Amino acid dipepetide frequency for Dielma fastidiosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.321AlaAla: 7.321 ± 0.108	1.293AlaCys: 1.293 ± 0.031	4.769AlaAsp: 4.769 ± 0.07	4.899AlaGlu: 4.899 ± 0.072	3.423AlaPhe: 3.423 ± 0.06	5.122AlaGly: 5.122 ± 0.077	1.29AlaHis: 1.29 ± 0.035	5.907AlaIle: 5.907 ± 0.086	4.727AlaLys: 4.727 ± 0.069	7.84AlaLeu: 7.84 ± 0.09	2.735AlaMet: 2.735 ± 0.054	3.157AlaAsn: 3.157 ± 0.061	1.754AlaPro: 1.754 ± 0.042	2.521AlaGln: 2.521 ± 0.051	2.341AlaArg: 2.341 ± 0.053	4.55AlaSer: 4.55 ± 0.069	2.811AlaThr: 2.811 ± 0.071	5.757AlaVal: 5.757 ± 0.077	0.673AlaTrp: 0.673 ± 0.025	3.282AlaTyr: 3.282 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.135CysAla: 1.135 ± 0.033	0.317CysCys: 0.317 ± 0.019	0.936CysAsp: 0.936 ± 0.031	1.067CysGlu: 1.067 ± 0.035	0.8CysPhe: 0.8 ± 0.03	1.275CysGly: 1.275 ± 0.039	0.332CysHis: 0.332 ± 0.019	1.214CysIle: 1.214 ± 0.036	0.693CysLys: 0.693 ± 0.025	1.55CysLeu: 1.55 ± 0.042	0.473CysMet: 0.473 ± 0.023	0.607CysAsn: 0.607 ± 0.027	0.549CysPro: 0.549 ± 0.025	0.491CysGln: 0.491 ± 0.025	0.595CysArg: 0.595 ± 0.026	1.012CysSer: 1.012 ± 0.031	0.807CysThr: 0.807 ± 0.029	1.054CysVal: 1.054 ± 0.034	0.168CysTrp: 0.168 ± 0.014	0.557CysTyr: 0.557 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.289AspAla: 4.289 ± 0.073	0.918AspCys: 0.918 ± 0.035	3.229AspAsp: 3.229 ± 0.061	5.623AspGlu: 5.623 ± 0.082	2.861AspPhe: 2.861 ± 0.05	3.673AspGly: 3.673 ± 0.071	1.184AspHis: 1.184 ± 0.035	4.166AspIle: 4.166 ± 0.067	3.681AspLys: 3.681 ± 0.065	5.446AspLeu: 5.446 ± 0.081	1.609AspMet: 1.609 ± 0.036	2.445AspAsn: 2.445 ± 0.051	1.829AspPro: 1.829 ± 0.046	2.211AspGln: 2.211 ± 0.049	1.978AspArg: 1.978 ± 0.039	2.968AspSer: 2.968 ± 0.064	2.877AspThr: 2.877 ± 0.053	3.708AspVal: 3.708 ± 0.067	0.557AspTrp: 0.557 ± 0.026	2.819AspTyr: 2.819 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	5.837GluAla: 5.837 ± 0.082	0.964GluCys: 0.964 ± 0.029	3.584GluAsp: 3.584 ± 0.069	5.135GluGlu: 5.135 ± 0.094	2.552GluPhe: 2.552 ± 0.049	3.707GluGly: 3.707 ± 0.066	1.356GluHis: 1.356 ± 0.04	5.666GluIle: 5.666 ± 0.074	5.495GluLys: 5.495 ± 0.073	7.071GluLeu: 7.071 ± 0.098	2.37GluMet: 2.37 ± 0.045	4.017GluAsn: 4.017 ± 0.064	1.761GluPro: 1.761 ± 0.039	2.538GluGln: 2.538 ± 0.052	2.762GluArg: 2.762 ± 0.056	3.126GluSer: 3.126 ± 0.06	3.556GluThr: 3.556 ± 0.067	4.344GluVal: 4.344 ± 0.078	0.616GluTrp: 0.616 ± 0.025	2.611GluTyr: 2.611 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.059PheAla: 3.059 ± 0.054	0.625PheCys: 0.625 ± 0.025	2.97PheAsp: 2.97 ± 0.055	2.715PheGlu: 2.715 ± 0.05	1.817PhePhe: 1.817 ± 0.045	2.785PheGly: 2.785 ± 0.056	0.765PheHis: 0.765 ± 0.029	3.727PheIle: 3.727 ± 0.067	2.816PheLys: 2.816 ± 0.058	3.631PheLeu: 3.631 ± 0.071	1.387PheMet: 1.387 ± 0.041	2.411PheAsn: 2.411 ± 0.043	1.257PhePro: 1.257 ± 0.035	1.18PheGln: 1.18 ± 0.032	1.193PheArg: 1.193 ± 0.037	2.86PheSer: 2.86 ± 0.053	2.634PheThr: 2.634 ± 0.053	2.744PheVal: 2.744 ± 0.052	0.354PheTrp: 0.354 ± 0.019	2.008PheTyr: 2.008 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.075GlyAla: 4.075 ± 0.083	1.336GlyCys: 1.336 ± 0.037	2.894GlyAsp: 2.894 ± 0.054	3.678GlyGlu: 3.678 ± 0.068	2.986GlyPhe: 2.986 ± 0.052	4.356GlyGly: 4.356 ± 0.111	1.155GlyHis: 1.155 ± 0.035	5.856GlyIle: 5.856 ± 0.087	4.381GlyLys: 4.381 ± 0.063	5.943GlyLeu: 5.943 ± 0.087	2.125GlyMet: 2.125 ± 0.052	2.947GlyAsn: 2.947 ± 0.058	1.183GlyPro: 1.183 ± 0.06	1.698GlyGln: 1.698 ± 0.043	2.254GlyArg: 2.254 ± 0.046	4.167GlySer: 4.167 ± 0.078	3.373GlyThr: 3.373 ± 0.068	4.246GlyVal: 4.246 ± 0.072	0.688GlyTrp: 0.688 ± 0.029	3.216GlyTyr: 3.216 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.322HisAla: 1.322 ± 0.034	0.389HisCys: 0.389 ± 0.02	1.215HisAsp: 1.215 ± 0.033	1.591HisGlu: 1.591 ± 0.043	0.931HisPhe: 0.931 ± 0.027	1.39HisGly: 1.39 ± 0.043	0.593HisHis: 0.593 ± 0.03	1.334HisIle: 1.334 ± 0.037	0.928HisLys: 0.928 ± 0.028	1.891HisLeu: 1.891 ± 0.045	0.497HisMet: 0.497 ± 0.024	0.752HisAsn: 0.752 ± 0.028	0.855HisPro: 0.855 ± 0.027	0.927HisGln: 0.927 ± 0.03	0.768HisArg: 0.768 ± 0.026	0.969HisSer: 0.969 ± 0.027	0.955HisThr: 0.955 ± 0.033	1.246HisVal: 1.246 ± 0.032	0.199HisTrp: 0.199 ± 0.013	0.93HisTyr: 0.93 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.289IleAla: 6.289 ± 0.089	1.265IleCys: 1.265 ± 0.031	5.289IleAsp: 5.289 ± 0.069	5.773IleGlu: 5.773 ± 0.083	3.095IlePhe: 3.095 ± 0.064	5.126IleGly: 5.126 ± 0.083	1.697IleHis: 1.697 ± 0.052	5.959IleIle: 5.959 ± 0.085	5.274IleLys: 5.274 ± 0.079	7.684IleLeu: 7.684 ± 0.111	2.095IleMet: 2.095 ± 0.044	4.083IleAsn: 4.083 ± 0.067	2.791IlePro: 2.791 ± 0.053	2.849IleGln: 2.849 ± 0.059	2.964IleArg: 2.964 ± 0.056	5.167IleSer: 5.167 ± 0.077	4.332IleThr: 4.332 ± 0.073	5.033IleVal: 5.033 ± 0.068	0.563IleTrp: 0.563 ± 0.025	3.025IleTyr: 3.025 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	5.663LysAla: 5.663 ± 0.078	0.714LysCys: 0.714 ± 0.025	4.048LysAsp: 4.048 ± 0.07	5.554LysGlu: 5.554 ± 0.074	1.755LysPhe: 1.755 ± 0.038	3.936LysGly: 3.936 ± 0.074	1.318LysHis: 1.318 ± 0.035	4.983LysIle: 4.983 ± 0.07	5.309LysLys: 5.309 ± 0.078	6.034LysLeu: 6.034 ± 0.082	2.253LysMet: 2.253 ± 0.047	3.554LysAsn: 3.554 ± 0.068	2.085LysPro: 2.085 ± 0.044	3.17LysGln: 3.17 ± 0.053	2.891LysArg: 2.891 ± 0.062	3.288LysSer: 3.288 ± 0.051	3.669LysThr: 3.669 ± 0.055	3.994LysVal: 3.994 ± 0.06	0.535LysTrp: 0.535 ± 0.023	2.51LysTyr: 2.51 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	7.627LeuAla: 7.627 ± 0.098	1.742LeuCys: 1.742 ± 0.044	5.681LeuAsp: 5.681 ± 0.08	5.53LeuGlu: 5.53 ± 0.076	4.492LeuPhe: 4.492 ± 0.079	5.705LeuGly: 5.705 ± 0.089	1.817LeuHis: 1.817 ± 0.044	8.353LeuIle: 8.353 ± 0.102	7.361LeuLys: 7.361 ± 0.082	10.321LeuLeu: 10.321 ± 0.142	3.27LeuMet: 3.27 ± 0.058	5.488LeuAsn: 5.488 ± 0.073	3.639LeuPro: 3.639 ± 0.056	2.983LeuGln: 2.983 ± 0.058	3.577LeuArg: 3.577 ± 0.062	7.102LeuSer: 7.102 ± 0.089	5.202LeuThr: 5.202 ± 0.072	5.568LeuVal: 5.568 ± 0.077	0.678LeuTrp: 0.678 ± 0.023	3.529LeuTyr: 3.529 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.355MetAla: 2.355 ± 0.043	0.335MetCys: 0.335 ± 0.02	1.701MetAsp: 1.701 ± 0.041	1.796MetGlu: 1.796 ± 0.044	1.077MetPhe: 1.077 ± 0.032	1.865MetGly: 1.865 ± 0.048	0.558MetHis: 0.558 ± 0.024	2.773MetIle: 2.773 ± 0.058	2.826MetLys: 2.826 ± 0.043	3.234MetLeu: 3.234 ± 0.064	1.072MetMet: 1.072 ± 0.035	2.07MetAsn: 2.07 ± 0.043	1.148MetPro: 1.148 ± 0.031	1.183MetGln: 1.183 ± 0.032	1.19MetArg: 1.19 ± 0.039	1.946MetSer: 1.946 ± 0.045	1.443MetThr: 1.443 ± 0.033	1.788MetVal: 1.788 ± 0.041	0.169MetTrp: 0.169 ± 0.012	0.742MetTyr: 0.742 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.625AsnAla: 3.625 ± 0.058	0.68AsnCys: 0.68 ± 0.027	3.162AsnAsp: 3.162 ± 0.059	4.154AsnGlu: 4.154 ± 0.063	1.814AsnPhe: 1.814 ± 0.037	3.467AsnGly: 3.467 ± 0.068	1.088AsnHis: 1.088 ± 0.035	3.547AsnIle: 3.547 ± 0.07	3.059AsnLys: 3.059 ± 0.05	4.25AsnLeu: 4.25 ± 0.068	1.299AsnMet: 1.299 ± 0.036	2.415AsnAsn: 2.415 ± 0.066	1.756AsnPro: 1.756 ± 0.041	2.297AsnGln: 2.297 ± 0.052	1.893AsnArg: 1.893 ± 0.049	2.477AsnSer: 2.477 ± 0.053	2.521AsnThr: 2.521 ± 0.051	3.115AsnVal: 3.115 ± 0.059	0.438AsnTrp: 0.438 ± 0.02	2.199AsnTyr: 2.199 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.401ProAla: 2.401 ± 0.051	0.441ProCys: 0.441 ± 0.021	1.815ProAsp: 1.815 ± 0.04	2.272ProGlu: 2.272 ± 0.048	1.599ProPhe: 1.599 ± 0.033	1.535ProGly: 1.535 ± 0.037	0.59ProHis: 0.59 ± 0.021	2.753ProIle: 2.753 ± 0.053	1.768ProLys: 1.768 ± 0.043	3.115ProLeu: 3.115 ± 0.067	0.981ProMet: 0.981 ± 0.031	1.41ProAsn: 1.41 ± 0.041	0.584ProPro: 0.584 ± 0.024	1.1ProGln: 1.1 ± 0.033	0.803ProArg: 0.803 ± 0.03	1.795ProSer: 1.795 ± 0.041	1.538ProThr: 1.538 ± 0.04	2.269ProVal: 2.269 ± 0.053	0.274ProTrp: 0.274 ± 0.015	1.459ProTyr: 1.459 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.866GlnAla: 2.866 ± 0.054	0.584GlnCys: 0.584 ± 0.022	1.551GlnAsp: 1.551 ± 0.039	2.162GlnGlu: 2.162 ± 0.052	1.502GlnPhe: 1.502 ± 0.045	2.185GlnGly: 2.185 ± 0.057	0.715GlnHis: 0.715 ± 0.025	2.949GlnIle: 2.949 ± 0.054	2.411GlnLys: 2.411 ± 0.052	4.318GlnLeu: 4.318 ± 0.064	1.135GlnMet: 1.135 ± 0.036	1.611GlnAsn: 1.611 ± 0.042	1.21GlnPro: 1.21 ± 0.04	1.672GlnGln: 1.672 ± 0.048	1.712GlnArg: 1.712 ± 0.045	2.038GlnSer: 2.038 ± 0.044	1.786GlnThr: 1.786 ± 0.043	2.04GlnVal: 2.04 ± 0.045	0.383GlnTrp: 0.383 ± 0.019	1.405GlnTyr: 1.405 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.125ArgAla: 2.125 ± 0.05	0.63ArgCys: 0.63 ± 0.026	1.872ArgAsp: 1.872 ± 0.046	2.589ArgGlu: 2.589 ± 0.049	1.821ArgPhe: 1.821 ± 0.047	1.74ArgGly: 1.74 ± 0.049	0.794ArgHis: 0.794 ± 0.027	3.104ArgIle: 3.104 ± 0.057	2.713ArgLys: 2.713 ± 0.058	3.859ArgLeu: 3.859 ± 0.069	1.291ArgMet: 1.291 ± 0.04	1.76ArgAsn: 1.76 ± 0.038	0.965ArgPro: 0.965 ± 0.031	1.597ArgGln: 1.597 ± 0.042	1.646ArgArg: 1.646 ± 0.044	2.107ArgSer: 2.107 ± 0.042	1.632ArgThr: 1.632 ± 0.039	2.201ArgVal: 2.201 ± 0.045	0.348ArgTrp: 0.348 ± 0.017	1.831ArgTyr: 1.831 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.512SerAla: 4.512 ± 0.062	0.882SerCys: 0.882 ± 0.029	3.537SerAsp: 3.537 ± 0.064	4.146SerGlu: 4.146 ± 0.055	2.846SerPhe: 2.846 ± 0.057	4.383SerGly: 4.383 ± 0.076	1.081SerHis: 1.081 ± 0.033	4.818SerIle: 4.818 ± 0.07	3.762SerLys: 3.762 ± 0.058	5.863SerLeu: 5.863 ± 0.08	1.876SerMet: 1.876 ± 0.043	2.63SerAsn: 2.63 ± 0.059	1.439SerPro: 1.439 ± 0.036	1.978SerGln: 1.978 ± 0.045	2.106SerArg: 2.106 ± 0.049	3.625SerSer: 3.625 ± 0.072	2.808SerThr: 2.808 ± 0.062	3.989SerVal: 3.989 ± 0.063	0.519SerTrp: 0.519 ± 0.023	2.48SerTyr: 2.48 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.15ThrAla: 4.15 ± 0.064	0.715ThrCys: 0.715 ± 0.025	2.726ThrAsp: 2.726 ± 0.058	2.662ThrGlu: 2.662 ± 0.058	2.24ThrPhe: 2.24 ± 0.047	3.407ThrGly: 3.407 ± 0.079	1.045ThrHis: 1.045 ± 0.031	4.52ThrIle: 4.52 ± 0.07	2.765ThrLys: 2.765 ± 0.056	5.495ThrLeu: 5.495 ± 0.078	1.495ThrMet: 1.495 ± 0.039	2.169ThrAsn: 2.169 ± 0.044	1.96ThrPro: 1.96 ± 0.05	1.622ThrGln: 1.622 ± 0.036	1.649ThrArg: 1.649 ± 0.038	3.073ThrSer: 3.073 ± 0.064	2.614ThrThr: 2.614 ± 0.062	3.682ThrVal: 3.682 ± 0.073	0.451ThrTrp: 0.451 ± 0.024	2.219ThrTyr: 2.219 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.01ValAla: 4.01 ± 0.078	1.079ValCys: 1.079 ± 0.031	3.873ValAsp: 3.873 ± 0.06	4.242ValGlu: 4.242 ± 0.07	2.832ValPhe: 2.832 ± 0.058	3.692ValGly: 3.692 ± 0.07	1.104ValHis: 1.104 ± 0.036	5.333ValIle: 5.333 ± 0.082	4.583ValLys: 4.583 ± 0.067	6.775ValLeu: 6.775 ± 0.089	2.001ValMet: 2.001 ± 0.043	3.38ValAsn: 3.38 ± 0.059	1.94ValPro: 1.94 ± 0.038	1.819ValGln: 1.819 ± 0.039	2.242ValArg: 2.242 ± 0.05	4.388ValSer: 4.388 ± 0.063	3.412ValThr: 3.412 ± 0.069	4.239ValVal: 4.239 ± 0.078	0.503ValTrp: 0.503 ± 0.022	2.64ValTyr: 2.64 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.497TrpAla: 0.497 ± 0.025	0.145TrpCys: 0.145 ± 0.012	0.428TrpAsp: 0.428 ± 0.021	0.463TrpGlu: 0.463 ± 0.021	0.411TrpPhe: 0.411 ± 0.02	0.551TrpGly: 0.551 ± 0.026	0.216TrpHis: 0.216 ± 0.016	0.768TrpIle: 0.768 ± 0.026	0.433TrpLys: 0.433 ± 0.019	1.078TrpLeu: 1.078 ± 0.036	0.245TrpMet: 0.245 ± 0.015	0.393TrpAsn: 0.393 ± 0.02	0.225TrpPro: 0.225 ± 0.015	0.472TrpGln: 0.472 ± 0.023	0.308TrpArg: 0.308 ± 0.016	0.44TrpSer: 0.44 ± 0.021	0.389TrpThr: 0.389 ± 0.022	0.554TrpVal: 0.554 ± 0.023	0.085TrpTrp: 0.085 ± 0.009	0.463TrpTyr: 0.463 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.012TyrAla: 3.012 ± 0.054	0.577TyrCys: 0.577 ± 0.025	2.791TyrAsp: 2.791 ± 0.052	3.021TyrGlu: 3.021 ± 0.058	2.083TyrPhe: 2.083 ± 0.05	2.657TyrGly: 2.657 ± 0.053	0.982TyrHis: 0.982 ± 0.03	2.624TyrIle: 2.624 ± 0.05	2.282TyrLys: 2.282 ± 0.052	4.264TyrLeu: 4.264 ± 0.064	1.062TyrMet: 1.062 ± 0.03	1.954TyrAsn: 1.954 ± 0.051	1.574TyrPro: 1.574 ± 0.036	1.927TyrGln: 1.927 ± 0.044	1.755TyrArg: 1.755 ± 0.046	2.182TyrSer: 2.182 ± 0.051	2.301TyrThr: 2.301 ± 0.05	2.514TyrVal: 2.514 ± 0.049	0.363TyrTrp: 0.363 ± 0.019	2.199TyrTyr: 2.199 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3467 proteins (1067974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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