Amino acid dipepetide frequency for Mossman virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.292AlaAla: 6.292 ± 1.004
0.953AlaCys: 0.953 ± 0.299
2.669AlaAsp: 2.669 ± 0.669
4.004AlaGlu: 4.004 ± 1.32
1.907AlaPhe: 1.907 ± 0.567
4.766AlaGly: 4.766 ± 1.236
1.144AlaHis: 1.144 ± 0.379
4.194AlaIle: 4.194 ± 1.089
2.288AlaLys: 2.288 ± 0.749
8.58AlaLeu: 8.58 ± 0.575
1.525AlaMet: 1.525 ± 0.603
3.432AlaAsn: 3.432 ± 0.848
2.669AlaPro: 2.669 ± 0.917
1.716AlaGln: 1.716 ± 0.422
3.622AlaArg: 3.622 ± 0.799
4.004AlaSer: 4.004 ± 0.88
3.432AlaThr: 3.432 ± 0.733
5.148AlaVal: 5.148 ± 0.91
1.144AlaTrp: 1.144 ± 0.263
1.907AlaTyr: 1.907 ± 0.495
0.0AlaXaa: 0.0 ± 0.0
Cys
0.572CysAla: 0.572 ± 0.286
0.381CysCys: 0.381 ± 0.194
0.763CysAsp: 0.763 ± 0.457
1.335CysGlu: 1.335 ± 0.358
0.572CysPhe: 0.572 ± 0.342
0.381CysGly: 0.381 ± 0.274
0.381CysHis: 0.381 ± 0.184
0.763CysIle: 0.763 ± 0.305
0.763CysLys: 0.763 ± 0.417
1.525CysLeu: 1.525 ± 0.415
0.381CysMet: 0.381 ± 0.194
1.144CysAsn: 1.144 ± 0.516
1.144CysPro: 1.144 ± 0.52
1.335CysGln: 1.335 ± 0.477
0.572CysArg: 0.572 ± 0.532
1.525CysSer: 1.525 ± 0.418
0.763CysThr: 0.763 ± 0.502
0.763CysVal: 0.763 ± 0.524
0.191CysTrp: 0.191 ± 0.251
1.144CysTyr: 1.144 ± 0.396
0.0CysXaa: 0.0 ± 0.0
Asp
2.86AspAla: 2.86 ± 0.399
0.191AspCys: 0.191 ± 0.114
3.813AspAsp: 3.813 ± 1.384
4.576AspGlu: 4.576 ± 1.308
1.716AspPhe: 1.716 ± 0.37
3.813AspGly: 3.813 ± 1.044
1.716AspHis: 1.716 ± 0.515
4.766AspIle: 4.766 ± 1.059
2.097AspLys: 2.097 ± 0.923
4.957AspLeu: 4.957 ± 1.137
1.525AspMet: 1.525 ± 0.401
1.907AspAsn: 1.907 ± 0.77
4.766AspPro: 4.766 ± 1.175
1.335AspGln: 1.335 ± 0.44
2.097AspArg: 2.097 ± 0.607
4.576AspSer: 4.576 ± 1.115
2.669AspThr: 2.669 ± 0.567
2.86AspVal: 2.86 ± 0.636
1.144AspTrp: 1.144 ± 0.288
1.335AspTyr: 1.335 ± 0.413
0.0AspXaa: 0.0 ± 0.0
Glu
4.385GluAla: 4.385 ± 1.038
1.335GluCys: 1.335 ± 0.534
3.051GluAsp: 3.051 ± 0.955
4.194GluGlu: 4.194 ± 1.229
1.907GluPhe: 1.907 ± 0.941
3.051GluGly: 3.051 ± 1.133
1.525GluHis: 1.525 ± 0.623
3.241GluIle: 3.241 ± 0.674
2.479GluLys: 2.479 ± 0.87
4.576GluLeu: 4.576 ± 0.43
1.716GluMet: 1.716 ± 0.713
2.669GluAsn: 2.669 ± 0.669
2.669GluPro: 2.669 ± 1.396
2.86GluGln: 2.86 ± 0.817
1.335GluArg: 1.335 ± 0.488
6.101GluSer: 6.101 ± 1.871
3.813GluThr: 3.813 ± 0.636
2.669GluVal: 2.669 ± 1.04
0.191GluTrp: 0.191 ± 0.114
2.479GluTyr: 2.479 ± 0.616
0.0GluXaa: 0.0 ± 0.0
Phe
1.525PheAla: 1.525 ± 0.546
0.572PheCys: 0.572 ± 0.342
1.525PheAsp: 1.525 ± 0.488
1.335PheGlu: 1.335 ± 0.381
1.335PhePhe: 1.335 ± 0.66
2.288PheGly: 2.288 ± 0.237
1.144PheHis: 1.144 ± 0.492
1.907PheIle: 1.907 ± 0.839
1.525PheLys: 1.525 ± 0.438
3.051PheLeu: 3.051 ± 0.887
0.763PheMet: 0.763 ± 0.861
1.907PheAsn: 1.907 ± 0.459
1.144PhePro: 1.144 ± 0.295
1.907PheGln: 1.907 ± 0.603
1.525PheArg: 1.525 ± 0.609
1.716PheSer: 1.716 ± 0.631
2.097PheThr: 2.097 ± 0.417
0.953PheVal: 0.953 ± 0.353
0.572PheTrp: 0.572 ± 0.288
1.144PheTyr: 1.144 ± 0.485
0.0PheXaa: 0.0 ± 0.0
Gly
3.432GlyAla: 3.432 ± 0.816
1.335GlyCys: 1.335 ± 0.527
5.148GlyAsp: 5.148 ± 1.43
2.097GlyGlu: 2.097 ± 0.693
2.288GlyPhe: 2.288 ± 0.694
3.622GlyGly: 3.622 ± 1.072
2.288GlyHis: 2.288 ± 0.848
4.576GlyIle: 4.576 ± 0.812
2.097GlyLys: 2.097 ± 1.008
6.864GlyLeu: 6.864 ± 0.747
1.335GlyMet: 1.335 ± 0.266
2.86GlyAsn: 2.86 ± 0.784
2.669GlyPro: 2.669 ± 1.0
2.669GlyGln: 2.669 ± 0.7
3.241GlyArg: 3.241 ± 1.126
5.148GlySer: 5.148 ± 1.406
3.432GlyThr: 3.432 ± 0.733
5.72GlyVal: 5.72 ± 1.198
0.381GlyTrp: 0.381 ± 0.337
2.288GlyTyr: 2.288 ± 0.533
0.0GlyXaa: 0.0 ± 0.0
His
1.716HisAla: 1.716 ± 0.351
0.381HisCys: 0.381 ± 0.228
1.716HisAsp: 1.716 ± 0.495
1.716HisGlu: 1.716 ± 0.524
0.953HisPhe: 0.953 ± 0.526
0.763HisGly: 0.763 ± 0.344
0.763HisHis: 0.763 ± 0.337
1.716HisIle: 1.716 ± 0.693
2.097HisLys: 2.097 ± 0.492
2.288HisLeu: 2.288 ± 0.508
0.953HisMet: 0.953 ± 0.389
1.716HisAsn: 1.716 ± 0.739
0.572HisPro: 0.572 ± 0.342
1.144HisGln: 1.144 ± 0.44
0.953HisArg: 0.953 ± 0.372
1.144HisSer: 1.144 ± 0.269
0.763HisThr: 0.763 ± 0.326
1.335HisVal: 1.335 ± 0.343
0.191HisTrp: 0.191 ± 0.182
1.144HisTyr: 1.144 ± 0.419
0.0HisXaa: 0.0 ± 0.0
Ile
5.529IleAla: 5.529 ± 0.827
0.381IleCys: 0.381 ± 0.274
3.622IleAsp: 3.622 ± 0.601
4.576IleGlu: 4.576 ± 0.66
2.097IlePhe: 2.097 ± 0.763
3.622IleGly: 3.622 ± 0.807
1.525IleHis: 1.525 ± 0.395
6.101IleIle: 6.101 ± 1.334
4.766IleLys: 4.766 ± 0.668
4.766IleLeu: 4.766 ± 0.897
1.525IleMet: 1.525 ± 0.525
3.051IleAsn: 3.051 ± 0.737
4.004IlePro: 4.004 ± 0.764
2.479IleGln: 2.479 ± 0.778
5.148IleArg: 5.148 ± 0.629
7.054IleSer: 7.054 ± 1.381
5.91IleThr: 5.91 ± 1.286
3.241IleVal: 3.241 ± 0.755
0.381IleTrp: 0.381 ± 0.18
3.241IleTyr: 3.241 ± 1.182
0.0IleXaa: 0.0 ± 0.0
Lys
3.241LysAla: 3.241 ± 0.298
1.716LysCys: 1.716 ± 0.499
2.479LysAsp: 2.479 ± 0.479
3.622LysGlu: 3.622 ± 1.809
1.716LysPhe: 1.716 ± 0.672
2.288LysGly: 2.288 ± 0.597
1.144LysHis: 1.144 ± 0.43
2.86LysIle: 2.86 ± 0.526
1.907LysLys: 1.907 ± 0.381
4.194LysLeu: 4.194 ± 0.835
1.525LysMet: 1.525 ± 0.492
2.479LysAsn: 2.479 ± 0.9
1.716LysPro: 1.716 ± 0.55
2.097LysGln: 2.097 ± 0.569
2.86LysArg: 2.86 ± 0.841
3.051LysSer: 3.051 ± 0.623
3.432LysThr: 3.432 ± 0.705
3.051LysVal: 3.051 ± 0.729
0.191LysTrp: 0.191 ± 0.219
1.716LysTyr: 1.716 ± 0.546
0.0LysXaa: 0.0 ± 0.0
Leu
7.436LeuAla: 7.436 ± 1.141
1.144LeuCys: 1.144 ± 0.422
4.766LeuAsp: 4.766 ± 0.651
5.72LeuGlu: 5.72 ± 0.681
2.288LeuPhe: 2.288 ± 0.864
7.817LeuGly: 7.817 ± 1.476
4.004LeuHis: 4.004 ± 0.775
6.864LeuIle: 6.864 ± 1.499
4.576LeuLys: 4.576 ± 1.148
7.436LeuLeu: 7.436 ± 1.438
3.051LeuMet: 3.051 ± 0.783
4.957LeuAsn: 4.957 ± 0.808
2.86LeuPro: 2.86 ± 0.647
2.86LeuGln: 2.86 ± 0.867
5.148LeuArg: 5.148 ± 0.843
7.245LeuSer: 7.245 ± 1.581
7.054LeuThr: 7.054 ± 0.841
4.766LeuVal: 4.766 ± 0.72
1.144LeuTrp: 1.144 ± 0.385
2.669LeuTyr: 2.669 ± 0.601
0.0LeuXaa: 0.0 ± 0.0
Met
1.335MetAla: 1.335 ± 0.716
0.763MetCys: 0.763 ± 0.344
1.525MetAsp: 1.525 ± 0.374
1.716MetGlu: 1.716 ± 0.896
0.191MetPhe: 0.191 ± 0.114
0.763MetGly: 0.763 ± 0.359
0.572MetHis: 0.572 ± 0.292
2.479MetIle: 2.479 ± 0.624
1.144MetLys: 1.144 ± 0.43
1.907MetLeu: 1.907 ± 0.543
0.953MetMet: 0.953 ± 0.523
2.288MetAsn: 2.288 ± 0.923
0.763MetPro: 0.763 ± 0.3
0.191MetGln: 0.191 ± 0.251
2.669MetArg: 2.669 ± 0.495
2.479MetSer: 2.479 ± 0.567
0.953MetThr: 0.953 ± 0.279
2.288MetVal: 2.288 ± 0.919
0.381MetTrp: 0.381 ± 0.228
0.572MetTyr: 0.572 ± 0.274
0.0MetXaa: 0.0 ± 0.0
Asn
3.432AsnAla: 3.432 ± 0.569
0.953AsnCys: 0.953 ± 0.636
3.051AsnAsp: 3.051 ± 0.806
2.288AsnGlu: 2.288 ± 0.552
0.953AsnPhe: 0.953 ± 0.293
2.669AsnGly: 2.669 ± 0.472
0.763AsnHis: 0.763 ± 0.337
4.004AsnIle: 4.004 ± 1.283
2.097AsnLys: 2.097 ± 0.595
4.385AsnLeu: 4.385 ± 0.832
1.144AsnMet: 1.144 ± 0.635
3.432AsnAsn: 3.432 ± 0.684
4.957AsnPro: 4.957 ± 0.834
4.004AsnGln: 4.004 ± 1.065
2.097AsnArg: 2.097 ± 0.721
1.907AsnSer: 1.907 ± 0.825
3.813AsnThr: 3.813 ± 0.525
1.907AsnVal: 1.907 ± 0.432
0.763AsnTrp: 0.763 ± 0.457
1.525AsnTyr: 1.525 ± 0.563
0.0AsnXaa: 0.0 ± 0.0
Pro
2.288ProAla: 2.288 ± 0.445
0.0ProCys: 0.0 ± 0.0
3.241ProAsp: 3.241 ± 0.757
2.288ProGlu: 2.288 ± 0.509
0.763ProPhe: 0.763 ± 0.45
2.86ProGly: 2.86 ± 1.361
1.335ProHis: 1.335 ± 0.454
5.338ProIle: 5.338 ± 1.275
4.004ProLys: 4.004 ± 0.784
3.241ProLeu: 3.241 ± 0.354
1.716ProMet: 1.716 ± 0.542
2.288ProAsn: 2.288 ± 0.468
3.051ProPro: 3.051 ± 0.417
1.907ProGln: 1.907 ± 0.642
3.051ProArg: 3.051 ± 0.721
4.004ProSer: 4.004 ± 0.771
2.097ProThr: 2.097 ± 0.429
2.86ProVal: 2.86 ± 0.661
0.572ProTrp: 0.572 ± 0.246
2.288ProTyr: 2.288 ± 0.825
0.0ProXaa: 0.0 ± 0.0
Gln
1.525GlnAla: 1.525 ± 0.54
0.381GlnCys: 0.381 ± 0.233
2.86GlnAsp: 2.86 ± 1.092
1.525GlnGlu: 1.525 ± 0.673
1.525GlnPhe: 1.525 ± 0.462
3.051GlnGly: 3.051 ± 1.056
0.763GlnHis: 0.763 ± 0.307
3.051GlnIle: 3.051 ± 0.678
1.907GlnLys: 1.907 ± 0.58
4.194GlnLeu: 4.194 ± 0.492
0.763GlnMet: 0.763 ± 0.257
1.525GlnAsn: 1.525 ± 0.729
2.288GlnPro: 2.288 ± 0.62
2.479GlnGln: 2.479 ± 0.581
2.669GlnArg: 2.669 ± 0.771
4.576GlnSer: 4.576 ± 1.707
2.288GlnThr: 2.288 ± 0.873
2.479GlnVal: 2.479 ± 0.623
0.572GlnTrp: 0.572 ± 0.342
1.335GlnTyr: 1.335 ± 0.342
0.0GlnXaa: 0.0 ± 0.0
Arg
3.051ArgAla: 3.051 ± 0.657
0.381ArgCys: 0.381 ± 0.274
1.525ArgAsp: 1.525 ± 0.382
3.432ArgGlu: 3.432 ± 1.543
1.525ArgPhe: 1.525 ± 0.49
4.385ArgGly: 4.385 ± 0.732
1.335ArgHis: 1.335 ± 0.474
2.86ArgIle: 2.86 ± 0.386
1.144ArgLys: 1.144 ± 0.896
6.673ArgLeu: 6.673 ± 1.071
1.716ArgMet: 1.716 ± 0.518
3.241ArgAsn: 3.241 ± 0.746
1.907ArgPro: 1.907 ± 0.694
1.716ArgGln: 1.716 ± 0.503
4.576ArgArg: 4.576 ± 1.476
5.91ArgSer: 5.91 ± 1.279
2.097ArgThr: 2.097 ± 0.996
4.957ArgVal: 4.957 ± 1.428
0.572ArgTrp: 0.572 ± 0.458
1.907ArgTyr: 1.907 ± 0.622
0.0ArgXaa: 0.0 ± 0.0
Ser
4.576SerAla: 4.576 ± 1.39
2.479SerCys: 2.479 ± 0.509
3.622SerAsp: 3.622 ± 0.899
4.766SerGlu: 4.766 ± 1.32
3.051SerPhe: 3.051 ± 0.469
7.436SerGly: 7.436 ± 1.862
1.716SerHis: 1.716 ± 0.804
4.576SerIle: 4.576 ± 1.105
4.194SerLys: 4.194 ± 0.686
8.77SerLeu: 8.77 ± 1.393
1.144SerMet: 1.144 ± 0.549
4.194SerAsn: 4.194 ± 0.938
3.813SerPro: 3.813 ± 0.514
2.097SerGln: 2.097 ± 0.489
3.813SerArg: 3.813 ± 0.539
7.436SerSer: 7.436 ± 1.918
7.054SerThr: 7.054 ± 1.707
4.194SerVal: 4.194 ± 0.462
0.763SerTrp: 0.763 ± 0.307
2.86SerTyr: 2.86 ± 0.78
0.0SerXaa: 0.0 ± 0.0
Thr
5.148ThrAla: 5.148 ± 1.338
1.335ThrCys: 1.335 ± 0.751
4.004ThrAsp: 4.004 ± 0.92
1.716ThrGlu: 1.716 ± 0.521
1.335ThrPhe: 1.335 ± 0.579
4.004ThrGly: 4.004 ± 1.155
0.381ThrHis: 0.381 ± 0.194
4.766ThrIle: 4.766 ± 1.311
2.86ThrLys: 2.86 ± 0.793
5.91ThrLeu: 5.91 ± 0.449
0.763ThrMet: 0.763 ± 0.37
2.479ThrAsn: 2.479 ± 0.578
2.669ThrPro: 2.669 ± 0.81
3.813ThrGln: 3.813 ± 1.341
3.622ThrArg: 3.622 ± 0.828
5.148ThrSer: 5.148 ± 0.778
4.194ThrThr: 4.194 ± 0.867
4.957ThrVal: 4.957 ± 1.118
0.572ThrTrp: 0.572 ± 0.246
3.051ThrTyr: 3.051 ± 0.588
0.0ThrXaa: 0.0 ± 0.0
Val
4.194ValAla: 4.194 ± 0.897
0.953ValCys: 0.953 ± 0.675
2.479ValAsp: 2.479 ± 0.524
4.004ValGlu: 4.004 ± 1.097
1.907ValPhe: 1.907 ± 0.473
4.385ValGly: 4.385 ± 0.851
1.335ValHis: 1.335 ± 0.399
5.529ValIle: 5.529 ± 1.052
3.241ValLys: 3.241 ± 0.704
5.72ValLeu: 5.72 ± 0.982
2.097ValMet: 2.097 ± 0.624
2.288ValAsn: 2.288 ± 0.525
2.669ValPro: 2.669 ± 0.442
3.241ValGln: 3.241 ± 0.517
2.86ValArg: 2.86 ± 0.858
3.813ValSer: 3.813 ± 0.986
4.576ValThr: 4.576 ± 1.516
5.148ValVal: 5.148 ± 1.202
0.381ValTrp: 0.381 ± 0.365
0.953ValTyr: 0.953 ± 0.305
0.0ValXaa: 0.0 ± 0.0
Trp
0.953TrpAla: 0.953 ± 0.362
0.381TrpCys: 0.381 ± 0.613
0.572TrpAsp: 0.572 ± 0.246
0.0TrpGlu: 0.0 ± 0.0
0.572TrpPhe: 0.572 ± 0.342
0.191TrpGly: 0.191 ± 0.114
0.0TrpHis: 0.0 ± 0.0
1.144TrpIle: 1.144 ± 0.369
0.763TrpLys: 0.763 ± 0.263
1.144TrpLeu: 1.144 ± 0.392
0.191TrpMet: 0.191 ± 0.205
0.381TrpAsn: 0.381 ± 0.228
0.191TrpPro: 0.191 ± 0.114
0.381TrpGln: 0.381 ± 0.34
0.763TrpArg: 0.763 ± 0.326
1.144TrpSer: 1.144 ± 0.441
0.572TrpThr: 0.572 ± 0.302
0.572TrpVal: 0.572 ± 0.336
0.381TrpTrp: 0.381 ± 0.184
0.763TrpTyr: 0.763 ± 0.353
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.907TyrAla: 1.907 ± 0.491
0.381TyrCys: 0.381 ± 0.233
2.288TyrAsp: 2.288 ± 0.715
1.335TyrGlu: 1.335 ± 0.271
1.335TyrPhe: 1.335 ± 0.463
1.335TyrGly: 1.335 ± 0.612
0.191TyrHis: 0.191 ± 0.191
2.288TyrIle: 2.288 ± 0.566
1.335TyrLys: 1.335 ± 0.377
3.622TyrLeu: 3.622 ± 0.841
0.953TyrMet: 0.953 ± 0.26
2.097TyrAsn: 2.097 ± 0.54
2.669TyrPro: 2.669 ± 0.55
1.525TyrGln: 1.525 ± 0.541
2.288TyrArg: 2.288 ± 0.628
4.576TyrSer: 4.576 ± 0.667
1.716TyrThr: 1.716 ± 0.61
1.907TyrVal: 1.907 ± 0.621
0.572TyrTrp: 0.572 ± 0.246
1.335TyrTyr: 1.335 ± 0.468
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (5246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski