Amino acid dipepetide frequency for Legionella rubrilucens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.159AlaAla: 8.159 ± 0.129	1.297AlaCys: 1.297 ± 0.033	3.934AlaAsp: 3.934 ± 0.067	4.736AlaGlu: 4.736 ± 0.075	3.655AlaPhe: 3.655 ± 0.06	5.769AlaGly: 5.769 ± 0.115	1.979AlaHis: 1.979 ± 0.055	6.308AlaIle: 6.308 ± 0.089	4.394AlaLys: 4.394 ± 0.076	10.827AlaLeu: 10.827 ± 0.135	2.568AlaMet: 2.568 ± 0.055	3.443AlaAsn: 3.443 ± 0.071	2.821AlaPro: 2.821 ± 0.06	3.6AlaGln: 3.6 ± 0.067	4.257AlaArg: 4.257 ± 0.087	5.147AlaSer: 5.147 ± 0.08	3.938AlaThr: 3.938 ± 0.062	5.828AlaVal: 5.828 ± 0.09	0.992AlaTrp: 0.992 ± 0.037	2.75AlaTyr: 2.75 ± 0.059	0.001AlaXaa: 0.001 ± 0.001
Cys	0.829CysAla: 0.829 ± 0.031	0.204CysCys: 0.204 ± 0.014	0.583CysAsp: 0.583 ± 0.025	0.659CysGlu: 0.659 ± 0.024	0.651CysPhe: 0.651 ± 0.029	0.874CysGly: 0.874 ± 0.033	0.413CysHis: 0.413 ± 0.022	0.658CysIle: 0.658 ± 0.026	0.501CysLys: 0.501 ± 0.02	1.407CysLeu: 1.407 ± 0.044	0.246CysMet: 0.246 ± 0.016	0.424CysAsn: 0.424 ± 0.019	0.539CysPro: 0.539 ± 0.026	0.612CysGln: 0.612 ± 0.03	0.641CysArg: 0.641 ± 0.025	0.676CysSer: 0.676 ± 0.028	0.543CysThr: 0.543 ± 0.026	0.677CysVal: 0.677 ± 0.023	0.142CysTrp: 0.142 ± 0.012	0.453CysTyr: 0.453 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.07AspAla: 4.07 ± 0.074	0.636AspCys: 0.636 ± 0.029	2.701AspAsp: 2.701 ± 0.061	3.834AspGlu: 3.834 ± 0.081	2.481AspPhe: 2.481 ± 0.051	2.86AspGly: 2.86 ± 0.071	1.089AspHis: 1.089 ± 0.037	3.4AspIle: 3.4 ± 0.058	3.261AspLys: 3.261 ± 0.066	5.062AspLeu: 5.062 ± 0.074	1.215AspMet: 1.215 ± 0.039	2.448AspAsn: 2.448 ± 0.053	1.992AspPro: 1.992 ± 0.046	1.687AspGln: 1.687 ± 0.049	2.112AspArg: 2.112 ± 0.05	2.909AspSer: 2.909 ± 0.064	2.416AspThr: 2.416 ± 0.054	3.185AspVal: 3.185 ± 0.059	0.761AspTrp: 0.761 ± 0.031	2.244AspTyr: 2.244 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.138GluAla: 5.138 ± 0.081	0.522GluCys: 0.522 ± 0.025	2.53GluAsp: 2.53 ± 0.058	4.046GluGlu: 4.046 ± 0.082	2.127GluPhe: 2.127 ± 0.046	3.35GluGly: 3.35 ± 0.065	1.472GluHis: 1.472 ± 0.043	3.719GluIle: 3.719 ± 0.07	4.459GluLys: 4.459 ± 0.083	6.507GluLeu: 6.507 ± 0.097	1.489GluMet: 1.489 ± 0.037	2.384GluAsn: 2.384 ± 0.052	2.035GluPro: 2.035 ± 0.054	3.492GluGln: 3.492 ± 0.063	3.181GluArg: 3.181 ± 0.068	3.2GluSer: 3.2 ± 0.062	3.078GluThr: 3.078 ± 0.063	3.402GluVal: 3.402 ± 0.059	0.649GluTrp: 0.649 ± 0.03	1.542GluTyr: 1.542 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.593PheAla: 3.593 ± 0.065	0.596PheCys: 0.596 ± 0.026	2.4PheAsp: 2.4 ± 0.059	2.102PheGlu: 2.102 ± 0.053	2.306PhePhe: 2.306 ± 0.063	2.55PheGly: 2.55 ± 0.055	1.035PheHis: 1.035 ± 0.032	3.154PheIle: 3.154 ± 0.064	2.386PheLys: 2.386 ± 0.05	4.439PheLeu: 4.439 ± 0.084	0.962PheMet: 0.962 ± 0.037	2.274PheAsn: 2.274 ± 0.055	1.696PhePro: 1.696 ± 0.047	1.333PheGln: 1.333 ± 0.042	1.546PheArg: 1.546 ± 0.04	3.24PheSer: 3.24 ± 0.058	2.393PheThr: 2.393 ± 0.045	2.427PheVal: 2.427 ± 0.058	0.516PheTrp: 0.516 ± 0.026	1.614PheTyr: 1.614 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.501GlyAla: 4.501 ± 0.089	0.863GlyCys: 0.863 ± 0.032	3.047GlyAsp: 3.047 ± 0.06	3.546GlyGlu: 3.546 ± 0.066	3.226GlyPhe: 3.226 ± 0.069	4.224GlyGly: 4.224 ± 0.099	1.811GlyHis: 1.811 ± 0.045	4.544GlyIle: 4.544 ± 0.075	3.671GlyLys: 3.671 ± 0.063	7.048GlyLeu: 7.048 ± 0.103	1.86GlyMet: 1.86 ± 0.042	2.492GlyAsn: 2.492 ± 0.06	1.718GlyPro: 1.718 ± 0.044	2.775GlyGln: 2.775 ± 0.056	3.015GlyArg: 3.015 ± 0.071	3.63GlySer: 3.63 ± 0.07	3.002GlyThr: 3.002 ± 0.086	4.226GlyVal: 4.226 ± 0.081	0.869GlyTrp: 0.869 ± 0.037	2.461GlyTyr: 2.461 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.278HisAla: 2.278 ± 0.049	0.46HisCys: 0.46 ± 0.022	1.344HisAsp: 1.344 ± 0.043	1.48HisGlu: 1.48 ± 0.043	1.447HisPhe: 1.447 ± 0.042	1.755HisGly: 1.755 ± 0.049	1.074HisHis: 1.074 ± 0.04	1.305HisIle: 1.305 ± 0.038	0.989HisLys: 0.989 ± 0.032	3.003HisLeu: 3.003 ± 0.063	0.508HisMet: 0.508 ± 0.023	0.81HisAsn: 0.81 ± 0.031	1.53HisPro: 1.53 ± 0.043	1.521HisGln: 1.521 ± 0.04	1.41HisArg: 1.41 ± 0.042	1.473HisSer: 1.473 ± 0.039	1.198HisThr: 1.198 ± 0.03	1.513HisVal: 1.513 ± 0.043	0.44HisTrp: 0.44 ± 0.022	1.397HisTyr: 1.397 ± 0.04	0.001HisXaa: 0.001 ± 0.001
Ile	6.195IleAla: 6.195 ± 0.087	0.603IleCys: 0.603 ± 0.028	3.938IleAsp: 3.938 ± 0.076	4.208IleGlu: 4.208 ± 0.075	1.976IlePhe: 1.976 ± 0.05	4.085IleGly: 4.085 ± 0.083	1.83IleHis: 1.83 ± 0.046	4.032IleIle: 4.032 ± 0.071	3.723IleLys: 3.723 ± 0.071	5.994IleLeu: 5.994 ± 0.096	1.288IleMet: 1.288 ± 0.039	3.305IleAsn: 3.305 ± 0.062	3.169IlePro: 3.169 ± 0.055	2.6IleGln: 2.6 ± 0.047	3.061IleArg: 3.061 ± 0.052	3.822IleSer: 3.822 ± 0.066	3.617IleThr: 3.617 ± 0.068	3.712IleVal: 3.712 ± 0.067	0.499IleTrp: 0.499 ± 0.024	1.85IleTyr: 1.85 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	5.159LysAla: 5.159 ± 0.088	0.309LysCys: 0.309 ± 0.018	2.668LysAsp: 2.668 ± 0.057	3.8LysGlu: 3.8 ± 0.073	1.238LysPhe: 1.238 ± 0.039	3.101LysGly: 3.101 ± 0.063	1.261LysHis: 1.261 ± 0.038	3.353LysIle: 3.353 ± 0.072	4.167LysLys: 4.167 ± 0.086	5.185LysLeu: 5.185 ± 0.088	1.334LysMet: 1.334 ± 0.04	2.701LysAsn: 2.701 ± 0.062	2.98LysPro: 2.98 ± 0.057	3.143LysGln: 3.143 ± 0.06	3.004LysArg: 3.004 ± 0.056	3.231LysSer: 3.231 ± 0.067	3.597LysThr: 3.597 ± 0.07	2.884LysVal: 2.884 ± 0.056	0.476LysTrp: 0.476 ± 0.022	1.246LysTyr: 1.246 ± 0.038	0.001LysXaa: 0.001 ± 0.001
Leu	10.559LeuAla: 10.559 ± 0.123	1.408LeuCys: 1.408 ± 0.041	5.499LeuAsp: 5.499 ± 0.083	5.359LeuGlu: 5.359 ± 0.085	5.066LeuPhe: 5.066 ± 0.094	6.706LeuGly: 6.706 ± 0.108	2.918LeuHis: 2.918 ± 0.056	7.313LeuIle: 7.313 ± 0.095	6.713LeuLys: 6.713 ± 0.115	13.325LeuLeu: 13.325 ± 0.197	2.667LeuMet: 2.667 ± 0.061	5.11LeuAsn: 5.11 ± 0.091	5.535LeuPro: 5.535 ± 0.074	5.023LeuGln: 5.023 ± 0.086	5.228LeuArg: 5.228 ± 0.073	8.243LeuSer: 8.243 ± 0.106	6.524LeuThr: 6.524 ± 0.083	6.62LeuVal: 6.62 ± 0.101	1.148LeuTrp: 1.148 ± 0.039	3.15LeuTyr: 3.15 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.467MetAla: 2.467 ± 0.058	0.153MetCys: 0.153 ± 0.012	1.322MetAsp: 1.322 ± 0.039	1.306MetGlu: 1.306 ± 0.04	0.618MetPhe: 0.618 ± 0.024	1.585MetGly: 1.585 ± 0.045	0.557MetHis: 0.557 ± 0.025	1.432MetIle: 1.432 ± 0.033	1.501MetLys: 1.501 ± 0.043	2.51MetLeu: 2.51 ± 0.057	0.747MetMet: 0.747 ± 0.026	1.142MetAsn: 1.142 ± 0.038	1.252MetPro: 1.252 ± 0.037	1.161MetGln: 1.161 ± 0.038	1.208MetArg: 1.208 ± 0.039	1.507MetSer: 1.507 ± 0.037	1.686MetThr: 1.686 ± 0.044	1.605MetVal: 1.605 ± 0.047	0.174MetTrp: 0.174 ± 0.014	0.483MetTyr: 0.483 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.491AsnAla: 3.491 ± 0.063	0.443AsnCys: 0.443 ± 0.023	2.326AsnAsp: 2.326 ± 0.059	2.638AsnGlu: 2.638 ± 0.053	1.397AsnPhe: 1.397 ± 0.038	2.476AsnGly: 2.476 ± 0.058	1.393AsnHis: 1.393 ± 0.04	2.215AsnIle: 2.215 ± 0.048	2.323AsnLys: 2.323 ± 0.058	4.172AsnLeu: 4.172 ± 0.076	0.792AsnMet: 0.792 ± 0.032	2.031AsnAsn: 2.031 ± 0.056	2.739AsnPro: 2.739 ± 0.062	2.662AsnGln: 2.662 ± 0.065	2.273AsnArg: 2.273 ± 0.049	2.297AsnSer: 2.297 ± 0.053	2.3AsnThr: 2.3 ± 0.049	2.215AsnVal: 2.215 ± 0.057	0.518AsnTrp: 0.518 ± 0.022	1.572AsnTyr: 1.572 ± 0.039	0.001AsnXaa: 0.001 ± 0.001
Pro	3.861ProAla: 3.861 ± 0.071	0.474ProCys: 0.474 ± 0.022	2.602ProAsp: 2.602 ± 0.055	3.094ProGlu: 3.094 ± 0.059	1.987ProPhe: 1.987 ± 0.046	2.937ProGly: 2.937 ± 0.059	1.128ProHis: 1.128 ± 0.037	2.309ProIle: 2.309 ± 0.059	1.889ProLys: 1.889 ± 0.051	5.189ProLeu: 5.189 ± 0.075	1.06ProMet: 1.06 ± 0.036	1.48ProAsn: 1.48 ± 0.038	1.845ProPro: 1.845 ± 0.051	1.929ProGln: 1.929 ± 0.043	1.72ProArg: 1.72 ± 0.045	2.679ProSer: 2.679 ± 0.057	2.011ProThr: 2.011 ± 0.047	3.68ProVal: 3.68 ± 0.075	0.546ProTrp: 0.546 ± 0.023	1.433ProTyr: 1.433 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.755GlnAla: 4.755 ± 0.076	0.565GlnCys: 0.565 ± 0.024	2.009GlnAsp: 2.009 ± 0.048	2.581GlnGlu: 2.581 ± 0.058	2.103GlnPhe: 2.103 ± 0.045	3.155GlnGly: 3.155 ± 0.062	1.311GlnHis: 1.311 ± 0.042	2.572GlnIle: 2.572 ± 0.056	2.43GlnLys: 2.43 ± 0.059	5.814GlnLeu: 5.814 ± 0.084	1.059GlnMet: 1.059 ± 0.036	1.696GlnAsn: 1.696 ± 0.042	1.953GlnPro: 1.953 ± 0.058	3.336GlnGln: 3.336 ± 0.075	2.56GlnArg: 2.56 ± 0.051	2.933GlnSer: 2.933 ± 0.052	2.476GlnThr: 2.476 ± 0.052	2.984GlnVal: 2.984 ± 0.051	0.829GlnTrp: 0.829 ± 0.03	1.473GlnTyr: 1.473 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.517ArgAla: 3.517 ± 0.064	0.553ArgCys: 0.553 ± 0.023	2.43ArgAsp: 2.43 ± 0.052	3.253ArgGlu: 3.253 ± 0.06	2.475ArgPhe: 2.475 ± 0.051	2.716ArgGly: 2.716 ± 0.056	1.627ArgHis: 1.627 ± 0.036	3.186ArgIle: 3.186 ± 0.062	2.398ArgLys: 2.398 ± 0.054	6.362ArgLeu: 6.362 ± 0.091	1.172ArgMet: 1.172 ± 0.036	1.834ArgAsn: 1.834 ± 0.044	1.68ArgPro: 1.68 ± 0.046	3.002ArgGln: 3.002 ± 0.062	2.564ArgArg: 2.564 ± 0.06	2.386ArgSer: 2.386 ± 0.051	2.102ArgThr: 2.102 ± 0.047	3.123ArgVal: 3.123 ± 0.06	0.648ArgTrp: 0.648 ± 0.025	1.96ArgTyr: 1.96 ± 0.044	0.001ArgXaa: 0.001 ± 0.001
Ser	4.689SerAla: 4.689 ± 0.078	0.702SerCys: 0.702 ± 0.033	3.036SerAsp: 3.036 ± 0.059	3.447SerGlu: 3.447 ± 0.062	2.721SerPhe: 2.721 ± 0.053	4.299SerGly: 4.299 ± 0.077	1.759SerHis: 1.759 ± 0.042	3.63SerIle: 3.63 ± 0.063	2.832SerLys: 2.832 ± 0.059	7.764SerLeu: 7.764 ± 0.107	1.635SerMet: 1.635 ± 0.048	2.332SerAsn: 2.332 ± 0.054	2.933SerPro: 2.933 ± 0.053	3.08SerGln: 3.08 ± 0.062	3.125SerArg: 3.125 ± 0.061	4.001SerSer: 4.001 ± 0.073	3.141SerThr: 3.141 ± 0.054	3.521SerVal: 3.521 ± 0.058	0.731SerTrp: 0.731 ± 0.03	1.887SerTyr: 1.887 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.682ThrAla: 4.682 ± 0.068	0.525ThrCys: 0.525 ± 0.025	2.424ThrAsp: 2.424 ± 0.049	2.66ThrGlu: 2.66 ± 0.049	1.917ThrPhe: 1.917 ± 0.05	3.761ThrGly: 3.761 ± 0.086	1.497ThrHis: 1.497 ± 0.037	3.426ThrIle: 3.426 ± 0.062	1.944ThrLys: 1.944 ± 0.048	6.917ThrLeu: 6.917 ± 0.09	1.164ThrMet: 1.164 ± 0.038	1.78ThrAsn: 1.78 ± 0.044	2.918ThrPro: 2.918 ± 0.058	2.394ThrGln: 2.394 ± 0.053	2.728ThrArg: 2.728 ± 0.057	2.942ThrSer: 2.942 ± 0.057	2.845ThrThr: 2.845 ± 0.063	3.769ThrVal: 3.769 ± 0.065	0.603ThrTrp: 0.603 ± 0.027	1.503ThrTyr: 1.503 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	5.173ValAla: 5.173 ± 0.084	0.732ValCys: 0.732 ± 0.029	3.431ValAsp: 3.431 ± 0.058	3.409ValGlu: 3.409 ± 0.07	2.883ValPhe: 2.883 ± 0.057	3.567ValGly: 3.567 ± 0.072	1.426ValHis: 1.426 ± 0.038	4.708ValIle: 4.708 ± 0.078	3.482ValLys: 3.482 ± 0.065	6.795ValLeu: 6.795 ± 0.091	1.73ValMet: 1.73 ± 0.046	3.017ValAsn: 3.017 ± 0.058	2.424ValPro: 2.424 ± 0.058	2.135ValGln: 2.135 ± 0.056	2.771ValArg: 2.771 ± 0.059	4.303ValSer: 4.303 ± 0.073	3.44ValThr: 3.44 ± 0.072	4.321ValVal: 4.321 ± 0.081	0.62ValTrp: 0.62 ± 0.027	1.961ValTyr: 1.961 ± 0.051	0.001ValXaa: 0.001 ± 0.001
Trp	0.774TrpAla: 0.774 ± 0.03	0.131TrpCys: 0.131 ± 0.011	0.501TrpAsp: 0.501 ± 0.023	0.489TrpGlu: 0.489 ± 0.022	0.61TrpPhe: 0.61 ± 0.026	0.677TrpGly: 0.677 ± 0.029	0.396TrpHis: 0.396 ± 0.021	0.714TrpIle: 0.714 ± 0.03	0.44TrpLys: 0.44 ± 0.022	1.775TrpLeu: 1.775 ± 0.049	0.318TrpMet: 0.318 ± 0.02	0.386TrpAsn: 0.386 ± 0.019	0.505TrpPro: 0.505 ± 0.024	0.993TrpGln: 0.993 ± 0.037	0.63TrpArg: 0.63 ± 0.028	0.585TrpSer: 0.585 ± 0.024	0.499TrpThr: 0.499 ± 0.021	0.829TrpVal: 0.829 ± 0.031	0.188TrpTrp: 0.188 ± 0.015	0.394TrpTyr: 0.394 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.515TyrAla: 2.515 ± 0.053	0.56TyrCys: 0.56 ± 0.024	1.638TyrAsp: 1.638 ± 0.042	1.672TyrGlu: 1.672 ± 0.045	1.676TyrPhe: 1.676 ± 0.046	2.083TyrGly: 2.083 ± 0.055	0.96TyrHis: 0.96 ± 0.032	1.523TyrIle: 1.523 ± 0.04	1.335TyrLys: 1.335 ± 0.044	4.02TyrLeu: 4.02 ± 0.072	0.6TyrMet: 0.6 ± 0.028	1.186TyrAsn: 1.186 ± 0.036	1.589TyrPro: 1.589 ± 0.036	2.114TyrGln: 2.114 ± 0.052	1.954TyrArg: 1.954 ± 0.05	2.059TyrSer: 2.059 ± 0.053	1.596TyrThr: 1.596 ± 0.041	1.807TyrVal: 1.807 ± 0.045	0.485TyrTrp: 0.485 ± 0.026	1.342TyrTyr: 1.342 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.018XaaXaa: 0.018 ± 0.007

Statistics based on 2847 proteins (955316 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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