Amino acid dipepetide frequency for Apis mellifera associated microvirus 12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.773AlaAla: 11.773 ± 4.475
0.0AlaCys: 0.0 ± 0.0
2.078AlaAsp: 2.078 ± 1.059
6.925AlaGlu: 6.925 ± 4.048
4.848AlaPhe: 4.848 ± 1.305
8.31AlaGly: 8.31 ± 1.555
1.385AlaHis: 1.385 ± 1.059
2.77AlaIle: 2.77 ± 0.949
2.078AlaLys: 2.078 ± 1.882
9.695AlaLeu: 9.695 ± 1.578
2.078AlaMet: 2.078 ± 1.488
2.078AlaAsn: 2.078 ± 1.076
4.155AlaPro: 4.155 ± 0.973
10.388AlaGln: 10.388 ± 1.944
6.925AlaArg: 6.925 ± 2.619
9.695AlaSer: 9.695 ± 2.566
7.618AlaThr: 7.618 ± 1.96
6.925AlaVal: 6.925 ± 2.232
2.77AlaTrp: 2.77 ± 1.495
2.77AlaTyr: 2.77 ± 0.571
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.693CysAsp: 0.693 ± 0.609
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.693CysGly: 0.693 ± 0.609
0.0CysHis: 0.0 ± 0.0
1.385CysIle: 1.385 ± 0.566
0.0CysLys: 0.0 ± 0.0
1.385CysLeu: 1.385 ± 0.566
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.385CysPro: 1.385 ± 0.924
0.0CysGln: 0.0 ± 0.0
0.693CysArg: 0.693 ± 0.609
0.0CysSer: 0.0 ± 0.0
0.693CysThr: 0.693 ± 0.609
0.693CysVal: 0.693 ± 0.868
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.31AspAla: 8.31 ± 1.873
0.693AspCys: 0.693 ± 0.804
2.078AspAsp: 2.078 ± 0.843
2.77AspGlu: 2.77 ± 1.387
2.77AspPhe: 2.77 ± 1.187
0.693AspGly: 0.693 ± 0.868
0.0AspHis: 0.0 ± 0.0
2.078AspIle: 2.078 ± 0.796
0.693AspLys: 0.693 ± 0.804
4.848AspLeu: 4.848 ± 1.205
0.693AspMet: 0.693 ± 0.627
0.693AspAsn: 0.693 ± 0.495
5.54AspPro: 5.54 ± 1.878
2.078AspGln: 2.078 ± 1.059
2.078AspArg: 2.078 ± 0.875
2.77AspSer: 2.77 ± 1.3
4.155AspThr: 4.155 ± 1.612
2.078AspVal: 2.078 ± 1.073
2.078AspTrp: 2.078 ± 0.872
3.463AspTyr: 3.463 ± 1.728
0.0AspXaa: 0.0 ± 0.0
Glu
9.695GluAla: 9.695 ± 4.172
0.693GluCys: 0.693 ± 0.868
0.693GluAsp: 0.693 ± 0.495
1.385GluGlu: 1.385 ± 1.255
2.078GluPhe: 2.078 ± 0.465
1.385GluGly: 1.385 ± 0.555
2.078GluHis: 2.078 ± 1.067
1.385GluIle: 1.385 ± 0.964
0.693GluLys: 0.693 ± 0.627
4.848GluLeu: 4.848 ± 2.392
0.693GluMet: 0.693 ± 0.627
0.693GluAsn: 0.693 ± 0.627
0.693GluPro: 0.693 ± 0.609
4.155GluGln: 4.155 ± 1.614
7.618GluArg: 7.618 ± 1.649
4.848GluSer: 4.848 ± 2.337
2.078GluThr: 2.078 ± 1.26
2.77GluVal: 2.77 ± 0.571
1.385GluTrp: 1.385 ± 0.566
2.078GluTyr: 2.078 ± 0.872
0.0GluXaa: 0.0 ± 0.0
Phe
0.693PheAla: 0.693 ± 0.495
0.0PheCys: 0.0 ± 0.0
4.848PheAsp: 4.848 ± 1.371
0.693PheGlu: 0.693 ± 0.495
1.385PhePhe: 1.385 ± 0.566
4.155PheGly: 4.155 ± 1.175
0.693PheHis: 0.693 ± 0.609
2.078PheIle: 2.078 ± 1.484
0.0PheLys: 0.0 ± 0.0
1.385PheLeu: 1.385 ± 0.772
2.078PheMet: 2.078 ± 0.807
1.385PheAsn: 1.385 ± 0.555
0.693PhePro: 0.693 ± 0.495
2.078PheGln: 2.078 ± 0.872
2.078PheArg: 2.078 ± 1.484
2.078PheSer: 2.078 ± 0.875
1.385PheThr: 1.385 ± 0.989
2.77PheVal: 2.77 ± 1.978
0.0PheTrp: 0.0 ± 0.0
2.078PheTyr: 2.078 ± 1.059
0.0PheXaa: 0.0 ± 0.0
Gly
10.388GlyAla: 10.388 ± 4.878
0.693GlyCys: 0.693 ± 0.609
6.925GlyAsp: 6.925 ± 1.643
4.848GlyGlu: 4.848 ± 2.243
1.385GlyPhe: 1.385 ± 0.989
9.695GlyGly: 9.695 ± 1.481
0.693GlyHis: 0.693 ± 0.804
4.848GlyIle: 4.848 ± 2.154
1.385GlyLys: 1.385 ± 0.989
6.233GlyLeu: 6.233 ± 4.017
0.0GlyMet: 0.0 ± 0.0
2.078GlyAsn: 2.078 ± 1.132
4.155GlyPro: 4.155 ± 1.624
1.385GlyGln: 1.385 ± 0.989
4.848GlyArg: 4.848 ± 1.334
6.233GlySer: 6.233 ± 2.459
6.233GlyThr: 6.233 ± 3.488
6.233GlyVal: 6.233 ± 2.637
1.385GlyTrp: 1.385 ± 0.566
4.155GlyTyr: 4.155 ± 1.574
0.0GlyXaa: 0.0 ± 0.0
His
0.693HisAla: 0.693 ± 0.609
0.693HisCys: 0.693 ± 0.609
3.463HisAsp: 3.463 ± 1.192
1.385HisGlu: 1.385 ± 1.059
1.385HisPhe: 1.385 ± 0.989
1.385HisGly: 1.385 ± 0.566
0.0HisHis: 0.0 ± 0.0
0.693HisIle: 0.693 ± 0.804
0.693HisLys: 0.693 ± 0.609
0.693HisLeu: 0.693 ± 0.609
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.693HisPro: 0.693 ± 0.804
0.0HisGln: 0.0 ± 0.0
2.77HisArg: 2.77 ± 1.527
1.385HisSer: 1.385 ± 1.217
0.693HisThr: 0.693 ± 0.609
1.385HisVal: 1.385 ± 0.924
1.385HisTrp: 1.385 ± 0.989
2.078HisTyr: 2.078 ± 0.872
0.0HisXaa: 0.0 ± 0.0
Ile
4.155IleAla: 4.155 ± 1.293
0.0IleCys: 0.0 ± 0.0
2.77IleAsp: 2.77 ± 0.774
1.385IleGlu: 1.385 ± 0.555
0.693IlePhe: 0.693 ± 0.495
5.54IleGly: 5.54 ± 2.168
0.693IleHis: 0.693 ± 0.495
2.77IleIle: 2.77 ± 1.03
2.078IleLys: 2.078 ± 0.843
1.385IleLeu: 1.385 ± 0.566
0.693IleMet: 0.693 ± 0.627
0.693IleAsn: 0.693 ± 0.495
4.155IlePro: 4.155 ± 2.967
0.693IleGln: 0.693 ± 0.495
1.385IleArg: 1.385 ± 0.772
1.385IleSer: 1.385 ± 0.989
1.385IleThr: 1.385 ± 0.555
3.463IleVal: 3.463 ± 1.84
0.693IleTrp: 0.693 ± 0.495
0.693IleTyr: 0.693 ± 0.804
0.0IleXaa: 0.0 ± 0.0
Lys
3.463LysAla: 3.463 ± 2.449
0.0LysCys: 0.0 ± 0.0
0.693LysAsp: 0.693 ± 0.627
0.693LysGlu: 0.693 ± 0.627
1.385LysPhe: 1.385 ± 0.989
0.0LysGly: 0.0 ± 0.0
0.693LysHis: 0.693 ± 0.609
0.693LysIle: 0.693 ± 0.627
0.693LysLys: 0.693 ± 0.609
2.078LysLeu: 2.078 ± 1.376
1.385LysMet: 1.385 ± 0.555
0.0LysAsn: 0.0 ± 0.0
0.693LysPro: 0.693 ± 0.627
2.078LysGln: 2.078 ± 1.276
1.385LysArg: 1.385 ± 1.217
1.385LysSer: 1.385 ± 0.989
0.693LysThr: 0.693 ± 0.495
0.693LysVal: 0.693 ± 0.627
0.0LysTrp: 0.0 ± 0.0
0.693LysTyr: 0.693 ± 0.609
0.0LysXaa: 0.0 ± 0.0
Leu
6.233LeuAla: 6.233 ± 1.522
0.693LeuCys: 0.693 ± 0.495
4.848LeuAsp: 4.848 ± 2.31
4.155LeuGlu: 4.155 ± 1.178
1.385LeuPhe: 1.385 ± 0.989
9.695LeuGly: 9.695 ± 2.796
2.078LeuHis: 2.078 ± 0.872
0.693LeuIle: 0.693 ± 0.627
2.078LeuLys: 2.078 ± 1.067
3.463LeuLeu: 3.463 ± 0.499
2.77LeuMet: 2.77 ± 0.949
3.463LeuAsn: 3.463 ± 1.609
7.618LeuPro: 7.618 ± 1.857
4.848LeuGln: 4.848 ± 0.754
6.925LeuArg: 6.925 ± 1.859
7.618LeuSer: 7.618 ± 1.345
2.77LeuThr: 2.77 ± 1.3
7.618LeuVal: 7.618 ± 1.719
0.693LeuTrp: 0.693 ± 0.868
1.385LeuTyr: 1.385 ± 0.924
0.0LeuXaa: 0.0 ± 0.0
Met
2.078MetAla: 2.078 ± 1.076
0.0MetCys: 0.0 ± 0.0
0.693MetAsp: 0.693 ± 0.495
3.463MetGlu: 3.463 ± 0.824
0.693MetPhe: 0.693 ± 0.804
2.078MetGly: 2.078 ± 0.843
0.0MetHis: 0.0 ± 0.0
0.693MetIle: 0.693 ± 0.495
0.693MetLys: 0.693 ± 0.627
0.0MetLeu: 0.0 ± 0.0
0.693MetMet: 0.693 ± 0.627
0.693MetAsn: 0.693 ± 0.495
2.078MetPro: 2.078 ± 1.063
2.078MetGln: 2.078 ± 1.882
4.848MetArg: 4.848 ± 2.129
2.77MetSer: 2.77 ± 1.39
1.385MetThr: 1.385 ± 0.833
0.693MetVal: 0.693 ± 0.868
0.693MetTrp: 0.693 ± 0.495
0.693MetTyr: 0.693 ± 0.868
0.0MetXaa: 0.0 ± 0.0
Asn
3.463AsnAla: 3.463 ± 1.866
0.0AsnCys: 0.0 ± 0.0
0.693AsnAsp: 0.693 ± 0.627
1.385AsnGlu: 1.385 ± 0.989
1.385AsnPhe: 1.385 ± 0.833
0.0AsnGly: 0.0 ± 0.0
0.693AsnHis: 0.693 ± 0.495
3.463AsnIle: 3.463 ± 1.107
0.0AsnLys: 0.0 ± 0.0
1.385AsnLeu: 1.385 ± 0.989
0.693AsnMet: 0.693 ± 0.627
0.0AsnAsn: 0.0 ± 0.0
4.155AsnPro: 4.155 ± 1.517
2.77AsnGln: 2.77 ± 1.266
2.078AsnArg: 2.078 ± 0.872
0.0AsnSer: 0.0 ± 0.0
1.385AsnThr: 1.385 ± 0.555
2.77AsnVal: 2.77 ± 1.041
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
7.618ProAla: 7.618 ± 1.669
1.385ProCys: 1.385 ± 1.217
3.463ProAsp: 3.463 ± 1.84
3.463ProGlu: 3.463 ± 2.234
1.385ProPhe: 1.385 ± 0.566
5.54ProGly: 5.54 ± 1.142
2.078ProHis: 2.078 ± 1.067
1.385ProIle: 1.385 ± 0.566
1.385ProLys: 1.385 ± 0.964
9.003ProLeu: 9.003 ± 1.176
4.155ProMet: 4.155 ± 1.362
2.078ProAsn: 2.078 ± 1.484
2.078ProPro: 2.078 ± 1.838
2.078ProGln: 2.078 ± 1.059
4.848ProArg: 4.848 ± 1.555
4.155ProSer: 4.155 ± 0.982
2.078ProThr: 2.078 ± 1.484
5.54ProVal: 5.54 ± 2.23
1.385ProTrp: 1.385 ± 0.555
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
8.31GlnAla: 8.31 ± 1.573
0.0GlnCys: 0.0 ± 0.0
3.463GlnAsp: 3.463 ± 0.825
2.77GlnGlu: 2.77 ± 0.798
0.693GlnPhe: 0.693 ± 0.495
4.848GlnGly: 4.848 ± 1.151
0.693GlnHis: 0.693 ± 0.609
0.693GlnIle: 0.693 ± 0.627
2.078GlnLys: 2.078 ± 1.076
3.463GlnLeu: 3.463 ± 1.339
1.385GlnMet: 1.385 ± 1.059
2.77GlnAsn: 2.77 ± 1.3
0.693GlnPro: 0.693 ± 0.627
2.078GlnGln: 2.078 ± 1.076
5.54GlnArg: 5.54 ± 3.05
4.155GlnSer: 4.155 ± 1.817
3.463GlnThr: 3.463 ± 1.339
3.463GlnVal: 3.463 ± 2.027
1.385GlnTrp: 1.385 ± 0.989
0.693GlnTyr: 0.693 ± 0.868
0.0GlnXaa: 0.0 ± 0.0
Arg
10.388ArgAla: 10.388 ± 2.36
2.078ArgCys: 2.078 ± 1.067
4.848ArgAsp: 4.848 ± 1.325
6.233ArgGlu: 6.233 ± 2.465
4.155ArgPhe: 4.155 ± 1.699
3.463ArgGly: 3.463 ± 1.468
1.385ArgHis: 1.385 ± 1.217
2.77ArgIle: 2.77 ± 1.266
1.385ArgLys: 1.385 ± 1.255
11.08ArgLeu: 11.08 ± 2.061
2.77ArgMet: 2.77 ± 1.041
0.0ArgAsn: 0.0 ± 0.0
4.848ArgPro: 4.848 ± 1.928
6.233ArgGln: 6.233 ± 2.329
7.618ArgArg: 7.618 ± 2.516
6.233ArgSer: 6.233 ± 2.306
3.463ArgThr: 3.463 ± 1.339
5.54ArgVal: 5.54 ± 1.797
0.693ArgTrp: 0.693 ± 0.495
2.77ArgTyr: 2.77 ± 0.571
0.0ArgXaa: 0.0 ± 0.0
Ser
4.848SerAla: 4.848 ± 0.588
0.0SerCys: 0.0 ± 0.0
2.77SerAsp: 2.77 ± 1.291
2.77SerGlu: 2.77 ± 1.041
2.078SerPhe: 2.078 ± 0.875
6.233SerGly: 6.233 ± 1.723
2.77SerHis: 2.77 ± 1.527
3.463SerIle: 3.463 ± 0.824
1.385SerLys: 1.385 ± 0.772
5.54SerLeu: 5.54 ± 1.854
1.385SerMet: 1.385 ± 0.566
2.77SerAsn: 2.77 ± 1.041
6.925SerPro: 6.925 ± 2.914
3.463SerGln: 3.463 ± 1.385
10.388SerArg: 10.388 ± 2.36
4.848SerSer: 4.848 ± 1.615
3.463SerThr: 3.463 ± 1.176
7.618SerVal: 7.618 ± 2.601
2.77SerTrp: 2.77 ± 1.642
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
6.233ThrAla: 6.233 ± 2.087
0.0ThrCys: 0.0 ± 0.0
2.078ThrAsp: 2.078 ± 1.26
2.078ThrGlu: 2.078 ± 0.465
1.385ThrPhe: 1.385 ± 0.989
4.848ThrGly: 4.848 ± 1.998
2.078ThrHis: 2.078 ± 1.132
2.078ThrIle: 2.078 ± 1.132
0.693ThrLys: 0.693 ± 0.609
4.848ThrLeu: 4.848 ± 1.574
1.385ThrMet: 1.385 ± 0.964
2.77ThrAsn: 2.77 ± 1.109
4.155ThrPro: 4.155 ± 1.686
2.77ThrGln: 2.77 ± 1.109
5.54ThrArg: 5.54 ± 1.357
3.463ThrSer: 3.463 ± 1.385
4.848ThrThr: 4.848 ± 2.154
2.078ThrVal: 2.078 ± 1.484
0.693ThrTrp: 0.693 ± 0.495
2.078ThrTyr: 2.078 ± 0.465
0.0ThrXaa: 0.0 ± 0.0
Val
5.54ValAla: 5.54 ± 2.03
0.693ValCys: 0.693 ± 0.609
0.693ValAsp: 0.693 ± 0.804
4.848ValGlu: 4.848 ± 1.356
0.693ValPhe: 0.693 ± 0.495
7.618ValGly: 7.618 ± 2.887
2.078ValHis: 2.078 ± 1.26
2.078ValIle: 2.078 ± 1.073
1.385ValLys: 1.385 ± 0.964
4.848ValLeu: 4.848 ± 1.603
3.463ValMet: 3.463 ± 1.87
2.77ValAsn: 2.77 ± 1.665
8.31ValPro: 8.31 ± 2.322
1.385ValGln: 1.385 ± 0.555
6.925ValArg: 6.925 ± 2.057
7.618ValSer: 7.618 ± 0.981
6.925ValThr: 6.925 ± 1.325
5.54ValVal: 5.54 ± 2.423
0.0ValTrp: 0.0 ± 0.0
0.693ValTyr: 0.693 ± 0.495
0.0ValXaa: 0.0 ± 0.0
Trp
0.693TrpAla: 0.693 ± 0.495
0.0TrpCys: 0.0 ± 0.0
0.693TrpAsp: 0.693 ± 0.495
0.693TrpGlu: 0.693 ± 0.495
1.385TrpPhe: 1.385 ± 0.989
1.385TrpGly: 1.385 ± 0.989
0.693TrpHis: 0.693 ± 0.495
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
2.77TrpLeu: 2.77 ± 1.495
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
1.385TrpPro: 1.385 ± 0.566
2.078TrpGln: 2.078 ± 0.843
2.078TrpArg: 2.078 ± 1.826
2.078TrpSer: 2.078 ± 1.059
0.693TrpThr: 0.693 ± 0.609
1.385TrpVal: 1.385 ± 0.566
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.385TyrAla: 1.385 ± 0.833
0.0TyrCys: 0.0 ± 0.0
2.078TyrAsp: 2.078 ± 0.796
0.0TyrGlu: 0.0 ± 0.0
1.385TyrPhe: 1.385 ± 0.555
6.233TyrGly: 6.233 ± 1.197
0.693TyrHis: 0.693 ± 0.609
0.693TyrIle: 0.693 ± 0.495
0.0TyrLys: 0.0 ± 0.0
2.078TyrLeu: 2.078 ± 1.067
0.0TyrMet: 0.0 ± 0.0
1.385TyrAsn: 1.385 ± 0.989
0.693TyrPro: 0.693 ± 0.868
0.0TyrGln: 0.0 ± 0.0
1.385TyrArg: 1.385 ± 0.989
2.77TyrSer: 2.77 ± 1.109
0.693TyrThr: 0.693 ± 0.495
4.848TyrVal: 4.848 ± 1.648
0.0TyrTrp: 0.0 ± 0.0
0.693TyrTyr: 0.693 ± 0.868
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski