Amino acid dipepetide frequency for Hubei virga-like virus 18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.697AlaAla: 4.697 ± 1.032
0.553AlaCys: 0.553 ± 0.29
3.868AlaAsp: 3.868 ± 0.746
1.382AlaGlu: 1.382 ± 0.522
3.04AlaPhe: 3.04 ± 0.335
3.592AlaGly: 3.592 ± 1.198
1.658AlaHis: 1.658 ± 0.871
3.592AlaIle: 3.592 ± 1.082
3.868AlaLys: 3.868 ± 2.017
5.25AlaLeu: 5.25 ± 2.303
1.382AlaMet: 1.382 ± 0.904
3.868AlaAsn: 3.868 ± 0.692
3.04AlaPro: 3.04 ± 0.538
3.04AlaGln: 3.04 ± 0.584
2.487AlaArg: 2.487 ± 0.688
4.974AlaSer: 4.974 ± 1.432
3.868AlaThr: 3.868 ± 1.308
3.04AlaVal: 3.04 ± 1.157
0.553AlaTrp: 0.553 ± 0.983
2.487AlaTyr: 2.487 ± 0.607
0.0AlaXaa: 0.0 ± 0.0
Cys
1.658CysAla: 1.658 ± 0.829
1.105CysCys: 1.105 ± 0.301
1.658CysAsp: 1.658 ± 1.219
0.829CysGlu: 0.829 ± 0.435
1.382CysPhe: 1.382 ± 0.424
1.382CysGly: 1.382 ± 0.536
0.0CysHis: 0.0 ± 0.0
0.829CysIle: 0.829 ± 0.435
1.658CysLys: 1.658 ± 0.617
0.553CysLeu: 0.553 ± 0.29
0.0CysMet: 0.0 ± 0.0
0.553CysAsn: 0.553 ± 0.294
1.658CysPro: 1.658 ± 0.514
0.276CysGln: 0.276 ± 0.384
1.658CysArg: 1.658 ± 0.514
3.316CysSer: 3.316 ± 1.11
1.382CysThr: 1.382 ± 0.536
0.553CysVal: 0.553 ± 0.936
0.553CysTrp: 0.553 ± 0.444
0.276CysTyr: 0.276 ± 0.145
0.0CysXaa: 0.0 ± 0.0
Asp
4.145AspAla: 4.145 ± 1.471
1.105AspCys: 1.105 ± 1.046
4.697AspAsp: 4.697 ± 1.012
2.763AspGlu: 2.763 ± 0.727
2.211AspPhe: 2.211 ± 0.832
1.105AspGly: 1.105 ± 0.581
2.487AspHis: 2.487 ± 1.306
6.355AspIle: 6.355 ± 2.251
4.421AspLys: 4.421 ± 1.168
5.25AspLeu: 5.25 ± 1.972
1.658AspMet: 1.658 ± 0.871
3.316AspAsn: 3.316 ± 1.384
3.592AspPro: 3.592 ± 1.318
1.658AspGln: 1.658 ± 0.514
3.04AspArg: 3.04 ± 0.538
5.803AspSer: 5.803 ± 1.359
3.04AspThr: 3.04 ± 0.963
3.592AspVal: 3.592 ± 1.155
0.553AspTrp: 0.553 ± 0.294
6.355AspTyr: 6.355 ± 2.636
0.0AspXaa: 0.0 ± 0.0
Glu
1.382GluAla: 1.382 ± 0.638
1.382GluCys: 1.382 ± 0.395
1.934GluAsp: 1.934 ± 0.436
1.105GluGlu: 1.105 ± 0.391
1.658GluPhe: 1.658 ± 0.693
0.829GluGly: 0.829 ± 0.435
1.934GluHis: 1.934 ± 0.643
3.316GluIle: 3.316 ± 0.641
1.934GluLys: 1.934 ± 0.643
3.868GluLeu: 3.868 ± 0.964
0.276GluMet: 0.276 ± 0.145
1.658GluAsn: 1.658 ± 0.871
0.276GluPro: 0.276 ± 0.384
0.829GluGln: 0.829 ± 0.26
2.763GluArg: 2.763 ± 1.056
1.382GluSer: 1.382 ± 0.726
1.934GluThr: 1.934 ± 0.592
2.763GluVal: 2.763 ± 2.147
0.276GluTrp: 0.276 ± 0.384
3.868GluTyr: 3.868 ± 0.964
0.0GluXaa: 0.0 ± 0.0
Phe
2.763PheAla: 2.763 ± 1.029
1.658PheCys: 1.658 ± 0.514
4.145PheAsp: 4.145 ± 2.116
3.316PheGlu: 3.316 ± 2.209
4.697PhePhe: 4.697 ± 2.272
4.145PheGly: 4.145 ± 1.026
0.829PheHis: 0.829 ± 0.26
3.868PheIle: 3.868 ± 2.825
1.382PheLys: 1.382 ± 0.424
4.697PheLeu: 4.697 ± 1.745
0.276PheMet: 0.276 ± 0.145
2.487PheAsn: 2.487 ± 0.916
1.382PhePro: 1.382 ± 0.395
1.105PheGln: 1.105 ± 0.604
1.934PheArg: 1.934 ± 0.738
6.908PheSer: 6.908 ± 1.602
3.592PheThr: 3.592 ± 1.16
4.697PheVal: 4.697 ± 1.809
0.0PheTrp: 0.0 ± 0.0
1.105PheTyr: 1.105 ± 0.896
0.0PheXaa: 0.0 ± 0.0
Gly
2.211GlyAla: 2.211 ± 0.901
0.276GlyCys: 0.276 ± 0.384
3.592GlyAsp: 3.592 ± 0.648
0.0GlyGlu: 0.0 ± 0.0
2.487GlyPhe: 2.487 ± 0.923
4.145GlyGly: 4.145 ± 0.686
0.829GlyHis: 0.829 ± 0.44
4.145GlyIle: 4.145 ± 0.583
0.829GlyLys: 0.829 ± 0.435
2.487GlyLeu: 2.487 ± 1.173
0.276GlyMet: 0.276 ± 0.145
2.487GlyAsn: 2.487 ± 1.037
1.105GlyPro: 1.105 ± 0.488
0.829GlyGln: 0.829 ± 0.26
1.934GlyArg: 1.934 ± 0.529
3.868GlySer: 3.868 ± 1.159
2.211GlyThr: 2.211 ± 0.901
3.868GlyVal: 3.868 ± 0.692
0.829GlyTrp: 0.829 ± 0.26
2.763GlyTyr: 2.763 ± 1.127
0.0GlyXaa: 0.0 ± 0.0
His
2.487HisAla: 2.487 ± 0.916
0.276HisCys: 0.276 ± 0.816
2.211HisAsp: 2.211 ± 1.161
0.0HisGlu: 0.0 ± 0.0
1.105HisPhe: 1.105 ± 0.896
0.829HisGly: 0.829 ± 0.488
2.211HisHis: 2.211 ± 2.952
0.553HisIle: 0.553 ± 0.29
1.105HisLys: 1.105 ± 0.581
3.592HisLeu: 3.592 ± 1.576
0.829HisMet: 0.829 ± 0.44
1.382HisAsn: 1.382 ± 0.726
0.553HisPro: 0.553 ± 0.738
0.553HisGln: 0.553 ± 0.294
1.382HisArg: 1.382 ± 0.658
3.592HisSer: 3.592 ± 0.985
2.211HisThr: 2.211 ± 1.176
0.829HisVal: 0.829 ± 0.435
0.0HisTrp: 0.0 ± 0.0
1.934HisTyr: 1.934 ± 0.544
0.0HisXaa: 0.0 ± 0.0
Ile
4.145IleAla: 4.145 ± 0.923
1.934IleCys: 1.934 ± 0.388
4.421IleAsp: 4.421 ± 1.298
3.04IleGlu: 3.04 ± 0.84
3.868IlePhe: 3.868 ± 1.481
3.04IleGly: 3.04 ± 0.939
1.382IleHis: 1.382 ± 0.395
4.145IleIle: 4.145 ± 2.399
3.04IleLys: 3.04 ± 0.616
7.184IleLeu: 7.184 ± 1.451
0.829IleMet: 0.829 ± 0.416
5.25IleAsn: 5.25 ± 1.568
3.868IlePro: 3.868 ± 1.2
2.487IleGln: 2.487 ± 0.915
3.04IleArg: 3.04 ± 0.71
6.632IleSer: 6.632 ± 0.853
3.592IleThr: 3.592 ± 0.625
7.184IleVal: 7.184 ± 2.481
0.276IleTrp: 0.276 ± 0.145
2.763IleTyr: 2.763 ± 1.122
0.0IleXaa: 0.0 ± 0.0
Lys
3.868LysAla: 3.868 ± 0.68
0.0LysCys: 0.0 ± 0.0
3.592LysAsp: 3.592 ± 0.985
2.487LysGlu: 2.487 ± 0.82
2.763LysPhe: 2.763 ± 1.452
1.658LysGly: 1.658 ± 0.568
0.829LysHis: 0.829 ± 0.435
2.487LysIle: 2.487 ± 0.916
2.487LysLys: 2.487 ± 0.916
4.974LysLeu: 4.974 ± 0.894
0.553LysMet: 0.553 ± 0.294
1.382LysAsn: 1.382 ± 0.395
4.145LysPro: 4.145 ± 1.172
1.382LysGln: 1.382 ± 0.726
1.382LysArg: 1.382 ± 0.626
4.697LysSer: 4.697 ± 0.947
3.868LysThr: 3.868 ± 0.832
0.829LysVal: 0.829 ± 0.435
0.0LysTrp: 0.0 ± 0.0
1.934LysTyr: 1.934 ± 0.729
0.0LysXaa: 0.0 ± 0.0
Leu
3.04LeuAla: 3.04 ± 0.905
1.105LeuCys: 1.105 ± 0.483
4.974LeuAsp: 4.974 ± 0.732
4.697LeuGlu: 4.697 ± 0.596
8.013LeuPhe: 8.013 ± 3.645
2.487LeuGly: 2.487 ± 1.336
1.382LeuHis: 1.382 ± 0.658
7.737LeuIle: 7.737 ± 1.384
5.803LeuLys: 5.803 ± 0.617
11.605LeuLeu: 11.605 ± 4.372
1.658LeuMet: 1.658 ± 0.617
6.079LeuAsn: 6.079 ± 1.718
4.145LeuPro: 4.145 ± 0.816
1.934LeuGln: 1.934 ± 0.643
4.421LeuArg: 4.421 ± 1.364
8.013LeuSer: 8.013 ± 1.605
6.908LeuThr: 6.908 ± 0.832
6.079LeuVal: 6.079 ± 1.285
1.105LeuTrp: 1.105 ± 0.581
4.697LeuTyr: 4.697 ± 1.892
0.0LeuXaa: 0.0 ± 0.0
Met
1.105MetAla: 1.105 ± 0.581
0.0MetCys: 0.0 ± 0.0
1.105MetAsp: 1.105 ± 0.581
0.829MetGlu: 0.829 ± 0.435
0.829MetPhe: 0.829 ± 0.435
0.829MetGly: 0.829 ± 0.682
0.276MetHis: 0.276 ± 0.145
1.105MetIle: 1.105 ± 0.581
0.829MetLys: 0.829 ± 0.668
1.658MetLeu: 1.658 ± 0.405
0.276MetMet: 0.276 ± 0.145
0.829MetAsn: 0.829 ± 1.172
0.829MetPro: 0.829 ± 0.682
0.829MetGln: 0.829 ± 0.26
1.382MetArg: 1.382 ± 0.332
0.829MetSer: 0.829 ± 0.925
0.276MetThr: 0.276 ± 0.145
0.553MetVal: 0.553 ± 0.294
0.276MetTrp: 0.276 ± 0.145
1.382MetTyr: 1.382 ± 0.63
0.0MetXaa: 0.0 ± 0.0
Asn
5.803AsnAla: 5.803 ± 1.978
1.105AsnCys: 1.105 ± 0.581
2.211AsnAsp: 2.211 ± 0.901
1.382AsnGlu: 1.382 ± 0.568
2.487AsnPhe: 2.487 ± 0.688
1.658AsnGly: 1.658 ± 0.331
2.211AsnHis: 2.211 ± 0.593
4.974AsnIle: 4.974 ± 0.845
2.763AsnLys: 2.763 ± 0.451
4.145AsnLeu: 4.145 ± 0.78
0.829AsnMet: 0.829 ± 0.378
3.868AsnAsn: 3.868 ± 1.557
3.592AsnPro: 3.592 ± 0.706
0.553AsnGln: 0.553 ± 0.29
3.04AsnArg: 3.04 ± 1.197
2.487AsnSer: 2.487 ± 0.48
3.04AsnThr: 3.04 ± 1.046
3.04AsnVal: 3.04 ± 0.859
0.276AsnTrp: 0.276 ± 0.145
4.145AsnTyr: 4.145 ± 0.78
0.0AsnXaa: 0.0 ± 0.0
Pro
3.04ProAla: 3.04 ± 3.223
0.276ProCys: 0.276 ± 0.384
2.763ProAsp: 2.763 ± 0.451
1.658ProGlu: 1.658 ± 0.514
1.658ProPhe: 1.658 ± 0.405
1.934ProGly: 1.934 ± 0.643
0.829ProHis: 0.829 ± 0.435
3.592ProIle: 3.592 ± 1.437
0.829ProLys: 0.829 ± 0.435
4.697ProLeu: 4.697 ± 0.665
0.276ProMet: 0.276 ± 0.606
3.316ProAsn: 3.316 ± 0.688
2.763ProPro: 2.763 ± 2.998
0.829ProGln: 0.829 ± 0.435
2.487ProArg: 2.487 ± 0.734
5.25ProSer: 5.25 ± 1.348
4.421ProThr: 4.421 ± 0.741
4.697ProVal: 4.697 ± 0.756
0.553ProTrp: 0.553 ± 0.29
2.211ProTyr: 2.211 ± 0.778
0.0ProXaa: 0.0 ± 0.0
Gln
1.934GlnAla: 1.934 ± 0.544
1.658GlnCys: 1.658 ± 0.52
2.211GlnAsp: 2.211 ± 0.484
0.829GlnGlu: 0.829 ± 0.435
2.211GlnPhe: 2.211 ± 0.912
0.553GlnGly: 0.553 ± 0.29
0.553GlnHis: 0.553 ± 0.294
2.763GlnIle: 2.763 ± 0.516
0.829GlnLys: 0.829 ± 0.427
2.211GlnLeu: 2.211 ± 0.778
1.105GlnMet: 1.105 ± 0.713
1.105GlnAsn: 1.105 ± 0.715
1.382GlnPro: 1.382 ± 0.561
1.658GlnGln: 1.658 ± 0.514
1.382GlnArg: 1.382 ± 0.726
0.829GlnSer: 0.829 ± 0.427
1.934GlnThr: 1.934 ± 0.913
1.658GlnVal: 1.658 ± 0.806
0.553GlnTrp: 0.553 ± 0.29
1.658GlnTyr: 1.658 ± 0.882
0.0GlnXaa: 0.0 ± 0.0
Arg
1.934ArgAla: 1.934 ± 0.818
1.382ArgCys: 1.382 ± 0.726
3.316ArgAsp: 3.316 ± 0.679
1.934ArgGlu: 1.934 ± 0.755
3.04ArgPhe: 3.04 ± 1.597
1.934ArgGly: 1.934 ± 0.446
1.658ArgHis: 1.658 ± 0.514
4.421ArgIle: 4.421 ± 1.071
1.105ArgLys: 1.105 ± 0.929
5.25ArgLeu: 5.25 ± 1.568
0.829ArgMet: 0.829 ± 0.488
3.04ArgAsn: 3.04 ± 1.197
1.934ArgPro: 1.934 ± 0.388
1.658ArgGln: 1.658 ± 0.882
2.763ArgArg: 2.763 ± 1.065
4.697ArgSer: 4.697 ± 0.448
3.868ArgThr: 3.868 ± 0.85
2.487ArgVal: 2.487 ± 1.305
0.829ArgTrp: 0.829 ± 0.26
3.316ArgTyr: 3.316 ± 1.339
0.0ArgXaa: 0.0 ± 0.0
Ser
4.421SerAla: 4.421 ± 2.652
1.934SerCys: 1.934 ± 1.006
5.25SerAsp: 5.25 ± 1.454
2.211SerGlu: 2.211 ± 0.484
4.974SerPhe: 4.974 ± 2.23
4.697SerGly: 4.697 ± 0.784
2.211SerHis: 2.211 ± 0.508
7.461SerIle: 7.461 ± 1.112
3.316SerLys: 3.316 ± 1.284
9.947SerLeu: 9.947 ± 1.689
2.211SerMet: 2.211 ± 0.484
3.316SerAsn: 3.316 ± 0.641
4.145SerPro: 4.145 ± 1.004
2.211SerGln: 2.211 ± 1.33
6.079SerArg: 6.079 ± 0.991
7.461SerSer: 7.461 ± 3.115
5.25SerThr: 5.25 ± 0.929
5.526SerVal: 5.526 ± 0.775
0.553SerTrp: 0.553 ± 0.294
4.145SerTyr: 4.145 ± 1.51
0.0SerXaa: 0.0 ± 0.0
Thr
3.316ThrAla: 3.316 ± 0.904
1.382ThrCys: 1.382 ± 0.923
5.25ThrAsp: 5.25 ± 0.63
1.105ThrGlu: 1.105 ± 0.581
2.487ThrPhe: 2.487 ± 0.78
1.934ThrGly: 1.934 ± 0.643
2.487ThrHis: 2.487 ± 1.589
4.974ThrIle: 4.974 ± 1.517
2.211ThrLys: 2.211 ± 1.161
5.526ThrLeu: 5.526 ± 1.692
1.105ThrMet: 1.105 ± 0.483
2.763ThrAsn: 2.763 ± 0.884
3.868ThrPro: 3.868 ± 1.31
3.04ThrGln: 3.04 ± 0.963
3.868ThrArg: 3.868 ± 1.625
6.632ThrSer: 6.632 ± 1.802
5.25ThrThr: 5.25 ± 1.084
4.145ThrVal: 4.145 ± 0.832
1.658ThrTrp: 1.658 ± 1.111
2.487ThrTyr: 2.487 ± 2.584
0.0ThrXaa: 0.0 ± 0.0
Val
4.974ValAla: 4.974 ± 0.985
1.382ValCys: 1.382 ± 0.934
4.974ValAsp: 4.974 ± 1.314
3.868ValGlu: 3.868 ± 0.68
3.316ValPhe: 3.316 ± 1.787
2.211ValGly: 2.211 ± 1.028
1.934ValHis: 1.934 ± 0.643
2.211ValIle: 2.211 ± 0.508
4.145ValLys: 4.145 ± 0.957
5.526ValLeu: 5.526 ± 1.556
0.829ValMet: 0.829 ± 0.26
3.04ValAsn: 3.04 ± 1.26
3.868ValPro: 3.868 ± 1.08
1.382ValGln: 1.382 ± 0.726
3.592ValArg: 3.592 ± 1.172
5.526ValSer: 5.526 ± 1.488
5.25ValThr: 5.25 ± 1.63
6.079ValVal: 6.079 ± 1.634
0.553ValTrp: 0.553 ± 0.29
1.382ValTyr: 1.382 ± 0.726
0.0ValXaa: 0.0 ± 0.0
Trp
0.553TrpAla: 0.553 ± 0.294
0.276TrpCys: 0.276 ± 0.145
1.105TrpAsp: 1.105 ± 0.301
0.276TrpGlu: 0.276 ± 0.145
0.553TrpPhe: 0.553 ± 0.294
0.553TrpGly: 0.553 ± 0.29
0.276TrpHis: 0.276 ± 0.145
0.829TrpIle: 0.829 ± 0.885
0.276TrpLys: 0.276 ± 0.145
1.934TrpLeu: 1.934 ± 0.921
0.276TrpMet: 0.276 ± 0.145
0.276TrpAsn: 0.276 ± 0.145
0.276TrpPro: 0.276 ± 0.145
0.276TrpGln: 0.276 ± 0.816
0.0TrpArg: 0.0 ± 0.0
0.276TrpSer: 0.276 ± 0.145
0.553TrpThr: 0.553 ± 0.29
0.276TrpVal: 0.276 ± 0.145
0.553TrpTrp: 0.553 ± 0.29
0.829TrpTyr: 0.829 ± 0.668
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.763TyrAla: 2.763 ± 0.616
2.487TyrCys: 2.487 ± 0.833
3.868TyrAsp: 3.868 ± 0.862
1.658TyrGlu: 1.658 ± 0.52
2.211TyrPhe: 2.211 ± 1.176
1.658TyrGly: 1.658 ± 0.67
1.658TyrHis: 1.658 ± 0.514
2.763TyrIle: 2.763 ± 0.61
2.487TyrLys: 2.487 ± 0.904
5.526TyrLeu: 5.526 ± 1.305
0.276TyrMet: 0.276 ± 0.511
3.592TyrAsn: 3.592 ± 1.383
1.934TyrPro: 1.934 ± 0.824
2.487TyrGln: 2.487 ± 0.916
2.763TyrArg: 2.763 ± 0.632
4.145TyrSer: 4.145 ± 0.907
3.04TyrThr: 3.04 ± 0.946
4.145TyrVal: 4.145 ± 0.742
0.276TyrTrp: 0.276 ± 0.816
1.934TyrTyr: 1.934 ± 1.006
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3620 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski