Amino acid dipepetide frequency for Acidisarcina polymorpha

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.006AlaAla: 13.006 ± 0.119	0.923AlaCys: 0.923 ± 0.024	5.188AlaAsp: 5.188 ± 0.053	6.257AlaGlu: 6.257 ± 0.069	3.821AlaPhe: 3.821 ± 0.049	8.63AlaGly: 8.63 ± 0.087	2.145AlaHis: 2.145 ± 0.033	5.777AlaIle: 5.777 ± 0.058	4.068AlaLys: 4.068 ± 0.048	10.616AlaLeu: 10.616 ± 0.085	2.506AlaMet: 2.506 ± 0.041	3.58AlaAsn: 3.58 ± 0.045	4.823AlaPro: 4.823 ± 0.057	4.06AlaGln: 4.06 ± 0.054	5.861AlaArg: 5.861 ± 0.072	7.211AlaSer: 7.211 ± 0.067	6.062AlaThr: 6.062 ± 0.075	7.615AlaVal: 7.615 ± 0.069	1.31AlaTrp: 1.31 ± 0.026	2.689AlaTyr: 2.689 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.869CysAla: 0.869 ± 0.021	0.149CysCys: 0.149 ± 0.009	0.454CysAsp: 0.454 ± 0.016	0.439CysGlu: 0.439 ± 0.015	0.399CysPhe: 0.399 ± 0.015	0.887CysGly: 0.887 ± 0.023	0.23CysHis: 0.23 ± 0.014	0.459CysIle: 0.459 ± 0.014	0.259CysLys: 0.259 ± 0.011	0.862CysLeu: 0.862 ± 0.024	0.185CysMet: 0.185 ± 0.009	0.248CysAsn: 0.248 ± 0.012	0.448CysPro: 0.448 ± 0.016	0.235CysGln: 0.235 ± 0.012	0.529CysArg: 0.529 ± 0.016	0.646CysSer: 0.646 ± 0.019	0.488CysThr: 0.488 ± 0.017	0.598CysVal: 0.598 ± 0.019	0.124CysTrp: 0.124 ± 0.008	0.255CysTyr: 0.255 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.311AspAla: 5.311 ± 0.044	0.443AspCys: 0.443 ± 0.015	2.402AspAsp: 2.402 ± 0.037	2.915AspGlu: 2.915 ± 0.046	2.272AspPhe: 2.272 ± 0.037	4.593AspGly: 4.593 ± 0.064	1.215AspHis: 1.215 ± 0.027	2.501AspIle: 2.501 ± 0.036	1.669AspLys: 1.669 ± 0.031	5.422AspLeu: 5.422 ± 0.048	0.877AspMet: 0.877 ± 0.021	1.425AspAsn: 1.425 ± 0.027	3.407AspPro: 3.407 ± 0.047	1.983AspGln: 1.983 ± 0.035	3.322AspArg: 3.322 ± 0.047	3.013AspSer: 3.013 ± 0.041	2.437AspThr: 2.437 ± 0.034	3.583AspVal: 3.583 ± 0.046	0.866AspTrp: 0.866 ± 0.023	1.623AspTyr: 1.623 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.951GluAla: 5.951 ± 0.06	0.408GluCys: 0.408 ± 0.015	2.7GluAsp: 2.7 ± 0.042	3.381GluGlu: 3.381 ± 0.053	2.085GluPhe: 2.085 ± 0.032	3.684GluGly: 3.684 ± 0.048	1.323GluHis: 1.323 ± 0.029	3.231GluIle: 3.231 ± 0.043	2.318GluLys: 2.318 ± 0.036	5.514GluLeu: 5.514 ± 0.061	1.402GluMet: 1.402 ± 0.031	1.733GluAsn: 1.733 ± 0.032	2.26GluPro: 2.26 ± 0.036	2.485GluGln: 2.485 ± 0.034	4.117GluArg: 4.117 ± 0.059	3.323GluSer: 3.323 ± 0.047	3.059GluThr: 3.059 ± 0.043	3.88GluVal: 3.88 ± 0.051	0.761GluTrp: 0.761 ± 0.021	1.425GluTyr: 1.425 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.207PheAla: 4.207 ± 0.048	0.399PheCys: 0.399 ± 0.015	2.47PheAsp: 2.47 ± 0.042	2.06PheGlu: 2.06 ± 0.036	1.693PhePhe: 1.693 ± 0.032	3.564PheGly: 3.564 ± 0.048	1.061PheHis: 1.061 ± 0.023	1.546PheIle: 1.546 ± 0.03	1.095PheLys: 1.095 ± 0.025	3.891PheLeu: 3.891 ± 0.051	0.67PheMet: 0.67 ± 0.018	1.442PheAsn: 1.442 ± 0.032	1.947PhePro: 1.947 ± 0.033	1.365PheGln: 1.365 ± 0.024	2.365PheArg: 2.365 ± 0.03	2.941PheSer: 2.941 ± 0.044	2.412PheThr: 2.412 ± 0.044	2.783PheVal: 2.783 ± 0.039	0.546PheTrp: 0.546 ± 0.017	1.193PheTyr: 1.193 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	7.578GlyAla: 7.578 ± 0.076	0.818GlyCys: 0.818 ± 0.022	3.969GlyAsp: 3.969 ± 0.051	4.069GlyGlu: 4.069 ± 0.052	3.472GlyPhe: 3.472 ± 0.051	6.6GlyGly: 6.6 ± 0.089	1.863GlyHis: 1.863 ± 0.029	4.624GlyIle: 4.624 ± 0.051	3.621GlyLys: 3.621 ± 0.053	7.567GlyLeu: 7.567 ± 0.072	1.905GlyMet: 1.905 ± 0.032	2.812GlyAsn: 2.812 ± 0.052	3.278GlyPro: 3.278 ± 0.046	2.936GlyGln: 2.936 ± 0.041	4.71GlyArg: 4.71 ± 0.056	5.823GlySer: 5.823 ± 0.066	5.081GlyThr: 5.081 ± 0.07	5.743GlyVal: 5.743 ± 0.061	1.318GlyTrp: 1.318 ± 0.031	2.509GlyTyr: 2.509 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.188HisAla: 2.188 ± 0.037	0.233HisCys: 0.233 ± 0.012	1.169HisAsp: 1.169 ± 0.023	1.177HisGlu: 1.177 ± 0.021	1.088HisPhe: 1.088 ± 0.02	1.913HisGly: 1.913 ± 0.031	0.6HisHis: 0.6 ± 0.018	1.083HisIle: 1.083 ± 0.024	0.612HisLys: 0.612 ± 0.018	2.4HisLeu: 2.4 ± 0.034	0.437HisMet: 0.437 ± 0.016	0.664HisAsn: 0.664 ± 0.019	1.495HisPro: 1.495 ± 0.027	0.786HisGln: 0.786 ± 0.02	1.444HisArg: 1.444 ± 0.029	1.436HisSer: 1.436 ± 0.026	1.121HisThr: 1.121 ± 0.026	1.495HisVal: 1.495 ± 0.03	0.395HisTrp: 0.395 ± 0.015	0.7HisTyr: 0.7 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.305IleAla: 6.305 ± 0.054	0.502IleCys: 0.502 ± 0.016	3.168IleAsp: 3.168 ± 0.036	3.227IleGlu: 3.227 ± 0.05	1.934IlePhe: 1.934 ± 0.03	4.36IleGly: 4.36 ± 0.053	1.179IleHis: 1.179 ± 0.021	1.89IleIle: 1.89 ± 0.035	1.484IleLys: 1.484 ± 0.031	4.712IleLeu: 4.712 ± 0.055	0.767IleMet: 0.767 ± 0.021	1.593IleAsn: 1.593 ± 0.03	2.848IlePro: 2.848 ± 0.029	1.833IleGln: 1.833 ± 0.034	3.117IleArg: 3.117 ± 0.042	3.462IleSer: 3.462 ± 0.038	2.975IleThr: 2.975 ± 0.042	3.867IleVal: 3.867 ± 0.05	0.625IleTrp: 0.625 ± 0.017	1.513IleTyr: 1.513 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.729LysAla: 3.729 ± 0.055	0.204LysCys: 0.204 ± 0.009	1.833LysAsp: 1.833 ± 0.036	1.927LysGlu: 1.927 ± 0.033	1.176LysPhe: 1.176 ± 0.025	2.365LysGly: 2.365 ± 0.037	0.82LysHis: 0.82 ± 0.021	1.955LysIle: 1.955 ± 0.034	1.554LysLys: 1.554 ± 0.038	3.859LysLeu: 3.859 ± 0.044	0.904LysMet: 0.904 ± 0.022	1.217LysAsn: 1.217 ± 0.028	2.144LysPro: 2.144 ± 0.04	1.607LysGln: 1.607 ± 0.032	2.328LysArg: 2.328 ± 0.034	2.283LysSer: 2.283 ± 0.04	2.332LysThr: 2.332 ± 0.035	2.551LysVal: 2.551 ± 0.038	0.415LysTrp: 0.415 ± 0.014	0.994LysTyr: 0.994 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.11LeuAla: 11.11 ± 0.09	0.924LeuCys: 0.924 ± 0.022	5.391LeuAsp: 5.391 ± 0.057	5.439LeuGlu: 5.439 ± 0.06	3.742LeuPhe: 3.742 ± 0.051	7.645LeuGly: 7.645 ± 0.072	2.338LeuHis: 2.338 ± 0.037	4.78LeuIle: 4.78 ± 0.05	3.815LeuLys: 3.815 ± 0.05	10.458LeuLeu: 10.458 ± 0.121	1.932LeuMet: 1.932 ± 0.038	3.516LeuAsn: 3.516 ± 0.047	5.676LeuPro: 5.676 ± 0.049	3.714LeuGln: 3.714 ± 0.05	6.901LeuArg: 6.901 ± 0.072	6.913LeuSer: 6.913 ± 0.066	5.927LeuThr: 5.927 ± 0.058	6.595LeuVal: 6.595 ± 0.067	1.24LeuTrp: 1.24 ± 0.031	2.483LeuTyr: 2.483 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.314MetAla: 2.314 ± 0.043	0.142MetCys: 0.142 ± 0.008	0.959MetAsp: 0.959 ± 0.021	1.08MetGlu: 1.08 ± 0.024	0.674MetPhe: 0.674 ± 0.017	1.443MetGly: 1.443 ± 0.033	0.478MetHis: 0.478 ± 0.016	1.07MetIle: 1.07 ± 0.022	1.045MetLys: 1.045 ± 0.024	2.287MetLeu: 2.287 ± 0.039	0.471MetMet: 0.471 ± 0.016	0.834MetAsn: 0.834 ± 0.02	1.259MetPro: 1.259 ± 0.026	0.896MetGln: 0.896 ± 0.02	1.522MetArg: 1.522 ± 0.029	1.436MetSer: 1.436 ± 0.025	1.378MetThr: 1.378 ± 0.028	1.419MetVal: 1.419 ± 0.029	0.232MetTrp: 0.232 ± 0.012	0.425MetTyr: 0.425 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.458AsnAla: 3.458 ± 0.045	0.325AsnCys: 0.325 ± 0.015	1.689AsnAsp: 1.689 ± 0.032	1.554AsnGlu: 1.554 ± 0.029	1.425AsnPhe: 1.425 ± 0.031	3.271AsnGly: 3.271 ± 0.061	0.757AsnHis: 0.757 ± 0.02	1.639AsnIle: 1.639 ± 0.03	0.93AsnLys: 0.93 ± 0.022	3.408AsnLeu: 3.408 ± 0.042	0.607AsnMet: 0.607 ± 0.017	1.247AsnAsn: 1.247 ± 0.034	2.406AsnPro: 2.406 ± 0.039	1.401AsnGln: 1.401 ± 0.03	1.926AsnArg: 1.926 ± 0.035	2.277AsnSer: 2.277 ± 0.041	1.864AsnThr: 1.864 ± 0.039	2.379AsnVal: 2.379 ± 0.039	0.516AsnTrp: 0.516 ± 0.016	1.128AsnTyr: 1.128 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.893ProAla: 5.893 ± 0.064	0.35ProCys: 0.35 ± 0.016	3.048ProAsp: 3.048 ± 0.043	3.539ProGlu: 3.539 ± 0.046	1.999ProPhe: 1.999 ± 0.037	4.744ProGly: 4.744 ± 0.056	1.081ProHis: 1.081 ± 0.021	2.525ProIle: 2.525 ± 0.038	1.875ProLys: 1.875 ± 0.034	4.857ProLeu: 4.857 ± 0.057	1.1ProMet: 1.1 ± 0.022	1.961ProAsn: 1.961 ± 0.034	2.684ProPro: 2.684 ± 0.051	1.999ProGln: 1.999 ± 0.029	2.615ProArg: 2.615 ± 0.043	3.746ProSer: 3.746 ± 0.05	3.025ProThr: 3.025 ± 0.048	3.971ProVal: 3.971 ± 0.042	0.691ProTrp: 0.691 ± 0.019	1.339ProTyr: 1.339 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.076GlnAla: 4.076 ± 0.053	0.264GlnCys: 0.264 ± 0.012	1.621GlnAsp: 1.621 ± 0.029	1.898GlnGlu: 1.898 ± 0.032	1.462GlnPhe: 1.462 ± 0.027	2.646GlnGly: 2.646 ± 0.036	0.874GlnHis: 0.874 ± 0.02	2.272GlnIle: 2.272 ± 0.038	1.375GlnLys: 1.375 ± 0.027	3.822GlnLeu: 3.822 ± 0.046	1.009GlnMet: 1.009 ± 0.024	1.333GlnAsn: 1.333 ± 0.032	2.173GlnPro: 2.173 ± 0.037	2.067GlnGln: 2.067 ± 0.044	2.629GlnArg: 2.629 ± 0.037	2.603GlnSer: 2.603 ± 0.042	2.305GlnThr: 2.305 ± 0.033	2.723GlnVal: 2.723 ± 0.037	0.515GlnTrp: 0.515 ± 0.016	1.027GlnTyr: 1.027 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.613ArgAla: 5.613 ± 0.066	0.521ArgCys: 0.521 ± 0.016	3.167ArgAsp: 3.167 ± 0.041	3.895ArgGlu: 3.895 ± 0.051	2.664ArgPhe: 2.664 ± 0.036	3.987ArgGly: 3.987 ± 0.044	1.432ArgHis: 1.432 ± 0.03	3.599ArgIle: 3.599 ± 0.048	2.451ArgLys: 2.451 ± 0.04	6.468ArgLeu: 6.468 ± 0.072	1.669ArgMet: 1.669 ± 0.03	2.159ArgAsn: 2.159 ± 0.032	2.873ArgPro: 2.873 ± 0.043	2.547ArgGln: 2.547 ± 0.041	4.344ArgArg: 4.344 ± 0.06	4.149ArgSer: 4.149 ± 0.048	3.238ArgThr: 3.238 ± 0.038	4.338ArgVal: 4.338 ± 0.05	1.001ArgTrp: 1.001 ± 0.027	1.881ArgTyr: 1.881 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.941SerAla: 6.941 ± 0.071	0.603SerCys: 0.603 ± 0.016	3.229SerAsp: 3.229 ± 0.043	3.329SerGlu: 3.329 ± 0.04	2.841SerPhe: 2.841 ± 0.041	6.371SerGly: 6.371 ± 0.08	1.418SerHis: 1.418 ± 0.026	3.593SerIle: 3.593 ± 0.045	2.34SerLys: 2.34 ± 0.039	6.828SerLeu: 6.828 ± 0.062	1.467SerMet: 1.467 ± 0.031	2.266SerAsn: 2.266 ± 0.039	3.791SerPro: 3.791 ± 0.048	2.506SerGln: 2.506 ± 0.039	3.906SerArg: 3.906 ± 0.053	5.305SerSer: 5.305 ± 0.068	4.085SerThr: 4.085 ± 0.056	4.643SerVal: 4.643 ± 0.053	0.927SerTrp: 0.927 ± 0.021	1.919SerTyr: 1.919 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.349ThrAla: 6.349 ± 0.077	0.475ThrCys: 0.475 ± 0.02	2.728ThrAsp: 2.728 ± 0.035	2.767ThrGlu: 2.767 ± 0.039	2.33ThrPhe: 2.33 ± 0.032	5.283ThrGly: 5.283 ± 0.068	1.183ThrHis: 1.183 ± 0.023	3.256ThrIle: 3.256 ± 0.044	1.776ThrLys: 1.776 ± 0.032	6.034ThrLeu: 6.034 ± 0.061	1.145ThrMet: 1.145 ± 0.025	2.042ThrAsn: 2.042 ± 0.049	3.69ThrPro: 3.69 ± 0.052	2.014ThrGln: 2.014 ± 0.036	2.948ThrArg: 2.948 ± 0.038	3.954ThrSer: 3.954 ± 0.054	3.591ThrThr: 3.591 ± 0.056	4.376ThrVal: 4.376 ± 0.049	0.753ThrTrp: 0.753 ± 0.019	1.684ThrTyr: 1.684 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.508ValAla: 7.508 ± 0.061	0.674ValCys: 0.674 ± 0.018	3.875ValAsp: 3.875 ± 0.047	4.048ValGlu: 4.048 ± 0.057	2.739ValPhe: 2.739 ± 0.037	5.028ValGly: 5.028 ± 0.059	1.465ValHis: 1.465 ± 0.029	3.602ValIle: 3.602 ± 0.044	2.446ValLys: 2.446 ± 0.033	7.178ValLeu: 7.178 ± 0.068	1.411ValMet: 1.411 ± 0.028	2.529ValAsn: 2.529 ± 0.039	3.751ValPro: 3.751 ± 0.046	2.506ValGln: 2.506 ± 0.037	4.456ValArg: 4.456 ± 0.059	4.742ValSer: 4.742 ± 0.051	4.563ValThr: 4.563 ± 0.061	5.365ValVal: 5.365 ± 0.066	0.87ValTrp: 0.87 ± 0.022	1.872ValTyr: 1.872 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.067TrpAla: 1.067 ± 0.024	0.129TrpCys: 0.129 ± 0.008	0.645TrpAsp: 0.645 ± 0.018	0.586TrpGlu: 0.586 ± 0.018	0.563TrpPhe: 0.563 ± 0.017	0.88TrpGly: 0.88 ± 0.022	0.368TrpHis: 0.368 ± 0.015	0.823TrpIle: 0.823 ± 0.025	0.627TrpLys: 0.627 ± 0.018	1.508TrpLeu: 1.508 ± 0.032	0.417TrpMet: 0.417 ± 0.017	0.618TrpAsn: 0.618 ± 0.018	0.611TrpPro: 0.611 ± 0.02	0.665TrpGln: 0.665 ± 0.021	0.988TrpArg: 0.988 ± 0.023	1.046TrpSer: 1.046 ± 0.024	0.787TrpThr: 0.787 ± 0.02	0.822TrpVal: 0.822 ± 0.02	0.234TrpTrp: 0.234 ± 0.011	0.38TrpTyr: 0.38 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.675TyrAla: 2.675 ± 0.039	0.279TyrCys: 0.279 ± 0.01	1.575TyrAsp: 1.575 ± 0.033	1.453TyrGlu: 1.453 ± 0.027	1.271TyrPhe: 1.271 ± 0.025	2.399TyrGly: 2.399 ± 0.038	0.608TyrHis: 0.608 ± 0.016	1.14TyrIle: 1.14 ± 0.023	0.837TyrLys: 0.837 ± 0.023	2.847TyrLeu: 2.847 ± 0.036	0.483TyrMet: 0.483 ± 0.015	0.989TyrAsn: 0.989 ± 0.028	1.477TyrPro: 1.477 ± 0.026	1.089TyrGln: 1.089 ± 0.026	1.967TyrArg: 1.967 ± 0.031	2.0TyrSer: 2.0 ± 0.037	1.649TyrThr: 1.649 ± 0.034	1.88TyrVal: 1.88 ± 0.033	0.426TyrTrp: 0.426 ± 0.014	0.87TyrTyr: 0.87 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7005 proteins (2052594 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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