Amino acid dipepetide frequency for Streptococcus satellite phage Javan364

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.576AlaAla: 1.576 ± 0.939
0.394AlaCys: 0.394 ± 0.452
4.728AlaAsp: 4.728 ± 1.047
7.092AlaGlu: 7.092 ± 2.037
4.334AlaPhe: 4.334 ± 1.594
2.758AlaGly: 2.758 ± 1.091
0.394AlaHis: 0.394 ± 0.447
2.758AlaIle: 2.758 ± 0.842
5.91AlaLys: 5.91 ± 1.208
6.304AlaLeu: 6.304 ± 1.398
2.758AlaMet: 2.758 ± 1.788
1.576AlaAsn: 1.576 ± 0.619
1.182AlaPro: 1.182 ± 0.682
2.758AlaGln: 2.758 ± 0.954
3.546AlaArg: 3.546 ± 0.906
2.758AlaSer: 2.758 ± 0.758
3.152AlaThr: 3.152 ± 0.724
2.758AlaVal: 2.758 ± 0.797
0.0AlaTrp: 0.0 ± 0.0
2.364AlaTyr: 2.364 ± 0.798
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.182CysAsp: 1.182 ± 0.794
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.182CysGly: 1.182 ± 0.898
0.0CysHis: 0.0 ± 0.0
0.394CysIle: 0.394 ± 0.363
0.394CysLys: 0.394 ± 0.329
0.394CysLeu: 0.394 ± 0.331
0.394CysMet: 0.394 ± 0.469
0.788CysAsn: 0.788 ± 0.658
0.788CysPro: 0.788 ± 0.531
1.576CysGln: 1.576 ± 0.965
0.394CysArg: 0.394 ± 0.384
0.0CysSer: 0.0 ± 0.0
0.394CysThr: 0.394 ± 0.447
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.394CysTyr: 0.394 ± 0.386
0.0CysXaa: 0.0 ± 0.0
Asp
0.394AspAla: 0.394 ± 0.367
1.182AspCys: 1.182 ± 0.585
1.97AspAsp: 1.97 ± 1.086
3.546AspGlu: 3.546 ± 0.682
2.364AspPhe: 2.364 ± 1.22
3.546AspGly: 3.546 ± 1.174
0.788AspHis: 0.788 ± 0.55
5.516AspIle: 5.516 ± 1.703
5.122AspLys: 5.122 ± 1.136
8.668AspLeu: 8.668 ± 1.582
1.97AspMet: 1.97 ± 0.867
2.364AspAsn: 2.364 ± 0.563
1.182AspPro: 1.182 ± 0.74
0.394AspGln: 0.394 ± 0.386
2.364AspArg: 2.364 ± 0.788
2.758AspSer: 2.758 ± 1.122
3.94AspThr: 3.94 ± 1.215
1.97AspVal: 1.97 ± 0.983
0.788AspTrp: 0.788 ± 0.41
5.516AspTyr: 5.516 ± 1.439
0.0AspXaa: 0.0 ± 0.0
Glu
5.91GluAla: 5.91 ± 1.467
1.182GluCys: 1.182 ± 0.584
4.728GluAsp: 4.728 ± 1.371
5.91GluGlu: 5.91 ± 1.555
1.97GluPhe: 1.97 ± 0.867
3.152GluGly: 3.152 ± 1.168
1.97GluHis: 1.97 ± 0.523
3.152GluIle: 3.152 ± 1.181
6.698GluLys: 6.698 ± 1.243
8.274GluLeu: 8.274 ± 1.659
2.364GluMet: 2.364 ± 1.051
2.758GluAsn: 2.758 ± 1.105
4.728GluPro: 4.728 ± 1.495
4.334GluGln: 4.334 ± 1.955
6.698GluArg: 6.698 ± 1.843
5.122GluSer: 5.122 ± 1.256
3.152GluThr: 3.152 ± 0.742
0.788GluVal: 0.788 ± 0.493
1.576GluTrp: 1.576 ± 0.723
5.516GluTyr: 5.516 ± 1.294
0.0GluXaa: 0.0 ± 0.0
Phe
1.576PheAla: 1.576 ± 0.774
0.788PheCys: 0.788 ± 0.487
2.758PheAsp: 2.758 ± 0.987
4.334PheGlu: 4.334 ± 1.343
0.788PhePhe: 0.788 ± 0.56
1.97PheGly: 1.97 ± 0.757
0.788PheHis: 0.788 ± 0.548
2.364PheIle: 2.364 ± 1.164
3.152PheLys: 3.152 ± 1.238
3.546PheLeu: 3.546 ± 0.839
0.394PheMet: 0.394 ± 0.507
2.364PheAsn: 2.364 ± 1.364
1.182PhePro: 1.182 ± 0.691
1.576PheGln: 1.576 ± 0.872
2.364PheArg: 2.364 ± 0.902
1.97PheSer: 1.97 ± 0.771
1.576PheThr: 1.576 ± 1.031
1.576PheVal: 1.576 ± 0.89
0.788PheTrp: 0.788 ± 0.455
1.576PheTyr: 1.576 ± 0.634
0.0PheXaa: 0.0 ± 0.0
Gly
3.546GlyAla: 3.546 ± 2.272
0.394GlyCys: 0.394 ± 0.384
3.152GlyAsp: 3.152 ± 1.213
2.758GlyGlu: 2.758 ± 1.095
2.364GlyPhe: 2.364 ± 0.905
3.546GlyGly: 3.546 ± 0.937
0.788GlyHis: 0.788 ± 0.47
3.546GlyIle: 3.546 ± 0.792
4.334GlyLys: 4.334 ± 1.093
6.304GlyLeu: 6.304 ± 1.518
1.182GlyMet: 1.182 ± 0.593
2.758GlyAsn: 2.758 ± 1.113
0.0GlyPro: 0.0 ± 0.0
1.182GlyGln: 1.182 ± 0.617
2.758GlyArg: 2.758 ± 0.775
2.758GlySer: 2.758 ± 1.174
3.546GlyThr: 3.546 ± 1.377
3.152GlyVal: 3.152 ± 1.341
1.576GlyTrp: 1.576 ± 0.702
3.94GlyTyr: 3.94 ± 1.093
0.0GlyXaa: 0.0 ± 0.0
His
2.364HisAla: 2.364 ± 0.756
0.0HisCys: 0.0 ± 0.0
1.576HisAsp: 1.576 ± 0.965
0.788HisGlu: 0.788 ± 0.658
0.788HisPhe: 0.788 ± 0.455
1.182HisGly: 1.182 ± 0.578
0.788HisHis: 0.788 ± 0.628
0.0HisIle: 0.0 ± 0.0
1.182HisLys: 1.182 ± 0.869
2.364HisLeu: 2.364 ± 0.908
0.0HisMet: 0.0 ± 0.0
1.182HisAsn: 1.182 ± 0.74
0.0HisPro: 0.0 ± 0.0
0.394HisGln: 0.394 ± 0.447
0.394HisArg: 0.394 ± 0.507
3.152HisSer: 3.152 ± 1.042
2.364HisThr: 2.364 ± 0.787
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.788HisTyr: 0.788 ± 0.455
0.0HisXaa: 0.0 ± 0.0
Ile
2.758IleAla: 2.758 ± 1.053
0.788IleCys: 0.788 ± 0.55
4.334IleAsp: 4.334 ± 1.522
5.91IleGlu: 5.91 ± 2.599
1.97IlePhe: 1.97 ± 0.918
3.546IleGly: 3.546 ± 0.881
0.394IleHis: 0.394 ± 0.384
3.94IleIle: 3.94 ± 1.138
5.516IleLys: 5.516 ± 1.639
3.94IleLeu: 3.94 ± 1.032
0.788IleMet: 0.788 ± 0.472
1.576IleAsn: 1.576 ± 0.649
2.758IlePro: 2.758 ± 0.77
1.97IleGln: 1.97 ± 0.828
1.576IleArg: 1.576 ± 0.484
8.274IleSer: 8.274 ± 1.477
2.758IleThr: 2.758 ± 0.973
2.364IleVal: 2.364 ± 0.919
0.0IleTrp: 0.0 ± 0.0
3.152IleTyr: 3.152 ± 1.148
0.0IleXaa: 0.0 ± 0.0
Lys
7.092LysAla: 7.092 ± 1.74
0.394LysCys: 0.394 ± 0.485
3.94LysAsp: 3.94 ± 1.085
8.668LysGlu: 8.668 ± 1.719
1.576LysPhe: 1.576 ± 0.528
6.304LysGly: 6.304 ± 1.475
2.758LysHis: 2.758 ± 1.02
5.122LysIle: 5.122 ± 1.335
8.668LysLys: 8.668 ± 3.113
9.062LysLeu: 9.062 ± 1.876
0.788LysMet: 0.788 ± 0.538
5.516LysAsn: 5.516 ± 1.217
5.91LysPro: 5.91 ± 1.509
3.94LysGln: 3.94 ± 1.67
6.698LysArg: 6.698 ± 1.32
4.334LysSer: 4.334 ± 1.291
7.88LysThr: 7.88 ± 2.123
5.91LysVal: 5.91 ± 0.864
0.788LysTrp: 0.788 ± 0.552
2.758LysTyr: 2.758 ± 0.972
0.0LysXaa: 0.0 ± 0.0
Leu
5.516LeuAla: 5.516 ± 1.268
0.394LeuCys: 0.394 ± 0.384
8.668LeuAsp: 8.668 ± 1.621
12.608LeuGlu: 12.608 ± 2.82
3.152LeuPhe: 3.152 ± 1.514
3.94LeuGly: 3.94 ± 1.441
1.182LeuHis: 1.182 ± 0.565
4.334LeuIle: 4.334 ± 1.443
10.638LeuLys: 10.638 ± 2.114
13.396LeuLeu: 13.396 ± 2.741
1.576LeuMet: 1.576 ± 0.649
7.092LeuAsn: 7.092 ± 1.784
2.758LeuPro: 2.758 ± 1.158
5.122LeuGln: 5.122 ± 1.395
3.94LeuArg: 3.94 ± 1.02
5.122LeuSer: 5.122 ± 1.093
5.91LeuThr: 5.91 ± 1.534
5.516LeuVal: 5.516 ± 1.342
1.182LeuTrp: 1.182 ± 0.845
4.334LeuTyr: 4.334 ± 0.864
0.0LeuXaa: 0.0 ± 0.0
Met
2.364MetAla: 2.364 ± 0.926
0.0MetCys: 0.0 ± 0.0
1.182MetAsp: 1.182 ± 0.584
1.576MetGlu: 1.576 ± 1.002
1.182MetPhe: 1.182 ± 0.716
0.788MetGly: 0.788 ± 0.41
0.0MetHis: 0.0 ± 0.0
1.182MetIle: 1.182 ± 0.652
2.758MetLys: 2.758 ± 1.093
1.97MetLeu: 1.97 ± 0.948
0.394MetMet: 0.394 ± 0.507
1.97MetAsn: 1.97 ± 1.075
1.182MetPro: 1.182 ± 0.74
0.394MetGln: 0.394 ± 0.447
1.182MetArg: 1.182 ± 0.488
1.576MetSer: 1.576 ± 0.729
3.94MetThr: 3.94 ± 1.802
1.576MetVal: 1.576 ± 0.632
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.364AsnAla: 2.364 ± 0.768
0.0AsnCys: 0.0 ± 0.0
3.94AsnAsp: 3.94 ± 0.932
3.546AsnGlu: 3.546 ± 1.078
0.788AsnPhe: 0.788 ± 0.452
3.94AsnGly: 3.94 ± 1.113
1.97AsnHis: 1.97 ± 0.649
1.97AsnIle: 1.97 ± 1.298
5.122AsnLys: 5.122 ± 0.815
5.122AsnLeu: 5.122 ± 1.087
0.788AsnMet: 0.788 ± 0.77
2.364AsnAsn: 2.364 ± 1.078
2.364AsnPro: 2.364 ± 0.938
1.182AsnGln: 1.182 ± 0.546
2.758AsnArg: 2.758 ± 1.347
3.546AsnSer: 3.546 ± 1.147
2.364AsnThr: 2.364 ± 1.113
2.364AsnVal: 2.364 ± 0.8
0.0AsnTrp: 0.0 ± 0.0
1.576AsnTyr: 1.576 ± 0.836
0.0AsnXaa: 0.0 ± 0.0
Pro
2.364ProAla: 2.364 ± 0.909
0.0ProCys: 0.0 ± 0.0
1.576ProAsp: 1.576 ± 0.559
2.364ProGlu: 2.364 ± 1.284
2.364ProPhe: 2.364 ± 1.308
1.576ProGly: 1.576 ± 0.93
0.394ProHis: 0.394 ± 0.38
2.364ProIle: 2.364 ± 0.841
5.91ProLys: 5.91 ± 1.39
1.97ProLeu: 1.97 ± 0.913
0.394ProMet: 0.394 ± 0.386
3.152ProAsn: 3.152 ± 1.547
0.788ProPro: 0.788 ± 0.41
1.182ProGln: 1.182 ± 0.663
2.758ProArg: 2.758 ± 1.103
1.97ProSer: 1.97 ± 0.558
1.97ProThr: 1.97 ± 0.523
2.364ProVal: 2.364 ± 0.853
0.394ProTrp: 0.394 ± 0.329
0.788ProTyr: 0.788 ± 0.505
0.0ProXaa: 0.0 ± 0.0
Gln
5.516GlnAla: 5.516 ± 1.934
0.0GlnCys: 0.0 ± 0.0
1.182GlnAsp: 1.182 ± 0.546
2.758GlnGlu: 2.758 ± 1.048
0.788GlnPhe: 0.788 ± 0.482
1.576GlnGly: 1.576 ± 1.141
0.394GlnHis: 0.394 ± 0.447
2.364GlnIle: 2.364 ± 0.708
4.334GlnLys: 4.334 ± 1.243
3.94GlnLeu: 3.94 ± 1.253
0.394GlnMet: 0.394 ± 0.373
0.788GlnAsn: 0.788 ± 0.637
1.97GlnPro: 1.97 ± 0.972
1.576GlnGln: 1.576 ± 0.684
1.97GlnArg: 1.97 ± 0.717
0.394GlnSer: 0.394 ± 0.38
1.576GlnThr: 1.576 ± 0.642
2.364GlnVal: 2.364 ± 0.972
0.0GlnTrp: 0.0 ± 0.0
2.758GlnTyr: 2.758 ± 0.918
0.0GlnXaa: 0.0 ± 0.0
Arg
3.546ArgAla: 3.546 ± 1.248
0.394ArgCys: 0.394 ± 0.384
1.97ArgAsp: 1.97 ± 0.945
3.546ArgGlu: 3.546 ± 1.282
1.97ArgPhe: 1.97 ± 1.019
2.364ArgGly: 2.364 ± 0.894
2.364ArgHis: 2.364 ± 0.936
3.546ArgIle: 3.546 ± 0.822
4.728ArgLys: 4.728 ± 2.128
6.698ArgLeu: 6.698 ± 1.739
0.788ArgMet: 0.788 ± 0.662
3.152ArgAsn: 3.152 ± 1.016
1.182ArgPro: 1.182 ± 0.602
1.97ArgGln: 1.97 ± 0.863
1.576ArgArg: 1.576 ± 0.965
2.758ArgSer: 2.758 ± 0.535
3.546ArgThr: 3.546 ± 1.343
3.152ArgVal: 3.152 ± 0.885
0.0ArgTrp: 0.0 ± 0.0
1.97ArgTyr: 1.97 ± 0.851
0.0ArgXaa: 0.0 ± 0.0
Ser
3.152SerAla: 3.152 ± 0.597
0.788SerCys: 0.788 ± 0.455
3.546SerAsp: 3.546 ± 1.213
3.546SerGlu: 3.546 ± 1.106
1.576SerPhe: 1.576 ± 0.64
3.94SerGly: 3.94 ± 0.781
1.576SerHis: 1.576 ± 0.653
5.516SerIle: 5.516 ± 1.064
3.546SerLys: 3.546 ± 0.724
5.122SerLeu: 5.122 ± 1.325
3.546SerMet: 3.546 ± 1.345
2.364SerAsn: 2.364 ± 0.934
1.576SerPro: 1.576 ± 0.583
1.182SerGln: 1.182 ± 0.601
1.182SerArg: 1.182 ± 0.984
2.758SerSer: 2.758 ± 1.135
3.94SerThr: 3.94 ± 1.113
2.364SerVal: 2.364 ± 1.359
1.182SerTrp: 1.182 ± 0.686
3.152SerTyr: 3.152 ± 1.151
0.0SerXaa: 0.0 ± 0.0
Thr
3.152ThrAla: 3.152 ± 0.948
0.0ThrCys: 0.0 ± 0.0
3.152ThrAsp: 3.152 ± 0.949
4.334ThrGlu: 4.334 ± 1.0
5.122ThrPhe: 5.122 ± 2.163
3.152ThrGly: 3.152 ± 0.551
1.182ThrHis: 1.182 ± 0.463
4.334ThrIle: 4.334 ± 1.491
5.91ThrLys: 5.91 ± 1.31
9.062ThrLeu: 9.062 ± 1.629
2.758ThrMet: 2.758 ± 0.79
2.364ThrAsn: 2.364 ± 0.973
1.97ThrPro: 1.97 ± 0.747
0.788ThrGln: 0.788 ± 0.574
3.152ThrArg: 3.152 ± 0.511
2.758ThrSer: 2.758 ± 1.165
3.152ThrThr: 3.152 ± 1.459
3.546ThrVal: 3.546 ± 1.716
0.788ThrTrp: 0.788 ± 0.505
2.758ThrTyr: 2.758 ± 1.211
0.0ThrXaa: 0.0 ± 0.0
Val
3.546ValAla: 3.546 ± 1.396
0.788ValCys: 0.788 ± 0.507
1.182ValAsp: 1.182 ± 0.714
3.152ValGlu: 3.152 ± 0.962
1.182ValPhe: 1.182 ± 0.669
1.576ValGly: 1.576 ± 0.619
0.0ValHis: 0.0 ± 0.0
2.364ValIle: 2.364 ± 1.357
5.122ValLys: 5.122 ± 1.33
5.516ValLeu: 5.516 ± 1.372
0.788ValMet: 0.788 ± 0.535
2.364ValAsn: 2.364 ± 0.938
3.152ValPro: 3.152 ± 1.325
1.576ValGln: 1.576 ± 0.964
1.97ValArg: 1.97 ± 0.922
0.0ValSer: 0.0 ± 0.0
5.91ValThr: 5.91 ± 1.305
3.152ValVal: 3.152 ± 1.346
0.394ValTrp: 0.394 ± 0.507
3.546ValTyr: 3.546 ± 0.939
0.0ValXaa: 0.0 ± 0.0
Trp
0.394TrpAla: 0.394 ± 0.331
0.0TrpCys: 0.0 ± 0.0
0.394TrpAsp: 0.394 ± 0.331
0.788TrpGlu: 0.788 ± 0.56
0.0TrpPhe: 0.0 ± 0.0
0.394TrpGly: 0.394 ± 0.507
0.394TrpHis: 0.394 ± 0.329
0.788TrpIle: 0.788 ± 0.493
0.0TrpLys: 0.0 ± 0.0
1.182TrpLeu: 1.182 ± 0.577
0.394TrpMet: 0.394 ± 0.449
0.0TrpAsn: 0.0 ± 0.0
0.788TrpPro: 0.788 ± 0.429
0.788TrpGln: 0.788 ± 0.503
0.788TrpArg: 0.788 ± 0.679
1.182TrpSer: 1.182 ± 0.585
0.0TrpThr: 0.0 ± 0.0
1.182TrpVal: 1.182 ± 0.607
0.394TrpTrp: 0.394 ± 0.331
0.394TrpTyr: 0.394 ± 0.329
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.97TyrAla: 1.97 ± 0.834
0.788TyrCys: 0.788 ± 0.482
1.576TyrAsp: 1.576 ± 0.674
2.758TyrGlu: 2.758 ± 1.339
3.152TyrPhe: 3.152 ± 1.586
3.152TyrGly: 3.152 ± 1.188
1.182TyrHis: 1.182 ± 0.56
2.758TyrIle: 2.758 ± 0.96
9.062TyrLys: 9.062 ± 3.342
3.546TyrLeu: 3.546 ± 1.213
2.364TyrMet: 2.364 ± 0.891
1.576TyrAsn: 1.576 ± 0.718
1.182TyrPro: 1.182 ± 1.088
2.758TyrGln: 2.758 ± 0.742
3.152TyrArg: 3.152 ± 1.204
2.364TyrSer: 2.364 ± 0.681
2.364TyrThr: 2.364 ± 0.942
1.182TyrVal: 1.182 ± 0.598
0.394TyrTrp: 0.394 ± 0.384
1.576TyrTyr: 1.576 ± 1.222
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2539 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski