Amino acid dipepetide frequency for Vibrio aerogenes CECT 7868

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.606AlaAla: 7.606 ± 0.091
1.047AlaCys: 1.047 ± 0.026
4.536AlaAsp: 4.536 ± 0.057
5.443AlaGlu: 5.443 ± 0.068
3.275AlaPhe: 3.275 ± 0.05
6.8AlaGly: 6.8 ± 0.087
1.737AlaHis: 1.737 ± 0.036
5.34AlaIle: 5.34 ± 0.057
4.083AlaLys: 4.083 ± 0.061
9.261AlaLeu: 9.261 ± 0.095
2.513AlaMet: 2.513 ± 0.038
2.731AlaAsn: 2.731 ± 0.042
2.776AlaPro: 2.776 ± 0.044
3.734AlaGln: 3.734 ± 0.056
3.978AlaArg: 3.978 ± 0.054
5.262AlaSer: 5.262 ± 0.072
4.343AlaThr: 4.343 ± 0.058
5.876AlaVal: 5.876 ± 0.066
0.89AlaTrp: 0.89 ± 0.027
2.382AlaTyr: 2.382 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.872CysAla: 0.872 ± 0.025
0.197CysCys: 0.197 ± 0.012
0.642CysAsp: 0.642 ± 0.021
0.673CysGlu: 0.673 ± 0.021
0.577CysPhe: 0.577 ± 0.02
1.044CysGly: 1.044 ± 0.027
0.432CysHis: 0.432 ± 0.018
0.709CysIle: 0.709 ± 0.024
0.402CysLys: 0.402 ± 0.016
1.188CysLeu: 1.188 ± 0.032
0.264CysMet: 0.264 ± 0.014
0.343CysAsn: 0.343 ± 0.014
0.529CysPro: 0.529 ± 0.021
0.59CysGln: 0.59 ± 0.02
0.658CysArg: 0.658 ± 0.021
0.771CysSer: 0.771 ± 0.021
0.518CysThr: 0.518 ± 0.018
0.689CysVal: 0.689 ± 0.022
0.178CysTrp: 0.178 ± 0.011
0.403CysTyr: 0.403 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.312AspAla: 4.312 ± 0.06
0.602AspCys: 0.602 ± 0.019
3.1AspAsp: 3.1 ± 0.052
3.846AspGlu: 3.846 ± 0.062
2.363AspPhe: 2.363 ± 0.044
3.813AspGly: 3.813 ± 0.068
1.31AspHis: 1.31 ± 0.031
4.142AspIle: 4.142 ± 0.053
2.931AspLys: 2.931 ± 0.051
4.92AspLeu: 4.92 ± 0.053
1.436AspMet: 1.436 ± 0.033
2.22AspAsn: 2.22 ± 0.048
2.256AspPro: 2.256 ± 0.039
2.274AspGln: 2.274 ± 0.039
2.25AspArg: 2.25 ± 0.035
3.286AspSer: 3.286 ± 0.056
2.723AspThr: 2.723 ± 0.052
3.733AspVal: 3.733 ± 0.063
0.813AspTrp: 0.813 ± 0.024
2.249AspTyr: 2.249 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.066GluAla: 5.066 ± 0.067
0.539GluCys: 0.539 ± 0.018
2.751GluAsp: 2.751 ± 0.048
3.531GluGlu: 3.531 ± 0.062
2.134GluPhe: 2.134 ± 0.038
3.219GluGly: 3.219 ± 0.038
1.626GluHis: 1.626 ± 0.034
3.919GluIle: 3.919 ± 0.054
4.063GluLys: 4.063 ± 0.058
6.19GluLeu: 6.19 ± 0.081
1.825GluMet: 1.825 ± 0.031
2.787GluAsn: 2.787 ± 0.051
2.05GluPro: 2.05 ± 0.036
3.735GluGln: 3.735 ± 0.055
3.05GluArg: 3.05 ± 0.053
3.868GluSer: 3.868 ± 0.052
3.556GluThr: 3.556 ± 0.05
3.935GluVal: 3.935 ± 0.057
0.685GluTrp: 0.685 ± 0.025
1.701GluTyr: 1.701 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.21PheAla: 3.21 ± 0.053
0.604PheCys: 0.604 ± 0.02
2.541PheAsp: 2.541 ± 0.041
2.318PheGlu: 2.318 ± 0.04
1.843PhePhe: 1.843 ± 0.042
3.043PheGly: 3.043 ± 0.057
1.043PheHis: 1.043 ± 0.025
2.937PheIle: 2.937 ± 0.046
1.699PheLys: 1.699 ± 0.036
3.471PheLeu: 3.471 ± 0.056
0.984PheMet: 0.984 ± 0.025
1.752PheAsn: 1.752 ± 0.035
1.557PhePro: 1.557 ± 0.038
1.434PheGln: 1.434 ± 0.027
1.919PheArg: 1.919 ± 0.037
3.502PheSer: 3.502 ± 0.057
2.245PheThr: 2.245 ± 0.041
2.535PheVal: 2.535 ± 0.048
0.579PheTrp: 0.579 ± 0.021
1.343PheTyr: 1.343 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.013GlyAla: 5.013 ± 0.069
1.032GlyCys: 1.032 ± 0.025
3.631GlyAsp: 3.631 ± 0.054
4.246GlyGlu: 4.246 ± 0.061
3.202GlyPhe: 3.202 ± 0.045
4.658GlyGly: 4.658 ± 0.079
1.809GlyHis: 1.809 ± 0.038
4.9GlyIle: 4.9 ± 0.07
3.915GlyLys: 3.915 ± 0.054
6.822GlyLeu: 6.822 ± 0.08
2.094GlyMet: 2.094 ± 0.044
2.57GlyAsn: 2.57 ± 0.049
1.82GlyPro: 1.82 ± 0.034
3.302GlyGln: 3.302 ± 0.054
3.221GlyArg: 3.221 ± 0.052
4.158GlySer: 4.158 ± 0.062
3.566GlyThr: 3.566 ± 0.064
4.897GlyVal: 4.897 ± 0.069
1.019GlyTrp: 1.019 ± 0.025
2.764GlyTyr: 2.764 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.893HisAla: 1.893 ± 0.039
0.38HisCys: 0.38 ± 0.015
1.292HisAsp: 1.292 ± 0.03
1.361HisGlu: 1.361 ± 0.026
1.214HisPhe: 1.214 ± 0.03
1.705HisGly: 1.705 ± 0.036
1.083HisHis: 1.083 ± 0.031
1.651HisIle: 1.651 ± 0.033
0.94HisLys: 0.94 ± 0.024
2.681HisLeu: 2.681 ± 0.051
0.587HisMet: 0.587 ± 0.019
0.842HisAsn: 0.842 ± 0.026
1.492HisPro: 1.492 ± 0.033
1.877HisGln: 1.877 ± 0.038
1.279HisArg: 1.279 ± 0.027
1.549HisSer: 1.549 ± 0.031
1.249HisThr: 1.249 ± 0.031
1.421HisVal: 1.421 ± 0.03
0.451HisTrp: 0.451 ± 0.017
0.967HisTyr: 0.967 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.964IleAla: 5.964 ± 0.072
0.823IleCys: 0.823 ± 0.024
3.955IleAsp: 3.955 ± 0.058
4.259IleGlu: 4.259 ± 0.061
2.383IlePhe: 2.383 ± 0.046
4.344IleGly: 4.344 ± 0.061
1.754IleHis: 1.754 ± 0.034
3.742IleIle: 3.742 ± 0.065
2.913IleLys: 2.913 ± 0.049
5.573IleLeu: 5.573 ± 0.073
1.276IleMet: 1.276 ± 0.032
2.539IleAsn: 2.539 ± 0.046
2.963IlePro: 2.963 ± 0.044
2.954IleGln: 2.954 ± 0.045
3.578IleArg: 3.578 ± 0.054
4.844IleSer: 4.844 ± 0.065
3.519IleThr: 3.519 ± 0.061
3.984IleVal: 3.984 ± 0.057
0.693IleTrp: 0.693 ± 0.021
1.922IleTyr: 1.922 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.499LysAla: 4.499 ± 0.06
0.322LysCys: 0.322 ± 0.015
2.635LysAsp: 2.635 ± 0.046
2.988LysGlu: 2.988 ± 0.051
1.439LysPhe: 1.439 ± 0.029
3.012LysGly: 3.012 ± 0.048
1.227LysHis: 1.227 ± 0.033
3.122LysIle: 3.122 ± 0.052
3.169LysLys: 3.169 ± 0.054
4.7LysLeu: 4.7 ± 0.058
1.367LysMet: 1.367 ± 0.032
2.402LysAsn: 2.402 ± 0.044
2.187LysPro: 2.187 ± 0.041
2.787LysGln: 2.787 ± 0.053
2.535LysArg: 2.535 ± 0.043
3.241LysSer: 3.241 ± 0.053
3.071LysThr: 3.071 ± 0.048
3.34LysVal: 3.34 ± 0.05
0.484LysTrp: 0.484 ± 0.019
1.464LysTyr: 1.464 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
9.026LeuAla: 9.026 ± 0.104
1.247LeuCys: 1.247 ± 0.029
5.241LeuAsp: 5.241 ± 0.064
5.444LeuGlu: 5.444 ± 0.068
4.203LeuPhe: 4.203 ± 0.071
6.234LeuGly: 6.234 ± 0.081
2.184LeuHis: 2.184 ± 0.039
6.613LeuIle: 6.613 ± 0.086
5.528LeuLys: 5.528 ± 0.063
10.032LeuLeu: 10.032 ± 0.128
2.864LeuMet: 2.864 ± 0.055
4.691LeuAsn: 4.691 ± 0.057
4.839LeuPro: 4.839 ± 0.064
3.728LeuGln: 3.728 ± 0.057
4.43LeuArg: 4.43 ± 0.064
8.48LeuSer: 8.48 ± 0.074
6.281LeuThr: 6.281 ± 0.076
6.309LeuVal: 6.309 ± 0.082
1.105LeuTrp: 1.105 ± 0.031
2.778LeuTyr: 2.778 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.447MetAla: 2.447 ± 0.039
0.226MetCys: 0.226 ± 0.013
1.253MetAsp: 1.253 ± 0.032
1.216MetGlu: 1.216 ± 0.032
0.906MetPhe: 0.906 ± 0.026
1.665MetGly: 1.665 ± 0.038
0.551MetHis: 0.551 ± 0.019
1.81MetIle: 1.81 ± 0.037
1.758MetLys: 1.758 ± 0.035
2.708MetLeu: 2.708 ± 0.046
0.968MetMet: 0.968 ± 0.03
1.38MetAsn: 1.38 ± 0.033
1.168MetPro: 1.168 ± 0.029
1.147MetGln: 1.147 ± 0.027
1.121MetArg: 1.121 ± 0.03
1.981MetSer: 1.981 ± 0.036
1.951MetThr: 1.951 ± 0.041
1.777MetVal: 1.777 ± 0.033
0.218MetTrp: 0.218 ± 0.012
0.588MetTyr: 0.588 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.03AsnAla: 3.03 ± 0.053
0.395AsnCys: 0.395 ± 0.019
2.026AsnAsp: 2.026 ± 0.039
2.107AsnGlu: 2.107 ± 0.041
1.44AsnPhe: 1.44 ± 0.03
2.803AsnGly: 2.803 ± 0.045
1.233AsnHis: 1.233 ± 0.026
2.678AsnIle: 2.678 ± 0.044
1.949AsnLys: 1.949 ± 0.041
3.666AsnLeu: 3.666 ± 0.053
0.938AsnMet: 0.938 ± 0.023
1.661AsnAsn: 1.661 ± 0.039
2.145AsnPro: 2.145 ± 0.041
2.46AsnGln: 2.46 ± 0.048
1.978AsnArg: 1.978 ± 0.04
2.185AsnSer: 2.185 ± 0.046
2.178AsnThr: 2.178 ± 0.043
2.28AsnVal: 2.28 ± 0.037
0.533AsnTrp: 0.533 ± 0.017
1.35AsnTyr: 1.35 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
3.76ProAla: 3.76 ± 0.062
0.38ProCys: 0.38 ± 0.014
3.215ProAsp: 3.215 ± 0.048
3.834ProGlu: 3.834 ± 0.056
1.739ProPhe: 1.739 ± 0.037
3.003ProGly: 3.003 ± 0.046
0.925ProHis: 0.925 ± 0.024
1.71ProIle: 1.71 ± 0.036
1.728ProLys: 1.728 ± 0.032
4.153ProLeu: 4.153 ± 0.057
0.924ProMet: 0.924 ± 0.025
1.17ProAsn: 1.17 ± 0.03
1.3ProPro: 1.3 ± 0.032
1.864ProGln: 1.864 ± 0.039
1.399ProArg: 1.399 ± 0.031
2.219ProSer: 2.219 ± 0.033
1.769ProThr: 1.769 ± 0.037
4.154ProVal: 4.154 ± 0.06
0.527ProTrp: 0.527 ± 0.019
1.447ProTyr: 1.447 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.632GlnAla: 4.632 ± 0.062
0.492GlnCys: 0.492 ± 0.018
2.167GlnAsp: 2.167 ± 0.046
2.521GlnGlu: 2.521 ± 0.042
1.762GlnPhe: 1.762 ± 0.032
3.076GlnGly: 3.076 ± 0.048
1.421GlnHis: 1.421 ± 0.034
3.079GlnIle: 3.079 ± 0.044
2.391GlnLys: 2.391 ± 0.049
5.41GlnLeu: 5.41 ± 0.076
1.334GlnMet: 1.334 ± 0.031
1.778GlnAsn: 1.778 ± 0.037
2.157GlnPro: 2.157 ± 0.048
3.268GlnGln: 3.268 ± 0.074
2.47GlnArg: 2.47 ± 0.045
3.282GlnSer: 3.282 ± 0.054
2.746GlnThr: 2.746 ± 0.049
3.32GlnVal: 3.32 ± 0.053
0.75GlnTrp: 0.75 ± 0.026
1.602GlnTyr: 1.602 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.282ArgAla: 3.282 ± 0.048
0.581ArgCys: 0.581 ± 0.022
2.408ArgAsp: 2.408 ± 0.038
3.051ArgGlu: 3.051 ± 0.051
2.302ArgPhe: 2.302 ± 0.039
2.575ArgGly: 2.575 ± 0.043
1.557ArgHis: 1.557 ± 0.032
3.193ArgIle: 3.193 ± 0.049
2.473ArgLys: 2.473 ± 0.045
5.48ArgLeu: 5.48 ± 0.064
1.314ArgMet: 1.314 ± 0.03
1.832ArgAsn: 1.832 ± 0.035
1.807ArgPro: 1.807 ± 0.032
2.959ArgGln: 2.959 ± 0.055
2.526ArgArg: 2.526 ± 0.047
2.698ArgSer: 2.698 ± 0.047
2.318ArgThr: 2.318 ± 0.041
3.079ArgVal: 3.079 ± 0.047
0.695ArgTrp: 0.695 ± 0.024
1.937ArgTyr: 1.937 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.607SerAla: 5.607 ± 0.069
0.744SerCys: 0.744 ± 0.025
4.0SerAsp: 4.0 ± 0.065
4.169SerGlu: 4.169 ± 0.058
2.852SerPhe: 2.852 ± 0.045
5.991SerGly: 5.991 ± 0.079
1.829SerHis: 1.829 ± 0.039
3.415SerIle: 3.415 ± 0.054
2.562SerLys: 2.562 ± 0.052
7.071SerLeu: 7.071 ± 0.08
1.761SerMet: 1.761 ± 0.036
2.082SerAsn: 2.082 ± 0.044
2.764SerPro: 2.764 ± 0.045
3.416SerGln: 3.416 ± 0.05
3.341SerArg: 3.341 ± 0.044
4.554SerSer: 4.554 ± 0.085
3.092SerThr: 3.092 ± 0.051
5.297SerVal: 5.297 ± 0.071
0.89SerTrp: 0.89 ± 0.025
2.055SerTyr: 2.055 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
4.524ThrAla: 4.524 ± 0.066
0.563ThrCys: 0.563 ± 0.02
3.109ThrAsp: 3.109 ± 0.052
3.346ThrGlu: 3.346 ± 0.051
2.049ThrPhe: 2.049 ± 0.042
4.63ThrGly: 4.63 ± 0.061
1.356ThrHis: 1.356 ± 0.031
3.454ThrIle: 3.454 ± 0.055
2.16ThrLys: 2.16 ± 0.044
6.081ThrLeu: 6.081 ± 0.081
1.251ThrMet: 1.251 ± 0.031
1.834ThrAsn: 1.834 ± 0.04
2.734ThrPro: 2.734 ± 0.042
2.532ThrGln: 2.532 ± 0.046
2.539ThrArg: 2.539 ± 0.04
3.53ThrSer: 3.53 ± 0.057
3.019ThrThr: 3.019 ± 0.06
3.802ThrVal: 3.802 ± 0.064
0.539ThrTrp: 0.539 ± 0.019
1.623ThrTyr: 1.623 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
5.737ValAla: 5.737 ± 0.063
0.9ValCys: 0.9 ± 0.027
3.671ValAsp: 3.671 ± 0.058
3.735ValGlu: 3.735 ± 0.057
2.836ValPhe: 2.836 ± 0.054
4.064ValGly: 4.064 ± 0.061
1.435ValHis: 1.435 ± 0.032
4.893ValIle: 4.893 ± 0.059
3.446ValLys: 3.446 ± 0.051
6.625ValLeu: 6.625 ± 0.077
2.084ValMet: 2.084 ± 0.043
2.856ValAsn: 2.856 ± 0.047
2.689ValPro: 2.689 ± 0.043
2.426ValGln: 2.426 ± 0.04
3.248ValArg: 3.248 ± 0.051
5.365ValSer: 5.365 ± 0.058
4.296ValThr: 4.296 ± 0.072
4.858ValVal: 4.858 ± 0.073
0.772ValTrp: 0.772 ± 0.023
1.992ValTyr: 1.992 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.796TrpAla: 0.796 ± 0.025
0.182TrpCys: 0.182 ± 0.01
0.621TrpAsp: 0.621 ± 0.019
0.589TrpGlu: 0.589 ± 0.02
0.602TrpPhe: 0.602 ± 0.021
0.798TrpGly: 0.798 ± 0.028
0.398TrpHis: 0.398 ± 0.016
0.747TrpIle: 0.747 ± 0.023
0.567TrpLys: 0.567 ± 0.022
1.71TrpLeu: 1.71 ± 0.035
0.344TrpMet: 0.344 ± 0.017
0.491TrpAsn: 0.491 ± 0.019
0.453TrpPro: 0.453 ± 0.018
0.913TrpGln: 0.913 ± 0.031
0.714TrpArg: 0.714 ± 0.023
0.736TrpSer: 0.736 ± 0.023
0.516TrpThr: 0.516 ± 0.018
0.788TrpVal: 0.788 ± 0.024
0.197TrpTrp: 0.197 ± 0.013
0.382TrpTyr: 0.382 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.337TyrAla: 2.337 ± 0.039
0.425TyrCys: 0.425 ± 0.017
1.785TyrAsp: 1.785 ± 0.046
1.553TyrGlu: 1.553 ± 0.032
1.436TyrPhe: 1.436 ± 0.034
2.16TyrGly: 2.16 ± 0.038
1.008TyrHis: 1.008 ± 0.027
1.927TyrIle: 1.927 ± 0.037
1.311TyrLys: 1.311 ± 0.036
3.515TyrLeu: 3.515 ± 0.05
0.712TyrMet: 0.712 ± 0.024
1.075TyrAsn: 1.075 ± 0.026
1.534TyrPro: 1.534 ± 0.029
2.257TyrGln: 2.257 ± 0.04
1.832TyrArg: 1.832 ± 0.035
1.983TyrSer: 1.983 ± 0.036
1.72TyrThr: 1.72 ± 0.035
1.853TyrVal: 1.853 ± 0.034
0.527TyrTrp: 0.527 ± 0.021
1.145TyrTyr: 1.145 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4565 proteins (1492859 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski