Amino acid dipepetide frequency for Geodermatophilus sp. DF01_2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.26AlaAla: 24.26 ± 0.22
1.057AlaCys: 1.057 ± 0.029
9.238AlaAsp: 9.238 ± 0.096
9.407AlaGlu: 9.407 ± 0.103
3.315AlaPhe: 3.315 ± 0.056
14.943AlaGly: 14.943 ± 0.129
2.672AlaHis: 2.672 ± 0.046
3.463AlaIle: 3.463 ± 0.053
1.704AlaLys: 1.704 ± 0.05
14.936AlaLeu: 14.936 ± 0.142
2.514AlaMet: 2.514 ± 0.047
1.681AlaAsn: 1.681 ± 0.041
7.382AlaPro: 7.382 ± 0.096
3.621AlaGln: 3.621 ± 0.06
11.47AlaArg: 11.47 ± 0.109
5.597AlaSer: 5.597 ± 0.063
7.461AlaThr: 7.461 ± 0.077
14.304AlaVal: 14.304 ± 0.139
1.928AlaTrp: 1.928 ± 0.041
2.121AlaTyr: 2.121 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.877CysAla: 0.877 ± 0.031
0.094CysCys: 0.094 ± 0.008
0.472CysAsp: 0.472 ± 0.021
0.36CysGlu: 0.36 ± 0.017
0.182CysPhe: 0.182 ± 0.014
0.897CysGly: 0.897 ± 0.029
0.153CysHis: 0.153 ± 0.013
0.187CysIle: 0.187 ± 0.013
0.077CysLys: 0.077 ± 0.008
0.662CysLeu: 0.662 ± 0.022
0.09CysMet: 0.09 ± 0.009
0.103CysAsn: 0.103 ± 0.009
0.497CysPro: 0.497 ± 0.022
0.155CysGln: 0.155 ± 0.01
0.674CysArg: 0.674 ± 0.025
0.404CysSer: 0.404 ± 0.018
0.483CysThr: 0.483 ± 0.022
0.617CysVal: 0.617 ± 0.021
0.109CysTrp: 0.109 ± 0.01
0.122CysTyr: 0.122 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
8.327AspAla: 8.327 ± 0.08
0.371AspCys: 0.371 ± 0.019
4.371AspAsp: 4.371 ± 0.071
4.155AspGlu: 4.155 ± 0.065
1.337AspPhe: 1.337 ± 0.034
6.652AspGly: 6.652 ± 0.086
1.153AspHis: 1.153 ± 0.032
1.395AspIle: 1.395 ± 0.04
0.685AspLys: 0.685 ± 0.022
7.121AspLeu: 7.121 ± 0.089
0.72AspMet: 0.72 ± 0.026
0.682AspAsn: 0.682 ± 0.027
4.951AspPro: 4.951 ± 0.066
1.45AspGln: 1.45 ± 0.036
5.76AspArg: 5.76 ± 0.081
2.095AspSer: 2.095 ± 0.045
2.767AspThr: 2.767 ± 0.04
6.588AspVal: 6.588 ± 0.078
0.924AspTrp: 0.924 ± 0.025
0.997AspTyr: 0.997 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
7.325GluAla: 7.325 ± 0.082
0.332GluCys: 0.332 ± 0.017
3.17GluAsp: 3.17 ± 0.06
3.77GluGlu: 3.77 ± 0.07
1.421GluPhe: 1.421 ± 0.041
4.293GluGly: 4.293 ± 0.058
1.555GluHis: 1.555 ± 0.038
1.905GluIle: 1.905 ± 0.045
0.937GluLys: 0.937 ± 0.032
7.174GluLeu: 7.174 ± 0.081
0.818GluMet: 0.818 ± 0.029
0.821GluAsn: 0.821 ± 0.026
3.517GluPro: 3.517 ± 0.067
2.507GluGln: 2.507 ± 0.042
5.613GluArg: 5.613 ± 0.068
2.288GluSer: 2.288 ± 0.045
2.711GluThr: 2.711 ± 0.049
5.962GluVal: 5.962 ± 0.084
0.734GluTrp: 0.734 ± 0.022
0.961GluTyr: 0.961 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.546PheAla: 3.546 ± 0.062
0.247PheCys: 0.247 ± 0.016
1.883PheAsp: 1.883 ± 0.043
1.256PheGlu: 1.256 ± 0.035
0.787PhePhe: 0.787 ± 0.027
2.854PheGly: 2.854 ± 0.052
0.451PheHis: 0.451 ± 0.019
0.601PheIle: 0.601 ± 0.027
0.306PheLys: 0.306 ± 0.014
2.535PheLeu: 2.535 ± 0.052
0.27PheMet: 0.27 ± 0.014
0.419PheAsn: 0.419 ± 0.02
1.325PhePro: 1.325 ± 0.037
0.538PheGln: 0.538 ± 0.019
1.643PheArg: 1.643 ± 0.039
1.289PheSer: 1.289 ± 0.035
1.672PheThr: 1.672 ± 0.036
2.373PheVal: 2.373 ± 0.044
0.37PheTrp: 0.37 ± 0.019
0.506PheTyr: 0.506 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
11.673GlyAla: 11.673 ± 0.116
0.825GlyCys: 0.825 ± 0.027
5.478GlyAsp: 5.478 ± 0.084
5.567GlyGlu: 5.567 ± 0.067
2.682GlyPhe: 2.682 ± 0.045
9.114GlyGly: 9.114 ± 0.104
2.04GlyHis: 2.04 ± 0.046
3.112GlyIle: 3.112 ± 0.054
1.604GlyLys: 1.604 ± 0.042
10.005GlyLeu: 10.005 ± 0.119
1.95GlyMet: 1.95 ± 0.042
1.469GlyAsn: 1.469 ± 0.04
5.468GlyPro: 5.468 ± 0.078
2.848GlyGln: 2.848 ± 0.056
8.687GlyArg: 8.687 ± 0.097
5.314GlySer: 5.314 ± 0.065
6.082GlyThr: 6.082 ± 0.084
8.649GlyVal: 8.649 ± 0.086
1.836GlyTrp: 1.836 ± 0.043
2.197GlyTyr: 2.197 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.528HisAla: 2.528 ± 0.048
0.179HisCys: 0.179 ± 0.013
1.2HisAsp: 1.2 ± 0.031
1.07HisGlu: 1.07 ± 0.031
0.511HisPhe: 0.511 ± 0.023
2.19HisGly: 2.19 ± 0.044
0.625HisHis: 0.625 ± 0.025
0.445HisIle: 0.445 ± 0.019
0.234HisLys: 0.234 ± 0.017
2.259HisLeu: 2.259 ± 0.048
0.26HisMet: 0.26 ± 0.015
0.3HisAsn: 0.3 ± 0.016
1.708HisPro: 1.708 ± 0.044
0.505HisGln: 0.505 ± 0.019
2.04HisArg: 2.04 ± 0.046
0.86HisSer: 0.86 ± 0.024
0.961HisThr: 0.961 ± 0.029
1.939HisVal: 1.939 ± 0.041
0.307HisTrp: 0.307 ± 0.014
0.363HisTyr: 0.363 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
4.3IleAla: 4.3 ± 0.062
0.23IleCys: 0.23 ± 0.015
2.076IleAsp: 2.076 ± 0.043
1.78IleGlu: 1.78 ± 0.042
0.506IlePhe: 0.506 ± 0.026
3.244IleGly: 3.244 ± 0.064
0.425IleHis: 0.425 ± 0.018
0.692IleIle: 0.692 ± 0.03
0.405IleLys: 0.405 ± 0.017
1.835IleLeu: 1.835 ± 0.046
0.326IleMet: 0.326 ± 0.018
0.501IleAsn: 0.501 ± 0.019
1.526IlePro: 1.526 ± 0.039
0.557IleGln: 0.557 ± 0.021
1.961IleArg: 1.961 ± 0.044
1.396IleSer: 1.396 ± 0.038
1.77IleThr: 1.77 ± 0.043
2.487IleVal: 2.487 ± 0.046
0.301IleTrp: 0.301 ± 0.016
0.409IleTyr: 0.409 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
1.794LysAla: 1.794 ± 0.046
0.06LysCys: 0.06 ± 0.007
0.741LysAsp: 0.741 ± 0.026
0.72LysGlu: 0.72 ± 0.031
0.241LysPhe: 0.241 ± 0.015
1.088LysGly: 1.088 ± 0.034
0.285LysHis: 0.285 ± 0.015
0.437LysIle: 0.437 ± 0.022
0.401LysLys: 0.401 ± 0.025
1.27LysLeu: 1.27 ± 0.033
0.242LysMet: 0.242 ± 0.015
0.262LysAsn: 0.262 ± 0.016
0.834LysPro: 0.834 ± 0.025
0.469LysGln: 0.469 ± 0.022
1.104LysArg: 1.104 ± 0.031
0.627LysSer: 0.627 ± 0.022
0.828LysThr: 0.828 ± 0.032
1.301LysVal: 1.301 ± 0.04
0.149LysTrp: 0.149 ± 0.01
0.254LysTyr: 0.254 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
17.128LeuAla: 17.128 ± 0.164
0.705LeuCys: 0.705 ± 0.022
7.031LeuAsp: 7.031 ± 0.091
5.138LeuGlu: 5.138 ± 0.067
2.443LeuPhe: 2.443 ± 0.055
9.909LeuGly: 9.909 ± 0.101
2.108LeuHis: 2.108 ± 0.042
2.397LeuIle: 2.397 ± 0.049
1.182LeuLys: 1.182 ± 0.04
11.92LeuLeu: 11.92 ± 0.154
1.347LeuMet: 1.347 ± 0.036
1.252LeuAsn: 1.252 ± 0.036
6.936LeuPro: 6.936 ± 0.087
2.639LeuGln: 2.639 ± 0.053
8.843LeuArg: 8.843 ± 0.092
5.044LeuSer: 5.044 ± 0.07
6.732LeuThr: 6.732 ± 0.074
10.9LeuVal: 10.9 ± 0.114
1.132LeuTrp: 1.132 ± 0.034
1.499LeuTyr: 1.499 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.288MetAla: 2.288 ± 0.042
0.13MetCys: 0.13 ± 0.009
0.811MetAsp: 0.811 ± 0.025
0.615MetGlu: 0.615 ± 0.023
0.324MetPhe: 0.324 ± 0.018
1.296MetGly: 1.296 ± 0.033
0.329MetHis: 0.329 ± 0.016
0.449MetIle: 0.449 ± 0.021
0.282MetLys: 0.282 ± 0.015
1.414MetLeu: 1.414 ± 0.036
0.207MetMet: 0.207 ± 0.012
0.311MetAsn: 0.311 ± 0.016
1.039MetPro: 1.039 ± 0.028
0.457MetGln: 0.457 ± 0.016
1.365MetArg: 1.365 ± 0.034
1.288MetSer: 1.288 ± 0.034
1.5MetThr: 1.5 ± 0.036
1.364MetVal: 1.364 ± 0.033
0.174MetTrp: 0.174 ± 0.012
0.234MetTyr: 0.234 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
1.838AsnAla: 1.838 ± 0.044
0.132AsnCys: 0.132 ± 0.011
0.74AsnAsp: 0.74 ± 0.027
0.674AsnGlu: 0.674 ± 0.021
0.368AsnPhe: 0.368 ± 0.02
1.373AsnGly: 1.373 ± 0.038
0.284AsnHis: 0.284 ± 0.018
0.456AsnIle: 0.456 ± 0.02
0.219AsnLys: 0.219 ± 0.014
1.458AsnLeu: 1.458 ± 0.04
0.226AsnMet: 0.226 ± 0.015
0.279AsnAsn: 0.279 ± 0.016
1.162AsnPro: 1.162 ± 0.033
0.38AsnGln: 0.38 ± 0.017
1.101AsnArg: 1.101 ± 0.025
0.64AsnSer: 0.64 ± 0.022
0.812AsnThr: 0.812 ± 0.028
1.292AsnVal: 1.292 ± 0.037
0.207AsnTrp: 0.207 ± 0.013
0.288AsnTyr: 0.288 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
9.614ProAla: 9.614 ± 0.126
0.318ProCys: 0.318 ± 0.017
4.836ProAsp: 4.836 ± 0.077
4.432ProGlu: 4.432 ± 0.075
1.492ProPhe: 1.492 ± 0.038
7.084ProGly: 7.084 ± 0.082
1.179ProHis: 1.179 ± 0.031
1.369ProIle: 1.369 ± 0.036
0.687ProLys: 0.687 ± 0.026
5.551ProLeu: 5.551 ± 0.074
1.023ProMet: 1.023 ± 0.032
0.707ProAsn: 0.707 ± 0.027
4.121ProPro: 4.121 ± 0.08
1.574ProGln: 1.574 ± 0.041
4.348ProArg: 4.348 ± 0.066
3.038ProSer: 3.038 ± 0.052
3.585ProThr: 3.585 ± 0.059
6.282ProVal: 6.282 ± 0.085
0.978ProTrp: 0.978 ± 0.032
1.071ProTyr: 1.071 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.79GlnAla: 3.79 ± 0.059
0.138GlnCys: 0.138 ± 0.011
1.21GlnAsp: 1.21 ± 0.03
1.413GlnGlu: 1.413 ± 0.037
0.664GlnPhe: 0.664 ± 0.023
1.97GlnGly: 1.97 ± 0.04
0.59GlnHis: 0.59 ± 0.023
0.873GlnIle: 0.873 ± 0.028
0.387GlnLys: 0.387 ± 0.021
3.336GlnLeu: 3.336 ± 0.051
0.485GlnMet: 0.485 ± 0.021
0.384GlnAsn: 0.384 ± 0.017
1.748GlnPro: 1.748 ± 0.054
1.2GlnGln: 1.2 ± 0.038
2.643GlnArg: 2.643 ± 0.046
1.025GlnSer: 1.025 ± 0.029
1.324GlnThr: 1.324 ± 0.03
2.909GlnVal: 2.909 ± 0.045
0.347GlnTrp: 0.347 ± 0.016
0.533GlnTyr: 0.533 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
10.936ArgAla: 10.936 ± 0.125
0.614ArgCys: 0.614 ± 0.021
4.543ArgAsp: 4.543 ± 0.066
4.79ArgGlu: 4.79 ± 0.077
2.295ArgPhe: 2.295 ± 0.052
6.469ArgGly: 6.469 ± 0.086
1.924ArgHis: 1.924 ± 0.047
2.726ArgIle: 2.726 ± 0.047
1.068ArgLys: 1.068 ± 0.035
9.59ArgLeu: 9.59 ± 0.105
1.843ArgMet: 1.843 ± 0.036
1.216ArgAsn: 1.216 ± 0.035
5.78ArgPro: 5.78 ± 0.08
2.389ArgGln: 2.389 ± 0.043
9.345ArgArg: 9.345 ± 0.119
4.421ArgSer: 4.421 ± 0.057
5.1ArgThr: 5.1 ± 0.064
7.061ArgVal: 7.061 ± 0.075
1.552ArgTrp: 1.552 ± 0.036
1.759ArgTyr: 1.759 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.339SerAla: 6.339 ± 0.074
0.373SerCys: 0.373 ± 0.017
2.498SerAsp: 2.498 ± 0.046
2.135SerGlu: 2.135 ± 0.045
1.351SerPhe: 1.351 ± 0.033
5.464SerGly: 5.464 ± 0.077
0.816SerHis: 0.816 ± 0.028
1.426SerIle: 1.426 ± 0.041
0.601SerLys: 0.601 ± 0.023
4.582SerLeu: 4.582 ± 0.053
0.976SerMet: 0.976 ± 0.028
0.685SerAsn: 0.685 ± 0.026
3.25SerPro: 3.25 ± 0.054
1.08SerGln: 1.08 ± 0.031
3.802SerArg: 3.802 ± 0.062
2.679SerSer: 2.679 ± 0.065
2.855SerThr: 2.855 ± 0.052
4.209SerVal: 4.209 ± 0.06
0.786SerTrp: 0.786 ± 0.024
0.977SerTyr: 0.977 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
8.639ThrAla: 8.639 ± 0.09
0.411ThrCys: 0.411 ± 0.02
3.564ThrAsp: 3.564 ± 0.057
3.126ThrGlu: 3.126 ± 0.046
1.484ThrPhe: 1.484 ± 0.036
6.574ThrGly: 6.574 ± 0.085
1.036ThrHis: 1.036 ± 0.029
1.631ThrIle: 1.631 ± 0.039
0.713ThrLys: 0.713 ± 0.026
5.479ThrLeu: 5.479 ± 0.064
0.908ThrMet: 0.908 ± 0.029
0.836ThrAsn: 0.836 ± 0.03
4.011ThrPro: 4.011 ± 0.062
1.204ThrGln: 1.204 ± 0.033
4.078ThrArg: 4.078 ± 0.062
2.838ThrSer: 2.838 ± 0.05
3.755ThrThr: 3.755 ± 0.065
6.205ThrVal: 6.205 ± 0.082
0.87ThrTrp: 0.87 ± 0.031
1.026ThrTyr: 1.026 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
13.767ValAla: 13.767 ± 0.127
0.715ValCys: 0.715 ± 0.026
6.578ValAsp: 6.578 ± 0.08
5.747ValGlu: 5.747 ± 0.067
2.509ValPhe: 2.509 ± 0.052
8.263ValGly: 8.263 ± 0.085
2.214ValHis: 2.214 ± 0.044
2.431ValIle: 2.431 ± 0.051
1.176ValLys: 1.176 ± 0.039
11.417ValLeu: 11.417 ± 0.123
1.238ValMet: 1.238 ± 0.032
1.512ValAsn: 1.512 ± 0.037
6.311ValPro: 6.311 ± 0.066
2.429ValGln: 2.429 ± 0.042
7.901ValArg: 7.901 ± 0.088
4.34ValSer: 4.34 ± 0.055
6.073ValThr: 6.073 ± 0.073
11.435ValVal: 11.435 ± 0.125
1.123ValTrp: 1.123 ± 0.034
1.517ValTyr: 1.517 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.731TrpAla: 1.731 ± 0.046
0.132TrpCys: 0.132 ± 0.01
0.79TrpAsp: 0.79 ± 0.026
0.63TrpGlu: 0.63 ± 0.024
0.455TrpPhe: 0.455 ± 0.019
1.01TrpGly: 1.01 ± 0.032
0.35TrpHis: 0.35 ± 0.017
0.381TrpIle: 0.381 ± 0.017
0.205TrpLys: 0.205 ± 0.014
1.864TrpLeu: 1.864 ± 0.044
0.252TrpMet: 0.252 ± 0.014
0.254TrpAsn: 0.254 ± 0.015
0.811TrpPro: 0.811 ± 0.028
0.513TrpGln: 0.513 ± 0.022
1.381TrpArg: 1.381 ± 0.038
0.928TrpSer: 0.928 ± 0.028
0.981TrpThr: 0.981 ± 0.03
1.148TrpVal: 1.148 ± 0.03
0.346TrpTrp: 0.346 ± 0.018
0.276TrpTyr: 0.276 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.375TyrAla: 2.375 ± 0.041
0.153TyrCys: 0.153 ± 0.01
1.271TyrAsp: 1.271 ± 0.034
1.026TyrGlu: 1.026 ± 0.033
0.505TyrPhe: 0.505 ± 0.022
1.919TyrGly: 1.919 ± 0.045
0.296TyrHis: 0.296 ± 0.015
0.35TyrIle: 0.35 ± 0.019
0.233TyrLys: 0.233 ± 0.014
1.876TyrLeu: 1.876 ± 0.044
0.182TyrMet: 0.182 ± 0.014
0.254TyrAsn: 0.254 ± 0.016
0.913TyrPro: 0.913 ± 0.027
0.453TyrGln: 0.453 ± 0.019
1.661TyrArg: 1.661 ± 0.038
0.774TyrSer: 0.774 ± 0.026
0.936TyrThr: 0.936 ± 0.03
1.674TyrVal: 1.674 ± 0.036
0.263TyrTrp: 0.263 ± 0.018
0.331TyrTyr: 0.331 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4069 proteins (1250318 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski