Amino acid dipepetide frequency for Gordonia Phage Jablanski

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.986AlaAla: 15.986 ± 1.521
0.756AlaCys: 0.756 ± 0.188
7.673AlaAsp: 7.673 ± 0.553
7.847AlaGlu: 7.847 ± 0.65
3.43AlaPhe: 3.43 ± 0.566
9.766AlaGly: 9.766 ± 0.957
2.383AlaHis: 2.383 ± 0.444
5.464AlaIle: 5.464 ± 0.537
4.302AlaLys: 4.302 ± 0.533
8.429AlaLeu: 8.429 ± 0.761
3.778AlaMet: 3.778 ± 0.614
3.255AlaAsn: 3.255 ± 0.61
5.115AlaPro: 5.115 ± 0.494
4.534AlaGln: 4.534 ± 0.733
8.429AlaArg: 8.429 ± 0.681
6.162AlaSer: 6.162 ± 0.677
8.022AlaThr: 8.022 ± 0.583
7.557AlaVal: 7.557 ± 0.618
1.918AlaTrp: 1.918 ± 0.276
2.151AlaTyr: 2.151 ± 0.33
0.0AlaXaa: 0.0 ± 0.0
Cys
0.872CysAla: 0.872 ± 0.251
0.058CysCys: 0.058 ± 0.062
1.046CysAsp: 1.046 ± 0.243
0.639CysGlu: 0.639 ± 0.177
0.116CysPhe: 0.116 ± 0.085
1.163CysGly: 1.163 ± 0.287
0.233CysHis: 0.233 ± 0.126
0.116CysIle: 0.116 ± 0.066
0.174CysLys: 0.174 ± 0.1
0.465CysLeu: 0.465 ± 0.155
0.233CysMet: 0.233 ± 0.106
0.349CysAsn: 0.349 ± 0.119
0.349CysPro: 0.349 ± 0.169
0.349CysGln: 0.349 ± 0.134
1.279CysArg: 1.279 ± 0.331
0.523CysSer: 0.523 ± 0.188
0.639CysThr: 0.639 ± 0.177
0.407CysVal: 0.407 ± 0.149
0.291CysTrp: 0.291 ± 0.157
0.349CysTyr: 0.349 ± 0.155
0.0CysXaa: 0.0 ± 0.0
Asp
7.964AspAla: 7.964 ± 0.533
0.872AspCys: 0.872 ± 0.257
5.057AspAsp: 5.057 ± 0.556
4.069AspGlu: 4.069 ± 0.49
1.453AspPhe: 1.453 ± 0.258
6.917AspGly: 6.917 ± 0.59
1.976AspHis: 1.976 ± 0.408
2.616AspIle: 2.616 ± 0.322
1.279AspLys: 1.279 ± 0.256
7.324AspLeu: 7.324 ± 0.555
1.046AspMet: 1.046 ± 0.237
1.86AspAsn: 1.86 ± 0.35
4.825AspPro: 4.825 ± 0.561
2.441AspGln: 2.441 ± 0.424
6.104AspArg: 6.104 ± 0.652
2.79AspSer: 2.79 ± 0.415
3.43AspThr: 3.43 ± 0.413
4.36AspVal: 4.36 ± 0.541
1.337AspTrp: 1.337 ± 0.312
1.628AspTyr: 1.628 ± 0.293
0.0AspXaa: 0.0 ± 0.0
Glu
5.929GluAla: 5.929 ± 0.568
0.756GluCys: 0.756 ± 0.219
3.081GluAsp: 3.081 ± 0.375
2.558GluGlu: 2.558 ± 0.391
2.383GluPhe: 2.383 ± 0.427
2.558GluGly: 2.558 ± 0.335
1.395GluHis: 1.395 ± 0.253
3.895GluIle: 3.895 ± 0.65
2.558GluLys: 2.558 ± 0.372
5.755GluLeu: 5.755 ± 0.662
0.93GluMet: 0.93 ± 0.231
1.279GluAsn: 1.279 ± 0.258
2.732GluPro: 2.732 ± 0.509
2.325GluGln: 2.325 ± 0.302
4.302GluArg: 4.302 ± 0.66
3.546GluSer: 3.546 ± 0.491
2.79GluThr: 2.79 ± 0.355
5.29GluVal: 5.29 ± 0.567
1.104GluTrp: 1.104 ± 0.272
1.569GluTyr: 1.569 ± 0.314
0.0GluXaa: 0.0 ± 0.0
Phe
2.732PheAla: 2.732 ± 0.403
0.174PheCys: 0.174 ± 0.101
2.209PheAsp: 2.209 ± 0.358
1.569PheGlu: 1.569 ± 0.353
0.639PhePhe: 0.639 ± 0.213
3.081PheGly: 3.081 ± 0.506
0.291PheHis: 0.291 ± 0.122
1.395PheIle: 1.395 ± 0.257
0.465PheLys: 0.465 ± 0.181
1.918PheLeu: 1.918 ± 0.352
0.349PheMet: 0.349 ± 0.16
0.814PheAsn: 0.814 ± 0.197
1.221PhePro: 1.221 ± 0.249
0.756PheGln: 0.756 ± 0.223
2.093PheArg: 2.093 ± 0.292
1.802PheSer: 1.802 ± 0.31
2.383PheThr: 2.383 ± 0.391
2.558PheVal: 2.558 ± 0.363
0.407PheTrp: 0.407 ± 0.169
0.523PheTyr: 0.523 ± 0.159
0.0PheXaa: 0.0 ± 0.0
Gly
8.196GlyAla: 8.196 ± 1.06
0.581GlyCys: 0.581 ± 0.195
6.51GlyAsp: 6.51 ± 0.652
5.115GlyGlu: 5.115 ± 0.467
2.674GlyPhe: 2.674 ± 0.442
9.126GlyGly: 9.126 ± 1.154
2.035GlyHis: 2.035 ± 0.376
3.895GlyIle: 3.895 ± 0.536
3.313GlyLys: 3.313 ± 0.445
5.697GlyLeu: 5.697 ± 0.576
1.628GlyMet: 1.628 ± 0.277
2.558GlyAsn: 2.558 ± 0.423
3.72GlyPro: 3.72 ± 0.399
3.953GlyGln: 3.953 ± 0.46
6.394GlyArg: 6.394 ± 0.704
4.883GlySer: 4.883 ± 0.728
5.464GlyThr: 5.464 ± 0.609
5.987GlyVal: 5.987 ± 0.602
2.093GlyTrp: 2.093 ± 0.328
1.686GlyTyr: 1.686 ± 0.311
0.0GlyXaa: 0.0 ± 0.0
His
1.918HisAla: 1.918 ± 0.374
0.523HisCys: 0.523 ± 0.194
1.86HisAsp: 1.86 ± 0.453
1.104HisGlu: 1.104 ± 0.251
0.407HisPhe: 0.407 ± 0.151
1.976HisGly: 1.976 ± 0.366
0.639HisHis: 0.639 ± 0.154
0.698HisIle: 0.698 ± 0.193
0.756HisLys: 0.756 ± 0.226
1.511HisLeu: 1.511 ± 0.324
0.116HisMet: 0.116 ± 0.084
0.756HisAsn: 0.756 ± 0.209
1.395HisPro: 1.395 ± 0.298
0.465HisGln: 0.465 ± 0.203
1.569HisArg: 1.569 ± 0.351
0.988HisSer: 0.988 ± 0.231
1.337HisThr: 1.337 ± 0.251
1.511HisVal: 1.511 ± 0.268
0.233HisTrp: 0.233 ± 0.102
0.756HisTyr: 0.756 ± 0.178
0.0HisXaa: 0.0 ± 0.0
Ile
6.162IleAla: 6.162 ± 0.572
0.407IleCys: 0.407 ± 0.169
3.837IleAsp: 3.837 ± 0.448
3.488IleGlu: 3.488 ± 0.518
0.872IlePhe: 0.872 ± 0.246
3.72IleGly: 3.72 ± 0.427
0.988IleHis: 0.988 ± 0.188
1.163IleIle: 1.163 ± 0.225
1.104IleLys: 1.104 ± 0.324
3.081IleLeu: 3.081 ± 0.352
0.291IleMet: 0.291 ± 0.172
1.337IleAsn: 1.337 ± 0.289
2.848IlePro: 2.848 ± 0.434
2.093IleGln: 2.093 ± 0.393
4.302IleArg: 4.302 ± 0.418
2.093IleSer: 2.093 ± 0.348
3.72IleThr: 3.72 ± 0.462
3.895IleVal: 3.895 ± 0.582
0.465IleTrp: 0.465 ± 0.165
0.581IleTyr: 0.581 ± 0.236
0.0IleXaa: 0.0 ± 0.0
Lys
4.011LysAla: 4.011 ± 0.501
0.116LysCys: 0.116 ± 0.083
1.569LysAsp: 1.569 ± 0.287
1.163LysGlu: 1.163 ± 0.256
0.93LysPhe: 0.93 ± 0.278
2.441LysGly: 2.441 ± 0.37
0.581LysHis: 0.581 ± 0.163
1.395LysIle: 1.395 ± 0.269
1.453LysLys: 1.453 ± 0.345
3.488LysLeu: 3.488 ± 0.449
0.523LysMet: 0.523 ± 0.168
1.511LysAsn: 1.511 ± 0.286
1.744LysPro: 1.744 ± 0.336
0.988LysGln: 0.988 ± 0.254
2.965LysArg: 2.965 ± 0.392
2.267LysSer: 2.267 ± 0.337
2.674LysThr: 2.674 ± 0.349
1.86LysVal: 1.86 ± 0.353
0.233LysTrp: 0.233 ± 0.12
1.221LysTyr: 1.221 ± 0.193
0.0LysXaa: 0.0 ± 0.0
Leu
9.94LeuAla: 9.94 ± 0.782
0.756LeuCys: 0.756 ± 0.201
5.639LeuAsp: 5.639 ± 0.648
4.65LeuGlu: 4.65 ± 0.471
2.383LeuPhe: 2.383 ± 0.422
6.162LeuGly: 6.162 ± 0.737
1.279LeuHis: 1.279 ± 0.261
3.488LeuIle: 3.488 ± 0.482
2.848LeuLys: 2.848 ± 0.491
4.127LeuLeu: 4.127 ± 0.477
1.744LeuMet: 1.744 ± 0.306
2.5LeuAsn: 2.5 ± 0.425
4.767LeuPro: 4.767 ± 0.681
2.441LeuGln: 2.441 ± 0.388
5.464LeuArg: 5.464 ± 0.728
4.825LeuSer: 4.825 ± 0.487
6.22LeuThr: 6.22 ± 0.629
4.418LeuVal: 4.418 ± 0.671
1.802LeuTrp: 1.802 ± 0.443
1.279LeuTyr: 1.279 ± 0.246
0.0LeuXaa: 0.0 ± 0.0
Met
2.267MetAla: 2.267 ± 0.285
0.349MetCys: 0.349 ± 0.147
0.523MetAsp: 0.523 ± 0.173
0.988MetGlu: 0.988 ± 0.221
0.349MetPhe: 0.349 ± 0.174
1.279MetGly: 1.279 ± 0.325
0.291MetHis: 0.291 ± 0.124
0.698MetIle: 0.698 ± 0.21
0.814MetLys: 0.814 ± 0.19
1.453MetLeu: 1.453 ± 0.247
0.291MetMet: 0.291 ± 0.123
0.523MetAsn: 0.523 ± 0.153
1.511MetPro: 1.511 ± 0.253
0.639MetGln: 0.639 ± 0.357
1.686MetArg: 1.686 ± 0.232
2.093MetSer: 2.093 ± 0.374
3.081MetThr: 3.081 ± 0.31
0.872MetVal: 0.872 ± 0.216
0.349MetTrp: 0.349 ± 0.145
0.174MetTyr: 0.174 ± 0.133
0.0MetXaa: 0.0 ± 0.0
Asn
4.418AsnAla: 4.418 ± 0.748
0.233AsnCys: 0.233 ± 0.106
1.744AsnAsp: 1.744 ± 0.32
1.337AsnGlu: 1.337 ± 0.25
0.523AsnPhe: 0.523 ± 0.188
2.848AsnGly: 2.848 ± 0.433
0.639AsnHis: 0.639 ± 0.183
0.872AsnIle: 0.872 ± 0.199
0.639AsnLys: 0.639 ± 0.169
2.441AsnLeu: 2.441 ± 0.417
0.291AsnMet: 0.291 ± 0.11
0.756AsnAsn: 0.756 ± 0.239
2.383AsnPro: 2.383 ± 0.41
1.453AsnGln: 1.453 ± 0.282
2.441AsnArg: 2.441 ± 0.395
1.802AsnSer: 1.802 ± 0.249
1.686AsnThr: 1.686 ± 0.292
1.628AsnVal: 1.628 ± 0.266
0.581AsnTrp: 0.581 ± 0.158
0.814AsnTyr: 0.814 ± 0.238
0.0AsnXaa: 0.0 ± 0.0
Pro
5.813ProAla: 5.813 ± 0.59
0.581ProCys: 0.581 ± 0.226
5.057ProAsp: 5.057 ± 0.582
3.255ProGlu: 3.255 ± 0.482
0.93ProPhe: 0.93 ± 0.205
5.232ProGly: 5.232 ± 0.632
1.104ProHis: 1.104 ± 0.294
2.558ProIle: 2.558 ± 0.42
1.86ProLys: 1.86 ± 0.353
3.313ProLeu: 3.313 ± 0.386
1.163ProMet: 1.163 ± 0.297
2.035ProAsn: 2.035 ± 0.385
3.778ProPro: 3.778 ± 0.78
2.267ProGln: 2.267 ± 0.357
3.778ProArg: 3.778 ± 0.519
2.906ProSer: 2.906 ± 0.356
3.43ProThr: 3.43 ± 0.518
3.953ProVal: 3.953 ± 0.475
1.395ProTrp: 1.395 ± 0.31
1.337ProTyr: 1.337 ± 0.251
0.0ProXaa: 0.0 ± 0.0
Gln
4.36GlnAla: 4.36 ± 0.76
0.291GlnCys: 0.291 ± 0.128
1.86GlnAsp: 1.86 ± 0.276
1.221GlnGlu: 1.221 ± 0.255
1.686GlnPhe: 1.686 ± 0.281
3.081GlnGly: 3.081 ± 0.43
0.814GlnHis: 0.814 ± 0.195
2.5GlnIle: 2.5 ± 0.317
1.395GlnLys: 1.395 ± 0.373
3.662GlnLeu: 3.662 ± 0.647
0.581GlnMet: 0.581 ± 0.171
1.046GlnAsn: 1.046 ± 0.307
1.628GlnPro: 1.628 ± 0.244
2.674GlnGln: 2.674 ± 0.654
2.732GlnArg: 2.732 ± 0.483
2.267GlnSer: 2.267 ± 0.379
2.093GlnThr: 2.093 ± 0.366
2.616GlnVal: 2.616 ± 0.407
0.756GlnTrp: 0.756 ± 0.186
0.581GlnTyr: 0.581 ± 0.167
0.0GlnXaa: 0.0 ± 0.0
Arg
7.15ArgAla: 7.15 ± 0.673
0.872ArgCys: 0.872 ± 0.257
4.534ArgAsp: 4.534 ± 0.481
4.825ArgGlu: 4.825 ± 0.551
2.325ArgPhe: 2.325 ± 0.357
4.883ArgGly: 4.883 ± 0.56
1.744ArgHis: 1.744 ± 0.372
4.767ArgIle: 4.767 ± 0.573
3.43ArgLys: 3.43 ± 0.527
6.162ArgLeu: 6.162 ± 0.58
2.5ArgMet: 2.5 ± 0.373
2.441ArgAsn: 2.441 ± 0.414
4.127ArgPro: 4.127 ± 0.46
2.674ArgGln: 2.674 ± 0.409
6.743ArgArg: 6.743 ± 0.759
3.778ArgSer: 3.778 ± 0.377
4.592ArgThr: 4.592 ± 0.488
5.464ArgVal: 5.464 ± 0.614
1.802ArgTrp: 1.802 ± 0.282
2.383ArgTyr: 2.383 ± 0.479
0.0ArgXaa: 0.0 ± 0.0
Ser
8.138SerAla: 8.138 ± 0.828
0.174SerCys: 0.174 ± 0.093
4.243SerAsp: 4.243 ± 0.416
2.965SerGlu: 2.965 ± 0.409
1.744SerPhe: 1.744 ± 0.362
6.394SerGly: 6.394 ± 0.548
0.756SerHis: 0.756 ± 0.19
2.325SerIle: 2.325 ± 0.427
1.569SerLys: 1.569 ± 0.306
3.778SerLeu: 3.778 ± 0.456
1.569SerMet: 1.569 ± 0.266
1.511SerAsn: 1.511 ± 0.351
3.023SerPro: 3.023 ± 0.441
2.151SerGln: 2.151 ± 0.361
3.43SerArg: 3.43 ± 0.513
3.953SerSer: 3.953 ± 0.453
3.72SerThr: 3.72 ± 0.469
3.313SerVal: 3.313 ± 0.436
1.337SerTrp: 1.337 ± 0.272
1.337SerTyr: 1.337 ± 0.276
0.0SerXaa: 0.0 ± 0.0
Thr
8.719ThrAla: 8.719 ± 0.694
0.988ThrCys: 0.988 ± 0.252
4.767ThrAsp: 4.767 ± 0.44
3.488ThrGlu: 3.488 ± 0.538
1.628ThrPhe: 1.628 ± 0.317
6.394ThrGly: 6.394 ± 0.642
1.279ThrHis: 1.279 ± 0.274
3.604ThrIle: 3.604 ± 0.51
1.802ThrLys: 1.802 ± 0.287
5.406ThrLeu: 5.406 ± 0.459
0.988ThrMet: 0.988 ± 0.213
1.337ThrAsn: 1.337 ± 0.231
4.069ThrPro: 4.069 ± 0.69
1.744ThrGln: 1.744 ± 0.309
4.767ThrArg: 4.767 ± 0.566
4.011ThrSer: 4.011 ± 0.488
4.999ThrThr: 4.999 ± 0.62
5.755ThrVal: 5.755 ± 0.674
1.686ThrTrp: 1.686 ± 0.308
1.104ThrTyr: 1.104 ± 0.284
0.0ThrXaa: 0.0 ± 0.0
Val
7.557ValAla: 7.557 ± 0.647
0.698ValCys: 0.698 ± 0.191
5.406ValAsp: 5.406 ± 0.594
4.476ValGlu: 4.476 ± 0.618
1.744ValPhe: 1.744 ± 0.335
5.406ValGly: 5.406 ± 0.563
1.163ValHis: 1.163 ± 0.228
4.011ValIle: 4.011 ± 0.562
1.86ValLys: 1.86 ± 0.304
5.29ValLeu: 5.29 ± 0.548
1.221ValMet: 1.221 ± 0.291
2.441ValAsn: 2.441 ± 0.4
4.302ValPro: 4.302 ± 0.387
2.267ValGln: 2.267 ± 0.413
4.534ValArg: 4.534 ± 0.475
4.476ValSer: 4.476 ± 0.515
5.406ValThr: 5.406 ± 0.586
5.115ValVal: 5.115 ± 0.606
1.221ValTrp: 1.221 ± 0.283
0.93ValTyr: 0.93 ± 0.21
0.0ValXaa: 0.0 ± 0.0
Trp
2.325TrpAla: 2.325 ± 0.49
0.233TrpCys: 0.233 ± 0.106
0.814TrpAsp: 0.814 ± 0.215
0.639TrpGlu: 0.639 ± 0.182
0.698TrpPhe: 0.698 ± 0.219
1.453TrpGly: 1.453 ± 0.265
0.523TrpHis: 0.523 ± 0.191
0.581TrpIle: 0.581 ± 0.186
0.93TrpLys: 0.93 ± 0.22
1.628TrpLeu: 1.628 ± 0.332
0.523TrpMet: 0.523 ± 0.159
0.523TrpAsn: 0.523 ± 0.182
0.872TrpPro: 0.872 ± 0.201
0.988TrpGln: 0.988 ± 0.226
1.976TrpArg: 1.976 ± 0.312
1.163TrpSer: 1.163 ± 0.22
1.163TrpThr: 1.163 ± 0.223
1.569TrpVal: 1.569 ± 0.241
0.523TrpTrp: 0.523 ± 0.198
0.814TrpTyr: 0.814 ± 0.168
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.558TyrAla: 2.558 ± 0.374
0.233TyrCys: 0.233 ± 0.119
1.918TyrAsp: 1.918 ± 0.303
1.337TyrGlu: 1.337 ± 0.251
0.465TyrPhe: 0.465 ± 0.15
1.628TyrGly: 1.628 ± 0.25
0.407TyrHis: 0.407 ± 0.206
0.407TyrIle: 0.407 ± 0.149
0.581TyrLys: 0.581 ± 0.221
1.802TyrLeu: 1.802 ± 0.277
0.407TyrMet: 0.407 ± 0.123
0.698TyrAsn: 0.698 ± 0.179
1.337TyrPro: 1.337 ± 0.263
0.639TyrGln: 0.639 ± 0.169
2.209TyrArg: 2.209 ± 0.383
1.104TyrSer: 1.104 ± 0.293
1.686TyrThr: 1.686 ± 0.339
1.395TyrVal: 1.395 ± 0.258
0.407TyrTrp: 0.407 ± 0.168
0.407TyrTyr: 0.407 ± 0.182
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 82 proteins (17204 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski