Amino acid dipepetide frequency for Notothenia coriiceps (black rockcod)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.399AlaAla: 6.399 ± 0.04	1.206AlaCys: 1.206 ± 0.012	3.148AlaAsp: 3.148 ± 0.016	4.776AlaGlu: 4.776 ± 0.031	2.269AlaPhe: 2.269 ± 0.014	4.529AlaGly: 4.529 ± 0.035	1.488AlaHis: 1.488 ± 0.011	2.526AlaIle: 2.526 ± 0.016	3.427AlaLys: 3.427 ± 0.03	6.269AlaLeu: 6.269 ± 0.028	1.616AlaMet: 1.616 ± 0.011	2.168AlaAsn: 2.168 ± 0.012	3.851AlaPro: 3.851 ± 0.026	2.987AlaGln: 2.987 ± 0.021	3.101AlaArg: 3.101 ± 0.016	5.674AlaSer: 5.674 ± 0.024	3.44AlaThr: 3.44 ± 0.019	4.719AlaVal: 4.719 ± 0.022	0.616AlaTrp: 0.616 ± 0.007	1.437AlaTyr: 1.437 ± 0.012	0.002AlaXaa: 0.002 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.011	0.597CysCys: 0.597 ± 0.009	1.086CysAsp: 1.086 ± 0.011	1.248CysGlu: 1.248 ± 0.015	0.834CysPhe: 0.834 ± 0.007	1.463CysGly: 1.463 ± 0.016	0.599CysHis: 0.599 ± 0.008	0.89CysIle: 0.89 ± 0.009	1.097CysLys: 1.097 ± 0.011	2.007CysLeu: 2.007 ± 0.016	0.46CysMet: 0.46 ± 0.005	0.798CysAsn: 0.798 ± 0.01	1.283CysPro: 1.283 ± 0.016	1.002CysGln: 1.002 ± 0.012	1.228CysArg: 1.228 ± 0.011	2.122CysSer: 2.122 ± 0.02	1.117CysThr: 1.117 ± 0.012	1.477CysVal: 1.477 ± 0.016	0.266CysTrp: 0.266 ± 0.004	0.561CysTyr: 0.561 ± 0.007	0.001CysXaa: 0.001 ± 0.0
Asp	2.881AspAla: 2.881 ± 0.015	1.12AspCys: 1.12 ± 0.012	3.144AspAsp: 3.144 ± 0.023	3.843AspGlu: 3.843 ± 0.023	2.064AspPhe: 2.064 ± 0.012	3.56AspGly: 3.56 ± 0.019	1.219AspHis: 1.219 ± 0.013	2.65AspIle: 2.65 ± 0.018	2.752AspLys: 2.752 ± 0.017	4.891AspLeu: 4.891 ± 0.023	1.353AspMet: 1.353 ± 0.011	1.99AspAsn: 1.99 ± 0.013	2.978AspPro: 2.978 ± 0.018	2.034AspGln: 2.034 ± 0.013	2.751AspArg: 2.751 ± 0.02	4.751AspSer: 4.751 ± 0.025	2.712AspThr: 2.712 ± 0.015	3.238AspVal: 3.238 ± 0.019	0.643AspTrp: 0.643 ± 0.008	1.481AspTyr: 1.481 ± 0.012	0.001AspXaa: 0.001 ± 0.0
Glu	4.868GluAla: 4.868 ± 0.03	1.206GluCys: 1.206 ± 0.014	4.656GluAsp: 4.656 ± 0.023	8.602GluGlu: 8.602 ± 0.057	1.878GluPhe: 1.878 ± 0.013	4.459GluGly: 4.459 ± 0.023	1.5GluHis: 1.5 ± 0.011	2.777GluIle: 2.777 ± 0.017	4.836GluLys: 4.836 ± 0.037	5.995GluLeu: 5.995 ± 0.033	1.826GluMet: 1.826 ± 0.014	2.717GluAsn: 2.717 ± 0.017	2.978GluPro: 2.978 ± 0.02	3.193GluGln: 3.193 ± 0.025	4.465GluArg: 4.465 ± 0.027	4.658GluSer: 4.658 ± 0.022	3.626GluThr: 3.626 ± 0.022	4.408GluVal: 4.408 ± 0.023	0.644GluTrp: 0.644 ± 0.007	1.5GluTyr: 1.5 ± 0.012	0.002GluXaa: 0.002 ± 0.0
Phe	1.817PheAla: 1.817 ± 0.013	0.865PheCys: 0.865 ± 0.008	1.715PheAsp: 1.715 ± 0.014	1.808PheGlu: 1.808 ± 0.013	1.457PhePhe: 1.457 ± 0.01	2.1PheGly: 2.1 ± 0.018	0.969PheHis: 0.969 ± 0.009	1.737PheIle: 1.737 ± 0.013	1.777PheLys: 1.777 ± 0.013	3.577PheLeu: 3.577 ± 0.02	0.791PheMet: 0.791 ± 0.009	1.433PheAsn: 1.433 ± 0.011	1.819PhePro: 1.819 ± 0.013	1.564PheGln: 1.564 ± 0.01	1.755PheArg: 1.755 ± 0.013	3.312PheSer: 3.312 ± 0.017	2.15PheThr: 2.15 ± 0.014	2.029PheVal: 2.029 ± 0.014	0.417PheTrp: 0.417 ± 0.006	1.072PheTyr: 1.072 ± 0.01	0.001PheXaa: 0.001 ± 0.0
Gly	4.24GlyAla: 4.24 ± 0.031	1.208GlyCys: 1.208 ± 0.011	3.267GlyAsp: 3.267 ± 0.022	4.275GlyGlu: 4.275 ± 0.03	2.365GlyPhe: 2.365 ± 0.019	6.255GlyGly: 6.255 ± 0.081	1.697GlyHis: 1.697 ± 0.013	2.484GlyIle: 2.484 ± 0.016	3.592GlyLys: 3.592 ± 0.022	5.486GlyLeu: 5.486 ± 0.031	1.563GlyMet: 1.563 ± 0.014	2.537GlyAsn: 2.537 ± 0.017	3.547GlyPro: 3.547 ± 0.048	2.936GlyGln: 2.936 ± 0.027	3.766GlyArg: 3.766 ± 0.026	6.098GlySer: 6.098 ± 0.03	3.419GlyThr: 3.419 ± 0.025	4.013GlyVal: 4.013 ± 0.03	0.731GlyTrp: 0.731 ± 0.008	1.874GlyTyr: 1.874 ± 0.02	0.003GlyXaa: 0.003 ± 0.0
His	1.342HisAla: 1.342 ± 0.01	0.727HisCys: 0.727 ± 0.01	0.968HisAsp: 0.968 ± 0.01	1.192HisGlu: 1.192 ± 0.009	1.007HisPhe: 1.007 ± 0.009	1.579HisGly: 1.579 ± 0.012	1.151HisHis: 1.151 ± 0.017	1.252HisIle: 1.252 ± 0.01	1.29HisLys: 1.29 ± 0.011	2.635HisLeu: 2.635 ± 0.017	0.709HisMet: 0.709 ± 0.008	1.048HisAsn: 1.048 ± 0.009	1.685HisPro: 1.685 ± 0.014	1.352HisGln: 1.352 ± 0.013	1.662HisArg: 1.662 ± 0.012	2.641HisSer: 2.641 ± 0.017	1.67HisThr: 1.67 ± 0.015	1.431HisVal: 1.431 ± 0.01	0.306HisTrp: 0.306 ± 0.005	0.82HisTyr: 0.82 ± 0.008	0.001HisXaa: 0.001 ± 0.0
Ile	2.396IleAla: 2.396 ± 0.016	0.974IleCys: 0.974 ± 0.01	2.054IleAsp: 2.054 ± 0.013	2.385IleGlu: 2.385 ± 0.017	1.615IlePhe: 1.615 ± 0.012	2.222IleGly: 2.222 ± 0.015	1.197IleHis: 1.197 ± 0.011	2.203IleIle: 2.203 ± 0.015	2.487IleLys: 2.487 ± 0.017	3.899IleLeu: 3.899 ± 0.019	1.052IleMet: 1.052 ± 0.01	1.866IleAsn: 1.866 ± 0.011	2.453IlePro: 2.453 ± 0.014	2.164IleGln: 2.164 ± 0.014	2.345IleArg: 2.345 ± 0.014	3.708IleSer: 3.708 ± 0.018	2.721IleThr: 2.721 ± 0.018	2.386IleVal: 2.386 ± 0.016	0.431IleTrp: 0.431 ± 0.007	1.216IleTyr: 1.216 ± 0.009	0.002IleXaa: 0.002 ± 0.0
Lys	3.82LysAla: 3.82 ± 0.022	1.003LysCys: 1.003 ± 0.01	3.313LysAsp: 3.313 ± 0.022	4.857LysGlu: 4.857 ± 0.034	1.464LysPhe: 1.464 ± 0.012	3.31LysGly: 3.31 ± 0.029	1.441LysHis: 1.441 ± 0.012	2.367LysIle: 2.367 ± 0.016	4.598LysLys: 4.598 ± 0.04	4.763LysLeu: 4.763 ± 0.025	1.524LysMet: 1.524 ± 0.013	2.186LysAsn: 2.186 ± 0.014	3.069LysPro: 3.069 ± 0.024	2.592LysGln: 2.592 ± 0.017	3.552LysArg: 3.552 ± 0.017	3.99LysSer: 3.99 ± 0.022	3.265LysThr: 3.265 ± 0.021	3.501LysVal: 3.501 ± 0.018	0.534LysTrp: 0.534 ± 0.006	1.429LysTyr: 1.429 ± 0.012	0.003LysXaa: 0.003 ± 0.0
Leu	5.721LeuAla: 5.721 ± 0.028	2.096LeuCys: 2.096 ± 0.017	4.744LeuAsp: 4.744 ± 0.022	6.298LeuGlu: 6.298 ± 0.036	3.177LeuPhe: 3.177 ± 0.02	5.038LeuGly: 5.038 ± 0.023	2.705LeuHis: 2.705 ± 0.018	3.544LeuIle: 3.544 ± 0.019	5.497LeuLys: 5.497 ± 0.029	9.626LeuLeu: 9.626 ± 0.044	2.107LeuMet: 2.107 ± 0.013	3.579LeuAsn: 3.579 ± 0.017	5.471LeuPro: 5.471 ± 0.026	5.432LeuGln: 5.432 ± 0.031	5.458LeuArg: 5.458 ± 0.022	8.435LeuSer: 8.435 ± 0.03	5.088LeuThr: 5.088 ± 0.022	5.065LeuVal: 5.065 ± 0.021	0.973LeuTrp: 0.973 ± 0.01	2.413LeuTyr: 2.413 ± 0.015	0.004LeuXaa: 0.004 ± 0.001
Met	1.95MetAla: 1.95 ± 0.014	0.466MetCys: 0.466 ± 0.006	1.513MetAsp: 1.513 ± 0.011	2.104MetGlu: 2.104 ± 0.013	0.846MetPhe: 0.846 ± 0.009	1.548MetGly: 1.548 ± 0.014	0.531MetHis: 0.531 ± 0.006	0.859MetIle: 0.859 ± 0.009	1.498MetLys: 1.498 ± 0.011	2.1MetLeu: 2.1 ± 0.014	0.766MetMet: 0.766 ± 0.009	0.946MetAsn: 0.946 ± 0.01	1.216MetPro: 1.216 ± 0.018	1.091MetGln: 1.091 ± 0.009	1.213MetArg: 1.213 ± 0.01	2.079MetSer: 2.079 ± 0.013	1.292MetThr: 1.292 ± 0.011	1.538MetVal: 1.538 ± 0.012	0.255MetTrp: 0.255 ± 0.004	0.62MetTyr: 0.62 ± 0.007	0.001MetXaa: 0.001 ± 0.0
Asn	2.134AsnAla: 2.134 ± 0.013	0.826AsnCys: 0.826 ± 0.01	1.671AsnAsp: 1.671 ± 0.012	2.066AsnGlu: 2.066 ± 0.014	1.298AsnPhe: 1.298 ± 0.011	2.792AsnGly: 2.792 ± 0.022	1.053AsnHis: 1.053 ± 0.009	2.068AsnIle: 2.068 ± 0.014	2.264AsnLys: 2.264 ± 0.013	3.437AsnLeu: 3.437 ± 0.018	1.124AsnMet: 1.124 ± 0.009	1.876AsnAsn: 1.876 ± 0.014	2.267AsnPro: 2.267 ± 0.016	1.785AsnGln: 1.785 ± 0.013	1.997AsnArg: 1.997 ± 0.013	3.338AsnSer: 3.338 ± 0.017	2.364AsnThr: 2.364 ± 0.015	2.26AsnVal: 2.26 ± 0.014	0.401AsnTrp: 0.401 ± 0.006	1.065AsnTyr: 1.065 ± 0.011	0.001AsnXaa: 0.001 ± 0.0
Pro	4.521ProAla: 4.521 ± 0.025	1.085ProCys: 1.085 ± 0.014	2.912ProAsp: 2.912 ± 0.018	3.965ProGlu: 3.965 ± 0.023	1.775ProPhe: 1.775 ± 0.013	4.42ProGly: 4.42 ± 0.056	1.639ProHis: 1.639 ± 0.013	1.956ProIle: 1.956 ± 0.015	2.746ProLys: 2.746 ± 0.024	5.076ProLeu: 5.076 ± 0.024	1.157ProMet: 1.157 ± 0.011	1.992ProAsn: 1.992 ± 0.013	6.074ProPro: 6.074 ± 0.052	2.88ProGln: 2.88 ± 0.021	2.909ProArg: 2.909 ± 0.019	6.145ProSer: 6.145 ± 0.033	3.355ProThr: 3.355 ± 0.018	3.777ProVal: 3.777 ± 0.021	0.539ProTrp: 0.539 ± 0.006	1.426ProTyr: 1.426 ± 0.01	0.003ProXaa: 0.003 ± 0.0
Gln	3.272GlnAla: 3.272 ± 0.022	0.925GlnCys: 0.925 ± 0.012	2.385GlnAsp: 2.385 ± 0.013	3.652GlnGlu: 3.652 ± 0.025	1.314GlnPhe: 1.314 ± 0.011	2.959GlnGly: 2.959 ± 0.024	1.461GlnHis: 1.461 ± 0.014	1.899GlnIle: 1.899 ± 0.012	2.577GlnLys: 2.577 ± 0.018	4.432GlnLeu: 4.432 ± 0.022	1.215GlnMet: 1.215 ± 0.011	1.781GlnAsn: 1.781 ± 0.013	2.778GlnPro: 2.778 ± 0.022	3.742GlnGln: 3.742 ± 0.047	3.242GlnArg: 3.242 ± 0.019	3.775GlnSer: 3.775 ± 0.022	2.681GlnThr: 2.681 ± 0.016	2.829GlnVal: 2.829 ± 0.018	0.51GlnTrp: 0.51 ± 0.006	1.211GlnTyr: 1.211 ± 0.01	0.002GlnXaa: 0.002 ± 0.0
Arg	3.438ArgAla: 3.438 ± 0.02	1.197ArgCys: 1.197 ± 0.013	2.952ArgAsp: 2.952 ± 0.02	4.088ArgGlu: 4.088 ± 0.024	1.848ArgPhe: 1.848 ± 0.011	3.738ArgGly: 3.738 ± 0.029	1.572ArgHis: 1.572 ± 0.014	2.294ArgIle: 2.294 ± 0.014	3.587ArgLys: 3.587 ± 0.019	5.195ArgLeu: 5.195 ± 0.023	1.347ArgMet: 1.347 ± 0.011	2.097ArgAsn: 2.097 ± 0.013	3.08ArgPro: 3.08 ± 0.023	2.711ArgGln: 2.711 ± 0.018	4.5ArgArg: 4.5 ± 0.028	4.76ArgSer: 4.76 ± 0.028	2.915ArgThr: 2.915 ± 0.017	3.246ArgVal: 3.246 ± 0.016	0.665ArgTrp: 0.665 ± 0.008	1.493ArgTyr: 1.493 ± 0.014	0.002ArgXaa: 0.002 ± 0.0
Ser	5.788SerAla: 5.788 ± 0.024	1.977SerCys: 1.977 ± 0.018	4.537SerAsp: 4.537 ± 0.025	5.326SerGlu: 5.326 ± 0.025	3.03SerPhe: 3.03 ± 0.015	5.817SerGly: 5.817 ± 0.028	2.324SerHis: 2.324 ± 0.015	3.337SerIle: 3.337 ± 0.018	4.202SerLys: 4.202 ± 0.024	8.454SerLeu: 8.454 ± 0.034	2.009SerMet: 2.009 ± 0.015	3.155SerAsn: 3.155 ± 0.016	6.679SerPro: 6.679 ± 0.042	4.166SerGln: 4.166 ± 0.02	4.747SerArg: 4.747 ± 0.027	11.318SerSer: 11.318 ± 0.063	5.073SerThr: 5.073 ± 0.024	5.404SerVal: 5.404 ± 0.021	0.983SerTrp: 0.983 ± 0.01	2.132SerTyr: 2.132 ± 0.014	0.003SerXaa: 0.003 ± 0.0
Thr	4.018ThrAla: 4.018 ± 0.021	1.242ThrCys: 1.242 ± 0.017	2.918ThrAsp: 2.918 ± 0.015	3.9ThrGlu: 3.9 ± 0.021	2.006ThrPhe: 2.006 ± 0.012	3.791ThrGly: 3.791 ± 0.027	1.414ThrHis: 1.414 ± 0.011	2.331ThrIle: 2.331 ± 0.016	2.751ThrLys: 2.751 ± 0.016	5.326ThrLeu: 5.326 ± 0.024	1.287ThrMet: 1.287 ± 0.01	1.963ThrAsn: 1.963 ± 0.014	3.965ThrPro: 3.965 ± 0.023	2.49ThrGln: 2.49 ± 0.017	2.491ThrArg: 2.491 ± 0.016	5.05ThrSer: 5.05 ± 0.022	3.547ThrThr: 3.547 ± 0.034	3.998ThrVal: 3.998 ± 0.021	0.616ThrTrp: 0.616 ± 0.007	1.349ThrTyr: 1.349 ± 0.011	0.003ThrXaa: 0.003 ± 0.0
Val	4.0ValAla: 4.0 ± 0.02	1.628ValCys: 1.628 ± 0.015	3.148ValAsp: 3.148 ± 0.017	4.19ValGlu: 4.19 ± 0.024	2.426ValPhe: 2.426 ± 0.015	3.502ValGly: 3.502 ± 0.026	1.51ValHis: 1.51 ± 0.011	2.754ValIle: 2.754 ± 0.018	3.568ValLys: 3.568 ± 0.02	5.806ValLeu: 5.806 ± 0.024	1.523ValMet: 1.523 ± 0.011	2.389ValAsn: 2.389 ± 0.014	3.405ValPro: 3.405 ± 0.02	2.794ValGln: 2.794 ± 0.019	3.202ValArg: 3.202 ± 0.018	5.352ValSer: 5.352 ± 0.022	3.819ValThr: 3.819 ± 0.021	4.17ValVal: 4.17 ± 0.023	0.705ValTrp: 0.705 ± 0.008	1.662ValTyr: 1.662 ± 0.011	0.003ValXaa: 0.003 ± 0.0
Trp	0.635TrpAla: 0.635 ± 0.008	0.223TrpCys: 0.223 ± 0.005	0.611TrpAsp: 0.611 ± 0.006	0.723TrpGlu: 0.723 ± 0.009	0.427TrpPhe: 0.427 ± 0.006	0.598TrpGly: 0.598 ± 0.007	0.256TrpHis: 0.256 ± 0.004	0.516TrpIle: 0.516 ± 0.008	0.671TrpLys: 0.671 ± 0.007	1.064TrpLeu: 1.064 ± 0.01	0.334TrpMet: 0.334 ± 0.005	0.448TrpAsn: 0.448 ± 0.006	0.415TrpPro: 0.415 ± 0.006	0.469TrpGln: 0.469 ± 0.006	0.701TrpArg: 0.701 ± 0.008	0.903TrpSer: 0.903 ± 0.01	0.655TrpThr: 0.655 ± 0.009	0.631TrpVal: 0.631 ± 0.007	0.173TrpTrp: 0.173 ± 0.004	0.299TrpTyr: 0.299 ± 0.004	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.307TyrAla: 1.307 ± 0.01	0.661TyrCys: 0.661 ± 0.008	1.314TyrAsp: 1.314 ± 0.012	1.494TyrGlu: 1.494 ± 0.012	1.065TyrPhe: 1.065 ± 0.01	1.674TyrGly: 1.674 ± 0.018	0.744TyrHis: 0.744 ± 0.008	1.328TyrIle: 1.328 ± 0.012	1.359TyrLys: 1.359 ± 0.011	2.431TyrLeu: 2.431 ± 0.014	0.667TyrMet: 0.667 ± 0.008	1.12TyrAsn: 1.12 ± 0.01	1.339TyrPro: 1.339 ± 0.014	1.257TyrGln: 1.257 ± 0.011	1.635TyrArg: 1.635 ± 0.013	2.347TyrSer: 2.347 ± 0.014	1.544TyrThr: 1.544 ± 0.012	1.432TyrVal: 1.432 ± 0.011	0.341TyrTrp: 0.341 ± 0.006	0.881TyrTyr: 0.881 ± 0.009	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.003XaaGly: 0.003 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.004XaaLeu: 0.004 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.003XaaPro: 0.003 ± 0.0	0.002XaaGln: 0.002 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.003XaaSer: 0.003 ± 0.0	0.002XaaThr: 0.002 ± 0.0	0.004XaaVal: 0.004 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.007XaaXaa: 0.007 ± 0.002

Statistics based on 30152 proteins (14412374 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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