Amino acid dipepetide frequency for Torque teno mini virus ALA22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.203AlaAla: 2.203 ± 2.574
0.0AlaCys: 0.0 ± 0.0
1.101AlaAsp: 1.101 ± 0.571
4.405AlaGlu: 4.405 ± 2.039
0.0AlaPhe: 0.0 ± 0.0
3.304AlaGly: 3.304 ± 5.533
3.304AlaHis: 3.304 ± 1.714
1.101AlaIle: 1.101 ± 0.571
1.101AlaLys: 1.101 ± 0.571
4.405AlaLeu: 4.405 ± 2.039
1.101AlaMet: 1.101 ± 0.571
1.101AlaAsn: 1.101 ± 0.571
1.101AlaPro: 1.101 ± 0.571
1.101AlaGln: 1.101 ± 0.571
0.0AlaArg: 0.0 ± 0.0
3.304AlaSer: 3.304 ± 1.714
5.507AlaThr: 5.507 ± 1.838
1.101AlaVal: 1.101 ± 0.571
1.101AlaTrp: 1.101 ± 0.571
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
2.203CysAsp: 2.203 ± 5.947
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.101CysGly: 1.101 ± 0.571
1.101CysHis: 1.101 ± 1.914
0.0CysIle: 0.0 ± 0.0
1.101CysLys: 1.101 ± 0.571
1.101CysLeu: 1.101 ± 2.973
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
1.101CysGln: 1.101 ± 2.973
1.101CysArg: 1.101 ± 1.914
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
2.203CysTyr: 2.203 ± 1.143
0.0CysXaa: 0.0 ± 0.0
Asp
1.101AspAla: 1.101 ± 2.973
1.101AspCys: 1.101 ± 2.973
0.0AspAsp: 0.0 ± 0.0
3.304AspGlu: 3.304 ± 1.489
2.203AspPhe: 2.203 ± 2.574
1.101AspGly: 1.101 ± 2.973
0.0AspHis: 0.0 ± 0.0
3.304AspIle: 3.304 ± 5.533
3.304AspLys: 3.304 ± 1.714
1.101AspLeu: 1.101 ± 0.571
1.101AspMet: 1.101 ± 1.525
2.203AspAsn: 2.203 ± 1.143
2.203AspPro: 2.203 ± 2.574
3.304AspGln: 3.304 ± 1.714
2.203AspArg: 2.203 ± 1.143
4.405AspSer: 4.405 ± 5.645
8.811AspThr: 8.811 ± 4.079
0.0AspVal: 0.0 ± 0.0
1.101AspTrp: 1.101 ± 0.571
2.203AspTyr: 2.203 ± 1.143
0.0AspXaa: 0.0 ± 0.0
Glu
3.304GluAla: 3.304 ± 2.251
0.0GluCys: 0.0 ± 0.0
3.304GluAsp: 3.304 ± 8.92
4.405GluGlu: 4.405 ± 5.149
1.101GluPhe: 1.101 ± 0.571
4.405GluGly: 4.405 ± 2.039
1.101GluHis: 1.101 ± 1.914
0.0GluIle: 0.0 ± 0.0
4.405GluLys: 4.405 ± 2.039
3.304GluLeu: 3.304 ± 2.251
2.203GluMet: 2.203 ± 1.023
2.203GluAsn: 2.203 ± 1.143
3.304GluPro: 3.304 ± 2.251
4.405GluGln: 4.405 ± 2.285
3.304GluArg: 3.304 ± 1.714
5.507GluSer: 5.507 ± 7.311
4.405GluThr: 4.405 ± 2.285
1.101GluVal: 1.101 ± 1.914
0.0GluTrp: 0.0 ± 0.0
1.101GluTyr: 1.101 ± 0.571
0.0GluXaa: 0.0 ± 0.0
Phe
1.101PheAla: 1.101 ± 0.571
1.101PheCys: 1.101 ± 2.973
2.203PheAsp: 2.203 ± 1.143
1.101PheGlu: 1.101 ± 0.571
1.101PhePhe: 1.101 ± 1.914
2.203PheGly: 2.203 ± 2.574
2.203PheHis: 2.203 ± 1.143
1.101PheIle: 1.101 ± 0.571
2.203PheLys: 2.203 ± 2.574
4.405PheLeu: 4.405 ± 2.285
0.0PheMet: 0.0 ± 0.0
1.101PheAsn: 1.101 ± 0.571
2.203PhePro: 2.203 ± 1.143
3.304PheGln: 3.304 ± 1.714
1.101PheArg: 1.101 ± 0.571
3.304PheSer: 3.304 ± 1.489
8.811PheThr: 8.811 ± 3.165
1.101PheVal: 1.101 ± 0.571
1.101PheTrp: 1.101 ± 0.571
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
1.101GlyAla: 1.101 ± 0.571
0.0GlyCys: 0.0 ± 0.0
3.304GlyAsp: 3.304 ± 5.533
2.203GlyGlu: 2.203 ± 3.462
3.304GlyPhe: 3.304 ± 1.714
5.507GlyGly: 5.507 ± 2.856
0.0GlyHis: 0.0 ± 0.0
1.101GlyIle: 1.101 ± 0.571
1.101GlyLys: 1.101 ± 0.571
3.304GlyLeu: 3.304 ± 2.251
0.0GlyMet: 0.0 ± 2.042
3.304GlyAsn: 3.304 ± 1.714
1.101GlyPro: 1.101 ± 0.571
1.101GlyGln: 1.101 ± 0.571
1.101GlyArg: 1.101 ± 0.571
1.101GlySer: 1.101 ± 0.571
7.709GlyThr: 7.709 ± 3.999
3.304GlyVal: 3.304 ± 2.251
0.0GlyTrp: 0.0 ± 0.0
2.203GlyTyr: 2.203 ± 1.143
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
2.203HisAsp: 2.203 ± 2.574
0.0HisGlu: 0.0 ± 0.0
1.101HisPhe: 1.101 ± 0.571
0.0HisGly: 0.0 ± 0.0
1.101HisHis: 1.101 ± 1.914
0.0HisIle: 0.0 ± 0.0
1.101HisLys: 1.101 ± 0.571
6.608HisLeu: 6.608 ± 6.994
0.0HisMet: 0.0 ± 0.0
1.101HisAsn: 1.101 ± 0.571
3.304HisPro: 3.304 ± 1.489
2.203HisGln: 2.203 ± 1.617
4.405HisArg: 4.405 ± 3.233
2.203HisSer: 2.203 ± 3.462
1.101HisThr: 1.101 ± 2.973
2.203HisVal: 2.203 ± 1.143
1.101HisTrp: 1.101 ± 0.571
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
1.101IleAla: 1.101 ± 0.571
1.101IleCys: 1.101 ± 2.973
0.0IleAsp: 0.0 ± 0.0
3.304IleGlu: 3.304 ± 5.533
1.101IlePhe: 1.101 ± 2.973
4.405IleGly: 4.405 ± 2.039
1.101IleHis: 1.101 ± 0.571
2.203IleIle: 2.203 ± 2.574
9.912IleLys: 9.912 ± 3.068
2.203IleLeu: 2.203 ± 2.574
1.101IleMet: 1.101 ± 0.571
2.203IleAsn: 2.203 ± 1.143
3.304IlePro: 3.304 ± 1.489
3.304IleGln: 3.304 ± 1.714
3.304IleArg: 3.304 ± 2.251
0.0IleSer: 0.0 ± 0.0
7.709IleThr: 7.709 ± 2.674
3.304IleVal: 3.304 ± 2.251
0.0IleTrp: 0.0 ± 0.0
1.101IleTyr: 1.101 ± 0.571
0.0IleXaa: 0.0 ± 0.0
Lys
1.101LysAla: 1.101 ± 0.571
2.203LysCys: 2.203 ± 3.462
8.811LysAsp: 8.811 ± 4.674
5.507LysGlu: 5.507 ± 1.782
0.0LysPhe: 0.0 ± 0.0
1.101LysGly: 1.101 ± 0.571
4.405LysHis: 4.405 ± 5.401
7.709LysIle: 7.709 ± 2.313
15.419LysLys: 15.419 ± 8.834
7.709LysLeu: 7.709 ± 3.008
1.101LysMet: 1.101 ± 0.571
2.203LysAsn: 2.203 ± 2.574
3.304LysPro: 3.304 ± 2.251
3.304LysGln: 3.304 ± 1.714
4.405LysArg: 4.405 ± 1.572
1.101LysSer: 1.101 ± 0.571
4.405LysThr: 4.405 ± 2.285
1.101LysVal: 1.101 ± 0.571
2.203LysTrp: 2.203 ± 2.574
6.608LysTyr: 6.608 ± 3.428
0.0LysXaa: 0.0 ± 0.0
Leu
3.304LeuAla: 3.304 ± 1.714
0.0LeuCys: 0.0 ± 0.0
6.608LeuAsp: 6.608 ± 2.074
3.304LeuGlu: 3.304 ± 1.714
4.405LeuPhe: 4.405 ± 2.337
3.304LeuGly: 3.304 ± 1.489
1.101LeuHis: 1.101 ± 0.571
13.216LeuIle: 13.216 ± 6.118
7.709LeuLys: 7.709 ± 4.17
13.216LeuLeu: 13.216 ± 2.485
1.101LeuMet: 1.101 ± 0.571
6.608LeuAsn: 6.608 ± 2.977
5.507LeuPro: 5.507 ± 3.055
8.811LeuGln: 8.811 ± 2.039
2.203LeuArg: 2.203 ± 1.617
4.405LeuSer: 4.405 ± 3.233
6.608LeuThr: 6.608 ± 3.428
2.203LeuVal: 2.203 ± 2.574
3.304LeuTrp: 3.304 ± 1.489
7.709LeuTyr: 7.709 ± 2.674
0.0LeuXaa: 0.0 ± 0.0
Met
1.101MetAla: 1.101 ± 0.571
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
1.101MetGlu: 1.101 ± 0.571
3.304MetPhe: 3.304 ± 1.489
1.101MetGly: 1.101 ± 0.571
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.101MetLys: 1.101 ± 0.571
1.101MetLeu: 1.101 ± 0.571
0.0MetMet: 0.0 ± 0.0
3.304MetAsn: 3.304 ± 2.251
2.203MetPro: 2.203 ± 1.143
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.101MetSer: 1.101 ± 0.571
1.101MetThr: 1.101 ± 2.973
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
1.101MetTyr: 1.101 ± 0.571
0.0MetXaa: 0.0 ± 0.0
Asn
3.304AsnAla: 3.304 ± 1.714
0.0AsnCys: 0.0 ± 0.0
2.203AsnAsp: 2.203 ± 1.143
1.101AsnGlu: 1.101 ± 0.571
3.304AsnPhe: 3.304 ± 1.714
0.0AsnGly: 0.0 ± 0.0
2.203AsnHis: 2.203 ± 1.143
2.203AsnIle: 2.203 ± 1.617
3.304AsnLys: 3.304 ± 1.489
4.405AsnLeu: 4.405 ± 5.149
1.101AsnMet: 1.101 ± 0.571
4.405AsnAsn: 4.405 ± 1.572
2.203AsnPro: 2.203 ± 1.143
4.405AsnGln: 4.405 ± 5.401
2.203AsnArg: 2.203 ± 1.143
4.405AsnSer: 4.405 ± 3.233
6.608AsnThr: 6.608 ± 2.977
1.101AsnVal: 1.101 ± 0.571
2.203AsnTrp: 2.203 ± 1.143
2.203AsnTyr: 2.203 ± 1.143
0.0AsnXaa: 0.0 ± 0.0
Pro
3.304ProAla: 3.304 ± 2.898
0.0ProCys: 0.0 ± 0.0
2.203ProAsp: 2.203 ± 1.143
2.203ProGlu: 2.203 ± 1.143
5.507ProPhe: 5.507 ± 2.856
3.304ProGly: 3.304 ± 1.714
1.101ProHis: 1.101 ± 0.571
3.304ProIle: 3.304 ± 2.898
5.507ProLys: 5.507 ± 1.782
9.912ProLeu: 9.912 ± 3.883
2.203ProMet: 2.203 ± 1.143
1.101ProAsn: 1.101 ± 0.571
4.405ProPro: 4.405 ± 2.285
4.405ProGln: 4.405 ± 2.285
1.101ProArg: 1.101 ± 0.571
2.203ProSer: 2.203 ± 1.143
2.203ProThr: 2.203 ± 2.574
1.101ProVal: 1.101 ± 0.571
0.0ProTrp: 0.0 ± 0.0
3.304ProTyr: 3.304 ± 1.714
0.0ProXaa: 0.0 ± 0.0
Gln
2.203GlnAla: 2.203 ± 1.143
0.0GlnCys: 0.0 ± 0.0
1.101GlnAsp: 1.101 ± 0.571
4.405GlnGlu: 4.405 ± 2.039
2.203GlnPhe: 2.203 ± 1.143
2.203GlnGly: 2.203 ± 1.143
3.304GlnHis: 3.304 ± 4.74
2.203GlnIle: 2.203 ± 1.143
4.405GlnLys: 4.405 ± 4.183
7.709GlnLeu: 7.709 ± 2.674
1.101GlnMet: 1.101 ± 0.571
5.507GlnAsn: 5.507 ± 7.311
3.304GlnPro: 3.304 ± 1.714
5.507GlnGln: 5.507 ± 1.976
3.304GlnArg: 3.304 ± 1.714
2.203GlnSer: 2.203 ± 1.143
5.507GlnThr: 5.507 ± 1.838
0.0GlnVal: 0.0 ± 0.0
1.101GlnTrp: 1.101 ± 0.571
3.304GlnTyr: 3.304 ± 1.714
0.0GlnXaa: 0.0 ± 0.0
Arg
0.0ArgAla: 0.0 ± 0.0
1.101ArgCys: 1.101 ± 1.914
0.0ArgAsp: 0.0 ± 0.0
0.0ArgGlu: 0.0 ± 0.0
4.405ArgPhe: 4.405 ± 2.285
1.101ArgGly: 1.101 ± 0.571
2.203ArgHis: 2.203 ± 1.617
3.304ArgIle: 3.304 ± 2.251
6.608ArgLys: 6.608 ± 2.222
6.608ArgLeu: 6.608 ± 2.977
1.101ArgMet: 1.101 ± 0.571
3.304ArgAsn: 3.304 ± 1.489
2.203ArgPro: 2.203 ± 1.143
4.405ArgGln: 4.405 ± 2.039
12.115ArgArg: 12.115 ± 6.284
2.203ArgSer: 2.203 ± 1.143
3.304ArgThr: 3.304 ± 1.489
2.203ArgVal: 2.203 ± 1.617
2.203ArgTrp: 2.203 ± 1.143
2.203ArgTyr: 2.203 ± 1.143
0.0ArgXaa: 0.0 ± 0.0
Ser
3.304SerAla: 3.304 ± 1.714
2.203SerCys: 2.203 ± 1.143
3.304SerAsp: 3.304 ± 1.714
5.507SerGlu: 5.507 ± 5.101
0.0SerPhe: 0.0 ± 0.0
1.101SerGly: 1.101 ± 0.571
1.101SerHis: 1.101 ± 2.973
2.203SerIle: 2.203 ± 2.574
2.203SerLys: 2.203 ± 3.829
8.811SerLeu: 8.811 ± 3.165
0.0SerMet: 0.0 ± 0.0
2.203SerAsn: 2.203 ± 1.143
4.405SerPro: 4.405 ± 2.039
3.304SerGln: 3.304 ± 3.497
3.304SerArg: 3.304 ± 3.497
11.013SerSer: 11.013 ± 16.875
8.811SerThr: 8.811 ± 6.467
0.0SerVal: 0.0 ± 0.0
0.0SerTrp: 0.0 ± 0.0
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
7.709ThrAla: 7.709 ± 2.313
1.101ThrCys: 1.101 ± 0.571
3.304ThrAsp: 3.304 ± 1.489
6.608ThrGlu: 6.608 ± 2.074
4.405ThrPhe: 4.405 ± 2.285
3.304ThrGly: 3.304 ± 1.714
1.101ThrHis: 1.101 ± 0.571
4.405ThrIle: 4.405 ± 2.285
6.608ThrLys: 6.608 ± 3.086
12.115ThrLeu: 12.115 ± 1.782
0.0ThrMet: 0.0 ± 0.0
4.405ThrAsn: 4.405 ± 3.233
7.709ThrPro: 7.709 ± 3.999
4.405ThrGln: 4.405 ± 1.572
3.304ThrArg: 3.304 ± 2.898
14.317ThrSer: 14.317 ± 4.93
14.317ThrThr: 14.317 ± 2.463
2.203ThrVal: 2.203 ± 1.143
2.203ThrTrp: 2.203 ± 1.143
1.101ThrTyr: 1.101 ± 0.571
0.0ThrXaa: 0.0 ± 0.0
Val
1.101ValAla: 1.101 ± 0.571
1.101ValCys: 1.101 ± 0.571
1.101ValAsp: 1.101 ± 0.571
1.101ValGlu: 1.101 ± 2.973
1.101ValPhe: 1.101 ± 0.571
2.203ValGly: 2.203 ± 1.143
2.203ValHis: 2.203 ± 3.462
2.203ValIle: 2.203 ± 1.143
1.101ValLys: 1.101 ± 0.571
1.101ValLeu: 1.101 ± 0.571
0.0ValMet: 0.0 ± 0.0
0.0ValAsn: 0.0 ± 0.0
3.304ValPro: 3.304 ± 2.251
1.101ValGln: 1.101 ± 1.914
5.507ValArg: 5.507 ± 2.856
0.0ValSer: 0.0 ± 0.0
1.101ValThr: 1.101 ± 0.571
0.0ValVal: 0.0 ± 0.0
0.0ValTrp: 0.0 ± 0.0
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.101TrpAsp: 1.101 ± 0.571
1.101TrpGlu: 1.101 ± 0.571
0.0TrpPhe: 0.0 ± 0.0
2.203TrpGly: 2.203 ± 1.143
1.101TrpHis: 1.101 ± 0.571
0.0TrpIle: 0.0 ± 0.0
2.203TrpLys: 2.203 ± 1.143
1.101TrpLeu: 1.101 ± 0.571
1.101TrpMet: 1.101 ± 2.973
0.0TrpAsn: 0.0 ± 0.0
1.101TrpPro: 1.101 ± 1.914
1.101TrpGln: 1.101 ± 0.571
4.405TrpArg: 4.405 ± 2.285
0.0TrpSer: 0.0 ± 0.0
1.101TrpThr: 1.101 ± 0.571
0.0TrpVal: 0.0 ± 0.0
1.101TrpTrp: 1.101 ± 0.571
1.101TrpTyr: 1.101 ± 0.571
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
2.203TyrGlu: 2.203 ± 1.143
2.203TyrPhe: 2.203 ± 1.143
0.0TyrGly: 0.0 ± 0.0
0.0TyrHis: 0.0 ± 0.0
2.203TyrIle: 2.203 ± 1.143
3.304TyrLys: 3.304 ± 1.714
4.405TyrLeu: 4.405 ± 2.285
2.203TyrMet: 2.203 ± 1.143
6.608TyrAsn: 6.608 ± 3.428
2.203TyrPro: 2.203 ± 1.617
0.0TyrGln: 0.0 ± 0.0
2.203TyrArg: 2.203 ± 1.143
0.0TyrSer: 0.0 ± 0.0
5.507TyrThr: 5.507 ± 2.856
3.304TyrVal: 3.304 ± 1.714
1.101TyrTrp: 1.101 ± 0.571
3.304TyrTyr: 3.304 ± 1.714
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski