Amino acid dipepetide frequency for Marivirga lumbricoides

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.407AlaAla: 4.407 ± 0.079
0.581AlaCys: 0.581 ± 0.026
3.642AlaAsp: 3.642 ± 0.068
4.612AlaGlu: 4.612 ± 0.072
3.409AlaPhe: 3.409 ± 0.067
4.575AlaGly: 4.575 ± 0.081
1.148AlaHis: 1.148 ± 0.032
5.255AlaIle: 5.255 ± 0.083
4.296AlaLys: 4.296 ± 0.082
6.299AlaLeu: 6.299 ± 0.102
1.464AlaMet: 1.464 ± 0.043
3.242AlaAsn: 3.242 ± 0.064
2.011AlaPro: 2.011 ± 0.051
2.406AlaGln: 2.406 ± 0.046
2.148AlaArg: 2.148 ± 0.053
4.206AlaSer: 4.206 ± 0.076
3.524AlaThr: 3.524 ± 0.066
3.933AlaVal: 3.933 ± 0.067
0.63AlaTrp: 0.63 ± 0.025
2.687AlaTyr: 2.687 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.413CysAla: 0.413 ± 0.02
0.088CysCys: 0.088 ± 0.01
0.389CysAsp: 0.389 ± 0.022
0.495CysGlu: 0.495 ± 0.023
0.413CysPhe: 0.413 ± 0.022
0.57CysGly: 0.57 ± 0.026
0.165CysHis: 0.165 ± 0.014
0.476CysIle: 0.476 ± 0.024
0.455CysLys: 0.455 ± 0.02
0.654CysLeu: 0.654 ± 0.026
0.125CysMet: 0.125 ± 0.011
0.422CysAsn: 0.422 ± 0.022
0.323CysPro: 0.323 ± 0.023
0.225CysGln: 0.225 ± 0.014
0.275CysArg: 0.275 ± 0.018
0.535CysSer: 0.535 ± 0.023
0.364CysThr: 0.364 ± 0.02
0.355CysVal: 0.355 ± 0.02
0.078CysTrp: 0.078 ± 0.009
0.293CysTyr: 0.293 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.401AspAla: 3.401 ± 0.059
0.384AspCys: 0.384 ± 0.024
2.826AspAsp: 2.826 ± 0.068
3.909AspGlu: 3.909 ± 0.065
3.612AspPhe: 3.612 ± 0.067
3.461AspGly: 3.461 ± 0.084
0.929AspHis: 0.929 ± 0.031
4.128AspIle: 4.128 ± 0.071
4.026AspLys: 4.026 ± 0.082
5.391AspLeu: 5.391 ± 0.077
1.119AspMet: 1.119 ± 0.032
3.011AspAsn: 3.011 ± 0.061
1.901AspPro: 1.901 ± 0.051
1.947AspGln: 1.947 ± 0.046
1.953AspArg: 1.953 ± 0.048
3.427AspSer: 3.427 ± 0.07
2.433AspThr: 2.433 ± 0.057
3.185AspVal: 3.185 ± 0.059
0.778AspTrp: 0.778 ± 0.026
2.602AspTyr: 2.602 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
4.901GluAla: 4.901 ± 0.088
0.35GluCys: 0.35 ± 0.019
3.684GluAsp: 3.684 ± 0.054
6.037GluGlu: 6.037 ± 0.11
3.047GluPhe: 3.047 ± 0.057
4.445GluGly: 4.445 ± 0.058
1.129GluHis: 1.129 ± 0.039
5.785GluIle: 5.785 ± 0.08
6.347GluLys: 6.347 ± 0.097
6.89GluLeu: 6.89 ± 0.092
1.859GluMet: 1.859 ± 0.043
4.579GluAsn: 4.579 ± 0.064
1.808GluPro: 1.808 ± 0.039
2.648GluGln: 2.648 ± 0.062
2.71GluArg: 2.71 ± 0.052
3.858GluSer: 3.858 ± 0.065
3.314GluThr: 3.314 ± 0.059
4.74GluVal: 4.74 ± 0.071
0.858GluTrp: 0.858 ± 0.031
2.529GluTyr: 2.529 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
2.846PheAla: 2.846 ± 0.061
0.41PheCys: 0.41 ± 0.019
3.002PheAsp: 3.002 ± 0.055
3.593PheGlu: 3.593 ± 0.059
2.63PhePhe: 2.63 ± 0.067
3.267PheGly: 3.267 ± 0.059
0.935PheHis: 0.935 ± 0.032
4.186PheIle: 4.186 ± 0.076
3.358PheLys: 3.358 ± 0.067
4.93PheLeu: 4.93 ± 0.087
1.107PheMet: 1.107 ± 0.037
3.274PheAsn: 3.274 ± 0.062
1.703PhePro: 1.703 ± 0.041
1.844PheGln: 1.844 ± 0.049
1.834PheArg: 1.834 ± 0.044
4.333PheSer: 4.333 ± 0.057
3.134PheThr: 3.134 ± 0.053
2.819PheVal: 2.819 ± 0.059
0.593PheTrp: 0.593 ± 0.025
2.279PheTyr: 2.279 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.045GlyAla: 4.045 ± 0.075
0.546GlyCys: 0.546 ± 0.029
3.334GlyAsp: 3.334 ± 0.078
4.084GlyGlu: 4.084 ± 0.075
3.577GlyPhe: 3.577 ± 0.054
4.449GlyGly: 4.449 ± 0.093
1.097GlyHis: 1.097 ± 0.038
5.108GlyIle: 5.108 ± 0.074
4.856GlyLys: 4.856 ± 0.074
6.027GlyLeu: 6.027 ± 0.086
1.531GlyMet: 1.531 ± 0.042
3.688GlyAsn: 3.688 ± 0.074
1.38GlyPro: 1.38 ± 0.037
2.009GlyGln: 2.009 ± 0.05
2.291GlyArg: 2.291 ± 0.05
4.172GlySer: 4.172 ± 0.074
3.706GlyThr: 3.706 ± 0.087
4.048GlyVal: 4.048 ± 0.066
0.806GlyTrp: 0.806 ± 0.03
2.759GlyTyr: 2.759 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
0.975HisAla: 0.975 ± 0.032
0.149HisCys: 0.149 ± 0.012
0.784HisAsp: 0.784 ± 0.032
1.071HisGlu: 1.071 ± 0.034
1.167HisPhe: 1.167 ± 0.035
0.998HisGly: 0.998 ± 0.034
0.501HisHis: 0.501 ± 0.023
1.322HisIle: 1.322 ± 0.035
1.113HisLys: 1.113 ± 0.034
1.8HisLeu: 1.8 ± 0.048
0.371HisMet: 0.371 ± 0.02
0.875HisAsn: 0.875 ± 0.028
0.954HisPro: 0.954 ± 0.036
0.908HisGln: 0.908 ± 0.03
0.645HisArg: 0.645 ± 0.025
1.173HisSer: 1.173 ± 0.036
0.895HisThr: 0.895 ± 0.031
0.944HisVal: 0.944 ± 0.028
0.199HisTrp: 0.199 ± 0.014
0.892HisTyr: 0.892 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.368IleAla: 5.368 ± 0.077
0.655IleCys: 0.655 ± 0.027
4.617IleAsp: 4.617 ± 0.066
5.307IleGlu: 5.307 ± 0.078
3.749IlePhe: 3.749 ± 0.074
4.772IleGly: 4.772 ± 0.078
1.46IleHis: 1.46 ± 0.033
5.957IleIle: 5.957 ± 0.107
5.308IleLys: 5.308 ± 0.086
7.022IleLeu: 7.022 ± 0.096
1.432IleMet: 1.432 ± 0.042
4.693IleAsn: 4.693 ± 0.072
3.054IlePro: 3.054 ± 0.051
2.758IleGln: 2.758 ± 0.051
2.82IleArg: 2.82 ± 0.056
6.077IleSer: 6.077 ± 0.102
4.417IleThr: 4.417 ± 0.073
4.433IleVal: 4.433 ± 0.074
0.774IleTrp: 0.774 ± 0.032
2.892IleTyr: 2.892 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.013LysAla: 5.013 ± 0.091
0.361LysCys: 0.361 ± 0.02
3.933LysAsp: 3.933 ± 0.07
6.481LysGlu: 6.481 ± 0.101
2.695LysPhe: 2.695 ± 0.052
4.296LysGly: 4.296 ± 0.074
1.278LysHis: 1.278 ± 0.039
5.765LysIle: 5.765 ± 0.083
6.104LysLys: 6.104 ± 0.102
6.516LysLeu: 6.516 ± 0.091
1.901LysMet: 1.901 ± 0.046
4.478LysAsn: 4.478 ± 0.072
2.43LysPro: 2.43 ± 0.053
2.66LysGln: 2.66 ± 0.058
2.809LysArg: 2.809 ± 0.056
4.686LysSer: 4.686 ± 0.07
3.668LysThr: 3.668 ± 0.067
4.696LysVal: 4.696 ± 0.07
0.813LysTrp: 0.813 ± 0.029
2.899LysTyr: 2.899 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
6.278LeuAla: 6.278 ± 0.097
0.659LeuCys: 0.659 ± 0.026
4.77LeuAsp: 4.77 ± 0.079
6.327LeuGlu: 6.327 ± 0.094
4.929LeuPhe: 4.929 ± 0.068
5.596LeuGly: 5.596 ± 0.072
1.617LeuHis: 1.617 ± 0.039
7.449LeuIle: 7.449 ± 0.107
7.839LeuLys: 7.839 ± 0.09
9.584LeuLeu: 9.584 ± 0.143
2.109LeuMet: 2.109 ± 0.05
5.894LeuAsn: 5.894 ± 0.095
3.668LeuPro: 3.668 ± 0.06
3.618LeuGln: 3.618 ± 0.073
3.442LeuArg: 3.442 ± 0.06
7.612LeuSer: 7.612 ± 0.097
5.01LeuThr: 5.01 ± 0.071
5.274LeuVal: 5.274 ± 0.072
0.904LeuTrp: 0.904 ± 0.037
3.405LeuTyr: 3.405 ± 0.069
0.001LeuXaa: 0.001 ± 0.001
Met
1.632MetAla: 1.632 ± 0.044
0.108MetCys: 0.108 ± 0.009
1.275MetAsp: 1.275 ± 0.036
1.617MetGlu: 1.617 ± 0.041
0.773MetPhe: 0.773 ± 0.031
1.42MetGly: 1.42 ± 0.044
0.465MetHis: 0.465 ± 0.026
1.548MetIle: 1.548 ± 0.044
2.064MetLys: 2.064 ± 0.048
1.975MetLeu: 1.975 ± 0.051
0.63MetMet: 0.63 ± 0.029
1.276MetAsn: 1.276 ± 0.038
0.829MetPro: 0.829 ± 0.03
0.896MetGln: 0.896 ± 0.029
0.945MetArg: 0.945 ± 0.027
1.374MetSer: 1.374 ± 0.041
0.931MetThr: 0.931 ± 0.03
1.338MetVal: 1.338 ± 0.037
0.171MetTrp: 0.171 ± 0.014
0.643MetTyr: 0.643 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.487AsnAla: 3.487 ± 0.057
0.441AsnCys: 0.441 ± 0.023
3.091AsnAsp: 3.091 ± 0.069
4.047AsnGlu: 4.047 ± 0.067
3.0AsnPhe: 3.0 ± 0.058
3.886AsnGly: 3.886 ± 0.086
1.005AsnHis: 1.005 ± 0.033
4.603AsnIle: 4.603 ± 0.082
4.105AsnLys: 4.105 ± 0.071
5.416AsnLeu: 5.416 ± 0.07
1.167AsnMet: 1.167 ± 0.033
3.681AsnAsn: 3.681 ± 0.082
2.603AsnPro: 2.603 ± 0.048
2.34AsnGln: 2.34 ± 0.057
2.235AsnArg: 2.235 ± 0.054
3.993AsnSer: 3.993 ± 0.085
3.171AsnThr: 3.171 ± 0.066
3.042AsnVal: 3.042 ± 0.058
0.748AsnTrp: 0.748 ± 0.023
2.835AsnTyr: 2.835 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.228ProAla: 2.228 ± 0.053
0.212ProCys: 0.212 ± 0.021
2.337ProAsp: 2.337 ± 0.049
3.198ProGlu: 3.198 ± 0.063
1.945ProPhe: 1.945 ± 0.047
2.145ProGly: 2.145 ± 0.062
0.644ProHis: 0.644 ± 0.024
2.484ProIle: 2.484 ± 0.053
2.15ProLys: 2.15 ± 0.05
3.057ProLeu: 3.057 ± 0.064
0.653ProMet: 0.653 ± 0.024
1.898ProAsn: 1.898 ± 0.049
0.922ProPro: 0.922 ± 0.036
1.207ProGln: 1.207 ± 0.04
0.91ProArg: 0.91 ± 0.029
2.243ProSer: 2.243 ± 0.05
1.783ProThr: 1.783 ± 0.046
2.566ProVal: 2.566 ± 0.056
0.364ProTrp: 0.364 ± 0.019
1.414ProTyr: 1.414 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
2.342GlnAla: 2.342 ± 0.052
0.178GlnCys: 0.178 ± 0.013
1.643GlnAsp: 1.643 ± 0.039
2.645GlnGlu: 2.645 ± 0.058
1.894GlnPhe: 1.894 ± 0.049
1.842GlnGly: 1.842 ± 0.043
0.652GlnHis: 0.652 ± 0.025
2.723GlnIle: 2.723 ± 0.051
3.018GlnLys: 3.018 ± 0.061
4.12GlnLeu: 4.12 ± 0.068
0.906GlnMet: 0.906 ± 0.031
2.264GlnAsn: 2.264 ± 0.055
1.172GlnPro: 1.172 ± 0.035
1.858GlnGln: 1.858 ± 0.051
1.359GlnArg: 1.359 ± 0.041
2.537GlnSer: 2.537 ± 0.055
1.787GlnThr: 1.787 ± 0.037
2.171GlnVal: 2.171 ± 0.049
0.514GlnTrp: 0.514 ± 0.021
1.535GlnTyr: 1.535 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.099ArgAla: 2.099 ± 0.051
0.182ArgCys: 0.182 ± 0.013
1.875ArgAsp: 1.875 ± 0.046
2.429ArgGlu: 2.429 ± 0.053
2.001ArgPhe: 2.001 ± 0.047
2.057ArgGly: 2.057 ± 0.05
0.556ArgHis: 0.556 ± 0.025
2.975ArgIle: 2.975 ± 0.052
3.012ArgLys: 3.012 ± 0.061
3.533ArgLeu: 3.533 ± 0.064
0.973ArgMet: 0.973 ± 0.033
2.374ArgAsn: 2.374 ± 0.054
1.139ArgPro: 1.139 ± 0.033
1.374ArgGln: 1.374 ± 0.04
1.387ArgArg: 1.387 ± 0.04
2.109ArgSer: 2.109 ± 0.045
1.834ArgThr: 1.834 ± 0.05
2.214ArgVal: 2.214 ± 0.049
0.439ArgTrp: 0.439 ± 0.021
1.532ArgTyr: 1.532 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
4.302SerAla: 4.302 ± 0.069
0.562SerCys: 0.562 ± 0.023
3.701SerAsp: 3.701 ± 0.064
4.618SerGlu: 4.618 ± 0.064
4.103SerPhe: 4.103 ± 0.071
5.177SerGly: 5.177 ± 0.08
1.16SerHis: 1.16 ± 0.04
5.576SerIle: 5.576 ± 0.079
4.493SerLys: 4.493 ± 0.067
6.855SerLeu: 6.855 ± 0.078
1.338SerMet: 1.338 ± 0.031
3.75SerAsn: 3.75 ± 0.076
2.325SerPro: 2.325 ± 0.054
2.396SerGln: 2.396 ± 0.054
2.36SerArg: 2.36 ± 0.049
4.913SerSer: 4.913 ± 0.099
3.62SerThr: 3.62 ± 0.076
4.08SerVal: 4.08 ± 0.065
0.763SerTrp: 0.763 ± 0.031
2.861SerTyr: 2.861 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
3.616ThrAla: 3.616 ± 0.067
0.349ThrCys: 0.349 ± 0.023
3.133ThrAsp: 3.133 ± 0.063
3.555ThrGlu: 3.555 ± 0.058
2.815ThrPhe: 2.815 ± 0.052
3.781ThrGly: 3.781 ± 0.078
0.915ThrHis: 0.915 ± 0.03
4.303ThrIle: 4.303 ± 0.075
3.042ThrLys: 3.042 ± 0.06
5.077ThrLeu: 5.077 ± 0.071
0.915ThrMet: 0.915 ± 0.029
2.75ThrAsn: 2.75 ± 0.056
2.193ThrPro: 2.193 ± 0.055
1.759ThrGln: 1.759 ± 0.044
1.59ThrArg: 1.59 ± 0.04
3.659ThrSer: 3.659 ± 0.063
2.951ThrThr: 2.951 ± 0.067
3.405ThrVal: 3.405 ± 0.076
0.554ThrTrp: 0.554 ± 0.024
2.184ThrTyr: 2.184 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.083ValAla: 4.083 ± 0.077
0.458ValCys: 0.458 ± 0.023
3.472ValAsp: 3.472 ± 0.059
4.077ValGlu: 4.077 ± 0.064
3.15ValPhe: 3.15 ± 0.056
3.612ValGly: 3.612 ± 0.07
1.006ValHis: 1.006 ± 0.033
4.539ValIle: 4.539 ± 0.069
4.357ValLys: 4.357 ± 0.073
5.614ValLeu: 5.614 ± 0.087
1.263ValMet: 1.263 ± 0.037
3.576ValAsn: 3.576 ± 0.066
2.119ValPro: 2.119 ± 0.047
1.898ValGln: 1.898 ± 0.043
2.135ValArg: 2.135 ± 0.048
4.35ValSer: 4.35 ± 0.074
3.277ValThr: 3.277 ± 0.069
3.89ValVal: 3.89 ± 0.073
0.639ValTrp: 0.639 ± 0.023
2.346ValTyr: 2.346 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.604TrpAla: 0.604 ± 0.023
0.091TrpCys: 0.091 ± 0.01
0.656TrpAsp: 0.656 ± 0.028
0.759TrpGlu: 0.759 ± 0.025
0.533TrpPhe: 0.533 ± 0.025
0.695TrpGly: 0.695 ± 0.031
0.214TrpHis: 0.214 ± 0.014
0.789TrpIle: 0.789 ± 0.031
0.827TrpLys: 0.827 ± 0.026
1.113TrpLeu: 1.113 ± 0.039
0.34TrpMet: 0.34 ± 0.017
0.735TrpAsn: 0.735 ± 0.029
0.321TrpPro: 0.321 ± 0.021
0.564TrpGln: 0.564 ± 0.024
0.499TrpArg: 0.499 ± 0.021
0.759TrpSer: 0.759 ± 0.029
0.512TrpThr: 0.512 ± 0.024
0.66TrpVal: 0.66 ± 0.025
0.171TrpTrp: 0.171 ± 0.012
0.437TrpTyr: 0.437 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.435TyrAla: 2.435 ± 0.046
0.351TyrCys: 0.351 ± 0.019
2.258TyrAsp: 2.258 ± 0.048
2.655TyrGlu: 2.655 ± 0.054
2.635TyrPhe: 2.635 ± 0.062
2.471TyrGly: 2.471 ± 0.048
0.863TyrHis: 0.863 ± 0.03
2.597TyrIle: 2.597 ± 0.052
2.713TyrLys: 2.713 ± 0.054
4.114TyrLeu: 4.114 ± 0.069
0.706TyrMet: 0.706 ± 0.03
2.435TyrAsn: 2.435 ± 0.065
1.508TyrPro: 1.508 ± 0.042
1.844TyrGln: 1.844 ± 0.053
1.741TyrArg: 1.741 ± 0.042
2.936TyrSer: 2.936 ± 0.06
2.212TyrThr: 2.212 ± 0.054
2.064TyrVal: 2.064 ± 0.042
0.486TyrTrp: 0.486 ± 0.023
2.019TyrTyr: 2.019 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.001
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 3452 proteins (1013358 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski