Amino acid dipepetide frequency for Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.44AlaAla: 5.44 ± 0.106	1.041AlaCys: 1.041 ± 0.036	3.109AlaAsp: 3.109 ± 0.058	4.075AlaGlu: 4.075 ± 0.062	2.997AlaPhe: 2.997 ± 0.056	4.619AlaGly: 4.619 ± 0.091	1.584AlaHis: 1.584 ± 0.048	5.954AlaIle: 5.954 ± 0.079	4.782AlaLys: 4.782 ± 0.073	8.487AlaLeu: 8.487 ± 0.111	2.098AlaMet: 2.098 ± 0.043	3.375AlaAsn: 3.375 ± 0.072	2.256AlaPro: 2.256 ± 0.048	3.162AlaGln: 3.162 ± 0.067	3.184AlaArg: 3.184 ± 0.065	4.53AlaSer: 4.53 ± 0.073	3.543AlaThr: 3.543 ± 0.066	4.476AlaVal: 4.476 ± 0.073	0.735AlaTrp: 0.735 ± 0.028	2.531AlaTyr: 2.531 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.757CysAla: 0.757 ± 0.03	0.201CysCys: 0.201 ± 0.015	0.602CysAsp: 0.602 ± 0.023	0.667CysGlu: 0.667 ± 0.027	0.734CysPhe: 0.734 ± 0.028	0.911CysGly: 0.911 ± 0.034	0.37CysHis: 0.37 ± 0.021	0.848CysIle: 0.848 ± 0.027	0.644CysLys: 0.644 ± 0.028	1.347CysLeu: 1.347 ± 0.035	0.265CysMet: 0.265 ± 0.02	0.504CysAsn: 0.504 ± 0.022	0.532CysPro: 0.532 ± 0.025	0.542CysGln: 0.542 ± 0.025	0.506CysArg: 0.506 ± 0.022	0.868CysSer: 0.868 ± 0.031	0.522CysThr: 0.522 ± 0.024	0.656CysVal: 0.656 ± 0.029	0.132CysTrp: 0.132 ± 0.012	0.493CysTyr: 0.493 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.175AspAla: 3.175 ± 0.059	0.615AspCys: 0.615 ± 0.026	2.228AspAsp: 2.228 ± 0.048	3.469AspGlu: 3.469 ± 0.062	2.502AspPhe: 2.502 ± 0.05	2.675AspGly: 2.675 ± 0.058	0.956AspHis: 0.956 ± 0.029	3.644AspIle: 3.644 ± 0.066	3.616AspLys: 3.616 ± 0.066	5.225AspLeu: 5.225 ± 0.082	1.118AspMet: 1.118 ± 0.032	2.425AspAsn: 2.425 ± 0.06	1.93AspPro: 1.93 ± 0.047	1.572AspGln: 1.572 ± 0.044	1.88AspArg: 1.88 ± 0.04	3.167AspSer: 3.167 ± 0.063	2.292AspThr: 2.292 ± 0.047	2.923AspVal: 2.923 ± 0.054	0.713AspTrp: 0.713 ± 0.024	2.081AspTyr: 2.081 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.144GluAla: 4.144 ± 0.071	0.536GluCys: 0.536 ± 0.026	2.546GluAsp: 2.546 ± 0.054	4.325GluGlu: 4.325 ± 0.086	2.522GluPhe: 2.522 ± 0.056	2.99GluGly: 2.99 ± 0.06	1.549GluHis: 1.549 ± 0.039	4.643GluIle: 4.643 ± 0.08	4.991GluLys: 4.991 ± 0.079	6.988GluLeu: 6.988 ± 0.087	1.549GluMet: 1.549 ± 0.041	3.072GluAsn: 3.072 ± 0.062	1.763GluPro: 1.763 ± 0.047	3.388GluGln: 3.388 ± 0.062	2.794GluArg: 2.794 ± 0.069	3.536GluSer: 3.536 ± 0.062	2.838GluThr: 2.838 ± 0.049	3.495GluVal: 3.495 ± 0.068	0.694GluTrp: 0.694 ± 0.025	1.946GluTyr: 1.946 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.271PheAla: 3.271 ± 0.061	0.713PheCys: 0.713 ± 0.03	2.487PheAsp: 2.487 ± 0.06	2.274PheGlu: 2.274 ± 0.054	2.391PhePhe: 2.391 ± 0.05	2.658PheGly: 2.658 ± 0.061	1.103PheHis: 1.103 ± 0.036	3.734PheIle: 3.734 ± 0.073	2.59PheLys: 2.59 ± 0.057	4.606PheLeu: 4.606 ± 0.087	1.015PheMet: 1.015 ± 0.032	2.503PheAsn: 2.503 ± 0.056	1.656PhePro: 1.656 ± 0.038	1.578PheGln: 1.578 ± 0.042	1.517PheArg: 1.517 ± 0.034	3.603PheSer: 3.603 ± 0.074	2.438PheThr: 2.438 ± 0.059	2.521PheVal: 2.521 ± 0.047	0.573PheTrp: 0.573 ± 0.025	1.777PheTyr: 1.777 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.036GlyAla: 4.036 ± 0.077	0.817GlyCys: 0.817 ± 0.035	2.771GlyAsp: 2.771 ± 0.055	3.351GlyGlu: 3.351 ± 0.07	3.213GlyPhe: 3.213 ± 0.068	3.98GlyGly: 3.98 ± 0.085	1.526GlyHis: 1.526 ± 0.044	5.033GlyIle: 5.033 ± 0.088	4.026GlyLys: 4.026 ± 0.061	6.611GlyLeu: 6.611 ± 0.088	1.722GlyMet: 1.722 ± 0.044	2.583GlyAsn: 2.583 ± 0.051	1.613GlyPro: 1.613 ± 0.058	2.389GlyGln: 2.389 ± 0.058	2.505GlyArg: 2.505 ± 0.053	3.66GlySer: 3.66 ± 0.075	2.96GlyThr: 2.96 ± 0.062	4.208GlyVal: 4.208 ± 0.072	0.825GlyTrp: 0.825 ± 0.032	2.517GlyTyr: 2.517 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.645HisAla: 1.645 ± 0.048	0.441HisCys: 0.441 ± 0.021	1.135HisAsp: 1.135 ± 0.031	1.355HisGlu: 1.355 ± 0.042	1.33HisPhe: 1.33 ± 0.04	1.59HisGly: 1.59 ± 0.043	0.854HisHis: 0.854 ± 0.037	1.549HisIle: 1.549 ± 0.043	1.222HisLys: 1.222 ± 0.032	2.779HisLeu: 2.779 ± 0.051	0.494HisMet: 0.494 ± 0.024	0.999HisAsn: 0.999 ± 0.032	1.275HisPro: 1.275 ± 0.039	1.291HisGln: 1.291 ± 0.04	1.089HisArg: 1.089 ± 0.035	1.57HisSer: 1.57 ± 0.044	1.144HisThr: 1.144 ± 0.038	1.312HisVal: 1.312 ± 0.037	0.399HisTrp: 0.399 ± 0.02	1.165HisTyr: 1.165 ± 0.039	0.0HisXaa: 0.0 ± 0.0
Ile	6.195IleAla: 6.195 ± 0.091	0.87IleCys: 0.87 ± 0.032	4.319IleAsp: 4.319 ± 0.056	4.764IleGlu: 4.764 ± 0.076	2.832IlePhe: 2.832 ± 0.067	4.618IleGly: 4.618 ± 0.077	1.886IleHis: 1.886 ± 0.047	5.562IleIle: 5.562 ± 0.104	5.318IleLys: 5.318 ± 0.085	7.325IleLeu: 7.325 ± 0.095	1.635IleMet: 1.635 ± 0.041	4.455IleAsn: 4.455 ± 0.073	3.616IlePro: 3.616 ± 0.062	3.074IleGln: 3.074 ± 0.053	3.028IleArg: 3.028 ± 0.057	5.357IleSer: 5.357 ± 0.073	4.198IleThr: 4.198 ± 0.073	4.131IleVal: 4.131 ± 0.065	0.668IleTrp: 0.668 ± 0.03	2.426IleTyr: 2.426 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.734LysAla: 4.734 ± 0.078	0.445LysCys: 0.445 ± 0.022	3.14LysAsp: 3.14 ± 0.064	4.898LysGlu: 4.898 ± 0.084	1.803LysPhe: 1.803 ± 0.044	3.434LysGly: 3.434 ± 0.075	1.437LysHis: 1.437 ± 0.042	5.24LysIle: 5.24 ± 0.092	5.034LysLys: 5.034 ± 0.076	6.423LysLeu: 6.423 ± 0.093	1.631LysMet: 1.631 ± 0.038	3.783LysAsn: 3.783 ± 0.081	2.927LysPro: 2.927 ± 0.055	3.428LysGln: 3.428 ± 0.067	2.985LysArg: 2.985 ± 0.053	4.112LysSer: 4.112 ± 0.07	3.808LysThr: 3.808 ± 0.065	3.291LysVal: 3.291 ± 0.064	0.61LysTrp: 0.61 ± 0.028	1.912LysTyr: 1.912 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	8.672LeuAla: 8.672 ± 0.097	1.382LeuCys: 1.382 ± 0.038	5.169LeuAsp: 5.169 ± 0.08	5.831LeuGlu: 5.831 ± 0.077	5.289LeuPhe: 5.289 ± 0.108	6.658LeuGly: 6.658 ± 0.092	2.454LeuHis: 2.454 ± 0.046	8.609LeuIle: 8.609 ± 0.114	6.988LeuLys: 6.988 ± 0.103	11.686LeuLeu: 11.686 ± 0.155	2.708LeuMet: 2.708 ± 0.05	5.735LeuAsn: 5.735 ± 0.068	4.871LeuPro: 4.871 ± 0.069	4.383LeuGln: 4.383 ± 0.072	4.36LeuArg: 4.36 ± 0.068	8.37LeuSer: 8.37 ± 0.107	5.85LeuThr: 5.85 ± 0.07	6.186LeuVal: 6.186 ± 0.088	1.058LeuTrp: 1.058 ± 0.037	3.316LeuTyr: 3.316 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.013MetAla: 2.013 ± 0.048	0.201MetCys: 0.201 ± 0.015	1.257MetAsp: 1.257 ± 0.038	1.301MetGlu: 1.301 ± 0.042	0.797MetPhe: 0.797 ± 0.031	1.538MetGly: 1.538 ± 0.04	0.572MetHis: 0.572 ± 0.024	1.762MetIle: 1.762 ± 0.043	1.666MetLys: 1.666 ± 0.044	2.49MetLeu: 2.49 ± 0.045	0.768MetMet: 0.768 ± 0.034	1.351MetAsn: 1.351 ± 0.04	1.146MetPro: 1.146 ± 0.038	1.152MetGln: 1.152 ± 0.038	1.145MetArg: 1.145 ± 0.037	1.715MetSer: 1.715 ± 0.045	1.433MetThr: 1.433 ± 0.042	1.535MetVal: 1.535 ± 0.043	0.195MetTrp: 0.195 ± 0.017	0.615MetTyr: 0.615 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.334AsnAla: 3.334 ± 0.064	0.565AsnCys: 0.565 ± 0.023	2.307AsnAsp: 2.307 ± 0.048	3.116AsnGlu: 3.116 ± 0.065	1.954AsnPhe: 1.954 ± 0.045	2.671AsnGly: 2.671 ± 0.05	1.451AsnHis: 1.451 ± 0.046	3.414AsnIle: 3.414 ± 0.058	3.549AsnLys: 3.549 ± 0.072	5.134AsnLeu: 5.134 ± 0.083	1.045AsnMet: 1.045 ± 0.031	2.814AsnAsn: 2.814 ± 0.063	2.832AsnPro: 2.832 ± 0.055	2.915AsnGln: 2.915 ± 0.065	2.11AsnArg: 2.11 ± 0.05	3.267AsnSer: 3.267 ± 0.061	2.636AsnThr: 2.636 ± 0.054	2.299AsnVal: 2.299 ± 0.052	0.669AsnTrp: 0.669 ± 0.027	2.014AsnTyr: 2.014 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.689ProAla: 2.689 ± 0.049	0.426ProCys: 0.426 ± 0.021	2.409ProAsp: 2.409 ± 0.05	3.069ProGlu: 3.069 ± 0.063	1.842ProPhe: 1.842 ± 0.042	2.707ProGly: 2.707 ± 0.062	0.926ProHis: 0.926 ± 0.034	2.828ProIle: 2.828 ± 0.052	2.354ProLys: 2.354 ± 0.052	4.307ProLeu: 4.307 ± 0.065	0.934ProMet: 0.934 ± 0.027	1.896ProAsn: 1.896 ± 0.044	1.442ProPro: 1.442 ± 0.044	1.827ProGln: 1.827 ± 0.049	1.335ProArg: 1.335 ± 0.034	2.531ProSer: 2.531 ± 0.053	1.983ProThr: 1.983 ± 0.05	3.178ProVal: 3.178 ± 0.057	0.474ProTrp: 0.474 ± 0.021	1.464ProTyr: 1.464 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.521GlnAla: 3.521 ± 0.058	0.504GlnCys: 0.504 ± 0.025	1.827GlnAsp: 1.827 ± 0.048	2.792GlnGlu: 2.792 ± 0.06	2.175GlnPhe: 2.175 ± 0.044	2.455GlnGly: 2.455 ± 0.056	1.128GlnHis: 1.128 ± 0.04	3.293GlnIle: 3.293 ± 0.054	2.939GlnLys: 2.939 ± 0.056	5.348GlnLeu: 5.348 ± 0.087	1.12GlnMet: 1.12 ± 0.038	2.165GlnAsn: 2.165 ± 0.053	1.565GlnPro: 1.565 ± 0.043	2.546GlnGln: 2.546 ± 0.063	2.022GlnArg: 2.022 ± 0.046	2.865GlnSer: 2.865 ± 0.062	2.245GlnThr: 2.245 ± 0.044	2.545GlnVal: 2.545 ± 0.05	0.635GlnTrp: 0.635 ± 0.021	1.673GlnTyr: 1.673 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.818ArgAla: 2.818 ± 0.066	0.478ArgCys: 0.478 ± 0.023	2.048ArgAsp: 2.048 ± 0.045	2.802ArgGlu: 2.802 ± 0.06	2.145ArgPhe: 2.145 ± 0.043	2.233ArgGly: 2.233 ± 0.046	1.088ArgHis: 1.088 ± 0.034	3.283ArgIle: 3.283 ± 0.069	2.605ArgLys: 2.605 ± 0.051	4.758ArgLeu: 4.758 ± 0.074	1.038ArgMet: 1.038 ± 0.034	1.996ArgAsn: 1.996 ± 0.051	1.332ArgPro: 1.332 ± 0.043	1.958ArgGln: 1.958 ± 0.051	1.854ArgArg: 1.854 ± 0.052	2.292ArgSer: 2.292 ± 0.053	1.955ArgThr: 1.955 ± 0.045	2.611ArgVal: 2.611 ± 0.046	0.493ArgTrp: 0.493 ± 0.024	1.819ArgTyr: 1.819 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.335SerAla: 4.335 ± 0.071	0.847SerCys: 0.847 ± 0.032	3.107SerAsp: 3.107 ± 0.051	3.789SerGlu: 3.789 ± 0.07	3.077SerPhe: 3.077 ± 0.065	4.514SerGly: 4.514 ± 0.063	1.713SerHis: 1.713 ± 0.041	5.05SerIle: 5.05 ± 0.071	3.967SerLys: 3.967 ± 0.07	7.807SerLeu: 7.807 ± 0.099	1.763SerMet: 1.763 ± 0.042	3.093SerAsn: 3.093 ± 0.055	2.822SerPro: 2.822 ± 0.062	3.04SerGln: 3.04 ± 0.059	2.712SerArg: 2.712 ± 0.056	4.823SerSer: 4.823 ± 0.106	3.322SerThr: 3.322 ± 0.068	3.827SerVal: 3.827 ± 0.064	0.796SerTrp: 0.796 ± 0.029	2.392SerTyr: 2.392 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.74ThrAla: 3.74 ± 0.074	0.57ThrCys: 0.57 ± 0.028	2.434ThrAsp: 2.434 ± 0.047	2.811ThrGlu: 2.811 ± 0.052	1.99ThrPhe: 1.99 ± 0.043	3.585ThrGly: 3.585 ± 0.066	1.336ThrHis: 1.336 ± 0.037	3.996ThrIle: 3.996 ± 0.07	2.712ThrLys: 2.712 ± 0.055	6.046ThrLeu: 6.046 ± 0.077	1.155ThrMet: 1.155 ± 0.031	2.272ThrAsn: 2.272 ± 0.058	2.737ThrPro: 2.737 ± 0.051	2.357ThrGln: 2.357 ± 0.057	2.126ThrArg: 2.126 ± 0.045	3.257ThrSer: 3.257 ± 0.059	2.832ThrThr: 2.832 ± 0.051	3.223ThrVal: 3.223 ± 0.058	0.527ThrTrp: 0.527 ± 0.023	1.662ThrTyr: 1.662 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	4.405ValAla: 4.405 ± 0.074	0.727ValCys: 0.727 ± 0.028	3.039ValAsp: 3.039 ± 0.054	3.251ValGlu: 3.251 ± 0.063	2.821ValPhe: 2.821 ± 0.057	3.555ValGly: 3.555 ± 0.062	1.305ValHis: 1.305 ± 0.043	4.825ValIle: 4.825 ± 0.081	3.546ValLys: 3.546 ± 0.07	6.335ValLeu: 6.335 ± 0.087	1.6ValMet: 1.6 ± 0.042	3.008ValAsn: 3.008 ± 0.064	2.255ValPro: 2.255 ± 0.051	1.985ValGln: 1.985 ± 0.05	2.311ValArg: 2.311 ± 0.056	4.112ValSer: 4.112 ± 0.07	3.298ValThr: 3.298 ± 0.065	3.899ValVal: 3.899 ± 0.067	0.596ValTrp: 0.596 ± 0.027	1.923ValTyr: 1.923 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.661TrpAla: 0.661 ± 0.025	0.158TrpCys: 0.158 ± 0.015	0.515TrpAsp: 0.515 ± 0.026	0.553TrpGlu: 0.553 ± 0.025	0.627TrpPhe: 0.627 ± 0.028	0.702TrpGly: 0.702 ± 0.028	0.361TrpHis: 0.361 ± 0.021	0.892TrpIle: 0.892 ± 0.031	0.555TrpLys: 0.555 ± 0.025	1.532TrpLeu: 1.532 ± 0.045	0.292TrpMet: 0.292 ± 0.016	0.531TrpAsn: 0.531 ± 0.025	0.432TrpPro: 0.432 ± 0.022	0.689TrpGln: 0.689 ± 0.032	0.559TrpArg: 0.559 ± 0.023	0.724TrpSer: 0.724 ± 0.029	0.453TrpThr: 0.453 ± 0.02	0.684TrpVal: 0.684 ± 0.026	0.171TrpTrp: 0.171 ± 0.015	0.419TrpTyr: 0.419 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.39TyrAla: 2.39 ± 0.049	0.564TyrCys: 0.564 ± 0.024	1.758TyrAsp: 1.758 ± 0.048	1.814TyrGlu: 1.814 ± 0.042	1.968TyrPhe: 1.968 ± 0.047	2.256TyrGly: 2.256 ± 0.044	1.04TyrHis: 1.04 ± 0.033	2.117TyrIle: 2.117 ± 0.046	1.967TyrLys: 1.967 ± 0.046	4.339TyrLeu: 4.339 ± 0.075	0.702TyrMet: 0.702 ± 0.029	1.536TyrAsn: 1.536 ± 0.045	1.619TyrPro: 1.619 ± 0.045	2.086TyrGln: 2.086 ± 0.046	1.582TyrArg: 1.582 ± 0.046	2.436TyrSer: 2.436 ± 0.058	1.622TyrThr: 1.622 ± 0.042	1.799TyrVal: 1.799 ± 0.044	0.549TyrTrp: 0.549 ± 0.024	1.525TyrTyr: 1.525 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2930 proteins (997422 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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