Amino acid dipepetide frequency for Alicyclobacillus acidoterrestris (strain ATCC 49025 / DSM 3922 / CIP 106132 / NCIMB 13137 / GD3B)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.185AlaAla: 9.185 ± 0.111	0.919AlaCys: 0.919 ± 0.031	4.684AlaAsp: 4.684 ± 0.067	5.194AlaGlu: 5.194 ± 0.073	3.663AlaPhe: 3.663 ± 0.067	6.915AlaGly: 6.915 ± 0.084	2.155AlaHis: 2.155 ± 0.045	5.891AlaIle: 5.891 ± 0.075	4.415AlaLys: 4.415 ± 0.059	9.813AlaLeu: 9.813 ± 0.124	2.894AlaMet: 2.894 ± 0.057	3.199AlaAsn: 3.199 ± 0.055	3.159AlaPro: 3.159 ± 0.058	3.935AlaGln: 3.935 ± 0.067	5.188AlaArg: 5.188 ± 0.085	5.551AlaSer: 5.551 ± 0.063	5.154AlaThr: 5.154 ± 0.064	7.693AlaVal: 7.693 ± 0.092	1.198AlaTrp: 1.198 ± 0.036	2.728AlaTyr: 2.728 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.828CysAla: 0.828 ± 0.029	0.109CysCys: 0.109 ± 0.011	0.546CysAsp: 0.546 ± 0.024	0.514CysGlu: 0.514 ± 0.024	0.351CysPhe: 0.351 ± 0.018	0.927CysGly: 0.927 ± 0.028	0.24CysHis: 0.24 ± 0.015	0.567CysIle: 0.567 ± 0.026	0.277CysLys: 0.277 ± 0.015	0.852CysLeu: 0.852 ± 0.03	0.228CysMet: 0.228 ± 0.015	0.279CysAsn: 0.279 ± 0.02	0.443CysPro: 0.443 ± 0.02	0.288CysGln: 0.288 ± 0.018	0.471CysArg: 0.471 ± 0.023	0.534CysSer: 0.534 ± 0.023	0.478CysThr: 0.478 ± 0.019	0.758CysVal: 0.758 ± 0.029	0.098CysTrp: 0.098 ± 0.009	0.251CysTyr: 0.251 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.424AspAla: 5.424 ± 0.073	0.421AspCys: 0.421 ± 0.02	2.978AspAsp: 2.978 ± 0.06	4.167AspGlu: 4.167 ± 0.076	2.011AspPhe: 2.011 ± 0.042	4.157AspGly: 4.157 ± 0.061	1.049AspHis: 1.049 ± 0.031	3.538AspIle: 3.538 ± 0.057	2.444AspLys: 2.444 ± 0.047	4.636AspLeu: 4.636 ± 0.06	1.387AspMet: 1.387 ± 0.033	1.501AspAsn: 1.501 ± 0.038	2.102AspPro: 2.102 ± 0.042	1.338AspGln: 1.338 ± 0.033	2.543AspArg: 2.543 ± 0.049	2.416AspSer: 2.416 ± 0.047	2.841AspThr: 2.841 ± 0.052	5.122AspVal: 5.122 ± 0.08	0.778AspTrp: 0.778 ± 0.029	1.581AspTyr: 1.581 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.792GluAla: 5.792 ± 0.089	0.437GluCys: 0.437 ± 0.019	2.898GluAsp: 2.898 ± 0.056	4.041GluGlu: 4.041 ± 0.067	1.88GluPhe: 1.88 ± 0.041	3.484GluGly: 3.484 ± 0.063	1.574GluHis: 1.574 ± 0.033	3.721GluIle: 3.721 ± 0.071	2.521GluLys: 2.521 ± 0.057	5.932GluLeu: 5.932 ± 0.08	1.796GluMet: 1.796 ± 0.042	1.987GluAsn: 1.987 ± 0.05	2.023GluPro: 2.023 ± 0.047	3.35GluGln: 3.35 ± 0.052	4.571GluArg: 4.571 ± 0.073	3.209GluSer: 3.209 ± 0.056	3.304GluThr: 3.304 ± 0.053	4.558GluVal: 4.558 ± 0.069	0.752GluTrp: 0.752 ± 0.025	1.569GluTyr: 1.569 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.74PheAla: 3.74 ± 0.065	0.416PheCys: 0.416 ± 0.021	2.267PheAsp: 2.267 ± 0.042	2.112PheGlu: 2.112 ± 0.045	1.524PhePhe: 1.524 ± 0.039	3.573PheGly: 3.573 ± 0.061	1.024PheHis: 1.024 ± 0.031	2.306PheIle: 2.306 ± 0.045	1.043PheLys: 1.043 ± 0.033	3.607PheLeu: 3.607 ± 0.06	0.906PheMet: 0.906 ± 0.031	1.078PheAsn: 1.078 ± 0.032	1.594PhePro: 1.594 ± 0.04	1.407PheGln: 1.407 ± 0.036	2.039PheArg: 2.039 ± 0.043	2.478PheSer: 2.478 ± 0.052	2.306PheThr: 2.306 ± 0.05	3.544PheVal: 3.544 ± 0.053	0.489PheTrp: 0.489 ± 0.024	1.221PheTyr: 1.221 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.67GlyAla: 6.67 ± 0.089	0.799GlyCys: 0.799 ± 0.025	3.595GlyAsp: 3.595 ± 0.056	3.987GlyGlu: 3.987 ± 0.057	3.252GlyPhe: 3.252 ± 0.055	5.6GlyGly: 5.6 ± 0.092	1.83GlyHis: 1.83 ± 0.047	5.363GlyIle: 5.363 ± 0.075	3.381GlyLys: 3.381 ± 0.061	7.272GlyLeu: 7.272 ± 0.09	2.216GlyMet: 2.216 ± 0.043	2.371GlyAsn: 2.371 ± 0.048	2.339GlyPro: 2.339 ± 0.05	3.084GlyGln: 3.084 ± 0.055	4.216GlyArg: 4.216 ± 0.064	4.182GlySer: 4.182 ± 0.077	4.689GlyThr: 4.689 ± 0.072	6.534GlyVal: 6.534 ± 0.072	1.147GlyTrp: 1.147 ± 0.031	2.768GlyTyr: 2.768 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.213HisAla: 2.213 ± 0.043	0.245HisCys: 0.245 ± 0.016	1.215HisAsp: 1.215 ± 0.03	1.414HisGlu: 1.414 ± 0.036	0.937HisPhe: 0.937 ± 0.028	1.943HisGly: 1.943 ± 0.045	0.854HisHis: 0.854 ± 0.034	1.441HisIle: 1.441 ± 0.035	0.821HisLys: 0.821 ± 0.027	2.491HisLeu: 2.491 ± 0.045	0.645HisMet: 0.645 ± 0.023	0.689HisAsn: 0.689 ± 0.027	1.514HisPro: 1.514 ± 0.034	1.019HisGln: 1.019 ± 0.029	1.554HisArg: 1.554 ± 0.034	1.21HisSer: 1.21 ± 0.032	1.23HisThr: 1.23 ± 0.036	2.155HisVal: 2.155 ± 0.046	0.363HisTrp: 0.363 ± 0.016	0.738HisTyr: 0.738 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.332IleAla: 6.332 ± 0.077	0.692IleCys: 0.692 ± 0.027	3.5IleAsp: 3.5 ± 0.057	3.866IleGlu: 3.866 ± 0.055	2.022IlePhe: 2.022 ± 0.041	5.351IleGly: 5.351 ± 0.084	1.592IleHis: 1.592 ± 0.04	3.063IleIle: 3.063 ± 0.062	1.698IleLys: 1.698 ± 0.042	5.521IleLeu: 5.521 ± 0.085	1.132IleMet: 1.132 ± 0.031	1.616IleAsn: 1.616 ± 0.037	3.088IlePro: 3.088 ± 0.053	2.557IleGln: 2.557 ± 0.052	3.954IleArg: 3.954 ± 0.066	3.641IleSer: 3.641 ± 0.061	3.186IleThr: 3.186 ± 0.058	5.438IleVal: 5.438 ± 0.065	0.677IleTrp: 0.677 ± 0.022	1.617IleTyr: 1.617 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.443LysAla: 3.443 ± 0.061	0.244LysCys: 0.244 ± 0.014	2.049LysAsp: 2.049 ± 0.044	2.443LysGlu: 2.443 ± 0.049	1.227LysPhe: 1.227 ± 0.037	2.488LysGly: 2.488 ± 0.056	1.03LysHis: 1.03 ± 0.03	2.069LysIle: 2.069 ± 0.042	1.808LysLys: 1.808 ± 0.047	3.827LysLeu: 3.827 ± 0.054	1.093LysMet: 1.093 ± 0.032	1.34LysAsn: 1.34 ± 0.04	1.923LysPro: 1.923 ± 0.046	1.936LysGln: 1.936 ± 0.046	2.952LysArg: 2.952 ± 0.058	2.542LysSer: 2.542 ± 0.051	2.429LysThr: 2.429 ± 0.044	3.045LysVal: 3.045 ± 0.057	0.581LysTrp: 0.581 ± 0.024	1.293LysTyr: 1.293 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	9.52LeuAla: 9.52 ± 0.099	1.039LeuCys: 1.039 ± 0.035	5.012LeuAsp: 5.012 ± 0.065	5.513LeuGlu: 5.513 ± 0.069	4.055LeuPhe: 4.055 ± 0.078	7.199LeuGly: 7.199 ± 0.093	2.483LeuHis: 2.483 ± 0.045	5.347LeuIle: 5.347 ± 0.077	3.663LeuLys: 3.663 ± 0.058	9.263LeuLeu: 9.263 ± 0.115	2.41LeuMet: 2.41 ± 0.046	3.278LeuAsn: 3.278 ± 0.054	4.441LeuPro: 4.441 ± 0.062	4.147LeuGln: 4.147 ± 0.064	6.025LeuArg: 6.025 ± 0.08	6.601LeuSer: 6.601 ± 0.08	5.753LeuThr: 5.753 ± 0.067	7.501LeuVal: 7.501 ± 0.097	1.183LeuTrp: 1.183 ± 0.042	2.734LeuTyr: 2.734 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.651MetAla: 2.651 ± 0.05	0.21MetCys: 0.21 ± 0.014	1.416MetAsp: 1.416 ± 0.038	1.527MetGlu: 1.527 ± 0.038	1.0MetPhe: 1.0 ± 0.029	1.91MetGly: 1.91 ± 0.042	0.569MetHis: 0.569 ± 0.023	1.542MetIle: 1.542 ± 0.033	1.266MetLys: 1.266 ± 0.03	2.45MetLeu: 2.45 ± 0.051	0.828MetMet: 0.828 ± 0.024	1.122MetAsn: 1.122 ± 0.036	1.112MetPro: 1.112 ± 0.031	1.15MetGln: 1.15 ± 0.032	1.548MetArg: 1.548 ± 0.037	1.835MetSer: 1.835 ± 0.047	1.72MetThr: 1.72 ± 0.041	2.036MetVal: 2.036 ± 0.044	0.304MetTrp: 0.304 ± 0.015	0.745MetTyr: 0.745 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.948AsnAla: 2.948 ± 0.052	0.237AsnCys: 0.237 ± 0.016	1.517AsnAsp: 1.517 ± 0.039	1.818AsnGlu: 1.818 ± 0.045	1.115AsnPhe: 1.115 ± 0.037	2.693AsnGly: 2.693 ± 0.057	0.897AsnHis: 0.897 ± 0.029	1.919AsnIle: 1.919 ± 0.047	1.14AsnLys: 1.14 ± 0.038	3.07AsnLeu: 3.07 ± 0.057	0.818AsnMet: 0.818 ± 0.024	1.042AsnAsn: 1.042 ± 0.042	2.067AsnPro: 2.067 ± 0.049	1.68AsnGln: 1.68 ± 0.044	2.142AsnArg: 2.142 ± 0.039	1.647AsnSer: 1.647 ± 0.046	1.862AsnThr: 1.862 ± 0.05	2.727AsnVal: 2.727 ± 0.052	0.524AsnTrp: 0.524 ± 0.024	0.922AsnTyr: 0.922 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	3.431ProAla: 3.431 ± 0.066	0.297ProCys: 0.297 ± 0.017	2.624ProAsp: 2.624 ± 0.051	2.775ProGlu: 2.775 ± 0.052	1.915ProPhe: 1.915 ± 0.042	3.272ProGly: 3.272 ± 0.055	1.011ProHis: 1.011 ± 0.034	2.578ProIle: 2.578 ± 0.047	1.766ProLys: 1.766 ± 0.044	3.847ProLeu: 3.847 ± 0.059	1.102ProMet: 1.102 ± 0.033	1.666ProAsn: 1.666 ± 0.044	1.395ProPro: 1.395 ± 0.04	1.549ProGln: 1.549 ± 0.034	1.867ProArg: 1.867 ± 0.044	2.873ProSer: 2.873 ± 0.05	2.704ProThr: 2.704 ± 0.054	3.802ProVal: 3.802 ± 0.06	0.583ProTrp: 0.583 ± 0.021	1.477ProTyr: 1.477 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.216GlnAla: 4.216 ± 0.074	0.281GlnCys: 0.281 ± 0.017	1.746GlnAsp: 1.746 ± 0.038	2.255GlnGlu: 2.255 ± 0.051	1.663GlnPhe: 1.663 ± 0.039	2.638GlnGly: 2.638 ± 0.046	1.002GlnHis: 1.002 ± 0.033	2.499GlnIle: 2.499 ± 0.052	1.742GlnLys: 1.742 ± 0.037	4.373GlnLeu: 4.373 ± 0.074	1.34GlnMet: 1.34 ± 0.038	1.412GlnAsn: 1.412 ± 0.043	1.794GlnPro: 1.794 ± 0.04	2.233GlnGln: 2.233 ± 0.053	2.5GlnArg: 2.5 ± 0.055	2.662GlnSer: 2.662 ± 0.054	2.522GlnThr: 2.522 ± 0.051	3.45GlnVal: 3.45 ± 0.058	0.598GlnTrp: 0.598 ± 0.022	1.31GlnTyr: 1.31 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	5.148ArgAla: 5.148 ± 0.077	0.494ArgCys: 0.494 ± 0.022	3.249ArgAsp: 3.249 ± 0.062	4.034ArgGlu: 4.034 ± 0.078	2.378ArgPhe: 2.378 ± 0.053	3.773ArgGly: 3.773 ± 0.065	1.543ArgHis: 1.543 ± 0.039	3.72ArgIle: 3.72 ± 0.053	2.831ArgLys: 2.831 ± 0.056	5.997ArgLeu: 5.997 ± 0.095	1.77ArgMet: 1.77 ± 0.043	2.008ArgAsn: 2.008 ± 0.041	2.34ArgPro: 2.34 ± 0.055	2.715ArgGln: 2.715 ± 0.058	4.414ArgArg: 4.414 ± 0.072	2.862ArgSer: 2.862 ± 0.052	3.127ArgThr: 3.127 ± 0.052	4.68ArgVal: 4.68 ± 0.069	0.803ArgTrp: 0.803 ± 0.028	1.915ArgTyr: 1.915 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.41SerAla: 5.41 ± 0.079	0.438SerCys: 0.438 ± 0.022	3.154SerAsp: 3.154 ± 0.056	3.211SerGlu: 3.211 ± 0.056	2.377SerPhe: 2.377 ± 0.045	5.07SerGly: 5.07 ± 0.086	1.319SerHis: 1.319 ± 0.033	3.708SerIle: 3.708 ± 0.059	2.146SerLys: 2.146 ± 0.041	5.717SerLeu: 5.717 ± 0.072	1.721SerMet: 1.721 ± 0.04	1.973SerAsn: 1.973 ± 0.048	2.63SerPro: 2.63 ± 0.047	2.343SerGln: 2.343 ± 0.05	3.228SerArg: 3.228 ± 0.058	4.027SerSer: 4.027 ± 0.081	3.807SerThr: 3.807 ± 0.073	4.887SerVal: 4.887 ± 0.071	0.764SerTrp: 0.764 ± 0.025	1.738SerTyr: 1.738 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.295ThrAla: 5.295 ± 0.071	0.474ThrCys: 0.474 ± 0.024	2.964ThrAsp: 2.964 ± 0.056	2.935ThrGlu: 2.935 ± 0.042	2.355ThrPhe: 2.355 ± 0.039	4.816ThrGly: 4.816 ± 0.081	1.32ThrHis: 1.32 ± 0.035	3.46ThrIle: 3.46 ± 0.058	2.212ThrLys: 2.212 ± 0.042	5.705ThrLeu: 5.705 ± 0.073	1.449ThrMet: 1.449 ± 0.036	2.043ThrAsn: 2.043 ± 0.047	2.991ThrPro: 2.991 ± 0.059	2.101ThrGln: 2.101 ± 0.053	2.879ThrArg: 2.879 ± 0.05	3.793ThrSer: 3.793 ± 0.074	3.632ThrThr: 3.632 ± 0.073	5.077ThrVal: 5.077 ± 0.068	0.851ThrTrp: 0.851 ± 0.033	1.87ThrTyr: 1.87 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.67ValAla: 7.67 ± 0.086	0.861ValCys: 0.861 ± 0.028	4.665ValAsp: 4.665 ± 0.068	5.17ValGlu: 5.17 ± 0.075	3.138ValPhe: 3.138 ± 0.052	6.094ValGly: 6.094 ± 0.082	2.082ValHis: 2.082 ± 0.039	5.22ValIle: 5.22 ± 0.07	3.087ValLys: 3.087 ± 0.065	8.03ValLeu: 8.03 ± 0.083	2.063ValMet: 2.063 ± 0.044	2.808ValAsn: 2.808 ± 0.054	3.714ValPro: 3.714 ± 0.057	3.347ValGln: 3.347 ± 0.052	4.797ValArg: 4.797 ± 0.067	5.243ValSer: 5.243 ± 0.073	4.996ValThr: 4.996 ± 0.072	7.275ValVal: 7.275 ± 0.103	1.001ValTrp: 1.001 ± 0.031	2.399ValTyr: 2.399 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.93TrpAla: 0.93 ± 0.026	0.115TrpCys: 0.115 ± 0.011	0.603TrpAsp: 0.603 ± 0.022	0.553TrpGlu: 0.553 ± 0.025	0.613TrpPhe: 0.613 ± 0.025	0.852TrpGly: 0.852 ± 0.03	0.319TrpHis: 0.319 ± 0.018	0.874TrpIle: 0.874 ± 0.033	0.537TrpLys: 0.537 ± 0.026	1.73TrpLeu: 1.73 ± 0.043	0.468TrpMet: 0.468 ± 0.02	0.493TrpAsn: 0.493 ± 0.021	0.482TrpPro: 0.482 ± 0.02	0.599TrpGln: 0.599 ± 0.028	0.898TrpArg: 0.898 ± 0.032	0.891TrpSer: 0.891 ± 0.029	0.779TrpThr: 0.779 ± 0.027	0.966TrpVal: 0.966 ± 0.033	0.247TrpTrp: 0.247 ± 0.017	0.413TrpTyr: 0.413 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.687TyrAla: 2.687 ± 0.051	0.312TyrCys: 0.312 ± 0.017	1.748TyrAsp: 1.748 ± 0.039	1.871TyrGlu: 1.871 ± 0.041	1.195TyrPhe: 1.195 ± 0.033	2.542TyrGly: 2.542 ± 0.05	0.799TyrHis: 0.799 ± 0.022	1.714TyrIle: 1.714 ± 0.041	0.964TyrLys: 0.964 ± 0.032	3.036TyrLeu: 3.036 ± 0.052	0.676TyrMet: 0.676 ± 0.023	0.879TyrAsn: 0.879 ± 0.03	1.381TyrPro: 1.381 ± 0.038	1.46TyrGln: 1.46 ± 0.036	2.013TyrArg: 2.013 ± 0.045	1.471TyrSer: 1.471 ± 0.038	1.708TyrThr: 1.708 ± 0.042	2.414TyrVal: 2.414 ± 0.049	0.421TyrTrp: 0.421 ± 0.021	0.968TyrTyr: 0.968 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4102 proteins (1149605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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