Amino acid dipepetide frequency for Roseivirga spongicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.8AlaAla: 4.8 ± 0.094	0.576AlaCys: 0.576 ± 0.021	3.728AlaAsp: 3.728 ± 0.069	4.843AlaGlu: 4.843 ± 0.079	3.526AlaPhe: 3.526 ± 0.049	4.682AlaGly: 4.682 ± 0.078	1.143AlaHis: 1.143 ± 0.027	5.23AlaIle: 5.23 ± 0.066	4.55AlaLys: 4.55 ± 0.071	6.766AlaLeu: 6.766 ± 0.089	1.806AlaMet: 1.806 ± 0.039	3.484AlaAsn: 3.484 ± 0.052	2.091AlaPro: 2.091 ± 0.047	2.833AlaGln: 2.833 ± 0.045	2.46AlaArg: 2.46 ± 0.045	4.498AlaSer: 4.498 ± 0.072	3.564AlaThr: 3.564 ± 0.087	4.16AlaVal: 4.16 ± 0.062	0.704AlaTrp: 0.704 ± 0.021	2.533AlaTyr: 2.533 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.418CysAla: 0.418 ± 0.015	0.086CysCys: 0.086 ± 0.007	0.364CysAsp: 0.364 ± 0.017	0.421CysGlu: 0.421 ± 0.018	0.407CysPhe: 0.407 ± 0.021	0.547CysGly: 0.547 ± 0.022	0.162CysHis: 0.162 ± 0.01	0.478CysIle: 0.478 ± 0.02	0.336CysLys: 0.336 ± 0.017	0.651CysLeu: 0.651 ± 0.022	0.136CysMet: 0.136 ± 0.012	0.305CysAsn: 0.305 ± 0.019	0.301CysPro: 0.301 ± 0.02	0.25CysGln: 0.25 ± 0.016	0.185CysArg: 0.185 ± 0.012	0.497CysSer: 0.497 ± 0.02	0.331CysThr: 0.331 ± 0.023	0.345CysVal: 0.345 ± 0.016	0.068CysTrp: 0.068 ± 0.007	0.256CysTyr: 0.256 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.574AspAla: 3.574 ± 0.068	0.352AspCys: 0.352 ± 0.017	2.952AspAsp: 2.952 ± 0.063	4.09AspGlu: 4.09 ± 0.059	3.421AspPhe: 3.421 ± 0.056	4.008AspGly: 4.008 ± 0.08	1.023AspHis: 1.023 ± 0.029	4.033AspIle: 4.033 ± 0.068	3.568AspLys: 3.568 ± 0.055	5.687AspLeu: 5.687 ± 0.073	1.267AspMet: 1.267 ± 0.031	2.812AspAsn: 2.812 ± 0.056	2.099AspPro: 2.099 ± 0.043	2.214AspGln: 2.214 ± 0.045	2.398AspArg: 2.398 ± 0.042	3.365AspSer: 3.365 ± 0.057	2.374AspThr: 2.374 ± 0.045	3.566AspVal: 3.566 ± 0.064	0.821AspTrp: 0.821 ± 0.027	2.582AspTyr: 2.582 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.206GluAla: 5.206 ± 0.071	0.313GluCys: 0.313 ± 0.015	3.909GluAsp: 3.909 ± 0.059	5.863GluGlu: 5.863 ± 0.094	3.299GluPhe: 3.299 ± 0.053	4.544GluGly: 4.544 ± 0.06	1.211GluHis: 1.211 ± 0.034	5.162GluIle: 5.162 ± 0.066	5.478GluLys: 5.478 ± 0.084	7.173GluLeu: 7.173 ± 0.097	1.833GluMet: 1.833 ± 0.042	3.926GluAsn: 3.926 ± 0.058	2.059GluPro: 2.059 ± 0.045	2.79GluGln: 2.79 ± 0.051	3.103GluArg: 3.103 ± 0.049	4.263GluSer: 4.263 ± 0.07	3.426GluThr: 3.426 ± 0.06	5.305GluVal: 5.305 ± 0.069	0.763GluTrp: 0.763 ± 0.026	2.534GluTyr: 2.534 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.029PheAla: 3.029 ± 0.049	0.361PheCys: 0.361 ± 0.016	3.296PheAsp: 3.296 ± 0.06	3.711PheGlu: 3.711 ± 0.055	2.606PhePhe: 2.606 ± 0.057	3.653PheGly: 3.653 ± 0.06	0.845PheHis: 0.845 ± 0.031	3.462PheIle: 3.462 ± 0.063	3.194PheLys: 3.194 ± 0.056	4.556PheLeu: 4.556 ± 0.084	1.129PheMet: 1.129 ± 0.032	3.109PheAsn: 3.109 ± 0.054	1.637PhePro: 1.637 ± 0.033	1.839PheGln: 1.839 ± 0.039	1.961PheArg: 1.961 ± 0.042	4.006PheSer: 4.006 ± 0.058	2.864PheThr: 2.864 ± 0.059	3.058PheVal: 3.058 ± 0.055	0.596PheTrp: 0.596 ± 0.023	1.99PheTyr: 1.99 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.533GlyAla: 4.533 ± 0.071	0.582GlyCys: 0.582 ± 0.038	3.598GlyAsp: 3.598 ± 0.058	4.487GlyGlu: 4.487 ± 0.064	3.722GlyPhe: 3.722 ± 0.063	5.007GlyGly: 5.007 ± 0.079	1.168GlyHis: 1.168 ± 0.031	5.021GlyIle: 5.021 ± 0.057	4.686GlyLys: 4.686 ± 0.063	6.515GlyLeu: 6.515 ± 0.073	1.717GlyMet: 1.717 ± 0.038	3.455GlyAsn: 3.455 ± 0.061	1.542GlyPro: 1.542 ± 0.033	2.521GlyGln: 2.521 ± 0.045	2.632GlyArg: 2.632 ± 0.05	4.456GlySer: 4.456 ± 0.068	4.033GlyThr: 4.033 ± 0.103	4.758GlyVal: 4.758 ± 0.057	0.837GlyTrp: 0.837 ± 0.029	2.795GlyTyr: 2.795 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.994HisAla: 0.994 ± 0.028	0.16HisCys: 0.16 ± 0.011	0.832HisAsp: 0.832 ± 0.027	1.073HisGlu: 1.073 ± 0.034	1.092HisPhe: 1.092 ± 0.035	1.143HisGly: 1.143 ± 0.031	0.465HisHis: 0.465 ± 0.019	1.244HisIle: 1.244 ± 0.03	1.03HisLys: 1.03 ± 0.027	1.781HisLeu: 1.781 ± 0.041	0.398HisMet: 0.398 ± 0.017	0.827HisAsn: 0.827 ± 0.026	0.884HisPro: 0.884 ± 0.029	0.722HisGln: 0.722 ± 0.027	0.733HisArg: 0.733 ± 0.022	1.152HisSer: 1.152 ± 0.031	0.884HisThr: 0.884 ± 0.023	0.952HisVal: 0.952 ± 0.028	0.26HisTrp: 0.26 ± 0.013	0.794HisTyr: 0.794 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.133IleAla: 5.133 ± 0.058	0.53IleCys: 0.53 ± 0.02	4.665IleAsp: 4.665 ± 0.054	5.402IleGlu: 5.402 ± 0.073	3.163IlePhe: 3.163 ± 0.06	5.109IleGly: 5.109 ± 0.072	1.264IleHis: 1.264 ± 0.032	4.767IleIle: 4.767 ± 0.075	4.532IleLys: 4.532 ± 0.062	6.111IleLeu: 6.111 ± 0.097	1.337IleMet: 1.337 ± 0.034	3.823IleAsn: 3.823 ± 0.054	2.922IlePro: 2.922 ± 0.047	2.59IleGln: 2.59 ± 0.044	2.84IleArg: 2.84 ± 0.057	5.397IleSer: 5.397 ± 0.07	4.033IleThr: 4.033 ± 0.081	4.222IleVal: 4.222 ± 0.06	0.706IleTrp: 0.706 ± 0.024	2.492IleTyr: 2.492 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.983LysAla: 4.983 ± 0.086	0.299LysCys: 0.299 ± 0.015	3.769LysAsp: 3.769 ± 0.065	5.671LysGlu: 5.671 ± 0.092	2.497LysPhe: 2.497 ± 0.045	4.277LysGly: 4.277 ± 0.065	1.235LysHis: 1.235 ± 0.035	4.297LysIle: 4.297 ± 0.062	5.082LysLys: 5.082 ± 0.088	6.196LysLeu: 6.196 ± 0.089	1.664LysMet: 1.664 ± 0.04	3.492LysAsn: 3.492 ± 0.061	2.435LysPro: 2.435 ± 0.045	2.384LysGln: 2.384 ± 0.049	3.062LysArg: 3.062 ± 0.057	4.433LysSer: 4.433 ± 0.073	3.698LysThr: 3.698 ± 0.058	4.677LysVal: 4.677 ± 0.068	0.741LysTrp: 0.741 ± 0.025	2.533LysTyr: 2.533 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	6.841LeuAla: 6.841 ± 0.084	0.625LeuCys: 0.625 ± 0.023	5.195LeuAsp: 5.195 ± 0.069	6.639LeuGlu: 6.639 ± 0.083	4.614LeuPhe: 4.614 ± 0.069	6.224LeuGly: 6.224 ± 0.078	1.427LeuHis: 1.427 ± 0.037	6.9LeuIle: 6.9 ± 0.093	7.172LeuLys: 7.172 ± 0.093	8.808LeuLeu: 8.808 ± 0.108	2.326LeuMet: 2.326 ± 0.045	5.599LeuAsn: 5.599 ± 0.064	3.58LeuPro: 3.58 ± 0.059	3.16LeuGln: 3.16 ± 0.054	3.734LeuArg: 3.734 ± 0.06	7.186LeuSer: 7.186 ± 0.079	5.35LeuThr: 5.35 ± 0.076	6.089LeuVal: 6.089 ± 0.082	0.911LeuTrp: 0.911 ± 0.027	3.056LeuTyr: 3.056 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	1.969MetAla: 1.969 ± 0.04	0.118MetCys: 0.118 ± 0.008	1.263MetAsp: 1.263 ± 0.033	1.585MetGlu: 1.585 ± 0.034	0.905MetPhe: 0.905 ± 0.03	1.62MetGly: 1.62 ± 0.043	0.421MetHis: 0.421 ± 0.019	1.569MetIle: 1.569 ± 0.041	2.051MetLys: 2.051 ± 0.039	2.17MetLeu: 2.17 ± 0.046	0.648MetMet: 0.648 ± 0.026	1.353MetAsn: 1.353 ± 0.025	0.946MetPro: 0.946 ± 0.026	0.821MetGln: 0.821 ± 0.028	0.993MetArg: 0.993 ± 0.028	1.7MetSer: 1.7 ± 0.037	1.201MetThr: 1.201 ± 0.029	1.504MetVal: 1.504 ± 0.036	0.178MetTrp: 0.178 ± 0.011	0.619MetTyr: 0.619 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.435AsnAla: 3.435 ± 0.059	0.34AsnCys: 0.34 ± 0.018	2.791AsnAsp: 2.791 ± 0.059	3.782AsnGlu: 3.782 ± 0.048	2.641AsnPhe: 2.641 ± 0.047	4.006AsnGly: 4.006 ± 0.094	1.044AsnHis: 1.044 ± 0.027	3.661AsnIle: 3.661 ± 0.051	3.178AsnLys: 3.178 ± 0.051	5.019AsnLeu: 5.019 ± 0.055	1.271AsnMet: 1.271 ± 0.031	2.834AsnAsn: 2.834 ± 0.062	2.601AsnPro: 2.601 ± 0.056	2.302AsnGln: 2.302 ± 0.048	2.35AsnArg: 2.35 ± 0.038	3.613AsnSer: 3.613 ± 0.06	2.863AsnThr: 2.863 ± 0.06	3.104AsnVal: 3.104 ± 0.053	0.75AsnTrp: 0.75 ± 0.026	2.364AsnTyr: 2.364 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.166ProAla: 2.166 ± 0.049	0.189ProCys: 0.189 ± 0.014	2.232ProAsp: 2.232 ± 0.047	3.253ProGlu: 3.253 ± 0.053	1.841ProPhe: 1.841 ± 0.038	2.132ProGly: 2.132 ± 0.042	0.611ProHis: 0.611 ± 0.024	2.477ProIle: 2.477 ± 0.044	2.338ProLys: 2.338 ± 0.047	2.966ProLeu: 2.966 ± 0.055	0.822ProMet: 0.822 ± 0.024	2.078ProAsn: 2.078 ± 0.044	0.936ProPro: 0.936 ± 0.035	1.268ProGln: 1.268 ± 0.03	1.111ProArg: 1.111 ± 0.032	2.439ProSer: 2.439 ± 0.046	1.989ProThr: 1.989 ± 0.047	2.475ProVal: 2.475 ± 0.045	0.409ProTrp: 0.409 ± 0.017	1.406ProTyr: 1.406 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.607GlnAla: 2.607 ± 0.051	0.163GlnCys: 0.163 ± 0.011	1.718GlnAsp: 1.718 ± 0.035	2.718GlnGlu: 2.718 ± 0.052	1.977GlnPhe: 1.977 ± 0.042	2.129GlnGly: 2.129 ± 0.044	0.626GlnHis: 0.626 ± 0.024	2.649GlnIle: 2.649 ± 0.052	2.574GlnLys: 2.574 ± 0.048	3.835GlnLeu: 3.835 ± 0.058	1.059GlnMet: 1.059 ± 0.025	1.973GlnAsn: 1.973 ± 0.042	1.297GlnPro: 1.297 ± 0.032	1.597GlnGln: 1.597 ± 0.048	1.594GlnArg: 1.594 ± 0.037	2.344GlnSer: 2.344 ± 0.042	1.923GlnThr: 1.923 ± 0.043	2.492GlnVal: 2.492 ± 0.044	0.451GlnTrp: 0.451 ± 0.019	1.401GlnTyr: 1.401 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.512ArgAla: 2.512 ± 0.045	0.178ArgCys: 0.178 ± 0.012	2.114ArgAsp: 2.114 ± 0.044	2.736ArgGlu: 2.736 ± 0.058	2.206ArgPhe: 2.206 ± 0.041	2.336ArgGly: 2.336 ± 0.045	0.654ArgHis: 0.654 ± 0.021	3.13ArgIle: 3.13 ± 0.045	3.044ArgLys: 3.044 ± 0.057	3.938ArgLeu: 3.938 ± 0.066	1.15ArgMet: 1.15 ± 0.028	2.266ArgAsn: 2.266 ± 0.037	1.365ArgPro: 1.365 ± 0.033	1.419ArgGln: 1.419 ± 0.032	1.769ArgArg: 1.769 ± 0.046	2.517ArgSer: 2.517 ± 0.049	2.142ArgThr: 2.142 ± 0.043	2.729ArgVal: 2.729 ± 0.043	0.478ArgTrp: 0.478 ± 0.02	1.606ArgTyr: 1.606 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.471SerAla: 4.471 ± 0.063	0.514SerCys: 0.514 ± 0.024	3.725SerAsp: 3.725 ± 0.058	4.487SerGlu: 4.487 ± 0.065	3.994SerPhe: 3.994 ± 0.07	5.096SerGly: 5.096 ± 0.071	1.086SerHis: 1.086 ± 0.026	5.247SerIle: 5.247 ± 0.065	4.299SerLys: 4.299 ± 0.068	6.758SerLeu: 6.758 ± 0.083	1.452SerMet: 1.452 ± 0.037	3.605SerAsn: 3.605 ± 0.063	2.326SerPro: 2.326 ± 0.049	2.419SerGln: 2.419 ± 0.049	2.613SerArg: 2.613 ± 0.045	4.687SerSer: 4.687 ± 0.087	3.745SerThr: 3.745 ± 0.067	4.35SerVal: 4.35 ± 0.066	0.769SerTrp: 0.769 ± 0.031	2.635SerTyr: 2.635 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.743ThrAla: 3.743 ± 0.09	0.32ThrCys: 0.32 ± 0.016	3.263ThrAsp: 3.263 ± 0.064	3.488ThrGlu: 3.488 ± 0.052	2.824ThrPhe: 2.824 ± 0.063	4.064ThrGly: 4.064 ± 0.084	0.95ThrHis: 0.95 ± 0.029	4.131ThrIle: 4.131 ± 0.077	3.037ThrLys: 3.037 ± 0.054	5.248ThrLeu: 5.248 ± 0.064	0.978ThrMet: 0.978 ± 0.025	2.731ThrAsn: 2.731 ± 0.059	2.172ThrPro: 2.172 ± 0.044	1.785ThrGln: 1.785 ± 0.04	1.839ThrArg: 1.839 ± 0.037	3.549ThrSer: 3.549 ± 0.063	3.008ThrThr: 3.008 ± 0.062	3.741ThrVal: 3.741 ± 0.089	0.636ThrTrp: 0.636 ± 0.031	2.217ThrTyr: 2.217 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.457ValAla: 4.457 ± 0.065	0.473ValCys: 0.473 ± 0.02	3.836ValAsp: 3.836 ± 0.063	4.659ValGlu: 4.659 ± 0.059	3.341ValPhe: 3.341 ± 0.062	4.196ValGly: 4.196 ± 0.064	1.071ValHis: 1.071 ± 0.031	4.63ValIle: 4.63 ± 0.067	4.208ValLys: 4.208 ± 0.068	6.253ValLeu: 6.253 ± 0.079	1.511ValMet: 1.511 ± 0.037	3.535ValAsn: 3.535 ± 0.062	2.215ValPro: 2.215 ± 0.039	2.139ValGln: 2.139 ± 0.04	2.563ValArg: 2.563 ± 0.048	4.626ValSer: 4.626 ± 0.07	3.633ValThr: 3.633 ± 0.094	4.589ValVal: 4.589 ± 0.063	0.701ValTrp: 0.701 ± 0.025	2.354ValTyr: 2.354 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.748TrpAla: 0.748 ± 0.024	0.086TrpCys: 0.086 ± 0.008	0.672TrpAsp: 0.672 ± 0.026	0.733TrpGlu: 0.733 ± 0.021	0.599TrpPhe: 0.599 ± 0.024	0.723TrpGly: 0.723 ± 0.024	0.214TrpHis: 0.214 ± 0.012	0.674TrpIle: 0.674 ± 0.021	0.795TrpLys: 0.795 ± 0.025	1.182TrpLeu: 1.182 ± 0.034	0.34TrpMet: 0.34 ± 0.016	0.682TrpAsn: 0.682 ± 0.024	0.322TrpPro: 0.322 ± 0.017	0.46TrpGln: 0.46 ± 0.02	0.519TrpArg: 0.519 ± 0.023	0.749TrpSer: 0.749 ± 0.034	0.603TrpThr: 0.603 ± 0.021	0.79TrpVal: 0.79 ± 0.027	0.177TrpTrp: 0.177 ± 0.014	0.398TrpTyr: 0.398 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.359TyrAla: 2.359 ± 0.048	0.279TyrCys: 0.279 ± 0.015	2.282TyrAsp: 2.282 ± 0.051	2.522TyrGlu: 2.522 ± 0.048	2.228TyrPhe: 2.228 ± 0.048	2.569TyrGly: 2.569 ± 0.049	0.802TyrHis: 0.802 ± 0.025	2.275TyrIle: 2.275 ± 0.049	2.276TyrLys: 2.276 ± 0.043	3.821TyrLeu: 3.821 ± 0.058	0.788TyrMet: 0.788 ± 0.023	2.06TyrAsn: 2.06 ± 0.045	1.407TyrPro: 1.407 ± 0.033	1.613TyrGln: 1.613 ± 0.036	1.829TyrArg: 1.829 ± 0.039	2.8TyrSer: 2.8 ± 0.051	2.061TyrThr: 2.061 ± 0.057	2.082TyrVal: 2.082 ± 0.043	0.509TyrTrp: 0.509 ± 0.021	1.679TyrTyr: 1.679 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3854 proteins (1330867 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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