Amino acid dipepetide frequency for Klebsiella phage ST13-OXA48phi12.2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.356AlaAla: 13.356 ± 2.278
1.049AlaCys: 1.049 ± 0.328
6.106AlaAsp: 6.106 ± 0.964
6.774AlaGlu: 6.774 ± 0.938
3.625AlaPhe: 3.625 ± 0.566
6.869AlaGly: 6.869 ± 0.837
0.954AlaHis: 0.954 ± 0.341
4.579AlaIle: 4.579 ± 0.767
5.438AlaLys: 5.438 ± 0.863
10.399AlaLeu: 10.399 ± 1.193
4.102AlaMet: 4.102 ± 0.867
2.767AlaAsn: 2.767 ± 0.583
3.53AlaPro: 3.53 ± 0.772
4.675AlaGln: 4.675 ± 0.763
5.342AlaArg: 5.342 ± 0.805
7.251AlaSer: 7.251 ± 0.968
5.247AlaThr: 5.247 ± 0.73
5.533AlaVal: 5.533 ± 0.62
1.431AlaTrp: 1.431 ± 0.293
2.003AlaTyr: 2.003 ± 0.382
0.0AlaXaa: 0.0 ± 0.0
Cys
0.859CysAla: 0.859 ± 0.312
0.286CysCys: 0.286 ± 0.184
0.954CysAsp: 0.954 ± 0.376
0.572CysGlu: 0.572 ± 0.233
0.477CysPhe: 0.477 ± 0.152
1.717CysGly: 1.717 ± 0.536
0.668CysHis: 0.668 ± 0.193
0.286CysIle: 0.286 ± 0.156
0.668CysLys: 0.668 ± 0.278
0.954CysLeu: 0.954 ± 0.307
0.095CysMet: 0.095 ± 0.108
0.572CysAsn: 0.572 ± 0.278
0.763CysPro: 0.763 ± 0.295
0.382CysGln: 0.382 ± 0.143
0.954CysArg: 0.954 ± 0.369
0.859CysSer: 0.859 ± 0.299
0.382CysThr: 0.382 ± 0.222
0.668CysVal: 0.668 ± 0.256
0.286CysTrp: 0.286 ± 0.138
0.382CysTyr: 0.382 ± 0.205
0.0CysXaa: 0.0 ± 0.0
Asp
5.152AspAla: 5.152 ± 0.761
0.763AspCys: 0.763 ± 0.289
4.675AspAsp: 4.675 ± 1.041
3.721AspGlu: 3.721 ± 0.442
2.957AspPhe: 2.957 ± 0.503
5.533AspGly: 5.533 ± 0.656
0.859AspHis: 0.859 ± 0.32
4.961AspIle: 4.961 ± 0.689
2.767AspLys: 2.767 ± 0.389
5.629AspLeu: 5.629 ± 0.773
0.668AspMet: 0.668 ± 0.234
2.671AspAsn: 2.671 ± 0.359
2.003AspPro: 2.003 ± 0.568
1.908AspGln: 1.908 ± 0.632
2.957AspArg: 2.957 ± 0.518
3.721AspSer: 3.721 ± 0.616
1.908AspThr: 1.908 ± 0.487
4.388AspVal: 4.388 ± 0.694
0.763AspTrp: 0.763 ± 0.27
1.145AspTyr: 1.145 ± 0.286
0.0AspXaa: 0.0 ± 0.0
Glu
6.106GluAla: 6.106 ± 0.842
0.763GluCys: 0.763 ± 0.285
2.957GluAsp: 2.957 ± 0.402
3.625GluGlu: 3.625 ± 0.581
2.48GluPhe: 2.48 ± 0.517
3.721GluGly: 3.721 ± 0.587
1.049GluHis: 1.049 ± 0.251
3.911GluIle: 3.911 ± 0.55
4.198GluLys: 4.198 ± 0.93
5.438GluLeu: 5.438 ± 0.737
1.431GluMet: 1.431 ± 0.299
2.862GluAsn: 2.862 ± 0.508
2.29GluPro: 2.29 ± 0.437
3.434GluGln: 3.434 ± 0.701
3.434GluArg: 3.434 ± 0.607
3.53GluSer: 3.53 ± 0.668
3.721GluThr: 3.721 ± 0.543
4.388GluVal: 4.388 ± 0.647
1.622GluTrp: 1.622 ± 0.56
1.813GluTyr: 1.813 ± 0.359
0.0GluXaa: 0.0 ± 0.0
Phe
3.339PheAla: 3.339 ± 0.427
0.668PheCys: 0.668 ± 0.218
1.813PheAsp: 1.813 ± 0.445
1.813PheGlu: 1.813 ± 0.485
0.954PhePhe: 0.954 ± 0.395
2.576PheGly: 2.576 ± 0.478
0.382PheHis: 0.382 ± 0.25
2.099PheIle: 2.099 ± 0.496
1.813PheLys: 1.813 ± 0.422
2.385PheLeu: 2.385 ± 0.389
1.145PheMet: 1.145 ± 0.275
2.099PheAsn: 2.099 ± 0.464
0.954PhePro: 0.954 ± 0.267
1.145PheGln: 1.145 ± 0.357
2.003PheArg: 2.003 ± 0.397
2.576PheSer: 2.576 ± 0.57
1.908PheThr: 1.908 ± 0.468
1.622PheVal: 1.622 ± 0.411
0.954PheTrp: 0.954 ± 0.248
1.431PheTyr: 1.431 ± 0.416
0.0PheXaa: 0.0 ± 0.0
Gly
6.297GlyAla: 6.297 ± 1.163
0.382GlyCys: 0.382 ± 0.183
3.911GlyAsp: 3.911 ± 0.803
3.911GlyGlu: 3.911 ± 0.561
3.053GlyPhe: 3.053 ± 0.589
5.724GlyGly: 5.724 ± 1.054
1.622GlyHis: 1.622 ± 0.384
4.675GlyIle: 4.675 ± 0.649
4.102GlyLys: 4.102 ± 0.683
6.964GlyLeu: 6.964 ± 0.905
1.908GlyMet: 1.908 ± 0.36
2.48GlyAsn: 2.48 ± 0.522
1.526GlyPro: 1.526 ± 0.388
2.385GlyGln: 2.385 ± 0.376
4.865GlyArg: 4.865 ± 0.508
5.342GlySer: 5.342 ± 0.775
4.484GlyThr: 4.484 ± 0.666
4.579GlyVal: 4.579 ± 0.672
1.336GlyTrp: 1.336 ± 0.311
1.813GlyTyr: 1.813 ± 0.373
0.0GlyXaa: 0.0 ± 0.0
His
1.24HisAla: 1.24 ± 0.43
0.382HisCys: 0.382 ± 0.162
1.145HisAsp: 1.145 ± 0.259
1.049HisGlu: 1.049 ± 0.322
0.286HisPhe: 0.286 ± 0.166
0.954HisGly: 0.954 ± 0.294
0.382HisHis: 0.382 ± 0.167
1.049HisIle: 1.049 ± 0.315
0.477HisLys: 0.477 ± 0.196
1.145HisLeu: 1.145 ± 0.291
0.382HisMet: 0.382 ± 0.185
0.668HisAsn: 0.668 ± 0.279
0.954HisPro: 0.954 ± 0.286
0.763HisGln: 0.763 ± 0.327
1.049HisArg: 1.049 ± 0.345
0.859HisSer: 0.859 ± 0.339
0.954HisThr: 0.954 ± 0.424
0.859HisVal: 0.859 ± 0.27
0.286HisTrp: 0.286 ± 0.212
0.763HisTyr: 0.763 ± 0.292
0.0HisXaa: 0.0 ± 0.0
Ile
6.678IleAla: 6.678 ± 0.87
1.145IleCys: 1.145 ± 0.309
4.102IleAsp: 4.102 ± 0.614
3.721IleGlu: 3.721 ± 0.832
2.003IlePhe: 2.003 ± 0.416
3.053IleGly: 3.053 ± 0.602
0.763IleHis: 0.763 ± 0.262
2.862IleIle: 2.862 ± 0.398
3.816IleLys: 3.816 ± 1.07
3.53IleLeu: 3.53 ± 0.574
1.145IleMet: 1.145 ± 0.263
2.099IleAsn: 2.099 ± 0.434
2.194IlePro: 2.194 ± 0.586
2.003IleGln: 2.003 ± 0.451
3.244IleArg: 3.244 ± 0.569
4.961IleSer: 4.961 ± 0.587
4.388IleThr: 4.388 ± 0.583
2.862IleVal: 2.862 ± 0.474
0.382IleTrp: 0.382 ± 0.209
2.48IleTyr: 2.48 ± 0.366
0.0IleXaa: 0.0 ± 0.0
Lys
5.915LysAla: 5.915 ± 0.873
0.477LysCys: 0.477 ± 0.232
2.003LysAsp: 2.003 ± 0.451
4.388LysGlu: 4.388 ± 0.803
1.526LysPhe: 1.526 ± 0.397
2.767LysGly: 2.767 ± 0.584
0.763LysHis: 0.763 ± 0.293
2.099LysIle: 2.099 ± 0.559
4.388LysLys: 4.388 ± 0.854
5.724LysLeu: 5.724 ± 0.784
1.336LysMet: 1.336 ± 0.347
2.767LysAsn: 2.767 ± 0.74
3.053LysPro: 3.053 ± 0.514
3.244LysGln: 3.244 ± 0.617
2.862LysArg: 2.862 ± 0.349
3.911LysSer: 3.911 ± 0.601
3.721LysThr: 3.721 ± 0.51
4.007LysVal: 4.007 ± 0.717
0.572LysTrp: 0.572 ± 0.236
1.813LysTyr: 1.813 ± 0.318
0.0LysXaa: 0.0 ± 0.0
Leu
8.968LeuAla: 8.968 ± 0.963
1.431LeuCys: 1.431 ± 0.465
4.865LeuAsp: 4.865 ± 0.717
5.915LeuGlu: 5.915 ± 0.805
2.48LeuPhe: 2.48 ± 0.444
4.77LeuGly: 4.77 ± 0.931
1.526LeuHis: 1.526 ± 0.514
5.247LeuIle: 5.247 ± 0.885
5.82LeuLys: 5.82 ± 0.831
6.01LeuLeu: 6.01 ± 0.939
2.099LeuMet: 2.099 ± 0.449
4.102LeuAsn: 4.102 ± 0.555
3.625LeuPro: 3.625 ± 0.569
4.007LeuGln: 4.007 ± 0.711
4.484LeuArg: 4.484 ± 0.665
4.961LeuSer: 4.961 ± 0.57
6.583LeuThr: 6.583 ± 0.822
4.865LeuVal: 4.865 ± 0.654
0.477LeuTrp: 0.477 ± 0.204
1.813LeuTyr: 1.813 ± 0.606
0.0LeuXaa: 0.0 ± 0.0
Met
2.29MetAla: 2.29 ± 0.57
0.191MetCys: 0.191 ± 0.125
1.24MetAsp: 1.24 ± 0.354
0.763MetGlu: 0.763 ± 0.267
1.049MetPhe: 1.049 ± 0.265
1.431MetGly: 1.431 ± 0.373
0.382MetHis: 0.382 ± 0.214
1.717MetIle: 1.717 ± 0.452
1.908MetLys: 1.908 ± 0.41
2.29MetLeu: 2.29 ± 0.516
0.382MetMet: 0.382 ± 0.215
1.526MetAsn: 1.526 ± 0.435
1.431MetPro: 1.431 ± 0.308
1.145MetGln: 1.145 ± 0.342
1.622MetArg: 1.622 ± 0.325
2.003MetSer: 2.003 ± 0.343
2.003MetThr: 2.003 ± 0.473
1.145MetVal: 1.145 ± 0.348
0.382MetTrp: 0.382 ± 0.199
0.191MetTyr: 0.191 ± 0.129
0.0MetXaa: 0.0 ± 0.0
Asn
4.484AsnAla: 4.484 ± 0.854
0.668AsnCys: 0.668 ± 0.207
2.48AsnAsp: 2.48 ± 0.412
1.813AsnGlu: 1.813 ± 0.399
1.145AsnPhe: 1.145 ± 0.334
3.625AsnGly: 3.625 ± 0.551
0.477AsnHis: 0.477 ± 0.331
2.29AsnIle: 2.29 ± 0.486
2.29AsnLys: 2.29 ± 0.359
2.862AsnLeu: 2.862 ± 0.575
0.954AsnMet: 0.954 ± 0.3
2.003AsnAsn: 2.003 ± 0.363
2.767AsnPro: 2.767 ± 0.517
2.099AsnGln: 2.099 ± 0.481
1.622AsnArg: 1.622 ± 0.42
2.576AsnSer: 2.576 ± 0.446
2.003AsnThr: 2.003 ± 0.529
2.194AsnVal: 2.194 ± 0.371
0.286AsnTrp: 0.286 ± 0.157
1.336AsnTyr: 1.336 ± 0.299
0.0AsnXaa: 0.0 ± 0.0
Pro
4.293ProAla: 4.293 ± 0.707
0.572ProCys: 0.572 ± 0.235
2.48ProAsp: 2.48 ± 0.493
3.53ProGlu: 3.53 ± 0.66
1.526ProPhe: 1.526 ± 0.379
3.244ProGly: 3.244 ± 0.514
1.24ProHis: 1.24 ± 0.306
1.813ProIle: 1.813 ± 0.476
1.908ProLys: 1.908 ± 0.423
3.244ProLeu: 3.244 ± 0.663
0.763ProMet: 0.763 ± 0.311
0.763ProAsn: 0.763 ± 0.275
1.717ProPro: 1.717 ± 0.415
1.908ProGln: 1.908 ± 0.417
1.717ProArg: 1.717 ± 0.364
3.339ProSer: 3.339 ± 0.63
2.48ProThr: 2.48 ± 0.542
3.244ProVal: 3.244 ± 0.776
0.477ProTrp: 0.477 ± 0.231
1.908ProTyr: 1.908 ± 0.427
0.0ProXaa: 0.0 ± 0.0
Gln
5.056GlnAla: 5.056 ± 1.046
0.668GlnCys: 0.668 ± 0.186
1.813GlnAsp: 1.813 ± 0.446
2.48GlnGlu: 2.48 ± 0.617
1.145GlnPhe: 1.145 ± 0.284
2.29GlnGly: 2.29 ± 0.525
0.668GlnHis: 0.668 ± 0.263
3.53GlnIle: 3.53 ± 0.688
2.099GlnLys: 2.099 ± 0.484
3.339GlnLeu: 3.339 ± 0.579
1.145GlnMet: 1.145 ± 0.317
2.767GlnAsn: 2.767 ± 0.627
1.336GlnPro: 1.336 ± 0.335
2.385GlnGln: 2.385 ± 0.632
2.862GlnArg: 2.862 ± 0.523
3.148GlnSer: 3.148 ± 0.8
2.576GlnThr: 2.576 ± 0.409
2.576GlnVal: 2.576 ± 0.414
0.477GlnTrp: 0.477 ± 0.157
1.049GlnTyr: 1.049 ± 0.228
0.0GlnXaa: 0.0 ± 0.0
Arg
4.865ArgAla: 4.865 ± 0.819
0.668ArgCys: 0.668 ± 0.235
3.434ArgAsp: 3.434 ± 0.549
4.77ArgGlu: 4.77 ± 0.844
2.194ArgPhe: 2.194 ± 0.417
3.625ArgGly: 3.625 ± 0.521
1.049ArgHis: 1.049 ± 0.337
3.053ArgIle: 3.053 ± 0.582
3.339ArgLys: 3.339 ± 0.594
6.201ArgLeu: 6.201 ± 0.722
1.908ArgMet: 1.908 ± 0.444
2.385ArgAsn: 2.385 ± 0.386
1.908ArgPro: 1.908 ± 0.359
1.622ArgGln: 1.622 ± 0.492
4.198ArgArg: 4.198 ± 0.603
2.099ArgSer: 2.099 ± 0.367
2.671ArgThr: 2.671 ± 0.583
3.244ArgVal: 3.244 ± 0.616
1.145ArgTrp: 1.145 ± 0.403
1.622ArgTyr: 1.622 ± 0.449
0.0ArgXaa: 0.0 ± 0.0
Ser
6.106SerAla: 6.106 ± 0.873
1.049SerCys: 1.049 ± 0.331
4.865SerAsp: 4.865 ± 0.536
3.339SerGlu: 3.339 ± 0.52
2.003SerPhe: 2.003 ± 0.421
7.441SerGly: 7.441 ± 1.178
0.763SerHis: 0.763 ± 0.33
3.148SerIle: 3.148 ± 0.509
2.957SerLys: 2.957 ± 0.547
5.247SerLeu: 5.247 ± 0.702
1.717SerMet: 1.717 ± 0.347
2.194SerAsn: 2.194 ± 0.465
2.767SerPro: 2.767 ± 0.459
2.957SerGln: 2.957 ± 0.829
3.911SerArg: 3.911 ± 0.826
6.106SerSer: 6.106 ± 0.998
4.198SerThr: 4.198 ± 0.626
5.533SerVal: 5.533 ± 0.631
1.526SerTrp: 1.526 ± 0.412
1.908SerTyr: 1.908 ± 0.548
0.0SerXaa: 0.0 ± 0.0
Thr
6.106ThrAla: 6.106 ± 0.837
0.477ThrCys: 0.477 ± 0.247
3.721ThrAsp: 3.721 ± 0.626
3.721ThrGlu: 3.721 ± 0.656
1.526ThrPhe: 1.526 ± 0.346
5.152ThrGly: 5.152 ± 0.909
0.763ThrHis: 0.763 ± 0.272
3.244ThrIle: 3.244 ± 0.713
3.148ThrLys: 3.148 ± 0.548
5.342ThrLeu: 5.342 ± 0.724
1.526ThrMet: 1.526 ± 0.353
1.717ThrAsn: 1.717 ± 0.439
3.721ThrPro: 3.721 ± 0.621
2.48ThrGln: 2.48 ± 0.588
3.053ThrArg: 3.053 ± 0.578
4.579ThrSer: 4.579 ± 0.76
2.194ThrThr: 2.194 ± 0.422
4.579ThrVal: 4.579 ± 0.802
1.24ThrTrp: 1.24 ± 0.386
1.813ThrTyr: 1.813 ± 0.549
0.0ThrXaa: 0.0 ± 0.0
Val
5.629ValAla: 5.629 ± 0.545
0.572ValCys: 0.572 ± 0.206
3.721ValAsp: 3.721 ± 0.553
4.484ValGlu: 4.484 ± 0.489
1.813ValPhe: 1.813 ± 0.412
2.862ValGly: 2.862 ± 0.428
0.668ValHis: 0.668 ± 0.291
4.579ValIle: 4.579 ± 0.785
3.816ValLys: 3.816 ± 0.663
4.007ValLeu: 4.007 ± 0.498
1.145ValMet: 1.145 ± 0.391
2.003ValAsn: 2.003 ± 0.435
3.434ValPro: 3.434 ± 0.624
2.767ValGln: 2.767 ± 0.448
3.434ValArg: 3.434 ± 0.556
4.293ValSer: 4.293 ± 0.61
6.106ValThr: 6.106 ± 0.711
5.629ValVal: 5.629 ± 1.023
1.049ValTrp: 1.049 ± 0.342
2.003ValTyr: 2.003 ± 0.406
0.0ValXaa: 0.0 ± 0.0
Trp
1.526TrpAla: 1.526 ± 0.474
0.191TrpCys: 0.191 ± 0.11
0.859TrpAsp: 0.859 ± 0.311
0.859TrpGlu: 0.859 ± 0.345
0.477TrpPhe: 0.477 ± 0.208
1.049TrpGly: 1.049 ± 0.391
0.095TrpHis: 0.095 ± 0.106
0.668TrpIle: 0.668 ± 0.325
0.763TrpLys: 0.763 ± 0.28
1.336TrpLeu: 1.336 ± 0.368
0.668TrpMet: 0.668 ± 0.241
0.668TrpAsn: 0.668 ± 0.216
0.763TrpPro: 0.763 ± 0.221
0.859TrpGln: 0.859 ± 0.26
0.859TrpArg: 0.859 ± 0.233
1.049TrpSer: 1.049 ± 0.317
0.763TrpThr: 0.763 ± 0.357
1.049TrpVal: 1.049 ± 0.218
0.191TrpTrp: 0.191 ± 0.119
0.763TrpTyr: 0.763 ± 0.306
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.767TyrAla: 2.767 ± 0.457
0.382TyrCys: 0.382 ± 0.195
2.003TyrAsp: 2.003 ± 0.524
1.526TyrGlu: 1.526 ± 0.39
0.954TyrPhe: 0.954 ± 0.321
2.957TyrGly: 2.957 ± 0.615
0.572TyrHis: 0.572 ± 0.24
1.622TyrIle: 1.622 ± 0.341
1.622TyrLys: 1.622 ± 0.486
2.003TyrLeu: 2.003 ± 0.448
0.477TyrMet: 0.477 ± 0.252
0.859TyrAsn: 0.859 ± 0.296
1.431TyrPro: 1.431 ± 0.405
1.336TyrGln: 1.336 ± 0.339
1.526TyrArg: 1.526 ± 0.399
2.576TyrSer: 2.576 ± 0.584
1.813TyrThr: 1.813 ± 0.584
1.049TyrVal: 1.049 ± 0.356
0.572TyrTrp: 0.572 ± 0.212
0.763TyrTyr: 0.763 ± 0.242
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (10483 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski