Amino acid dipepetide frequency for Halorubrum sp. JWXQ-INN 858

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.143AlaAla: 17.143 ± 0.227
0.771AlaCys: 0.771 ± 0.031
12.147AlaAsp: 12.147 ± 0.183
8.991AlaGlu: 8.991 ± 0.129
4.398AlaPhe: 4.398 ± 0.073
11.466AlaGly: 11.466 ± 0.152
1.915AlaHis: 1.915 ± 0.05
5.103AlaIle: 5.103 ± 0.084
1.655AlaLys: 1.655 ± 0.043
10.917AlaLeu: 10.917 ± 0.154
2.045AlaMet: 2.045 ± 0.047
2.233AlaAsn: 2.233 ± 0.051
4.15AlaPro: 4.15 ± 0.063
1.584AlaGln: 1.584 ± 0.045
7.004AlaArg: 7.004 ± 0.116
5.344AlaSer: 5.344 ± 0.097
7.535AlaThr: 7.535 ± 0.12
12.604AlaVal: 12.604 ± 0.16
1.126AlaTrp: 1.126 ± 0.041
2.947AlaTyr: 2.947 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.668CysAla: 0.668 ± 0.03
0.087CysCys: 0.087 ± 0.009
0.511CysAsp: 0.511 ± 0.024
0.481CysGlu: 0.481 ± 0.026
0.174CysPhe: 0.174 ± 0.013
0.821CysGly: 0.821 ± 0.035
0.187CysHis: 0.187 ± 0.014
0.211CysIle: 0.211 ± 0.015
0.092CysLys: 0.092 ± 0.011
0.533CysLeu: 0.533 ± 0.025
0.08CysMet: 0.08 ± 0.009
0.163CysAsn: 0.163 ± 0.014
0.491CysPro: 0.491 ± 0.028
0.119CysGln: 0.119 ± 0.013
0.495CysArg: 0.495 ± 0.025
0.375CysSer: 0.375 ± 0.02
0.377CysThr: 0.377 ± 0.021
0.517CysVal: 0.517 ± 0.025
0.064CysTrp: 0.064 ± 0.008
0.178CysTyr: 0.178 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
12.973AspAla: 12.973 ± 0.203
0.598AspCys: 0.598 ± 0.028
9.486AspAsp: 9.486 ± 0.187
7.317AspGlu: 7.317 ± 0.125
1.834AspPhe: 1.834 ± 0.051
10.175AspGly: 10.175 ± 0.166
2.02AspHis: 2.02 ± 0.05
2.105AspIle: 2.105 ± 0.061
0.758AspLys: 0.758 ± 0.04
7.43AspLeu: 7.43 ± 0.102
1.099AspMet: 1.099 ± 0.039
1.107AspAsn: 1.107 ± 0.042
5.79AspPro: 5.79 ± 0.106
1.159AspGln: 1.159 ± 0.041
8.009AspArg: 8.009 ± 0.123
3.01AspSer: 3.01 ± 0.066
4.05AspThr: 4.05 ± 0.091
9.173AspVal: 9.173 ± 0.127
0.937AspTrp: 0.937 ± 0.032
1.668AspTyr: 1.668 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
8.967GluAla: 8.967 ± 0.122
0.41GluCys: 0.41 ± 0.025
4.835GluAsp: 4.835 ± 0.11
5.945GluGlu: 5.945 ± 0.139
2.739GluPhe: 2.739 ± 0.063
5.87GluGly: 5.87 ± 0.087
1.835GluHis: 1.835 ± 0.045
3.33GluIle: 3.33 ± 0.078
1.504GluLys: 1.504 ± 0.051
6.881GluLeu: 6.881 ± 0.097
1.551GluMet: 1.551 ± 0.051
1.78GluAsn: 1.78 ± 0.053
4.459GluPro: 4.459 ± 0.088
1.62GluGln: 1.62 ± 0.047
7.722GluArg: 7.722 ± 0.121
4.165GluSer: 4.165 ± 0.08
5.875GluThr: 5.875 ± 0.106
5.747GluVal: 5.747 ± 0.096
1.029GluTrp: 1.029 ± 0.034
2.152GluTyr: 2.152 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.832PheAla: 3.832 ± 0.078
0.249PheCys: 0.249 ± 0.018
3.227PheAsp: 3.227 ± 0.066
2.897PheGlu: 2.897 ± 0.064
0.973PhePhe: 0.973 ± 0.038
3.257PheGly: 3.257 ± 0.081
0.643PheHis: 0.643 ± 0.026
0.97PheIle: 0.97 ± 0.041
0.438PheLys: 0.438 ± 0.021
2.939PheLeu: 2.939 ± 0.074
0.486PheMet: 0.486 ± 0.026
0.6PheAsn: 0.6 ± 0.03
1.37PhePro: 1.37 ± 0.041
0.569PheGln: 0.569 ± 0.027
1.884PheArg: 1.884 ± 0.045
1.568PheSer: 1.568 ± 0.048
1.837PheThr: 1.837 ± 0.05
3.308PheVal: 3.308 ± 0.078
0.349PheTrp: 0.349 ± 0.021
0.766PheTyr: 0.766 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
9.204GlyAla: 9.204 ± 0.135
0.696GlyCys: 0.696 ± 0.028
8.372GlyAsp: 8.372 ± 0.137
7.012GlyGlu: 7.012 ± 0.092
3.471GlyPhe: 3.471 ± 0.067
8.837GlyGly: 8.837 ± 0.155
1.742GlyHis: 1.742 ± 0.05
4.445GlyIle: 4.445 ± 0.074
1.707GlyLys: 1.707 ± 0.055
7.577GlyLeu: 7.577 ± 0.116
1.667GlyMet: 1.667 ± 0.045
1.892GlyAsn: 1.892 ± 0.056
3.879GlyPro: 3.879 ± 0.082
1.599GlyGln: 1.599 ± 0.04
5.768GlyArg: 5.768 ± 0.084
5.824GlySer: 5.824 ± 0.096
6.439GlyThr: 6.439 ± 0.102
8.971GlyVal: 8.971 ± 0.107
1.206GlyTrp: 1.206 ± 0.036
2.709GlyTyr: 2.709 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.242HisAla: 2.242 ± 0.052
0.145HisCys: 0.145 ± 0.013
1.977HisAsp: 1.977 ± 0.05
1.676HisGlu: 1.676 ± 0.047
0.465HisPhe: 0.465 ± 0.023
2.195HisGly: 2.195 ± 0.056
0.506HisHis: 0.506 ± 0.024
0.466HisIle: 0.466 ± 0.022
0.244HisLys: 0.244 ± 0.016
1.632HisLeu: 1.632 ± 0.048
0.267HisMet: 0.267 ± 0.017
0.415HisAsn: 0.415 ± 0.024
1.212HisPro: 1.212 ± 0.038
0.388HisGln: 0.388 ± 0.022
1.291HisArg: 1.291 ± 0.042
0.656HisSer: 0.656 ± 0.028
1.076HisThr: 1.076 ± 0.034
2.073HisVal: 2.073 ± 0.05
0.2HisTrp: 0.2 ± 0.015
0.486HisTyr: 0.486 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.199IleAla: 5.199 ± 0.075
0.226IleCys: 0.226 ± 0.015
4.275IleAsp: 4.275 ± 0.07
3.905IleGlu: 3.905 ± 0.088
0.601IlePhe: 0.601 ± 0.028
3.992IleGly: 3.992 ± 0.07
0.781IleHis: 0.781 ± 0.03
0.932IleIle: 0.932 ± 0.041
0.593IleLys: 0.593 ± 0.028
2.305IleLeu: 2.305 ± 0.061
0.414IleMet: 0.414 ± 0.027
0.892IleAsn: 0.892 ± 0.034
1.85IlePro: 1.85 ± 0.052
0.805IleGln: 0.805 ± 0.04
2.438IleArg: 2.438 ± 0.053
1.671IleSer: 1.671 ± 0.054
2.069IleThr: 2.069 ± 0.055
3.751IleVal: 3.751 ± 0.082
0.25IleTrp: 0.25 ± 0.018
0.726IleTyr: 0.726 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
1.656LysAla: 1.656 ± 0.053
0.085LysCys: 0.085 ± 0.011
0.824LysAsp: 0.824 ± 0.036
1.084LysGlu: 1.084 ± 0.04
0.436LysPhe: 0.436 ± 0.024
1.285LysGly: 1.285 ± 0.042
0.417LysHis: 0.417 ± 0.023
0.599LysIle: 0.599 ± 0.032
0.427LysLys: 0.427 ± 0.025
1.38LysLeu: 1.38 ± 0.044
0.293LysMet: 0.293 ± 0.019
0.47LysAsn: 0.47 ± 0.028
0.842LysPro: 0.842 ± 0.031
0.513LysGln: 0.513 ± 0.03
1.679LysArg: 1.679 ± 0.054
0.947LysSer: 0.947 ± 0.04
1.03LysThr: 1.03 ± 0.033
1.088LysVal: 1.088 ± 0.042
0.179LysTrp: 0.179 ± 0.015
0.462LysTyr: 0.462 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
11.599LeuAla: 11.599 ± 0.158
0.54LeuCys: 0.54 ± 0.028
7.567LeuAsp: 7.567 ± 0.101
5.926LeuGlu: 5.926 ± 0.099
3.031LeuPhe: 3.031 ± 0.074
7.514LeuGly: 7.514 ± 0.11
1.423LeuHis: 1.423 ± 0.038
2.992LeuIle: 2.992 ± 0.074
1.403LeuLys: 1.403 ± 0.048
8.169LeuLeu: 8.169 ± 0.126
1.244LeuMet: 1.244 ± 0.04
1.521LeuAsn: 1.521 ± 0.044
4.222LeuPro: 4.222 ± 0.075
1.557LeuGln: 1.557 ± 0.048
5.89LeuArg: 5.89 ± 0.076
5.258LeuSer: 5.258 ± 0.079
4.952LeuThr: 4.952 ± 0.074
8.435LeuVal: 8.435 ± 0.129
0.845LeuTrp: 0.845 ± 0.037
2.034LeuTyr: 2.034 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
1.785MetAla: 1.785 ± 0.047
0.109MetCys: 0.109 ± 0.011
1.241MetAsp: 1.241 ± 0.04
0.99MetGlu: 0.99 ± 0.038
0.455MetPhe: 0.455 ± 0.026
1.372MetGly: 1.372 ± 0.042
0.312MetHis: 0.312 ± 0.019
0.635MetIle: 0.635 ± 0.031
0.408MetLys: 0.408 ± 0.023
1.225MetLeu: 1.225 ± 0.04
0.278MetMet: 0.278 ± 0.021
0.58MetAsn: 0.58 ± 0.03
0.716MetPro: 0.716 ± 0.033
0.395MetGln: 0.395 ± 0.019
1.048MetArg: 1.048 ± 0.034
1.346MetSer: 1.346 ± 0.043
1.524MetThr: 1.524 ± 0.041
1.192MetVal: 1.192 ± 0.043
0.144MetTrp: 0.144 ± 0.014
0.431MetTyr: 0.431 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.57AsnAla: 2.57 ± 0.058
0.178AsnCys: 0.178 ± 0.014
1.651AsnAsp: 1.651 ± 0.042
1.57AsnGlu: 1.57 ± 0.046
0.505AsnPhe: 0.505 ± 0.026
1.896AsnGly: 1.896 ± 0.053
0.42AsnHis: 0.42 ± 0.019
0.611AsnIle: 0.611 ± 0.03
0.377AsnLys: 0.377 ± 0.022
1.625AsnLeu: 1.625 ± 0.045
0.34AsnMet: 0.34 ± 0.021
0.451AsnAsn: 0.451 ± 0.027
1.402AsnPro: 1.402 ± 0.042
0.43AsnGln: 0.43 ± 0.025
1.57AsnArg: 1.57 ± 0.046
0.718AsnSer: 0.718 ± 0.033
1.15AsnThr: 1.15 ± 0.039
2.197AsnVal: 2.197 ± 0.054
0.245AsnTrp: 0.245 ± 0.017
0.536AsnTyr: 0.536 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
5.447ProAla: 5.447 ± 0.081
0.233ProCys: 0.233 ± 0.016
5.534ProAsp: 5.534 ± 0.088
4.383ProGlu: 4.383 ± 0.078
1.643ProPhe: 1.643 ± 0.045
4.454ProGly: 4.454 ± 0.075
0.918ProHis: 0.918 ± 0.04
2.01ProIle: 2.01 ± 0.054
0.696ProLys: 0.696 ± 0.028
3.713ProLeu: 3.713 ± 0.068
0.826ProMet: 0.826 ± 0.027
1.068ProAsn: 1.068 ± 0.037
2.353ProPro: 2.353 ± 0.058
0.719ProGln: 0.719 ± 0.029
2.528ProArg: 2.528 ± 0.068
2.596ProSer: 2.596 ± 0.058
3.423ProThr: 3.423 ± 0.082
4.609ProVal: 4.609 ± 0.077
0.513ProTrp: 0.513 ± 0.025
1.129ProTyr: 1.129 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
1.832GlnAla: 1.832 ± 0.05
0.133GlnCys: 0.133 ± 0.012
0.937GlnAsp: 0.937 ± 0.036
1.289GlnGlu: 1.289 ± 0.045
0.658GlnPhe: 0.658 ± 0.032
1.455GlnGly: 1.455 ± 0.046
0.41GlnHis: 0.41 ± 0.022
0.743GlnIle: 0.743 ± 0.033
0.385GlnLys: 0.385 ± 0.021
1.733GlnLeu: 1.733 ± 0.045
0.371GlnMet: 0.371 ± 0.021
0.471GlnAsn: 0.471 ± 0.024
0.934GlnPro: 0.934 ± 0.034
0.586GlnGln: 0.586 ± 0.036
1.603GlnArg: 1.603 ± 0.045
1.044GlnSer: 1.044 ± 0.035
1.037GlnThr: 1.037 ± 0.036
1.447GlnVal: 1.447 ± 0.043
0.251GlnTrp: 0.251 ± 0.017
0.639GlnTyr: 0.639 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
7.367ArgAla: 7.367 ± 0.126
0.469ArgCys: 0.469 ± 0.03
5.709ArgAsp: 5.709 ± 0.083
6.727ArgGlu: 6.727 ± 0.118
2.622ArgPhe: 2.622 ± 0.06
5.278ArgGly: 5.278 ± 0.083
1.268ArgHis: 1.268 ± 0.039
3.297ArgIle: 3.297 ± 0.063
1.259ArgLys: 1.259 ± 0.044
6.485ArgLeu: 6.485 ± 0.093
1.443ArgMet: 1.443 ± 0.04
1.659ArgAsn: 1.659 ± 0.048
2.931ArgPro: 2.931 ± 0.062
1.422ArgGln: 1.422 ± 0.041
5.54ArgArg: 5.54 ± 0.095
3.739ArgSer: 3.739 ± 0.074
4.201ArgThr: 4.201 ± 0.079
6.19ArgVal: 6.19 ± 0.101
0.766ArgTrp: 0.766 ± 0.029
1.982ArgTyr: 1.982 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
5.244SerAla: 5.244 ± 0.076
0.305SerCys: 0.305 ± 0.026
4.292SerAsp: 4.292 ± 0.086
3.611SerGlu: 3.611 ± 0.08
1.698SerPhe: 1.698 ± 0.044
5.173SerGly: 5.173 ± 0.084
0.903SerHis: 0.903 ± 0.033
2.15SerIle: 2.15 ± 0.051
1.016SerLys: 1.016 ± 0.033
4.324SerLeu: 4.324 ± 0.077
0.937SerMet: 0.937 ± 0.031
1.101SerAsn: 1.101 ± 0.036
2.583SerPro: 2.583 ± 0.061
0.985SerGln: 0.985 ± 0.044
3.241SerArg: 3.241 ± 0.058
2.55SerSer: 2.55 ± 0.073
3.351SerThr: 3.351 ± 0.069
4.756SerVal: 4.756 ± 0.077
0.56SerTrp: 0.56 ± 0.026
1.212SerTyr: 1.212 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
7.282ThrAla: 7.282 ± 0.098
0.385ThrCys: 0.385 ± 0.021
5.771ThrAsp: 5.771 ± 0.11
4.205ThrGlu: 4.205 ± 0.076
2.174ThrPhe: 2.174 ± 0.06
5.935ThrGly: 5.935 ± 0.091
1.189ThrHis: 1.189 ± 0.044
2.496ThrIle: 2.496 ± 0.063
0.867ThrLys: 0.867 ± 0.033
5.667ThrLeu: 5.667 ± 0.093
0.97ThrMet: 0.97 ± 0.033
1.356ThrAsn: 1.356 ± 0.04
3.241ThrPro: 3.241 ± 0.076
1.081ThrGln: 1.081 ± 0.033
3.565ThrArg: 3.565 ± 0.067
2.619ThrSer: 2.619 ± 0.066
4.05ThrThr: 4.05 ± 0.081
7.331ThrVal: 7.331 ± 0.116
0.593ThrTrp: 0.593 ± 0.028
1.708ThrTyr: 1.708 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
12.228ValAla: 12.228 ± 0.167
0.715ValCys: 0.715 ± 0.031
9.111ValAsp: 9.111 ± 0.107
7.571ValGlu: 7.571 ± 0.121
3.142ValPhe: 3.142 ± 0.074
8.825ValGly: 8.825 ± 0.127
1.915ValHis: 1.915 ± 0.045
3.53ValIle: 3.53 ± 0.075
1.273ValLys: 1.273 ± 0.043
8.177ValLeu: 8.177 ± 0.124
1.304ValMet: 1.304 ± 0.047
1.885ValAsn: 1.885 ± 0.045
4.763ValPro: 4.763 ± 0.082
1.578ValGln: 1.578 ± 0.045
6.346ValArg: 6.346 ± 0.102
4.994ValSer: 4.994 ± 0.09
6.333ValThr: 6.333 ± 0.112
10.513ValVal: 10.513 ± 0.145
0.813ValTrp: 0.813 ± 0.035
2.15ValTyr: 2.15 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.975TrpAla: 0.975 ± 0.035
0.102TrpCys: 0.102 ± 0.01
0.756TrpAsp: 0.756 ± 0.035
0.751TrpGlu: 0.751 ± 0.03
0.385TrpPhe: 0.385 ± 0.022
0.824TrpGly: 0.824 ± 0.037
0.213TrpHis: 0.213 ± 0.016
0.465TrpIle: 0.465 ± 0.023
0.218TrpLys: 0.218 ± 0.019
1.084TrpLeu: 1.084 ± 0.031
0.223TrpMet: 0.223 ± 0.016
0.296TrpAsn: 0.296 ± 0.017
0.417TrpPro: 0.417 ± 0.024
0.266TrpGln: 0.266 ± 0.016
0.876TrpArg: 0.876 ± 0.033
0.558TrpSer: 0.558 ± 0.027
0.761TrpThr: 0.761 ± 0.028
0.868TrpVal: 0.868 ± 0.031
0.158TrpTrp: 0.158 ± 0.012
0.337TrpTyr: 0.337 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.865TyrAla: 2.865 ± 0.06
0.189TyrCys: 0.189 ± 0.017
2.477TyrAsp: 2.477 ± 0.061
2.086TyrGlu: 2.086 ± 0.052
0.759TyrPhe: 0.759 ± 0.033
2.393TyrGly: 2.393 ± 0.057
0.597TyrHis: 0.597 ± 0.023
0.585TyrIle: 0.585 ± 0.029
0.377TyrLys: 0.377 ± 0.021
2.33TyrLeu: 2.33 ± 0.057
0.345TyrMet: 0.345 ± 0.02
0.505TyrAsn: 0.505 ± 0.026
1.188TyrPro: 1.188 ± 0.039
0.578TyrGln: 0.578 ± 0.027
1.857TyrArg: 1.857 ± 0.048
1.009TyrSer: 1.009 ± 0.04
1.417TyrThr: 1.417 ± 0.047
2.394TyrVal: 2.394 ± 0.056
0.301TyrTrp: 0.301 ± 0.023
0.741TyrTyr: 0.741 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2889 proteins (872988 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski