Amino acid dipepetide frequency for Hartmannibacter diazotrophicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.614AlaAla: 16.614 ± 0.155	1.086AlaCys: 1.086 ± 0.028	7.207AlaAsp: 7.207 ± 0.08	7.712AlaGlu: 7.712 ± 0.079	4.788AlaPhe: 4.788 ± 0.061	11.022AlaGly: 11.022 ± 0.087	2.208AlaHis: 2.208 ± 0.039	6.797AlaIle: 6.797 ± 0.071	4.013AlaLys: 4.013 ± 0.065	12.878AlaLeu: 12.878 ± 0.112	3.701AlaMet: 3.701 ± 0.046	2.869AlaAsn: 2.869 ± 0.04	5.196AlaPro: 5.196 ± 0.071	2.998AlaGln: 2.998 ± 0.045	8.495AlaArg: 8.495 ± 0.08	6.974AlaSer: 6.974 ± 0.074	6.129AlaThr: 6.129 ± 0.071	8.978AlaVal: 8.978 ± 0.09	1.324AlaTrp: 1.324 ± 0.031	2.551AlaTyr: 2.551 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.894CysAla: 0.894 ± 0.024	0.104CysCys: 0.104 ± 0.008	0.52CysAsp: 0.52 ± 0.02	0.464CysGlu: 0.464 ± 0.019	0.317CysPhe: 0.317 ± 0.015	0.921CysGly: 0.921 ± 0.026	0.26CysHis: 0.26 ± 0.014	0.361CysIle: 0.361 ± 0.016	0.202CysLys: 0.202 ± 0.012	0.874CysLeu: 0.874 ± 0.022	0.182CysMet: 0.182 ± 0.01	0.209CysAsn: 0.209 ± 0.013	0.468CysPro: 0.468 ± 0.018	0.237CysGln: 0.237 ± 0.012	0.654CysArg: 0.654 ± 0.022	0.483CysSer: 0.483 ± 0.016	0.393CysThr: 0.393 ± 0.015	0.602CysVal: 0.602 ± 0.018	0.116CysTrp: 0.116 ± 0.01	0.204CysTyr: 0.204 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.889AspAla: 6.889 ± 0.072	0.546AspCys: 0.546 ± 0.018	3.536AspAsp: 3.536 ± 0.053	3.799AspGlu: 3.799 ± 0.05	2.355AspPhe: 2.355 ± 0.042	5.466AspGly: 5.466 ± 0.076	1.318AspHis: 1.318 ± 0.032	3.305AspIle: 3.305 ± 0.05	1.845AspLys: 1.845 ± 0.044	6.599AspLeu: 6.599 ± 0.075	1.453AspMet: 1.453 ± 0.03	1.325AspAsn: 1.325 ± 0.03	3.564AspPro: 3.564 ± 0.053	1.629AspGln: 1.629 ± 0.033	4.42AspArg: 4.42 ± 0.063	2.129AspSer: 2.129 ± 0.04	2.499AspThr: 2.499 ± 0.041	4.503AspVal: 4.503 ± 0.052	0.976AspTrp: 0.976 ± 0.025	1.475AspTyr: 1.475 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.232GluAla: 8.232 ± 0.088	0.367GluCys: 0.367 ± 0.016	3.083GluAsp: 3.083 ± 0.051	3.508GluGlu: 3.508 ± 0.065	1.746GluPhe: 1.746 ± 0.032	4.459GluGly: 4.459 ± 0.053	1.143GluHis: 1.143 ± 0.028	3.694GluIle: 3.694 ± 0.05	2.417GluLys: 2.417 ± 0.043	4.932GluLeu: 4.932 ± 0.067	1.653GluMet: 1.653 ± 0.033	1.545GluAsn: 1.545 ± 0.036	2.867GluPro: 2.867 ± 0.055	1.872GluGln: 1.872 ± 0.03	4.779GluArg: 4.779 ± 0.064	2.386GluSer: 2.386 ± 0.04	4.065GluThr: 4.065 ± 0.056	4.083GluVal: 4.083 ± 0.059	0.658GluTrp: 0.658 ± 0.02	0.864GluTyr: 0.864 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.72PheAla: 4.72 ± 0.062	0.385PheCys: 0.385 ± 0.016	2.819PheAsp: 2.819 ± 0.046	2.176PheGlu: 2.176 ± 0.036	1.51PhePhe: 1.51 ± 0.038	3.839PheGly: 3.839 ± 0.053	0.781PheHis: 0.781 ± 0.023	1.719PheIle: 1.719 ± 0.035	1.058PheLys: 1.058 ± 0.026	3.626PheLeu: 3.626 ± 0.058	0.874PheMet: 0.874 ± 0.025	1.018PheAsn: 1.018 ± 0.025	1.58PhePro: 1.58 ± 0.034	1.016PheGln: 1.016 ± 0.025	2.286PheArg: 2.286 ± 0.038	2.385PheSer: 2.385 ± 0.042	1.818PheThr: 1.818 ± 0.031	3.068PheVal: 3.068 ± 0.046	0.569PheTrp: 0.569 ± 0.024	0.877PheTyr: 0.877 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.089GlyAla: 9.089 ± 0.088	0.857GlyCys: 0.857 ± 0.025	4.606GlyAsp: 4.606 ± 0.057	5.125GlyGlu: 5.125 ± 0.065	3.655GlyPhe: 3.655 ± 0.049	7.167GlyGly: 7.167 ± 0.086	1.995GlyHis: 1.995 ± 0.041	4.827GlyIle: 4.827 ± 0.061	3.392GlyLys: 3.392 ± 0.055	9.39GlyLeu: 9.39 ± 0.095	2.336GlyMet: 2.336 ± 0.037	2.206GlyAsn: 2.206 ± 0.043	3.634GlyPro: 3.634 ± 0.047	2.681GlyGln: 2.681 ± 0.042	6.11GlyArg: 6.11 ± 0.074	4.786GlySer: 4.786 ± 0.053	4.627GlyThr: 4.627 ± 0.055	5.98GlyVal: 5.98 ± 0.063	1.313GlyTrp: 1.313 ± 0.03	2.263GlyTyr: 2.263 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.266HisAla: 2.266 ± 0.043	0.219HisCys: 0.219 ± 0.011	1.311HisAsp: 1.311 ± 0.029	1.045HisGlu: 1.045 ± 0.029	0.887HisPhe: 0.887 ± 0.023	1.895HisGly: 1.895 ± 0.043	0.58HisHis: 0.58 ± 0.027	0.879HisIle: 0.879 ± 0.029	0.462HisLys: 0.462 ± 0.017	2.115HisLeu: 2.115 ± 0.031	0.497HisMet: 0.497 ± 0.017	0.439HisAsn: 0.439 ± 0.015	1.366HisPro: 1.366 ± 0.03	0.563HisGln: 0.563 ± 0.018	1.371HisArg: 1.371 ± 0.032	0.929HisSer: 0.929 ± 0.023	0.794HisThr: 0.794 ± 0.021	1.629HisVal: 1.629 ± 0.032	0.315HisTrp: 0.315 ± 0.015	0.551HisTyr: 0.551 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.733IleAla: 7.733 ± 0.084	0.518IleCys: 0.518 ± 0.019	3.881IleAsp: 3.881 ± 0.047	3.78IleGlu: 3.78 ± 0.057	1.864IlePhe: 1.864 ± 0.038	5.333IleGly: 5.333 ± 0.059	0.942IleHis: 0.942 ± 0.024	2.165IleIle: 2.165 ± 0.045	1.448IleLys: 1.448 ± 0.034	4.847IleLeu: 4.847 ± 0.066	1.012IleMet: 1.012 ± 0.023	1.377IleAsn: 1.377 ± 0.031	2.377IlePro: 2.377 ± 0.036	1.163IleGln: 1.163 ± 0.031	3.365IleArg: 3.365 ± 0.052	2.994IleSer: 2.994 ± 0.048	2.548IleThr: 2.548 ± 0.048	4.61IleVal: 4.61 ± 0.061	0.576IleTrp: 0.576 ± 0.021	1.105IleTyr: 1.105 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.715LysAla: 4.715 ± 0.054	0.165LysCys: 0.165 ± 0.011	1.92LysAsp: 1.92 ± 0.036	1.672LysGlu: 1.672 ± 0.035	0.921LysPhe: 0.921 ± 0.028	2.791LysGly: 2.791 ± 0.045	0.516LysHis: 0.516 ± 0.018	1.795LysIle: 1.795 ± 0.04	1.226LysLys: 1.226 ± 0.035	3.119LysLeu: 3.119 ± 0.048	0.796LysMet: 0.796 ± 0.023	0.789LysAsn: 0.789 ± 0.024	2.024LysPro: 2.024 ± 0.039	0.831LysGln: 0.831 ± 0.025	2.213LysArg: 2.213 ± 0.041	1.984LysSer: 1.984 ± 0.033	2.187LysThr: 2.187 ± 0.04	2.653LysVal: 2.653 ± 0.052	0.36LysTrp: 0.36 ± 0.015	0.584LysTyr: 0.584 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.988LeuAla: 13.988 ± 0.127	0.927LeuCys: 0.927 ± 0.026	6.204LeuAsp: 6.204 ± 0.066	5.219LeuGlu: 5.219 ± 0.057	3.706LeuPhe: 3.706 ± 0.055	8.432LeuGly: 8.432 ± 0.085	1.748LeuHis: 1.748 ± 0.033	5.024LeuIle: 5.024 ± 0.068	3.877LeuLys: 3.877 ± 0.051	9.48LeuLeu: 9.48 ± 0.111	2.515LeuMet: 2.515 ± 0.041	2.422LeuAsn: 2.422 ± 0.04	5.614LeuPro: 5.614 ± 0.07	2.563LeuGln: 2.563 ± 0.042	6.121LeuArg: 6.121 ± 0.06	6.586LeuSer: 6.586 ± 0.076	5.577LeuThr: 5.577 ± 0.056	7.895LeuVal: 7.895 ± 0.081	1.094LeuTrp: 1.094 ± 0.026	1.985LeuTyr: 1.985 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.374MetAla: 3.374 ± 0.045	0.138MetCys: 0.138 ± 0.009	1.257MetAsp: 1.257 ± 0.029	1.233MetGlu: 1.233 ± 0.028	0.674MetPhe: 0.674 ± 0.021	1.773MetGly: 1.773 ± 0.037	0.443MetHis: 0.443 ± 0.017	1.471MetIle: 1.471 ± 0.031	1.042MetLys: 1.042 ± 0.027	2.507MetLeu: 2.507 ± 0.039	0.712MetMet: 0.712 ± 0.022	0.786MetAsn: 0.786 ± 0.023	1.606MetPro: 1.606 ± 0.035	0.782MetGln: 0.782 ± 0.021	1.86MetArg: 1.86 ± 0.031	1.777MetSer: 1.777 ± 0.033	2.18MetThr: 2.18 ± 0.036	1.817MetVal: 1.817 ± 0.04	0.203MetTrp: 0.203 ± 0.012	0.258MetTyr: 0.258 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.077AsnAla: 3.077 ± 0.047	0.228AsnCys: 0.228 ± 0.013	1.482AsnAsp: 1.482 ± 0.034	1.32AsnGlu: 1.32 ± 0.028	0.932AsnPhe: 0.932 ± 0.026	2.359AsnGly: 2.359 ± 0.039	0.503AsnHis: 0.503 ± 0.017	1.337AsnIle: 1.337 ± 0.03	0.632AsnLys: 0.632 ± 0.023	2.427AsnLeu: 2.427 ± 0.037	0.584AsnMet: 0.584 ± 0.022	0.621AsnAsn: 0.621 ± 0.023	1.772AsnPro: 1.772 ± 0.037	0.642AsnGln: 0.642 ± 0.02	1.705AsnArg: 1.705 ± 0.036	1.232AsnSer: 1.232 ± 0.029	1.133AsnThr: 1.133 ± 0.027	1.95AsnVal: 1.95 ± 0.035	0.399AsnTrp: 0.399 ± 0.016	0.603AsnTyr: 0.603 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.091ProAla: 6.091 ± 0.073	0.304ProCys: 0.304 ± 0.014	3.855ProAsp: 3.855 ± 0.054	3.786ProGlu: 3.786 ± 0.056	2.03ProPhe: 2.03 ± 0.037	4.35ProGly: 4.35 ± 0.056	1.067ProHis: 1.067 ± 0.024	2.459ProIle: 2.459 ± 0.04	1.792ProLys: 1.792 ± 0.039	4.697ProLeu: 4.697 ± 0.061	1.297ProMet: 1.297 ± 0.029	1.29ProAsn: 1.29 ± 0.03	2.471ProPro: 2.471 ± 0.049	1.416ProGln: 1.416 ± 0.032	2.746ProArg: 2.746 ± 0.039	2.842ProSer: 2.842 ± 0.044	2.531ProThr: 2.531 ± 0.045	4.36ProVal: 4.36 ± 0.053	0.612ProTrp: 0.612 ± 0.02	1.224ProTyr: 1.224 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.479GlnAla: 3.479 ± 0.054	0.193GlnCys: 0.193 ± 0.013	1.362GlnAsp: 1.362 ± 0.032	1.434GlnGlu: 1.434 ± 0.031	1.033GlnPhe: 1.033 ± 0.024	2.027GlnGly: 2.027 ± 0.036	0.541GlnHis: 0.541 ± 0.019	1.748GlnIle: 1.748 ± 0.034	1.021GlnLys: 1.021 ± 0.029	2.587GlnLeu: 2.587 ± 0.044	0.842GlnMet: 0.842 ± 0.023	0.808GlnAsn: 0.808 ± 0.024	1.528GlnPro: 1.528 ± 0.036	1.034GlnGln: 1.034 ± 0.03	2.126GlnArg: 2.126 ± 0.04	1.748GlnSer: 1.748 ± 0.038	1.67GlnThr: 1.67 ± 0.031	2.004GlnVal: 2.004 ± 0.036	0.302GlnTrp: 0.302 ± 0.014	0.521GlnTyr: 0.521 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.028ArgAla: 7.028 ± 0.075	0.502ArgCys: 0.502 ± 0.016	3.756ArgAsp: 3.756 ± 0.051	3.997ArgGlu: 3.997 ± 0.061	2.897ArgPhe: 2.897 ± 0.042	4.571ArgGly: 4.571 ± 0.059	1.777ArgHis: 1.777 ± 0.037	4.147ArgIle: 4.147 ± 0.05	2.251ArgLys: 2.251 ± 0.037	8.141ArgLeu: 8.141 ± 0.075	1.882ArgMet: 1.882 ± 0.03	1.729ArgAsn: 1.729 ± 0.031	3.523ArgPro: 3.523 ± 0.048	2.641ArgGln: 2.641 ± 0.043	5.64ArgArg: 5.64 ± 0.08	3.747ArgSer: 3.747 ± 0.052	3.397ArgThr: 3.397 ± 0.048	4.409ArgVal: 4.409 ± 0.059	0.874ArgTrp: 0.874 ± 0.026	1.549ArgTyr: 1.549 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.368SerAla: 6.368 ± 0.072	0.42SerCys: 0.42 ± 0.016	3.232SerAsp: 3.232 ± 0.045	3.048SerGlu: 3.048 ± 0.045	2.292SerPhe: 2.292 ± 0.04	5.758SerGly: 5.758 ± 0.063	1.086SerHis: 1.086 ± 0.024	3.025SerIle: 3.025 ± 0.044	1.589SerLys: 1.589 ± 0.031	5.787SerLeu: 5.787 ± 0.075	1.45SerMet: 1.45 ± 0.029	1.339SerAsn: 1.339 ± 0.031	2.922SerPro: 2.922 ± 0.043	1.603SerGln: 1.603 ± 0.035	3.845SerArg: 3.845 ± 0.047	3.23SerSer: 3.23 ± 0.061	2.685SerThr: 2.685 ± 0.049	4.195SerVal: 4.195 ± 0.053	0.697SerTrp: 0.697 ± 0.023	1.232SerTyr: 1.232 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.19ThrAla: 6.19 ± 0.076	0.442ThrCys: 0.442 ± 0.018	2.962ThrAsp: 2.962 ± 0.044	2.675ThrGlu: 2.675 ± 0.044	2.088ThrPhe: 2.088 ± 0.035	5.038ThrGly: 5.038 ± 0.069	1.022ThrHis: 1.022 ± 0.025	3.161ThrIle: 3.161 ± 0.042	1.513ThrLys: 1.513 ± 0.031	5.75ThrLeu: 5.75 ± 0.065	1.334ThrMet: 1.334 ± 0.032	1.293ThrAsn: 1.293 ± 0.03	3.139ThrPro: 3.139 ± 0.05	1.267ThrGln: 1.267 ± 0.026	3.241ThrArg: 3.241 ± 0.049	3.154ThrSer: 3.154 ± 0.049	2.96ThrThr: 2.96 ± 0.047	4.541ThrVal: 4.541 ± 0.052	0.651ThrTrp: 0.651 ± 0.023	1.242ThrTyr: 1.242 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.34ValAla: 9.34 ± 0.096	0.661ValCys: 0.661 ± 0.017	4.562ValAsp: 4.562 ± 0.063	4.646ValGlu: 4.646 ± 0.061	3.003ValPhe: 3.003 ± 0.05	5.935ValGly: 5.935 ± 0.067	1.414ValHis: 1.414 ± 0.033	4.18ValIle: 4.18 ± 0.052	2.398ValLys: 2.398 ± 0.046	7.472ValLeu: 7.472 ± 0.085	1.986ValMet: 1.986 ± 0.031	1.925ValAsn: 1.925 ± 0.036	3.822ValPro: 3.822 ± 0.06	1.897ValGln: 1.897 ± 0.036	4.838ValArg: 4.838 ± 0.061	4.493ValSer: 4.493 ± 0.057	4.717ValThr: 4.717 ± 0.056	6.21ValVal: 6.21 ± 0.073	0.887ValTrp: 0.887 ± 0.028	1.557ValTyr: 1.557 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.131TrpAla: 1.131 ± 0.028	0.146TrpCys: 0.146 ± 0.009	0.581TrpAsp: 0.581 ± 0.02	0.514TrpGlu: 0.514 ± 0.019	0.517TrpPhe: 0.517 ± 0.015	0.819TrpGly: 0.819 ± 0.027	0.315TrpHis: 0.315 ± 0.013	0.681TrpIle: 0.681 ± 0.023	0.464TrpLys: 0.464 ± 0.016	1.501TrpLeu: 1.501 ± 0.031	0.342TrpMet: 0.342 ± 0.016	0.412TrpAsn: 0.412 ± 0.017	0.674TrpPro: 0.674 ± 0.022	0.523TrpGln: 0.523 ± 0.018	1.015TrpArg: 1.015 ± 0.027	0.81TrpSer: 0.81 ± 0.025	0.79TrpThr: 0.79 ± 0.022	0.734TrpVal: 0.734 ± 0.022	0.224TrpTrp: 0.224 ± 0.012	0.265TrpTyr: 0.265 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.321TyrAla: 2.321 ± 0.035	0.258TyrCys: 0.258 ± 0.011	1.491TyrAsp: 1.491 ± 0.036	1.201TyrGlu: 1.201 ± 0.032	0.91TyrPhe: 0.91 ± 0.024	2.085TyrGly: 2.085 ± 0.04	0.457TyrHis: 0.457 ± 0.019	0.862TyrIle: 0.862 ± 0.025	0.618TyrLys: 0.618 ± 0.023	2.247TyrLeu: 2.247 ± 0.038	0.444TyrMet: 0.444 ± 0.017	0.536TyrAsn: 0.536 ± 0.02	1.071TyrPro: 1.071 ± 0.028	0.649TyrGln: 0.649 ± 0.022	1.631TyrArg: 1.631 ± 0.035	1.137TyrSer: 1.137 ± 0.028	0.96TyrThr: 0.96 ± 0.025	1.723TyrVal: 1.723 ± 0.036	0.31TyrTrp: 0.31 ± 0.014	0.566TyrTyr: 0.566 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4966 proteins (1563237 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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