Amino acid dipepetide frequency for Anaerocolumna xylanovorans DSM 12503

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.603AlaAla: 6.603 ± 0.084	0.894AlaCys: 0.894 ± 0.026	4.024AlaAsp: 4.024 ± 0.052	4.703AlaGlu: 4.703 ± 0.058	3.104AlaPhe: 3.104 ± 0.048	5.801AlaGly: 5.801 ± 0.086	0.894AlaHis: 0.894 ± 0.027	5.155AlaIle: 5.155 ± 0.062	4.793AlaLys: 4.793 ± 0.058	6.578AlaLeu: 6.578 ± 0.067	1.916AlaMet: 1.916 ± 0.036	2.606AlaAsn: 2.606 ± 0.043	1.84AlaPro: 1.84 ± 0.041	1.712AlaGln: 1.712 ± 0.035	2.435AlaArg: 2.435 ± 0.043	4.034AlaSer: 4.034 ± 0.055	3.065AlaThr: 3.065 ± 0.068	5.646AlaVal: 5.646 ± 0.072	0.593AlaTrp: 0.593 ± 0.022	2.733AlaTyr: 2.733 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.773CysAla: 0.773 ± 0.023	0.202CysCys: 0.202 ± 0.012	0.723CysAsp: 0.723 ± 0.022	0.76CysGlu: 0.76 ± 0.023	0.592CysPhe: 0.592 ± 0.021	1.163CysGly: 1.163 ± 0.032	0.27CysHis: 0.27 ± 0.013	1.124CysIle: 1.124 ± 0.029	0.824CysLys: 0.824 ± 0.025	1.079CysLeu: 1.079 ± 0.028	0.321CysMet: 0.321 ± 0.014	0.605CysAsn: 0.605 ± 0.021	0.499CysPro: 0.499 ± 0.02	0.324CysGln: 0.324 ± 0.015	0.557CysArg: 0.557 ± 0.018	0.839CysSer: 0.839 ± 0.023	0.637CysThr: 0.637 ± 0.017	0.73CysVal: 0.73 ± 0.022	0.102CysTrp: 0.102 ± 0.008	0.559CysTyr: 0.559 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.331AspAla: 3.331 ± 0.044	0.695AspCys: 0.695 ± 0.022	2.415AspAsp: 2.415 ± 0.048	3.813AspGlu: 3.813 ± 0.056	2.764AspPhe: 2.764 ± 0.04	3.916AspGly: 3.916 ± 0.06	0.616AspHis: 0.616 ± 0.018	5.213AspIle: 5.213 ± 0.059	4.333AspLys: 4.333 ± 0.053	4.275AspLeu: 4.275 ± 0.053	1.732AspMet: 1.732 ± 0.033	2.864AspAsn: 2.864 ± 0.045	1.453AspPro: 1.453 ± 0.033	1.093AspGln: 1.093 ± 0.026	2.178AspArg: 2.178 ± 0.042	3.482AspSer: 3.482 ± 0.055	3.328AspThr: 3.328 ± 0.055	3.111AspVal: 3.111 ± 0.046	0.602AspTrp: 0.602 ± 0.022	3.073AspTyr: 3.073 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.256GluAla: 5.256 ± 0.069	0.741GluCys: 0.741 ± 0.024	4.099GluAsp: 4.099 ± 0.061	7.537GluGlu: 7.537 ± 0.106	2.7GluPhe: 2.7 ± 0.049	4.417GluGly: 4.417 ± 0.059	1.104GluHis: 1.104 ± 0.029	5.728GluIle: 5.728 ± 0.073	6.727GluLys: 6.727 ± 0.075	6.76GluLeu: 6.76 ± 0.071	2.028GluMet: 2.028 ± 0.037	4.204GluAsn: 4.204 ± 0.056	1.696GluPro: 1.696 ± 0.034	2.472GluGln: 2.472 ± 0.048	3.03GluArg: 3.03 ± 0.052	3.486GluSer: 3.486 ± 0.057	3.374GluThr: 3.374 ± 0.05	4.332GluVal: 4.332 ± 0.054	0.63GluTrp: 0.63 ± 0.023	3.314GluTyr: 3.314 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.685PheAla: 2.685 ± 0.041	0.628PheCys: 0.628 ± 0.021	2.521PheAsp: 2.521 ± 0.041	2.647PheGlu: 2.647 ± 0.041	1.948PhePhe: 1.948 ± 0.041	2.889PheGly: 2.889 ± 0.045	0.905PheHis: 0.905 ± 0.026	3.374PheIle: 3.374 ± 0.051	2.414PheLys: 2.414 ± 0.038	4.39PheLeu: 4.39 ± 0.075	1.156PheMet: 1.156 ± 0.026	1.87PheAsn: 1.87 ± 0.035	1.339PhePro: 1.339 ± 0.03	1.313PheGln: 1.313 ± 0.032	1.588PheArg: 1.588 ± 0.032	3.058PheSer: 3.058 ± 0.043	2.69PheThr: 2.69 ± 0.037	2.575PheVal: 2.575 ± 0.037	0.437PheTrp: 0.437 ± 0.016	2.009PheTyr: 2.009 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	4.498GlyAla: 4.498 ± 0.079	1.066GlyCys: 1.066 ± 0.029	3.37GlyAsp: 3.37 ± 0.053	4.611GlyGlu: 4.611 ± 0.056	3.14GlyPhe: 3.14 ± 0.038	4.652GlyGly: 4.652 ± 0.069	1.095GlyHis: 1.095 ± 0.025	6.704GlyIle: 6.704 ± 0.075	5.569GlyLys: 5.569 ± 0.065	5.851GlyLeu: 5.851 ± 0.073	2.113GlyMet: 2.113 ± 0.039	3.419GlyAsn: 3.419 ± 0.059	1.365GlyPro: 1.365 ± 0.076	1.828GlyGln: 1.828 ± 0.038	2.659GlyArg: 2.659 ± 0.039	4.232GlySer: 4.232 ± 0.063	4.216GlyThr: 4.216 ± 0.07	4.419GlyVal: 4.419 ± 0.06	0.644GlyTrp: 0.644 ± 0.023	3.488GlyTyr: 3.488 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	0.84HisAla: 0.84 ± 0.022	0.247HisCys: 0.247 ± 0.014	0.78HisAsp: 0.78 ± 0.021	0.907HisGlu: 0.907 ± 0.027	0.782HisPhe: 0.782 ± 0.025	1.104HisGly: 1.104 ± 0.026	0.335HisHis: 0.335 ± 0.016	1.424HisIle: 1.424 ± 0.028	0.994HisLys: 0.994 ± 0.025	1.442HisLeu: 1.442 ± 0.03	0.462HisMet: 0.462 ± 0.018	0.813HisAsn: 0.813 ± 0.023	0.72HisPro: 0.72 ± 0.023	0.492HisGln: 0.492 ± 0.016	0.631HisArg: 0.631 ± 0.02	0.979HisSer: 0.979 ± 0.025	0.867HisThr: 0.867 ± 0.027	0.839HisVal: 0.839 ± 0.024	0.173HisTrp: 0.173 ± 0.01	0.813HisTyr: 0.813 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.701IleAla: 5.701 ± 0.064	1.167IleCys: 1.167 ± 0.03	4.259IleAsp: 4.259 ± 0.055	5.124IleGlu: 5.124 ± 0.065	3.168IlePhe: 3.168 ± 0.055	5.292IleGly: 5.292 ± 0.06	1.369IleHis: 1.369 ± 0.03	6.552IleIle: 6.552 ± 0.078	5.82IleLys: 5.82 ± 0.065	7.997IleLeu: 7.997 ± 0.087	2.072IleMet: 2.072 ± 0.036	4.088IleAsn: 4.088 ± 0.053	3.342IlePro: 3.342 ± 0.046	2.36IleGln: 2.36 ± 0.035	3.481IleArg: 3.481 ± 0.051	5.802IleSer: 5.802 ± 0.07	5.179IleThr: 5.179 ± 0.064	4.638IleVal: 4.638 ± 0.065	0.686IleTrp: 0.686 ± 0.022	3.234IleTyr: 3.234 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.359LysAla: 5.359 ± 0.063	0.641LysCys: 0.641 ± 0.022	4.786LysAsp: 4.786 ± 0.064	8.209LysGlu: 8.209 ± 0.09	2.095LysPhe: 2.095 ± 0.037	4.738LysGly: 4.738 ± 0.054	0.993LysHis: 0.993 ± 0.026	5.544LysIle: 5.544 ± 0.062	6.562LysLys: 6.562 ± 0.081	6.231LysLeu: 6.231 ± 0.07	2.001LysMet: 2.001 ± 0.038	4.263LysAsn: 4.263 ± 0.058	1.966LysPro: 1.966 ± 0.038	2.405LysGln: 2.405 ± 0.04	3.009LysArg: 3.009 ± 0.06	4.043LysSer: 4.043 ± 0.047	4.019LysThr: 4.019 ± 0.052	4.675LysVal: 4.675 ± 0.057	0.651LysTrp: 0.651 ± 0.021	3.131LysTyr: 3.131 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.337LeuAla: 6.337 ± 0.072	1.327LeuCys: 1.327 ± 0.03	4.771LeuAsp: 4.771 ± 0.056	6.205LeuGlu: 6.205 ± 0.069	4.085LeuPhe: 4.085 ± 0.062	5.634LeuGly: 5.634 ± 0.065	1.468LeuHis: 1.468 ± 0.033	6.897LeuIle: 6.897 ± 0.075	7.522LeuLys: 7.522 ± 0.072	9.524LeuLeu: 9.524 ± 0.108	2.489LeuMet: 2.489 ± 0.044	4.612LeuAsn: 4.612 ± 0.059	3.516LeuPro: 3.516 ± 0.053	2.644LeuGln: 2.644 ± 0.045	3.509LeuArg: 3.509 ± 0.052	7.171LeuSer: 7.171 ± 0.075	5.486LeuThr: 5.486 ± 0.063	5.216LeuVal: 5.216 ± 0.065	0.83LeuTrp: 0.83 ± 0.025	3.878LeuTyr: 3.878 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.088MetAla: 2.088 ± 0.042	0.282MetCys: 0.282 ± 0.012	1.708MetAsp: 1.708 ± 0.033	2.317MetGlu: 2.317 ± 0.041	0.981MetPhe: 0.981 ± 0.028	1.874MetGly: 1.874 ± 0.031	0.395MetHis: 0.395 ± 0.015	1.967MetIle: 1.967 ± 0.035	2.539MetLys: 2.539 ± 0.041	2.529MetLeu: 2.529 ± 0.041	0.738MetMet: 0.738 ± 0.021	1.505MetAsn: 1.505 ± 0.03	1.062MetPro: 1.062 ± 0.026	0.904MetGln: 0.904 ± 0.026	0.959MetArg: 0.959 ± 0.025	1.571MetSer: 1.571 ± 0.031	1.456MetThr: 1.456 ± 0.031	1.707MetVal: 1.707 ± 0.031	0.222MetTrp: 0.222 ± 0.012	0.871MetTyr: 0.871 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.146AsnAla: 3.146 ± 0.052	0.644AsnCys: 0.644 ± 0.02	2.297AsnAsp: 2.297 ± 0.034	3.171AsnGlu: 3.171 ± 0.044	1.903AsnPhe: 1.903 ± 0.037	3.728AsnGly: 3.728 ± 0.055	0.875AsnHis: 0.875 ± 0.025	4.345AsnIle: 4.345 ± 0.054	3.519AsnLys: 3.519 ± 0.043	4.362AsnLeu: 4.362 ± 0.067	1.418AsnMet: 1.418 ± 0.034	2.681AsnAsn: 2.681 ± 0.053	2.086AsnPro: 2.086 ± 0.038	1.649AsnGln: 1.649 ± 0.034	2.048AsnArg: 2.048 ± 0.037	3.153AsnSer: 3.153 ± 0.052	3.079AsnThr: 3.079 ± 0.051	2.803AsnVal: 2.803 ± 0.042	0.548AsnTrp: 0.548 ± 0.022	2.357AsnTyr: 2.357 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.339ProAla: 2.339 ± 0.051	0.377ProCys: 0.377 ± 0.016	2.136ProAsp: 2.136 ± 0.039	2.562ProGlu: 2.562 ± 0.047	1.531ProPhe: 1.531 ± 0.031	2.231ProGly: 2.231 ± 0.048	0.513ProHis: 0.513 ± 0.021	2.127ProIle: 2.127 ± 0.038	1.914ProLys: 1.914 ± 0.035	2.84ProLeu: 2.84 ± 0.045	0.836ProMet: 0.836 ± 0.022	1.265ProAsn: 1.265 ± 0.03	0.721ProPro: 0.721 ± 0.025	0.892ProGln: 0.892 ± 0.036	0.902ProArg: 0.902 ± 0.025	1.934ProSer: 1.934 ± 0.039	1.673ProThr: 1.673 ± 0.056	2.856ProVal: 2.856 ± 0.05	0.359ProTrp: 0.359 ± 0.019	1.51ProTyr: 1.51 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.079GlnAla: 2.079 ± 0.036	0.293GlnCys: 0.293 ± 0.014	1.359GlnAsp: 1.359 ± 0.028	2.215GlnGlu: 2.215 ± 0.04	1.166GlnPhe: 1.166 ± 0.026	1.889GlnGly: 1.889 ± 0.048	0.362GlnHis: 0.362 ± 0.015	2.46GlnIle: 2.46 ± 0.048	2.502GlnLys: 2.502 ± 0.038	2.771GlnLeu: 2.771 ± 0.047	0.949GlnMet: 0.949 ± 0.024	1.637GlnAsn: 1.637 ± 0.034	0.762GlnPro: 0.762 ± 0.021	0.972GlnGln: 0.972 ± 0.031	1.176GlnArg: 1.176 ± 0.03	1.625GlnSer: 1.625 ± 0.034	1.554GlnThr: 1.554 ± 0.033	1.823GlnVal: 1.823 ± 0.037	0.287GlnTrp: 0.287 ± 0.015	1.359GlnTyr: 1.359 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.19ArgAla: 2.19 ± 0.037	0.431ArgCys: 0.431 ± 0.017	1.92ArgAsp: 1.92 ± 0.036	3.493ArgGlu: 3.493 ± 0.053	1.643ArgPhe: 1.643 ± 0.038	2.179ArgGly: 2.179 ± 0.037	0.599ArgHis: 0.599 ± 0.02	3.597ArgIle: 3.597 ± 0.054	3.244ArgLys: 3.244 ± 0.05	3.659ArgLeu: 3.659 ± 0.056	1.233ArgMet: 1.233 ± 0.029	2.131ArgAsn: 2.131 ± 0.034	1.028ArgPro: 1.028 ± 0.03	1.325ArgGln: 1.325 ± 0.027	1.712ArgArg: 1.712 ± 0.034	1.92ArgSer: 1.92 ± 0.04	1.995ArgThr: 1.995 ± 0.034	2.224ArgVal: 2.224 ± 0.041	0.329ArgTrp: 0.329 ± 0.016	1.902ArgTyr: 1.902 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.231SerAla: 4.231 ± 0.061	0.835SerCys: 0.835 ± 0.022	3.433SerAsp: 3.433 ± 0.048	3.923SerGlu: 3.923 ± 0.053	3.146SerPhe: 3.146 ± 0.045	5.078SerGly: 5.078 ± 0.063	1.041SerHis: 1.041 ± 0.027	5.098SerIle: 5.098 ± 0.063	4.205SerLys: 4.205 ± 0.053	6.187SerLeu: 6.187 ± 0.077	1.745SerMet: 1.745 ± 0.031	2.782SerAsn: 2.782 ± 0.045	1.844SerPro: 1.844 ± 0.034	1.826SerGln: 1.826 ± 0.04	2.398SerArg: 2.398 ± 0.038	4.215SerSer: 4.215 ± 0.067	3.148SerThr: 3.148 ± 0.05	4.24SerVal: 4.24 ± 0.057	0.595SerTrp: 0.595 ± 0.022	2.92SerTyr: 2.92 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.614ThrAla: 4.614 ± 0.069	0.576ThrCys: 0.576 ± 0.017	3.325ThrAsp: 3.325 ± 0.055	3.803ThrGlu: 3.803 ± 0.057	2.248ThrPhe: 2.248 ± 0.037	5.036ThrGly: 5.036 ± 0.1	0.804ThrHis: 0.804 ± 0.024	4.413ThrIle: 4.413 ± 0.063	3.449ThrLys: 3.449 ± 0.051	5.272ThrLeu: 5.272 ± 0.066	1.295ThrMet: 1.295 ± 0.03	2.3ThrAsn: 2.3 ± 0.045	2.177ThrPro: 2.177 ± 0.055	1.34ThrGln: 1.34 ± 0.032	1.817ThrArg: 1.817 ± 0.036	3.332ThrSer: 3.332 ± 0.055	2.872ThrThr: 2.872 ± 0.061	4.601ThrVal: 4.601 ± 0.073	0.499ThrTrp: 0.499 ± 0.021	2.303ThrTyr: 2.303 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	3.92ValAla: 3.92 ± 0.06	0.896ValCys: 0.896 ± 0.023	3.21ValAsp: 3.21 ± 0.049	3.757ValGlu: 3.757 ± 0.048	2.948ValPhe: 2.948 ± 0.045	3.585ValGly: 3.585 ± 0.058	0.934ValHis: 0.934 ± 0.024	5.516ValIle: 5.516 ± 0.067	4.826ValLys: 4.826 ± 0.061	6.353ValLeu: 6.353 ± 0.072	1.735ValMet: 1.735 ± 0.033	3.245ValAsn: 3.245 ± 0.043	2.286ValPro: 2.286 ± 0.042	1.663ValGln: 1.663 ± 0.038	2.389ValArg: 2.389 ± 0.032	4.548ValSer: 4.548 ± 0.066	4.342ValThr: 4.342 ± 0.069	3.982ValVal: 3.982 ± 0.057	0.572ValTrp: 0.572 ± 0.021	2.686ValTyr: 2.686 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.524TrpAla: 0.524 ± 0.019	0.128TrpCys: 0.128 ± 0.008	0.564TrpAsp: 0.564 ± 0.021	0.681TrpGlu: 0.681 ± 0.024	0.419TrpPhe: 0.419 ± 0.016	0.713TrpGly: 0.713 ± 0.025	0.172TrpHis: 0.172 ± 0.011	0.657TrpIle: 0.657 ± 0.021	0.638TrpLys: 0.638 ± 0.023	0.873TrpLeu: 0.873 ± 0.025	0.282TrpMet: 0.282 ± 0.015	0.615TrpAsn: 0.615 ± 0.021	0.226TrpPro: 0.226 ± 0.012	0.355TrpGln: 0.355 ± 0.017	0.333TrpArg: 0.333 ± 0.014	0.59TrpSer: 0.59 ± 0.023	0.444TrpThr: 0.444 ± 0.02	0.528TrpVal: 0.528 ± 0.02	0.131TrpTrp: 0.131 ± 0.01	0.431TrpTyr: 0.431 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.616TyrAla: 2.616 ± 0.05	0.61TyrCys: 0.61 ± 0.024	2.587TyrAsp: 2.587 ± 0.047	3.195TyrGlu: 3.195 ± 0.05	2.074TyrPhe: 2.074 ± 0.037	3.024TyrGly: 3.024 ± 0.048	0.899TyrHis: 0.899 ± 0.024	3.439TyrIle: 3.439 ± 0.047	2.927TyrLys: 2.927 ± 0.048	4.146TyrLeu: 4.146 ± 0.059	1.152TyrMet: 1.152 ± 0.027	2.308TyrAsn: 2.308 ± 0.044	1.593TyrPro: 1.593 ± 0.032	1.671TyrGln: 1.671 ± 0.035	1.942TyrArg: 1.942 ± 0.038	2.873TyrSer: 2.873 ± 0.042	2.653TyrThr: 2.653 ± 0.053	2.45TyrVal: 2.45 ± 0.037	0.413TyrTrp: 0.413 ± 0.017	2.245TyrTyr: 2.245 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4651 proteins (1598021 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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