Amino acid dipepetide frequency for Actinoplanes atraurantiacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.102AlaAla: 23.102 ± 0.142	0.898AlaCys: 0.898 ± 0.019	8.229AlaAsp: 8.229 ± 0.059	8.472AlaGlu: 8.472 ± 0.074	3.572AlaPhe: 3.572 ± 0.036	14.377AlaGly: 14.377 ± 0.088	2.426AlaHis: 2.426 ± 0.03	4.561AlaIle: 4.561 ± 0.046	2.746AlaLys: 2.746 ± 0.035	14.249AlaLeu: 14.249 ± 0.1	2.631AlaMet: 2.631 ± 0.03	2.267AlaAsn: 2.267 ± 0.035	6.808AlaPro: 6.808 ± 0.067	3.675AlaGln: 3.675 ± 0.037	9.671AlaArg: 9.671 ± 0.064	6.37AlaSer: 6.37 ± 0.055	7.918AlaThr: 7.918 ± 0.06	12.286AlaVal: 12.286 ± 0.075	1.964AlaTrp: 1.964 ± 0.027	2.857AlaTyr: 2.857 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.842CysAla: 0.842 ± 0.018	0.081CysCys: 0.081 ± 0.005	0.424CysAsp: 0.424 ± 0.012	0.301CysGlu: 0.301 ± 0.011	0.194CysPhe: 0.194 ± 0.009	0.819CysGly: 0.819 ± 0.02	0.15CysHis: 0.15 ± 0.006	0.154CysIle: 0.154 ± 0.007	0.091CysLys: 0.091 ± 0.005	0.657CysLeu: 0.657 ± 0.015	0.096CysMet: 0.096 ± 0.006	0.13CysAsn: 0.13 ± 0.008	0.431CysPro: 0.431 ± 0.012	0.16CysGln: 0.16 ± 0.007	0.557CysArg: 0.557 ± 0.013	0.377CysSer: 0.377 ± 0.013	0.4CysThr: 0.4 ± 0.012	0.531CysVal: 0.531 ± 0.013	0.118CysTrp: 0.118 ± 0.006	0.141CysTyr: 0.141 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	7.048AspAla: 7.048 ± 0.053	0.373AspCys: 0.373 ± 0.012	4.028AspAsp: 4.028 ± 0.038	3.878AspGlu: 3.878 ± 0.035	1.669AspPhe: 1.669 ± 0.026	6.175AspGly: 6.175 ± 0.052	1.291AspHis: 1.291 ± 0.022	1.86AspIle: 1.86 ± 0.022	1.19AspLys: 1.19 ± 0.021	6.645AspLeu: 6.645 ± 0.05	0.819AspMet: 0.819 ± 0.014	1.14AspAsn: 1.14 ± 0.023	4.479AspPro: 4.479 ± 0.045	1.736AspGln: 1.736 ± 0.024	4.973AspArg: 4.973 ± 0.045	2.447AspSer: 2.447 ± 0.029	2.8AspThr: 2.8 ± 0.031	4.961AspVal: 4.961 ± 0.044	0.974AspTrp: 0.974 ± 0.015	1.207AspTyr: 1.207 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.975GluAla: 6.975 ± 0.061	0.278GluCys: 0.278 ± 0.009	2.332GluAsp: 2.332 ± 0.03	2.599GluGlu: 2.599 ± 0.032	1.453GluPhe: 1.453 ± 0.023	3.518GluGly: 3.518 ± 0.038	1.326GluHis: 1.326 ± 0.021	2.48GluIle: 2.48 ± 0.027	1.322GluLys: 1.322 ± 0.021	6.182GluLeu: 6.182 ± 0.054	0.954GluMet: 0.954 ± 0.015	0.971GluAsn: 0.971 ± 0.019	3.346GluPro: 3.346 ± 0.038	2.145GluGln: 2.145 ± 0.03	4.754GluArg: 4.754 ± 0.05	2.503GluSer: 2.503 ± 0.029	2.849GluThr: 2.849 ± 0.031	4.418GluVal: 4.418 ± 0.041	0.787GluTrp: 0.787 ± 0.018	1.013GluTyr: 1.013 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.965PheAla: 3.965 ± 0.037	0.228PheCys: 0.228 ± 0.009	2.062PheAsp: 2.062 ± 0.026	1.385PheGlu: 1.385 ± 0.023	0.911PhePhe: 0.911 ± 0.022	3.128PheGly: 3.128 ± 0.032	0.59PheHis: 0.59 ± 0.014	0.801PheIle: 0.801 ± 0.019	0.498PheLys: 0.498 ± 0.012	2.651PheLeu: 2.651 ± 0.029	0.371PheMet: 0.371 ± 0.01	0.589PheAsn: 0.589 ± 0.014	1.457PhePro: 1.457 ± 0.024	0.705PheGln: 0.705 ± 0.014	1.926PheArg: 1.926 ± 0.026	1.5PheSer: 1.5 ± 0.022	2.078PheThr: 2.078 ± 0.029	2.383PheVal: 2.383 ± 0.032	0.461PheTrp: 0.461 ± 0.013	0.648PheTyr: 0.648 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.808GlyAla: 10.808 ± 0.072	0.698GlyCys: 0.698 ± 0.018	5.676GlyAsp: 5.676 ± 0.049	4.732GlyGlu: 4.732 ± 0.046	2.99GlyPhe: 2.99 ± 0.032	8.388GlyGly: 8.388 ± 0.081	2.092GlyHis: 2.092 ± 0.03	3.356GlyIle: 3.356 ± 0.035	2.337GlyLys: 2.337 ± 0.028	9.477GlyLeu: 9.477 ± 0.058	1.799GlyMet: 1.799 ± 0.021	1.986GlyAsn: 1.986 ± 0.038	4.957GlyPro: 4.957 ± 0.046	2.599GlyGln: 2.599 ± 0.03	7.472GlyArg: 7.472 ± 0.048	5.152GlySer: 5.152 ± 0.047	5.721GlyThr: 5.721 ± 0.062	7.625GlyVal: 7.625 ± 0.05	1.787GlyTrp: 1.787 ± 0.027	2.343GlyTyr: 2.343 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.355HisAla: 2.355 ± 0.03	0.168HisCys: 0.168 ± 0.007	1.366HisAsp: 1.366 ± 0.024	1.095HisGlu: 1.095 ± 0.019	0.598HisPhe: 0.598 ± 0.013	1.956HisGly: 1.956 ± 0.024	0.633HisHis: 0.633 ± 0.017	0.635HisIle: 0.635 ± 0.016	0.325HisLys: 0.325 ± 0.012	2.374HisLeu: 2.374 ± 0.03	0.296HisMet: 0.296 ± 0.011	0.385HisAsn: 0.385 ± 0.01	1.662HisPro: 1.662 ± 0.025	0.621HisGln: 0.621 ± 0.013	1.873HisArg: 1.873 ± 0.026	0.899HisSer: 0.899 ± 0.019	1.066HisThr: 1.066 ± 0.017	1.564HisVal: 1.564 ± 0.021	0.344HisTrp: 0.344 ± 0.009	0.431HisTyr: 0.431 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	5.681IleAla: 5.681 ± 0.049	0.287IleCys: 0.287 ± 0.01	2.655IleAsp: 2.655 ± 0.03	2.217IleGlu: 2.217 ± 0.029	0.943IlePhe: 0.943 ± 0.018	3.922IleGly: 3.922 ± 0.036	0.577IleHis: 0.577 ± 0.013	1.197IleIle: 1.197 ± 0.021	0.792IleLys: 0.792 ± 0.018	2.864IleLeu: 2.864 ± 0.032	0.476IleMet: 0.476 ± 0.011	0.852IleAsn: 0.852 ± 0.017	1.877IlePro: 1.877 ± 0.023	0.803IleGln: 0.803 ± 0.017	2.47IleArg: 2.47 ± 0.027	1.997IleSer: 1.997 ± 0.026	2.538IleThr: 2.538 ± 0.029	3.32IleVal: 3.32 ± 0.039	0.495IleTrp: 0.495 ± 0.013	0.672IleTyr: 0.672 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.802LysAla: 2.802 ± 0.038	0.117LysCys: 0.117 ± 0.007	1.059LysAsp: 1.059 ± 0.018	0.891LysGlu: 0.891 ± 0.019	0.506LysPhe: 0.506 ± 0.013	1.504LysGly: 1.504 ± 0.021	0.423LysHis: 0.423 ± 0.011	0.964LysIle: 0.964 ± 0.02	0.662LysLys: 0.662 ± 0.018	2.129LysLeu: 2.129 ± 0.028	0.371LysMet: 0.371 ± 0.011	0.492LysAsn: 0.492 ± 0.014	1.423LysPro: 1.423 ± 0.022	0.71LysGln: 0.71 ± 0.015	1.508LysArg: 1.508 ± 0.023	1.134LysSer: 1.134 ± 0.02	1.323LysThr: 1.323 ± 0.023	1.888LysVal: 1.888 ± 0.031	0.303LysTrp: 0.303 ± 0.009	0.45LysTyr: 0.45 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	15.344LeuAla: 15.344 ± 0.09	0.698LeuCys: 0.698 ± 0.014	6.573LeuAsp: 6.573 ± 0.051	4.332LeuGlu: 4.332 ± 0.043	2.739LeuPhe: 2.739 ± 0.036	9.134LeuGly: 9.134 ± 0.068	2.159LeuHis: 2.159 ± 0.03	4.211LeuIle: 4.211 ± 0.043	1.824LeuLys: 1.824 ± 0.025	11.176LeuLeu: 11.176 ± 0.088	1.593LeuMet: 1.593 ± 0.024	1.873LeuAsn: 1.873 ± 0.025	6.285LeuPro: 6.285 ± 0.052	2.21LeuGln: 2.21 ± 0.019	8.674LeuArg: 8.674 ± 0.063	5.704LeuSer: 5.704 ± 0.041	7.128LeuThr: 7.128 ± 0.048	8.583LeuVal: 8.583 ± 0.067	1.316LeuTrp: 1.316 ± 0.023	1.788LeuTyr: 1.788 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.268MetAla: 2.268 ± 0.029	0.109MetCys: 0.109 ± 0.006	0.787MetAsp: 0.787 ± 0.017	0.627MetGlu: 0.627 ± 0.013	0.472MetPhe: 0.472 ± 0.013	1.14MetGly: 1.14 ± 0.02	0.333MetHis: 0.333 ± 0.011	0.807MetIle: 0.807 ± 0.014	0.405MetLys: 0.405 ± 0.012	1.836MetLeu: 1.836 ± 0.025	0.29MetMet: 0.29 ± 0.01	0.401MetAsn: 0.401 ± 0.01	1.155MetPro: 1.155 ± 0.019	0.434MetGln: 0.434 ± 0.011	1.552MetArg: 1.552 ± 0.021	1.268MetSer: 1.268 ± 0.018	1.648MetThr: 1.648 ± 0.024	1.29MetVal: 1.29 ± 0.021	0.216MetTrp: 0.216 ± 0.009	0.297MetTyr: 0.297 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.45AsnAla: 2.45 ± 0.032	0.158AsnCys: 0.158 ± 0.007	1.156AsnAsp: 1.156 ± 0.023	0.903AsnGlu: 0.903 ± 0.016	0.557AsnPhe: 0.557 ± 0.014	2.217AsnGly: 2.217 ± 0.043	0.375AsnHis: 0.375 ± 0.01	0.687AsnIle: 0.687 ± 0.016	0.429AsnLys: 0.429 ± 0.012	1.843AsnLeu: 1.843 ± 0.026	0.299AsnMet: 0.299 ± 0.01	0.552AsnAsn: 0.552 ± 0.016	1.51AsnPro: 1.51 ± 0.026	0.597AsnGln: 0.597 ± 0.02	1.435AsnArg: 1.435 ± 0.021	0.968AsnSer: 0.968 ± 0.02	1.162AsnThr: 1.162 ± 0.026	1.553AsnVal: 1.553 ± 0.023	0.356AsnTrp: 0.356 ± 0.011	0.473AsnTyr: 0.473 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.475ProAla: 9.475 ± 0.083	0.275ProCys: 0.275 ± 0.01	4.131ProAsp: 4.131 ± 0.035	3.664ProGlu: 3.664 ± 0.041	1.558ProPhe: 1.558 ± 0.023	6.456ProGly: 6.456 ± 0.05	1.161ProHis: 1.161 ± 0.021	1.856ProIle: 1.856 ± 0.024	1.094ProLys: 1.094 ± 0.024	5.142ProLeu: 5.142 ± 0.04	0.996ProMet: 0.996 ± 0.016	1.092ProAsn: 1.092 ± 0.02	3.92ProPro: 3.92 ± 0.052	1.594ProGln: 1.594 ± 0.029	3.729ProArg: 3.729 ± 0.042	3.702ProSer: 3.702 ± 0.05	3.322ProThr: 3.322 ± 0.041	5.229ProVal: 5.229 ± 0.041	0.912ProTrp: 0.912 ± 0.016	1.298ProTyr: 1.298 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.808GlnAla: 3.808 ± 0.033	0.151GlnCys: 0.151 ± 0.007	1.18GlnAsp: 1.18 ± 0.021	1.254GlnGlu: 1.254 ± 0.02	0.812GlnPhe: 0.812 ± 0.019	1.951GlnGly: 1.951 ± 0.026	0.575GlnHis: 0.575 ± 0.013	1.299GlnIle: 1.299 ± 0.022	0.585GlnLys: 0.585 ± 0.015	3.067GlnLeu: 3.067 ± 0.028	0.518GlnMet: 0.518 ± 0.012	0.571GlnAsn: 0.571 ± 0.015	1.858GlnPro: 1.858 ± 0.036	1.163GlnGln: 1.163 ± 0.021	2.481GlnArg: 2.481 ± 0.027	1.327GlnSer: 1.327 ± 0.022	1.481GlnThr: 1.481 ± 0.023	2.495GlnVal: 2.495 ± 0.03	0.546GlnTrp: 0.546 ± 0.014	0.586GlnTyr: 0.586 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.596ArgAla: 9.596 ± 0.069	0.518ArgCys: 0.518 ± 0.012	4.504ArgAsp: 4.504 ± 0.048	4.23ArgGlu: 4.23 ± 0.044	2.38ArgPhe: 2.38 ± 0.026	5.417ArgGly: 5.417 ± 0.05	2.01ArgHis: 2.01 ± 0.025	3.072ArgIle: 3.072 ± 0.034	1.612ArgLys: 1.612 ± 0.023	8.906ArgLeu: 8.906 ± 0.067	1.781ArgMet: 1.781 ± 0.024	1.468ArgAsn: 1.468 ± 0.023	4.808ArgPro: 4.808 ± 0.046	2.478ArgGln: 2.478 ± 0.028	7.885ArgArg: 7.885 ± 0.072	4.138ArgSer: 4.138 ± 0.041	4.551ArgThr: 4.551 ± 0.045	5.848ArgVal: 5.848 ± 0.045	1.496ArgTrp: 1.496 ± 0.025	1.869ArgTyr: 1.869 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	7.263SerAla: 7.263 ± 0.062	0.345SerCys: 0.345 ± 0.011	2.796SerAsp: 2.796 ± 0.031	2.331SerGlu: 2.331 ± 0.029	1.624SerPhe: 1.624 ± 0.026	5.821SerGly: 5.821 ± 0.055	0.95SerHis: 0.95 ± 0.021	1.797SerIle: 1.797 ± 0.025	1.022SerLys: 1.022 ± 0.021	4.94SerLeu: 4.94 ± 0.04	1.14SerMet: 1.14 ± 0.019	0.951SerAsn: 0.951 ± 0.02	3.444SerPro: 3.444 ± 0.044	1.349SerGln: 1.349 ± 0.02	3.848SerArg: 3.848 ± 0.041	3.286SerSer: 3.286 ± 0.046	3.189SerThr: 3.189 ± 0.04	4.268SerVal: 4.268 ± 0.035	1.017SerTrp: 1.017 ± 0.02	1.316SerTyr: 1.316 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.816ThrAla: 8.816 ± 0.075	0.381ThrCys: 0.381 ± 0.013	3.468ThrAsp: 3.468 ± 0.038	3.014ThrGlu: 3.014 ± 0.031	1.797ThrPhe: 1.797 ± 0.026	6.437ThrGly: 6.437 ± 0.062	1.063ThrHis: 1.063 ± 0.021	2.38ThrIle: 2.38 ± 0.028	1.249ThrLys: 1.249 ± 0.021	5.74ThrLeu: 5.74 ± 0.047	1.042ThrMet: 1.042 ± 0.016	1.215ThrAsn: 1.215 ± 0.024	4.122ThrPro: 4.122 ± 0.043	1.34ThrGln: 1.34 ± 0.023	3.768ThrArg: 3.768 ± 0.035	3.348ThrSer: 3.348 ± 0.041	4.206ThrThr: 4.206 ± 0.052	6.04ThrVal: 6.04 ± 0.046	0.961ThrTrp: 0.961 ± 0.016	1.411ThrTyr: 1.411 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	11.913ValAla: 11.913 ± 0.077	0.586ValCys: 0.586 ± 0.014	5.033ValAsp: 5.033 ± 0.04	4.445ValGlu: 4.445 ± 0.038	2.381ValPhe: 2.381 ± 0.033	6.452ValGly: 6.452 ± 0.052	1.684ValHis: 1.684 ± 0.024	3.367ValIle: 3.367 ± 0.033	1.722ValLys: 1.722 ± 0.025	9.328ValLeu: 9.328 ± 0.074	1.309ValMet: 1.309 ± 0.023	1.824ValAsn: 1.824 ± 0.023	5.034ValPro: 5.034 ± 0.04	2.024ValGln: 2.024 ± 0.026	6.655ValArg: 6.655 ± 0.057	4.505ValSer: 4.505 ± 0.04	6.119ValThr: 6.119 ± 0.057	8.161ValVal: 8.161 ± 0.065	1.118ValTrp: 1.118 ± 0.018	1.557ValTyr: 1.557 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.768TrpAla: 1.768 ± 0.026	0.132TrpCys: 0.132 ± 0.005	0.779TrpAsp: 0.779 ± 0.019	0.659TrpGlu: 0.659 ± 0.016	0.507TrpPhe: 0.507 ± 0.015	1.02TrpGly: 1.02 ± 0.018	0.428TrpHis: 0.428 ± 0.012	0.638TrpIle: 0.638 ± 0.015	0.334TrpLys: 0.334 ± 0.011	1.91TrpLeu: 1.91 ± 0.031	0.313TrpMet: 0.313 ± 0.01	0.473TrpAsn: 0.473 ± 0.013	0.901TrpPro: 0.901 ± 0.016	0.673TrpGln: 0.673 ± 0.017	1.473TrpArg: 1.473 ± 0.022	1.051TrpSer: 1.051 ± 0.019	1.063TrpThr: 1.063 ± 0.02	1.049TrpVal: 1.049 ± 0.017	0.398TrpTrp: 0.398 ± 0.01	0.361TrpTyr: 0.361 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.801TyrAla: 2.801 ± 0.027	0.171TyrCys: 0.171 ± 0.007	1.455TyrAsp: 1.455 ± 0.031	1.18TyrGlu: 1.18 ± 0.018	0.673TyrPhe: 0.673 ± 0.015	2.165TyrGly: 2.165 ± 0.028	0.399TyrHis: 0.399 ± 0.011	0.516TyrIle: 0.516 ± 0.012	0.417TyrLys: 0.417 ± 0.011	2.228TyrLeu: 2.228 ± 0.028	0.241TyrMet: 0.241 ± 0.009	0.449TyrAsn: 0.449 ± 0.015	1.127TyrPro: 1.127 ± 0.018	0.694TyrGln: 0.694 ± 0.015	1.861TyrArg: 1.861 ± 0.025	1.02TyrSer: 1.02 ± 0.02	1.236TyrThr: 1.236 ± 0.023	1.724TyrVal: 1.724 ± 0.022	0.361TyrTrp: 0.361 ± 0.011	0.491TyrTyr: 0.491 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.002

Statistics based on 10240 proteins (3323307 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---