Amino acid dipepetide frequency for Gordonia phage OneUp

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.689AlaAla: 10.689 ± 0.738
0.657AlaCys: 0.657 ± 0.161
7.334AlaAsp: 7.334 ± 0.457
6.711AlaGlu: 6.711 ± 0.621
2.664AlaPhe: 2.664 ± 0.361
7.507AlaGly: 7.507 ± 0.689
1.66AlaHis: 1.66 ± 0.252
4.428AlaIle: 4.428 ± 0.435
4.117AlaLys: 4.117 ± 0.549
7.922AlaLeu: 7.922 ± 0.563
2.594AlaMet: 2.594 ± 0.28
4.082AlaAsn: 4.082 ± 0.346
3.286AlaPro: 3.286 ± 0.3
4.013AlaGln: 4.013 ± 0.448
6.054AlaArg: 6.054 ± 0.414
4.808AlaSer: 4.808 ± 0.526
5.915AlaThr: 5.915 ± 0.497
6.953AlaVal: 6.953 ± 0.42
2.214AlaTrp: 2.214 ± 0.255
2.94AlaTyr: 2.94 ± 0.357
0.0AlaXaa: 0.0 ± 0.0
Cys
1.28CysAla: 1.28 ± 0.229
0.138CysCys: 0.138 ± 0.065
0.796CysAsp: 0.796 ± 0.192
0.657CysGlu: 0.657 ± 0.168
0.277CysPhe: 0.277 ± 0.09
1.176CysGly: 1.176 ± 0.268
0.381CysHis: 0.381 ± 0.138
0.242CysIle: 0.242 ± 0.082
0.415CysLys: 0.415 ± 0.12
0.277CysLeu: 0.277 ± 0.116
0.069CysMet: 0.069 ± 0.051
0.553CysAsn: 0.553 ± 0.133
0.588CysPro: 0.588 ± 0.171
0.208CysGln: 0.208 ± 0.09
0.83CysArg: 0.83 ± 0.18
0.381CysSer: 0.381 ± 0.113
0.381CysThr: 0.381 ± 0.108
0.657CysVal: 0.657 ± 0.186
0.069CysTrp: 0.069 ± 0.054
0.311CysTyr: 0.311 ± 0.118
0.0CysXaa: 0.0 ± 0.0
Asp
6.815AspAla: 6.815 ± 0.423
0.657AspCys: 0.657 ± 0.179
5.569AspAsp: 5.569 ± 0.599
4.601AspGlu: 4.601 ± 0.585
1.937AspPhe: 1.937 ± 0.275
6.019AspGly: 6.019 ± 0.788
2.041AspHis: 2.041 ± 0.288
3.148AspIle: 3.148 ± 0.363
3.079AspLys: 3.079 ± 0.428
6.261AspLeu: 6.261 ± 0.475
1.557AspMet: 1.557 ± 0.239
1.903AspAsn: 1.903 ± 0.217
4.428AspPro: 4.428 ± 0.356
2.283AspGln: 2.283 ± 0.244
4.255AspArg: 4.255 ± 0.404
3.528AspSer: 3.528 ± 0.333
3.701AspThr: 3.701 ± 0.383
5.154AspVal: 5.154 ± 0.504
1.695AspTrp: 1.695 ± 0.244
2.525AspTyr: 2.525 ± 0.333
0.0AspXaa: 0.0 ± 0.0
Glu
7.368GluAla: 7.368 ± 0.598
0.623GluCys: 0.623 ± 0.165
4.22GluAsp: 4.22 ± 0.535
5.154GluGlu: 5.154 ± 0.585
2.318GluPhe: 2.318 ± 0.289
4.601GluGly: 4.601 ± 0.434
1.764GluHis: 1.764 ± 0.274
3.84GluIle: 3.84 ± 0.403
3.355GluLys: 3.355 ± 0.434
6.019GluLeu: 6.019 ± 0.498
1.695GluMet: 1.695 ± 0.232
2.249GluAsn: 2.249 ± 0.24
2.733GluPro: 2.733 ± 0.376
2.837GluGln: 2.837 ± 0.343
4.186GluArg: 4.186 ± 0.421
3.459GluSer: 3.459 ± 0.351
3.286GluThr: 3.286 ± 0.382
4.947GluVal: 4.947 ± 0.445
1.418GluTrp: 1.418 ± 0.212
2.733GluTyr: 2.733 ± 0.298
0.0GluXaa: 0.0 ± 0.0
Phe
2.871PheAla: 2.871 ± 0.283
0.415PheCys: 0.415 ± 0.12
2.283PheAsp: 2.283 ± 0.26
1.868PheGlu: 1.868 ± 0.263
0.934PhePhe: 0.934 ± 0.186
3.044PheGly: 3.044 ± 0.43
0.623PheHis: 0.623 ± 0.15
1.66PheIle: 1.66 ± 0.275
1.038PheLys: 1.038 ± 0.178
1.799PheLeu: 1.799 ± 0.247
0.934PheMet: 0.934 ± 0.191
1.384PheAsn: 1.384 ± 0.221
1.038PhePro: 1.038 ± 0.187
0.934PheGln: 0.934 ± 0.166
1.453PheArg: 1.453 ± 0.221
2.006PheSer: 2.006 ± 0.261
1.903PheThr: 1.903 ± 0.209
2.249PheVal: 2.249 ± 0.342
0.692PheTrp: 0.692 ± 0.17
0.761PheTyr: 0.761 ± 0.145
0.0PheXaa: 0.0 ± 0.0
Gly
5.881GlyAla: 5.881 ± 0.712
0.83GlyCys: 0.83 ± 0.208
5.777GlyAsp: 5.777 ± 0.733
5.777GlyGlu: 5.777 ± 0.423
2.387GlyPhe: 2.387 ± 0.309
6.4GlyGly: 6.4 ± 0.624
1.522GlyHis: 1.522 ± 0.18
3.771GlyIle: 3.771 ± 0.416
4.393GlyLys: 4.393 ± 0.522
5.708GlyLeu: 5.708 ± 0.528
2.006GlyMet: 2.006 ± 0.428
3.563GlyAsn: 3.563 ± 0.398
3.494GlyPro: 3.494 ± 0.439
3.079GlyGln: 3.079 ± 0.331
4.393GlyArg: 4.393 ± 0.419
5.051GlySer: 5.051 ± 0.468
5.604GlyThr: 5.604 ± 0.523
5.673GlyVal: 5.673 ± 0.495
1.73GlyTrp: 1.73 ± 0.278
2.664GlyTyr: 2.664 ± 0.276
0.0GlyXaa: 0.0 ± 0.0
His
1.522HisAla: 1.522 ± 0.293
0.381HisCys: 0.381 ± 0.118
1.418HisAsp: 1.418 ± 0.217
1.107HisGlu: 1.107 ± 0.178
1.072HisPhe: 1.072 ± 0.222
1.695HisGly: 1.695 ± 0.215
0.519HisHis: 0.519 ± 0.144
1.28HisIle: 1.28 ± 0.251
0.692HisLys: 0.692 ± 0.15
1.903HisLeu: 1.903 ± 0.282
0.623HisMet: 0.623 ± 0.151
0.623HisAsn: 0.623 ± 0.143
1.176HisPro: 1.176 ± 0.234
0.761HisGln: 0.761 ± 0.144
1.626HisArg: 1.626 ± 0.251
1.072HisSer: 1.072 ± 0.231
1.557HisThr: 1.557 ± 0.191
1.384HisVal: 1.384 ± 0.232
0.242HisTrp: 0.242 ± 0.103
1.211HisTyr: 1.211 ± 0.209
0.0HisXaa: 0.0 ± 0.0
Ile
5.12IleAla: 5.12 ± 0.483
0.588IleCys: 0.588 ± 0.156
3.944IleAsp: 3.944 ± 0.394
4.151IleGlu: 4.151 ± 0.457
1.107IlePhe: 1.107 ± 0.183
3.563IleGly: 3.563 ± 0.442
1.28IleHis: 1.28 ± 0.198
2.076IleIle: 2.076 ± 0.305
2.594IleLys: 2.594 ± 0.256
3.01IleLeu: 3.01 ± 0.296
0.796IleMet: 0.796 ± 0.165
2.11IleAsn: 2.11 ± 0.377
2.733IlePro: 2.733 ± 0.414
1.868IleGln: 1.868 ± 0.258
3.321IleArg: 3.321 ± 0.365
2.387IleSer: 2.387 ± 0.325
3.217IleThr: 3.217 ± 0.461
3.079IleVal: 3.079 ± 0.319
0.726IleTrp: 0.726 ± 0.165
1.211IleTyr: 1.211 ± 0.237
0.0IleXaa: 0.0 ± 0.0
Lys
4.22LysAla: 4.22 ± 0.518
0.242LysCys: 0.242 ± 0.114
2.352LysAsp: 2.352 ± 0.244
3.528LysGlu: 3.528 ± 0.382
1.591LysPhe: 1.591 ± 0.302
3.736LysGly: 3.736 ± 0.563
1.072LysHis: 1.072 ± 0.206
2.006LysIle: 2.006 ± 0.36
2.56LysLys: 2.56 ± 0.389
3.944LysLeu: 3.944 ± 0.561
1.384LysMet: 1.384 ± 0.219
1.418LysAsn: 1.418 ± 0.199
2.249LysPro: 2.249 ± 0.262
1.211LysGln: 1.211 ± 0.23
3.805LysArg: 3.805 ± 0.42
2.664LysSer: 2.664 ± 0.354
2.249LysThr: 2.249 ± 0.308
3.632LysVal: 3.632 ± 0.33
0.865LysTrp: 0.865 ± 0.19
1.384LysTyr: 1.384 ± 0.23
0.0LysXaa: 0.0 ± 0.0
Leu
7.195LeuAla: 7.195 ± 0.509
0.761LeuCys: 0.761 ± 0.182
5.673LeuAsp: 5.673 ± 0.535
5.777LeuGlu: 5.777 ± 0.6
2.041LeuPhe: 2.041 ± 0.237
5.708LeuGly: 5.708 ± 0.437
1.764LeuHis: 1.764 ± 0.264
3.217LeuIle: 3.217 ± 0.324
3.355LeuLys: 3.355 ± 0.337
5.085LeuLeu: 5.085 ± 0.472
1.66LeuMet: 1.66 ± 0.237
3.044LeuAsn: 3.044 ± 0.451
3.909LeuPro: 3.909 ± 0.449
2.975LeuGln: 2.975 ± 0.361
5.051LeuArg: 5.051 ± 0.412
4.359LeuSer: 4.359 ± 0.421
4.912LeuThr: 4.912 ± 0.422
4.705LeuVal: 4.705 ± 0.441
1.557LeuTrp: 1.557 ± 0.244
2.076LeuTyr: 2.076 ± 0.289
0.0LeuXaa: 0.0 ± 0.0
Met
3.044MetAla: 3.044 ± 0.356
0.242MetCys: 0.242 ± 0.077
1.384MetAsp: 1.384 ± 0.209
1.142MetGlu: 1.142 ± 0.184
0.692MetPhe: 0.692 ± 0.164
1.73MetGly: 1.73 ± 0.254
0.484MetHis: 0.484 ± 0.127
1.315MetIle: 1.315 ± 0.257
0.865MetLys: 0.865 ± 0.145
1.591MetLeu: 1.591 ± 0.239
0.519MetMet: 0.519 ± 0.147
1.28MetAsn: 1.28 ± 0.176
1.245MetPro: 1.245 ± 0.197
0.865MetGln: 0.865 ± 0.179
1.107MetArg: 1.107 ± 0.204
2.837MetSer: 2.837 ± 0.386
2.076MetThr: 2.076 ± 0.233
1.453MetVal: 1.453 ± 0.233
0.415MetTrp: 0.415 ± 0.105
0.692MetTyr: 0.692 ± 0.131
0.0MetXaa: 0.0 ± 0.0
Asn
4.013AsnAla: 4.013 ± 0.397
0.519AsnCys: 0.519 ± 0.138
2.421AsnAsp: 2.421 ± 0.304
2.629AsnGlu: 2.629 ± 0.297
1.142AsnPhe: 1.142 ± 0.207
3.217AsnGly: 3.217 ± 0.38
0.657AsnHis: 0.657 ± 0.149
1.557AsnIle: 1.557 ± 0.232
1.626AsnLys: 1.626 ± 0.223
3.286AsnLeu: 3.286 ± 0.38
1.072AsnMet: 1.072 ± 0.236
1.487AsnAsn: 1.487 ± 0.272
2.733AsnPro: 2.733 ± 0.317
1.349AsnGln: 1.349 ± 0.223
2.767AsnArg: 2.767 ± 0.43
1.972AsnSer: 1.972 ± 0.293
2.491AsnThr: 2.491 ± 0.333
2.076AsnVal: 2.076 ± 0.282
1.003AsnTrp: 1.003 ± 0.193
1.142AsnTyr: 1.142 ± 0.208
0.0AsnXaa: 0.0 ± 0.0
Pro
4.67ProAla: 4.67 ± 0.343
0.519ProCys: 0.519 ± 0.127
3.425ProAsp: 3.425 ± 0.372
3.459ProGlu: 3.459 ± 0.474
1.833ProPhe: 1.833 ± 0.254
4.532ProGly: 4.532 ± 0.531
1.003ProHis: 1.003 ± 0.185
1.972ProIle: 1.972 ± 0.282
2.11ProLys: 2.11 ± 0.284
2.525ProLeu: 2.525 ± 0.262
0.865ProMet: 0.865 ± 0.146
1.73ProAsn: 1.73 ± 0.275
1.903ProPro: 1.903 ± 0.252
1.211ProGln: 1.211 ± 0.215
2.283ProArg: 2.283 ± 0.358
3.079ProSer: 3.079 ± 0.445
3.183ProThr: 3.183 ± 0.403
3.286ProVal: 3.286 ± 0.36
0.623ProTrp: 0.623 ± 0.163
1.591ProTyr: 1.591 ± 0.205
0.0ProXaa: 0.0 ± 0.0
Gln
3.459GlnAla: 3.459 ± 0.43
0.311GlnCys: 0.311 ± 0.098
2.041GlnAsp: 2.041 ± 0.395
1.937GlnGlu: 1.937 ± 0.28
1.245GlnPhe: 1.245 ± 0.22
3.252GlnGly: 3.252 ± 0.435
0.415GlnHis: 0.415 ± 0.127
1.868GlnIle: 1.868 ± 0.328
1.73GlnLys: 1.73 ± 0.328
3.217GlnLeu: 3.217 ± 0.34
1.28GlnMet: 1.28 ± 0.21
1.28GlnAsn: 1.28 ± 0.279
1.315GlnPro: 1.315 ± 0.208
1.799GlnGln: 1.799 ± 0.345
2.94GlnArg: 2.94 ± 0.463
1.315GlnSer: 1.315 ± 0.294
2.041GlnThr: 2.041 ± 0.283
3.252GlnVal: 3.252 ± 0.319
0.692GlnTrp: 0.692 ± 0.164
1.038GlnTyr: 1.038 ± 0.198
0.0GlnXaa: 0.0 ± 0.0
Arg
5.535ArgAla: 5.535 ± 0.483
0.761ArgCys: 0.761 ± 0.205
4.532ArgAsp: 4.532 ± 0.382
4.428ArgGlu: 4.428 ± 0.456
1.626ArgPhe: 1.626 ± 0.245
4.635ArgGly: 4.635 ± 0.435
1.591ArgHis: 1.591 ± 0.316
3.425ArgIle: 3.425 ± 0.308
3.736ArgLys: 3.736 ± 0.481
4.739ArgLeu: 4.739 ± 0.46
1.833ArgMet: 1.833 ± 0.279
2.525ArgAsn: 2.525 ± 0.319
2.387ArgPro: 2.387 ± 0.309
2.837ArgGln: 2.837 ± 0.355
4.635ArgArg: 4.635 ± 0.51
2.871ArgSer: 2.871 ± 0.305
3.39ArgThr: 3.39 ± 0.356
5.016ArgVal: 5.016 ± 0.398
1.695ArgTrp: 1.695 ± 0.254
2.11ArgTyr: 2.11 ± 0.256
0.0ArgXaa: 0.0 ± 0.0
Ser
4.428SerAla: 4.428 ± 0.489
0.311SerCys: 0.311 ± 0.113
3.978SerAsp: 3.978 ± 0.345
3.355SerGlu: 3.355 ± 0.28
1.418SerPhe: 1.418 ± 0.216
4.705SerGly: 4.705 ± 0.59
1.349SerHis: 1.349 ± 0.297
2.975SerIle: 2.975 ± 0.436
2.179SerLys: 2.179 ± 0.315
4.359SerLeu: 4.359 ± 0.397
1.73SerMet: 1.73 ± 0.283
2.491SerAsn: 2.491 ± 0.312
2.076SerPro: 2.076 ± 0.221
1.799SerGln: 1.799 ± 0.303
3.632SerArg: 3.632 ± 0.329
3.286SerSer: 3.286 ± 0.487
3.528SerThr: 3.528 ± 0.343
4.22SerVal: 4.22 ± 0.418
1.557SerTrp: 1.557 ± 0.283
1.903SerTyr: 1.903 ± 0.277
0.0SerXaa: 0.0 ± 0.0
Thr
6.78ThrAla: 6.78 ± 0.616
0.415ThrCys: 0.415 ± 0.125
4.082ThrAsp: 4.082 ± 0.431
3.805ThrGlu: 3.805 ± 0.341
2.041ThrPhe: 2.041 ± 0.228
5.5ThrGly: 5.5 ± 0.614
1.003ThrHis: 1.003 ± 0.194
3.355ThrIle: 3.355 ± 0.426
2.767ThrLys: 2.767 ± 0.31
4.774ThrLeu: 4.774 ± 0.367
1.28ThrMet: 1.28 ± 0.196
2.283ThrAsn: 2.283 ± 0.264
3.355ThrPro: 3.355 ± 0.314
1.903ThrGln: 1.903 ± 0.286
3.183ThrArg: 3.183 ± 0.305
3.667ThrSer: 3.667 ± 0.451
4.082ThrThr: 4.082 ± 0.511
4.843ThrVal: 4.843 ± 0.478
1.072ThrTrp: 1.072 ± 0.189
2.041ThrTyr: 2.041 ± 0.289
0.0ThrXaa: 0.0 ± 0.0
Val
7.61ValAla: 7.61 ± 0.568
0.796ValCys: 0.796 ± 0.193
5.881ValAsp: 5.881 ± 0.43
5.016ValGlu: 5.016 ± 0.453
1.73ValPhe: 1.73 ± 0.219
4.947ValGly: 4.947 ± 0.476
1.28ValHis: 1.28 ± 0.269
4.151ValIle: 4.151 ± 0.492
3.286ValLys: 3.286 ± 0.281
4.739ValLeu: 4.739 ± 0.386
1.868ValMet: 1.868 ± 0.292
2.664ValAsn: 2.664 ± 0.324
3.148ValPro: 3.148 ± 0.324
2.594ValGln: 2.594 ± 0.343
4.843ValArg: 4.843 ± 0.461
3.494ValSer: 3.494 ± 0.541
4.878ValThr: 4.878 ± 0.525
4.808ValVal: 4.808 ± 0.56
1.211ValTrp: 1.211 ± 0.217
2.283ValTyr: 2.283 ± 0.337
0.0ValXaa: 0.0 ± 0.0
Trp
1.695TrpAla: 1.695 ± 0.246
0.173TrpCys: 0.173 ± 0.083
1.695TrpAsp: 1.695 ± 0.248
1.176TrpGlu: 1.176 ± 0.232
0.692TrpPhe: 0.692 ± 0.198
1.211TrpGly: 1.211 ± 0.209
0.83TrpHis: 0.83 ± 0.195
1.176TrpIle: 1.176 ± 0.186
0.865TrpLys: 0.865 ± 0.157
1.591TrpLeu: 1.591 ± 0.276
0.45TrpMet: 0.45 ± 0.119
1.072TrpAsn: 1.072 ± 0.181
0.761TrpPro: 0.761 ± 0.174
0.865TrpGln: 0.865 ± 0.169
1.28TrpArg: 1.28 ± 0.187
1.349TrpSer: 1.349 ± 0.217
1.73TrpThr: 1.73 ± 0.226
1.418TrpVal: 1.418 ± 0.202
0.553TrpTrp: 0.553 ± 0.154
0.381TrpTyr: 0.381 ± 0.112
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.352TyrAla: 2.352 ± 0.278
0.346TyrCys: 0.346 ± 0.154
2.352TyrAsp: 2.352 ± 0.323
2.525TyrGlu: 2.525 ± 0.339
1.142TyrPhe: 1.142 ± 0.195
2.56TyrGly: 2.56 ± 0.334
0.623TyrHis: 0.623 ± 0.166
1.418TyrIle: 1.418 ± 0.193
1.349TyrLys: 1.349 ± 0.217
2.076TyrLeu: 2.076 ± 0.324
0.726TyrMet: 0.726 ± 0.175
1.418TyrAsn: 1.418 ± 0.203
1.245TyrPro: 1.245 ± 0.221
1.038TyrGln: 1.038 ± 0.181
2.664TyrArg: 2.664 ± 0.3
1.695TyrSer: 1.695 ± 0.283
2.11TyrThr: 2.11 ± 0.261
2.421TyrVal: 2.421 ± 0.335
0.934TyrTrp: 0.934 ± 0.218
1.176TyrTyr: 1.176 ± 0.264
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 163 proteins (28909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski