ± 0.006	0.234TrpCys: 0.234 ± 0.004	0.647TrpAsp: 0.647 ± 0.007	0.82TrpGlu: 0.82 ± 0.007	0.406TrpPhe: 0.406 ± 0.005	0.702TrpGly: 0.702 ± 0.008	0.288TrpHis: 0.288 ± 0.004	0.512TrpIle: 0.512 ± 0.006	0.761TrpLys: 0.761 ± 0.006	1.179TrpLeu: 1.179 ± 0.01	0.312TrpMet: 0.312 ± 0.004	0.508TrpAsn: 0.508 ± 0.005	0.51TrpPro: 0.51 ± 0.005	0.517TrpGln: 0.517 ± 0.005	0.727TrpArg: 0.727 ± 0.006	0.867TrpSer: 0.867 ± 0.007	0.646TrpThr: 0.646 ± 0.006	0.67TrpVal: 0.67 ± 0.006	0.171TrpTrp: 0.171 ± 0.003	0.31TrpTyr: 0.31 ± 0.005	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.302TyrAla: 1.302 ± 0.008	0.623TyrCys: 0.623 ± 0.006	1.241TyrAsp: 1.241 ± 0.01	1.705TyrGlu: 1.705 ± 0.016	1.111TyrPhe: 1.111 ± 0.008	1.562TyrGly: 1.562 ± 0.009	0.728TyrHis: 0.728 ± 0.006	1.287TyrIle: 1.287 ± 0.009	1.654TyrLys: 1.654 ± 0.04	2.502TyrLeu: 2.502 ± 0.012	0.565TyrMet: 0.565 ± 0.005	1.038TyrAsn: 1.038 ± 0.009	1.214TyrPro: 1.214 ± 0.009	1.224TyrGln: 1.224 ± 0.008	1.633TyrArg: 1.633 ± 0.016	2.123TyrSer: 2.123 ± 0.012	1.454TyrThr: 1.454 ± 0.011	1.521TyrVal: 1.521 ± 0.009	0.325TyrTrp: 0.325 ± 0.005	0.847TyrTyr: 0.847 ± 0.007	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.008XaaAla: 0.008 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.003XaaAsp: 0.003 ± 0.0	0.006XaaGlu: 0.006 ± 0.001	0.005XaaPhe: 0.005 ± 0.0	0.011XaaGly: 0.011 ± 0.001	0.002XaaHis: 0.002 ± 0.0	0.003XaaIle: 0.003 ± 0.0	0.005XaaLys: 0.005 ± 0.001	0.01XaaLeu: 0.01 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.003XaaAsn: 0.003 ± 0.0	0.011XaaPro: 0.011 ± 0.001	0.003XaaGln: 0.003 ± 0.0	0.006XaaArg: 0.006 ± 0.001	0.007XaaSer: 0.007 ± 0.0	0.004XaaThr: 0.004 ± 0.0	0.005XaaVal: 0.005 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.2XaaXaa: 0.2 ± 0.013

Statistics based on 36880 proteins (24174655 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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