Amino acid dipepetide frequency for Martelella endophytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.574AlaAla: 15.574 ± 0.169	0.916AlaCys: 0.916 ± 0.03	7.124AlaAsp: 7.124 ± 0.083	8.278AlaGlu: 8.278 ± 0.101	4.877AlaPhe: 4.877 ± 0.063	10.665AlaGly: 10.665 ± 0.109	2.036AlaHis: 2.036 ± 0.046	6.966AlaIle: 6.966 ± 0.085	3.822AlaLys: 3.822 ± 0.053	13.001AlaLeu: 13.001 ± 0.125	3.75AlaMet: 3.75 ± 0.056	2.879AlaAsn: 2.879 ± 0.053	4.87AlaPro: 4.87 ± 0.066	2.906AlaGln: 2.906 ± 0.049	7.884AlaArg: 7.884 ± 0.106	6.112AlaSer: 6.112 ± 0.081	5.839AlaThr: 5.839 ± 0.083	8.576AlaVal: 8.576 ± 0.089	1.338AlaTrp: 1.338 ± 0.032	2.717AlaTyr: 2.717 ± 0.046	0.001AlaXaa: 0.001 ± 0.001
Cys	0.804CysAla: 0.804 ± 0.024	0.104CysCys: 0.104 ± 0.009	0.495CysAsp: 0.495 ± 0.021	0.403CysGlu: 0.403 ± 0.016	0.329CysPhe: 0.329 ± 0.016	0.912CysGly: 0.912 ± 0.031	0.253CysHis: 0.253 ± 0.015	0.352CysIle: 0.352 ± 0.016	0.181CysLys: 0.181 ± 0.012	0.733CysLeu: 0.733 ± 0.024	0.164CysMet: 0.164 ± 0.012	0.221CysAsn: 0.221 ± 0.013	0.408CysPro: 0.408 ± 0.02	0.21CysGln: 0.21 ± 0.013	0.544CysArg: 0.544 ± 0.023	0.433CysSer: 0.433 ± 0.02	0.381CysThr: 0.381 ± 0.017	0.545CysVal: 0.545 ± 0.023	0.115CysTrp: 0.115 ± 0.009	0.215CysTyr: 0.215 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.751AspAla: 6.751 ± 0.08	0.529AspCys: 0.529 ± 0.023	3.73AspAsp: 3.73 ± 0.067	3.849AspGlu: 3.849 ± 0.068	2.553AspPhe: 2.553 ± 0.044	5.667AspGly: 5.667 ± 0.083	1.247AspHis: 1.247 ± 0.037	3.695AspIle: 3.695 ± 0.055	1.794AspLys: 1.794 ± 0.039	5.556AspLeu: 5.556 ± 0.064	1.632AspMet: 1.632 ± 0.037	1.639AspAsn: 1.639 ± 0.041	3.302AspPro: 3.302 ± 0.05	1.654AspGln: 1.654 ± 0.035	4.025AspArg: 4.025 ± 0.066	2.126AspSer: 2.126 ± 0.046	2.783AspThr: 2.783 ± 0.051	4.177AspVal: 4.177 ± 0.066	1.009AspTrp: 1.009 ± 0.031	1.671AspTyr: 1.671 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.019GluAla: 8.019 ± 0.102	0.349GluCys: 0.349 ± 0.017	3.286GluAsp: 3.286 ± 0.058	3.724GluGlu: 3.724 ± 0.076	1.768GluPhe: 1.768 ± 0.039	4.684GluGly: 4.684 ± 0.061	1.221GluHis: 1.221 ± 0.032	3.832GluIle: 3.832 ± 0.054	2.901GluLys: 2.901 ± 0.05	5.174GluLeu: 5.174 ± 0.074	1.668GluMet: 1.668 ± 0.038	2.202GluAsn: 2.202 ± 0.045	2.756GluPro: 2.756 ± 0.052	1.889GluGln: 1.889 ± 0.042	4.806GluArg: 4.806 ± 0.076	2.395GluSer: 2.395 ± 0.041	4.222GluThr: 4.222 ± 0.059	3.714GluVal: 3.714 ± 0.063	0.717GluTrp: 0.717 ± 0.025	1.138GluTyr: 1.138 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.822PheAla: 4.822 ± 0.059	0.4PheCys: 0.4 ± 0.018	2.875PheAsp: 2.875 ± 0.048	2.357PheGlu: 2.357 ± 0.046	1.728PhePhe: 1.728 ± 0.047	3.915PheGly: 3.915 ± 0.061	0.78PheHis: 0.78 ± 0.026	2.111PheIle: 2.111 ± 0.047	0.973PheLys: 0.973 ± 0.03	3.684PheLeu: 3.684 ± 0.067	0.975PheMet: 0.975 ± 0.027	1.222PheAsn: 1.222 ± 0.032	1.729PhePro: 1.729 ± 0.04	1.077PheGln: 1.077 ± 0.026	2.3PheArg: 2.3 ± 0.048	2.816PheSer: 2.816 ± 0.052	2.181PheThr: 2.181 ± 0.042	2.983PheVal: 2.983 ± 0.054	0.585PheTrp: 0.585 ± 0.026	1.064PheTyr: 1.064 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.901GlyAla: 8.901 ± 0.093	0.818GlyCys: 0.818 ± 0.031	4.683GlyAsp: 4.683 ± 0.086	5.079GlyGlu: 5.079 ± 0.063	3.905GlyPhe: 3.905 ± 0.063	7.616GlyGly: 7.616 ± 0.25	1.879GlyHis: 1.879 ± 0.041	5.146GlyIle: 5.146 ± 0.069	3.456GlyLys: 3.456 ± 0.058	9.085GlyLeu: 9.085 ± 0.101	2.474GlyMet: 2.474 ± 0.043	2.429GlyAsn: 2.429 ± 0.056	3.382GlyPro: 3.382 ± 0.055	2.519GlyGln: 2.519 ± 0.05	5.787GlyArg: 5.787 ± 0.074	4.651GlySer: 4.651 ± 0.088	4.616GlyThr: 4.616 ± 0.086	5.954GlyVal: 5.954 ± 0.083	1.3GlyTrp: 1.3 ± 0.033	2.424GlyTyr: 2.424 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.176HisAla: 2.176 ± 0.049	0.225HisCys: 0.225 ± 0.014	1.275HisAsp: 1.275 ± 0.035	1.08HisGlu: 1.08 ± 0.028	0.959HisPhe: 0.959 ± 0.031	1.837HisGly: 1.837 ± 0.039	0.571HisHis: 0.571 ± 0.024	1.025HisIle: 1.025 ± 0.028	0.489HisLys: 0.489 ± 0.021	1.895HisLeu: 1.895 ± 0.035	0.55HisMet: 0.55 ± 0.02	0.497HisAsn: 0.497 ± 0.024	1.214HisPro: 1.214 ± 0.034	0.578HisGln: 0.578 ± 0.021	1.306HisArg: 1.306 ± 0.036	0.867HisSer: 0.867 ± 0.026	0.811HisThr: 0.811 ± 0.029	1.436HisVal: 1.436 ± 0.031	0.308HisTrp: 0.308 ± 0.016	0.575HisTyr: 0.575 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	8.123IleAla: 8.123 ± 0.083	0.537IleCys: 0.537 ± 0.022	3.956IleAsp: 3.956 ± 0.052	3.824IleGlu: 3.824 ± 0.058	2.116IlePhe: 2.116 ± 0.05	5.46IleGly: 5.46 ± 0.08	0.899IleHis: 0.899 ± 0.026	2.813IleIle: 2.813 ± 0.053	1.351IleLys: 1.351 ± 0.032	4.725IleLeu: 4.725 ± 0.067	1.197IleMet: 1.197 ± 0.031	1.592IleAsn: 1.592 ± 0.04	2.533IlePro: 2.533 ± 0.047	1.06IleGln: 1.06 ± 0.033	3.242IleArg: 3.242 ± 0.051	3.348IleSer: 3.348 ± 0.05	2.954IleThr: 2.954 ± 0.053	4.674IleVal: 4.674 ± 0.068	0.659IleTrp: 0.659 ± 0.025	1.334IleTyr: 1.334 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.515LysAla: 4.515 ± 0.07	0.164LysCys: 0.164 ± 0.012	1.798LysAsp: 1.798 ± 0.046	1.692LysGlu: 1.692 ± 0.038	0.912LysPhe: 0.912 ± 0.027	2.759LysGly: 2.759 ± 0.051	0.592LysHis: 0.592 ± 0.024	1.799LysIle: 1.799 ± 0.035	1.393LysLys: 1.393 ± 0.039	3.356LysLeu: 3.356 ± 0.05	0.86LysMet: 0.86 ± 0.025	0.975LysAsn: 0.975 ± 0.029	2.177LysPro: 2.177 ± 0.039	0.925LysGln: 0.925 ± 0.025	2.406LysArg: 2.406 ± 0.047	1.885LysSer: 1.885 ± 0.043	2.12LysThr: 2.12 ± 0.042	2.541LysVal: 2.541 ± 0.048	0.367LysTrp: 0.367 ± 0.017	0.643LysTyr: 0.643 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.753LeuAla: 12.753 ± 0.137	0.819LeuCys: 0.819 ± 0.021	5.879LeuAsp: 5.879 ± 0.064	5.52LeuGlu: 5.52 ± 0.066	3.981LeuPhe: 3.981 ± 0.07	7.912LeuGly: 7.912 ± 0.087	1.603LeuHis: 1.603 ± 0.039	5.302LeuIle: 5.302 ± 0.071	4.038LeuLys: 4.038 ± 0.061	8.855LeuLeu: 8.855 ± 0.114	2.608LeuMet: 2.608 ± 0.048	2.662LeuAsn: 2.662 ± 0.045	5.283LeuPro: 5.283 ± 0.065	2.611LeuGln: 2.611 ± 0.046	5.571LeuArg: 5.571 ± 0.074	7.259LeuSer: 7.259 ± 0.085	5.701LeuThr: 5.701 ± 0.072	7.153LeuVal: 7.153 ± 0.096	1.067LeuTrp: 1.067 ± 0.031	2.291LeuTyr: 2.291 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.399MetAla: 3.399 ± 0.055	0.141MetCys: 0.141 ± 0.012	1.211MetAsp: 1.211 ± 0.032	1.357MetGlu: 1.357 ± 0.034	0.821MetPhe: 0.821 ± 0.029	1.788MetGly: 1.788 ± 0.04	0.502MetHis: 0.502 ± 0.019	1.64MetIle: 1.64 ± 0.035	1.147MetLys: 1.147 ± 0.03	2.782MetLeu: 2.782 ± 0.05	0.804MetMet: 0.804 ± 0.029	0.909MetAsn: 0.909 ± 0.027	1.618MetPro: 1.618 ± 0.036	0.86MetGln: 0.86 ± 0.029	1.886MetArg: 1.886 ± 0.038	1.716MetSer: 1.716 ± 0.035	2.12MetThr: 2.12 ± 0.041	1.862MetVal: 1.862 ± 0.038	0.222MetTrp: 0.222 ± 0.012	0.334MetTyr: 0.334 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.474AsnAla: 3.474 ± 0.062	0.197AsnCys: 0.197 ± 0.013	1.639AsnAsp: 1.639 ± 0.044	1.381AsnGlu: 1.381 ± 0.038	1.123AsnPhe: 1.123 ± 0.033	2.724AsnGly: 2.724 ± 0.062	0.551AsnHis: 0.551 ± 0.022	1.596AsnIle: 1.596 ± 0.04	0.685AsnLys: 0.685 ± 0.024	2.717AsnLeu: 2.717 ± 0.05	0.735AsnMet: 0.735 ± 0.023	0.78AsnAsn: 0.78 ± 0.029	1.945AsnPro: 1.945 ± 0.039	0.77AsnGln: 0.77 ± 0.029	1.863AsnArg: 1.863 ± 0.039	1.339AsnSer: 1.339 ± 0.041	1.434AsnThr: 1.434 ± 0.042	2.068AsnVal: 2.068 ± 0.042	0.476AsnTrp: 0.476 ± 0.021	0.819AsnTyr: 0.819 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.774ProAla: 5.774 ± 0.067	0.275ProCys: 0.275 ± 0.014	3.58ProAsp: 3.58 ± 0.054	4.158ProGlu: 4.158 ± 0.062	2.126ProPhe: 2.126 ± 0.042	4.212ProGly: 4.212 ± 0.063	1.041ProHis: 1.041 ± 0.032	2.252ProIle: 2.252 ± 0.04	1.675ProLys: 1.675 ± 0.038	4.672ProLeu: 4.672 ± 0.068	1.205ProMet: 1.205 ± 0.034	1.275ProAsn: 1.275 ± 0.032	2.201ProPro: 2.201 ± 0.051	1.48ProGln: 1.48 ± 0.038	2.445ProArg: 2.445 ± 0.05	2.526ProSer: 2.526 ± 0.047	2.284ProThr: 2.284 ± 0.046	4.275ProVal: 4.275 ± 0.06	0.649ProTrp: 0.649 ± 0.024	1.328ProTyr: 1.328 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.338GlnAla: 3.338 ± 0.048	0.168GlnCys: 0.168 ± 0.011	1.357GlnAsp: 1.357 ± 0.034	1.409GlnGlu: 1.409 ± 0.036	1.102GlnPhe: 1.102 ± 0.027	1.942GlnGly: 1.942 ± 0.04	0.547GlnHis: 0.547 ± 0.021	1.635GlnIle: 1.635 ± 0.041	1.141GlnLys: 1.141 ± 0.028	2.521GlnLeu: 2.521 ± 0.043	0.93GlnMet: 0.93 ± 0.029	0.864GlnAsn: 0.864 ± 0.027	1.402GlnPro: 1.402 ± 0.035	1.084GlnGln: 1.084 ± 0.032	1.954GlnArg: 1.954 ± 0.041	1.689GlnSer: 1.689 ± 0.042	1.596GlnThr: 1.596 ± 0.039	1.957GlnVal: 1.957 ± 0.042	0.348GlnTrp: 0.348 ± 0.016	0.683GlnTyr: 0.683 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.99ArgAla: 6.99 ± 0.075	0.42ArgCys: 0.42 ± 0.017	3.725ArgAsp: 3.725 ± 0.06	3.945ArgGlu: 3.945 ± 0.059	2.912ArgPhe: 2.912 ± 0.054	4.238ArgGly: 4.238 ± 0.053	1.595ArgHis: 1.595 ± 0.038	3.868ArgIle: 3.868 ± 0.058	2.307ArgLys: 2.307 ± 0.048	7.23ArgLeu: 7.23 ± 0.099	1.926ArgMet: 1.926 ± 0.04	1.865ArgAsn: 1.865 ± 0.033	3.226ArgPro: 3.226 ± 0.052	2.344ArgGln: 2.344 ± 0.047	4.843ArgArg: 4.843 ± 0.079	3.283ArgSer: 3.283 ± 0.056	2.979ArgThr: 2.979 ± 0.05	4.183ArgVal: 4.183 ± 0.061	0.829ArgTrp: 0.829 ± 0.024	1.766ArgTyr: 1.766 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.215SerAla: 6.215 ± 0.079	0.378SerCys: 0.378 ± 0.018	3.226SerAsp: 3.226 ± 0.053	3.169SerGlu: 3.169 ± 0.046	2.44SerPhe: 2.44 ± 0.045	5.956SerGly: 5.956 ± 0.089	1.105SerHis: 1.105 ± 0.03	2.904SerIle: 2.904 ± 0.053	1.611SerLys: 1.611 ± 0.036	5.664SerLeu: 5.664 ± 0.076	1.37SerMet: 1.37 ± 0.031	1.519SerAsn: 1.519 ± 0.042	2.579SerPro: 2.579 ± 0.039	1.42SerGln: 1.42 ± 0.035	3.404SerArg: 3.404 ± 0.068	2.855SerSer: 2.855 ± 0.068	2.721SerThr: 2.721 ± 0.053	4.214SerVal: 4.214 ± 0.063	0.763SerTrp: 0.763 ± 0.024	1.4SerTyr: 1.4 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.221ThrAla: 6.221 ± 0.096	0.412ThrCys: 0.412 ± 0.019	2.986ThrAsp: 2.986 ± 0.053	2.843ThrGlu: 2.843 ± 0.046	2.258ThrPhe: 2.258 ± 0.045	5.371ThrGly: 5.371 ± 0.077	1.068ThrHis: 1.068 ± 0.031	3.298ThrIle: 3.298 ± 0.055	1.42ThrLys: 1.42 ± 0.032	6.058ThrLeu: 6.058 ± 0.088	1.296ThrMet: 1.296 ± 0.026	1.367ThrAsn: 1.367 ± 0.052	3.166ThrPro: 3.166 ± 0.048	1.158ThrGln: 1.158 ± 0.028	3.13ThrArg: 3.13 ± 0.054	2.772ThrSer: 2.772 ± 0.05	2.924ThrThr: 2.924 ± 0.058	4.722ThrVal: 4.722 ± 0.073	0.642ThrTrp: 0.642 ± 0.024	1.322ThrTyr: 1.322 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.564ValAla: 8.564 ± 0.08	0.56ValCys: 0.56 ± 0.021	4.199ValAsp: 4.199 ± 0.06	4.464ValGlu: 4.464 ± 0.064	3.078ValPhe: 3.078 ± 0.06	5.33ValGly: 5.33 ± 0.073	1.324ValHis: 1.324 ± 0.036	4.436ValIle: 4.436 ± 0.07	2.335ValLys: 2.335 ± 0.045	7.27ValLeu: 7.27 ± 0.099	2.084ValMet: 2.084 ± 0.047	2.158ValAsn: 2.158 ± 0.05	3.662ValPro: 3.662 ± 0.055	1.696ValGln: 1.696 ± 0.036	4.287ValArg: 4.287 ± 0.061	4.708ValSer: 4.708 ± 0.066	4.804ValThr: 4.804 ± 0.073	5.464ValVal: 5.464 ± 0.072	0.916ValTrp: 0.916 ± 0.03	1.667ValTyr: 1.667 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.094TrpAla: 1.094 ± 0.032	0.125TrpCys: 0.125 ± 0.01	0.636TrpAsp: 0.636 ± 0.023	0.582TrpGlu: 0.582 ± 0.021	0.536TrpPhe: 0.536 ± 0.022	0.885TrpGly: 0.885 ± 0.027	0.328TrpHis: 0.328 ± 0.019	0.654TrpIle: 0.654 ± 0.023	0.488TrpLys: 0.488 ± 0.023	1.516TrpLeu: 1.516 ± 0.039	0.384TrpMet: 0.384 ± 0.02	0.503TrpAsn: 0.503 ± 0.019	0.674TrpPro: 0.674 ± 0.022	0.61TrpGln: 0.61 ± 0.019	0.991TrpArg: 0.991 ± 0.028	0.835TrpSer: 0.835 ± 0.028	0.733TrpThr: 0.733 ± 0.028	0.799TrpVal: 0.799 ± 0.024	0.246TrpTrp: 0.246 ± 0.014	0.309TrpTyr: 0.309 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.622TyrAla: 2.622 ± 0.049	0.264TyrCys: 0.264 ± 0.015	1.727TyrAsp: 1.727 ± 0.036	1.352TyrGlu: 1.352 ± 0.032	1.055TyrPhe: 1.055 ± 0.026	2.235TyrGly: 2.235 ± 0.045	0.531TyrHis: 0.531 ± 0.023	1.073TyrIle: 1.073 ± 0.032	0.671TyrLys: 0.671 ± 0.022	2.374TyrLeu: 2.374 ± 0.051	0.504TyrMet: 0.504 ± 0.021	0.758TyrAsn: 0.758 ± 0.025	1.308TyrPro: 1.308 ± 0.031	0.815TyrGln: 0.815 ± 0.026	1.798TyrArg: 1.798 ± 0.04	1.299TyrSer: 1.299 ± 0.031	1.23TyrThr: 1.23 ± 0.028	1.71TyrVal: 1.71 ± 0.039	0.373TyrTrp: 0.373 ± 0.017	0.72TyrTyr: 0.72 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4020 proteins (1282831 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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