Amino acid dipepetide frequency for Prevotella brunnea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.188AlaAla: 5.188 ± 0.116	0.877AlaCys: 0.877 ± 0.039	4.347AlaAsp: 4.347 ± 0.076	4.605AlaGlu: 4.605 ± 0.098	3.151AlaPhe: 3.151 ± 0.072	4.646AlaGly: 4.646 ± 0.1	1.36AlaHis: 1.36 ± 0.039	4.906AlaIle: 4.906 ± 0.094	4.835AlaLys: 4.835 ± 0.105	6.425AlaLeu: 6.425 ± 0.11	2.067AlaMet: 2.067 ± 0.063	3.512AlaAsn: 3.512 ± 0.077	2.106AlaPro: 2.106 ± 0.056	2.749AlaGln: 2.749 ± 0.079	3.134AlaArg: 3.134 ± 0.066	3.807AlaSer: 3.807 ± 0.069	4.033AlaThr: 4.033 ± 0.084	4.584AlaVal: 4.584 ± 0.097	0.631AlaTrp: 0.631 ± 0.028	2.851AlaTyr: 2.851 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.815CysAla: 0.815 ± 0.037	0.199CysCys: 0.199 ± 0.02	0.688CysAsp: 0.688 ± 0.032	0.674CysGlu: 0.674 ± 0.035	0.611CysPhe: 0.611 ± 0.03	1.088CysGly: 1.088 ± 0.048	0.318CysHis: 0.318 ± 0.022	0.844CysIle: 0.844 ± 0.032	0.806CysLys: 0.806 ± 0.037	1.07CysLeu: 1.07 ± 0.04	0.343CysMet: 0.343 ± 0.02	0.605CysAsn: 0.605 ± 0.029	0.562CysPro: 0.562 ± 0.031	0.36CysGln: 0.36 ± 0.024	0.643CysArg: 0.643 ± 0.034	0.738CysSer: 0.738 ± 0.033	0.622CysThr: 0.622 ± 0.031	0.756CysVal: 0.756 ± 0.036	0.148CysTrp: 0.148 ± 0.014	0.519CysTyr: 0.519 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.934AspAla: 3.934 ± 0.076	0.671AspCys: 0.671 ± 0.035	2.968AspAsp: 2.968 ± 0.071	4.006AspGlu: 4.006 ± 0.082	3.16AspPhe: 3.16 ± 0.067	3.925AspGly: 3.925 ± 0.107	0.918AspHis: 0.918 ± 0.037	4.208AspIle: 4.208 ± 0.078	4.169AspLys: 4.169 ± 0.083	4.531AspLeu: 4.531 ± 0.087	1.583AspMet: 1.583 ± 0.043	3.041AspAsn: 3.041 ± 0.069	1.692AspPro: 1.692 ± 0.055	1.066AspGln: 1.066 ± 0.039	2.399AspArg: 2.399 ± 0.055	3.027AspSer: 3.027 ± 0.073	2.814AspThr: 2.814 ± 0.057	3.51AspVal: 3.51 ± 0.073	0.809AspTrp: 0.809 ± 0.032	2.871AspTyr: 2.871 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.49GluAla: 4.49 ± 0.102	0.671GluCys: 0.671 ± 0.033	3.183GluAsp: 3.183 ± 0.06	5.047GluGlu: 5.047 ± 0.089	2.437GluPhe: 2.437 ± 0.062	3.885GluGly: 3.885 ± 0.088	1.356GluHis: 1.356 ± 0.043	4.515GluIle: 4.515 ± 0.093	5.549GluLys: 5.549 ± 0.095	5.927GluLeu: 5.927 ± 0.103	2.021GluMet: 2.021 ± 0.056	3.563GluAsn: 3.563 ± 0.08	1.79GluPro: 1.79 ± 0.06	2.869GluGln: 2.869 ± 0.067	3.673GluArg: 3.673 ± 0.08	2.889GluSer: 2.889 ± 0.069	3.491GluThr: 3.491 ± 0.07	4.02GluVal: 4.02 ± 0.077	0.756GluTrp: 0.756 ± 0.034	2.472GluTyr: 2.472 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	3.041PheAla: 3.041 ± 0.07	0.703PheCys: 0.703 ± 0.034	2.712PheAsp: 2.712 ± 0.059	2.505PheGlu: 2.505 ± 0.061	2.325PhePhe: 2.325 ± 0.078	3.327PheGly: 3.327 ± 0.074	1.066PheHis: 1.066 ± 0.04	3.25PheIle: 3.25 ± 0.083	2.681PheLys: 2.681 ± 0.062	4.056PheLeu: 4.056 ± 0.094	1.243PheMet: 1.243 ± 0.04	2.461PheAsn: 2.461 ± 0.067	1.699PhePro: 1.699 ± 0.051	1.236PheGln: 1.236 ± 0.04	2.197PheArg: 2.197 ± 0.057	3.299PheSer: 3.299 ± 0.075	2.823PheThr: 2.823 ± 0.066	2.892PheVal: 2.892 ± 0.069	0.46PheTrp: 0.46 ± 0.03	1.859PheTyr: 1.859 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.355GlyAla: 4.355 ± 0.102	0.89GlyCys: 0.89 ± 0.042	3.381GlyAsp: 3.381 ± 0.072	4.003GlyGlu: 4.003 ± 0.091	3.224GlyPhe: 3.224 ± 0.07	4.796GlyGly: 4.796 ± 0.122	1.406GlyHis: 1.406 ± 0.046	5.221GlyIle: 5.221 ± 0.088	5.711GlyLys: 5.711 ± 0.111	5.626GlyLeu: 5.626 ± 0.096	2.124GlyMet: 2.124 ± 0.052	3.784GlyAsn: 3.784 ± 0.088	1.135GlyPro: 1.135 ± 0.041	2.115GlyGln: 2.115 ± 0.061	3.056GlyArg: 3.056 ± 0.076	3.751GlySer: 3.751 ± 0.087	4.154GlyThr: 4.154 ± 0.08	4.451GlyVal: 4.451 ± 0.094	0.883GlyTrp: 0.883 ± 0.036	3.013GlyTyr: 3.013 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	1.279HisAla: 1.279 ± 0.046	0.371HisCys: 0.371 ± 0.024	1.031HisAsp: 1.031 ± 0.041	1.087HisGlu: 1.087 ± 0.038	1.108HisPhe: 1.108 ± 0.039	1.308HisGly: 1.308 ± 0.049	0.586HisHis: 0.586 ± 0.031	1.684HisIle: 1.684 ± 0.05	1.23HisLys: 1.23 ± 0.037	1.993HisLeu: 1.993 ± 0.051	0.325HisMet: 0.325 ± 0.018	1.016HisAsn: 1.016 ± 0.041	1.12HisPro: 1.12 ± 0.042	0.769HisGln: 0.769 ± 0.031	1.135HisArg: 1.135 ± 0.04	1.166HisSer: 1.166 ± 0.036	1.123HisThr: 1.123 ± 0.05	1.123HisVal: 1.123 ± 0.042	0.276HisTrp: 0.276 ± 0.02	0.872HisTyr: 0.872 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.405IleAla: 5.405 ± 0.082	0.942IleCys: 0.942 ± 0.038	4.793IleAsp: 4.793 ± 0.087	4.46IleGlu: 4.46 ± 0.089	2.836IlePhe: 2.836 ± 0.079	4.663IleGly: 4.663 ± 0.09	1.346IleHis: 1.346 ± 0.042	5.057IleIle: 5.057 ± 0.116	4.644IleLys: 4.644 ± 0.09	5.796IleLeu: 5.796 ± 0.113	1.645IleMet: 1.645 ± 0.053	3.77IleAsn: 3.77 ± 0.072	3.02IlePro: 3.02 ± 0.068	2.067IleGln: 2.067 ± 0.061	3.55IleArg: 3.55 ± 0.074	4.58IleSer: 4.58 ± 0.082	4.256IleThr: 4.256 ± 0.071	4.681IleVal: 4.681 ± 0.084	0.608IleTrp: 0.608 ± 0.028	2.726IleTyr: 2.726 ± 0.072	0.0IleXaa: 0.0 ± 0.0
Lys	5.377LysAla: 5.377 ± 0.101	0.615LysCys: 0.615 ± 0.031	4.042LysAsp: 4.042 ± 0.077	5.659LysGlu: 5.659 ± 0.102	2.597LysPhe: 2.597 ± 0.054	4.709LysGly: 4.709 ± 0.09	1.427LysHis: 1.427 ± 0.045	4.718LysIle: 4.718 ± 0.089	5.574LysLys: 5.574 ± 0.104	5.636LysLeu: 5.636 ± 0.09	2.215LysMet: 2.215 ± 0.058	4.027LysAsn: 4.027 ± 0.076	2.42LysPro: 2.42 ± 0.061	2.855LysGln: 2.855 ± 0.07	3.638LysArg: 3.638 ± 0.079	3.847LysSer: 3.847 ± 0.078	4.036LysThr: 4.036 ± 0.071	4.5LysVal: 4.5 ± 0.081	0.869LysTrp: 0.869 ± 0.039	2.957LysTyr: 2.957 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	6.11LeuAla: 6.11 ± 0.106	1.3LeuCys: 1.3 ± 0.045	4.434LeuAsp: 4.434 ± 0.089	4.783LeuGlu: 4.783 ± 0.084	4.229LeuPhe: 4.229 ± 0.099	5.601LeuGly: 5.601 ± 0.09	1.921LeuHis: 1.921 ± 0.048	5.485LeuIle: 5.485 ± 0.105	6.14LeuLys: 6.14 ± 0.094	8.607LeuLeu: 8.607 ± 0.135	2.657LeuMet: 2.657 ± 0.059	4.66LeuAsn: 4.66 ± 0.096	3.934LeuPro: 3.934 ± 0.072	3.293LeuGln: 3.293 ± 0.084	4.729LeuArg: 4.729 ± 0.079	6.618LeuSer: 6.618 ± 0.101	5.475LeuThr: 5.475 ± 0.087	4.864LeuVal: 4.864 ± 0.086	0.935LeuTrp: 0.935 ± 0.039	3.461LeuTyr: 3.461 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.318MetAla: 2.318 ± 0.061	0.237MetCys: 0.237 ± 0.019	1.438MetAsp: 1.438 ± 0.042	2.045MetGlu: 2.045 ± 0.051	1.069MetPhe: 1.069 ± 0.05	2.078MetGly: 2.078 ± 0.056	0.459MetHis: 0.459 ± 0.026	1.716MetIle: 1.716 ± 0.048	2.657MetLys: 2.657 ± 0.067	2.472MetLeu: 2.472 ± 0.057	0.875MetMet: 0.875 ± 0.031	1.643MetAsn: 1.643 ± 0.045	1.251MetPro: 1.251 ± 0.04	1.101MetGln: 1.101 ± 0.042	1.481MetArg: 1.481 ± 0.048	1.568MetSer: 1.568 ± 0.04	1.583MetThr: 1.583 ± 0.047	1.621MetVal: 1.621 ± 0.045	0.202MetTrp: 0.202 ± 0.015	0.79MetTyr: 0.79 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.734AsnAla: 3.734 ± 0.083	0.568AsnCys: 0.568 ± 0.031	2.882AsnAsp: 2.882 ± 0.067	3.232AsnGlu: 3.232 ± 0.076	2.431AsnPhe: 2.431 ± 0.059	4.049AsnGly: 4.049 ± 0.088	1.105AsnHis: 1.105 ± 0.037	4.208AsnIle: 4.208 ± 0.082	3.653AsnLys: 3.653 ± 0.08	4.479AsnLeu: 4.479 ± 0.094	1.382AsnMet: 1.382 ± 0.044	2.942AsnAsn: 2.942 ± 0.088	2.392AsnPro: 2.392 ± 0.058	1.636AsnGln: 1.636 ± 0.05	2.588AsnArg: 2.588 ± 0.062	2.989AsnSer: 2.989 ± 0.077	2.741AsnThr: 2.741 ± 0.078	3.3AsnVal: 3.3 ± 0.075	0.654AsnTrp: 0.654 ± 0.031	2.279AsnTyr: 2.279 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.355ProAla: 2.355 ± 0.061	0.379ProCys: 0.379 ± 0.028	2.343ProAsp: 2.343 ± 0.063	2.748ProGlu: 2.748 ± 0.068	1.79ProPhe: 1.79 ± 0.054	2.172ProGly: 2.172 ± 0.065	0.812ProHis: 0.812 ± 0.033	2.628ProIle: 2.628 ± 0.063	2.392ProLys: 2.392 ± 0.061	3.044ProLeu: 3.044 ± 0.055	1.094ProMet: 1.094 ± 0.037	1.852ProAsn: 1.852 ± 0.053	0.777ProPro: 0.777 ± 0.035	1.345ProGln: 1.345 ± 0.041	1.292ProArg: 1.292 ± 0.048	2.083ProSer: 2.083 ± 0.061	2.293ProThr: 2.293 ± 0.058	2.327ProVal: 2.327 ± 0.053	0.37ProTrp: 0.37 ± 0.02	1.607ProTyr: 1.607 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.367GlnAla: 2.367 ± 0.067	0.317GlnCys: 0.317 ± 0.022	1.6GlnAsp: 1.6 ± 0.053	2.214GlnGlu: 2.214 ± 0.063	1.423GlnPhe: 1.423 ± 0.049	2.084GlnGly: 2.084 ± 0.054	0.699GlnHis: 0.699 ± 0.036	2.455GlnIle: 2.455 ± 0.061	2.511GlnLys: 2.511 ± 0.07	3.406GlnLeu: 3.406 ± 0.076	1.123GlnMet: 1.123 ± 0.038	1.78GlnAsn: 1.78 ± 0.066	1.409GlnPro: 1.409 ± 0.044	1.597GlnGln: 1.597 ± 0.061	2.002GlnArg: 2.002 ± 0.059	1.946GlnSer: 1.946 ± 0.052	2.056GlnThr: 2.056 ± 0.053	2.005GlnVal: 2.005 ± 0.051	0.471GlnTrp: 0.471 ± 0.026	1.434GlnTyr: 1.434 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	2.878ArgAla: 2.878 ± 0.069	0.577ArgCys: 0.577 ± 0.031	2.263ArgAsp: 2.263 ± 0.048	3.266ArgGlu: 3.266 ± 0.063	2.222ArgPhe: 2.222 ± 0.06	2.635ArgGly: 2.635 ± 0.062	1.223ArgHis: 1.223 ± 0.046	3.542ArgIle: 3.542 ± 0.073	4.167ArgLys: 4.167 ± 0.096	4.769ArgLeu: 4.769 ± 0.088	1.744ArgMet: 1.744 ± 0.045	2.765ArgAsn: 2.765 ± 0.07	1.614ArgPro: 1.614 ± 0.046	2.226ArgGln: 2.226 ± 0.061	2.719ArgArg: 2.719 ± 0.074	2.514ArgSer: 2.514 ± 0.062	2.459ArgThr: 2.459 ± 0.06	2.581ArgVal: 2.581 ± 0.067	0.603ArgTrp: 0.603 ± 0.031	2.306ArgTyr: 2.306 ± 0.067	0.0ArgXaa: 0.0 ± 0.0
Ser	3.971SerAla: 3.971 ± 0.081	0.799SerCys: 0.799 ± 0.038	3.3SerAsp: 3.3 ± 0.065	3.571SerGlu: 3.571 ± 0.078	3.199SerPhe: 3.199 ± 0.074	4.295SerGly: 4.295 ± 0.094	1.176SerHis: 1.176 ± 0.042	4.161SerIle: 4.161 ± 0.078	3.738SerLys: 3.738 ± 0.08	5.545SerLeu: 5.545 ± 0.101	1.629SerMet: 1.629 ± 0.046	2.818SerAsn: 2.818 ± 0.085	2.176SerPro: 2.176 ± 0.052	1.887SerGln: 1.887 ± 0.052	2.673SerArg: 2.673 ± 0.069	3.618SerSer: 3.618 ± 0.093	3.231SerThr: 3.231 ± 0.066	3.998SerVal: 3.998 ± 0.073	0.728SerTrp: 0.728 ± 0.032	2.476SerTyr: 2.476 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	4.302ThrAla: 4.302 ± 0.094	0.619ThrCys: 0.619 ± 0.033	3.462ThrAsp: 3.462 ± 0.063	3.445ThrGlu: 3.445 ± 0.077	2.71ThrPhe: 2.71 ± 0.063	4.003ThrGly: 4.003 ± 0.085	1.116ThrHis: 1.116 ± 0.041	4.266ThrIle: 4.266 ± 0.067	3.423ThrLys: 3.423 ± 0.074	5.478ThrLeu: 5.478 ± 0.088	1.394ThrMet: 1.394 ± 0.044	2.77ThrAsn: 2.77 ± 0.076	2.547ThrPro: 2.547 ± 0.061	1.818ThrGln: 1.818 ± 0.053	2.29ThrArg: 2.29 ± 0.068	3.27ThrSer: 3.27 ± 0.073	3.465ThrThr: 3.465 ± 0.084	3.611ThrVal: 3.611 ± 0.085	0.587ThrTrp: 0.587 ± 0.027	2.335ThrTyr: 2.335 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	4.552ValAla: 4.552 ± 0.097	0.944ValCys: 0.944 ± 0.038	3.261ValAsp: 3.261 ± 0.07	4.122ValGlu: 4.122 ± 0.068	2.794ValPhe: 2.794 ± 0.07	4.178ValGly: 4.178 ± 0.086	1.089ValHis: 1.089 ± 0.034	4.383ValIle: 4.383 ± 0.089	4.26ValLys: 4.26 ± 0.072	5.502ValLeu: 5.502 ± 0.101	1.739ValMet: 1.739 ± 0.048	3.104ValAsn: 3.104 ± 0.064	2.325ValPro: 2.325 ± 0.058	1.878ValGln: 1.878 ± 0.051	3.052ValArg: 3.052 ± 0.07	4.301ValSer: 4.301 ± 0.075	3.313ValThr: 3.313 ± 0.08	4.313ValVal: 4.313 ± 0.085	0.7ValTrp: 0.7 ± 0.033	2.38ValTyr: 2.38 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.681TrpAla: 0.681 ± 0.029	0.146TrpCys: 0.146 ± 0.016	0.628TrpAsp: 0.628 ± 0.03	0.642TrpGlu: 0.642 ± 0.03	0.516TrpPhe: 0.516 ± 0.03	0.791TrpGly: 0.791 ± 0.038	0.258TrpHis: 0.258 ± 0.018	0.826TrpIle: 0.826 ± 0.036	0.896TrpLys: 0.896 ± 0.039	1.183TrpLeu: 1.183 ± 0.044	0.395TrpMet: 0.395 ± 0.024	0.731TrpAsn: 0.731 ± 0.035	0.188TrpPro: 0.188 ± 0.016	0.555TrpGln: 0.555 ± 0.031	0.52TrpArg: 0.52 ± 0.026	0.575TrpSer: 0.575 ± 0.029	0.622TrpThr: 0.622 ± 0.027	0.587TrpVal: 0.587 ± 0.028	0.197TrpTrp: 0.197 ± 0.02	0.438TrpTyr: 0.438 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.663TyrAla: 2.663 ± 0.059	0.582TyrCys: 0.582 ± 0.029	2.544TyrAsp: 2.544 ± 0.058	2.491TyrGlu: 2.491 ± 0.064	2.005TyrPhe: 2.005 ± 0.056	2.846TyrGly: 2.846 ± 0.075	0.961TyrHis: 0.961 ± 0.039	2.772TyrIle: 2.772 ± 0.061	2.682TyrLys: 2.682 ± 0.068	3.692TyrLeu: 3.692 ± 0.083	1.004TyrMet: 1.004 ± 0.043	2.402TyrAsn: 2.402 ± 0.074	1.543TyrPro: 1.543 ± 0.047	1.476TyrGln: 1.476 ± 0.048	2.3TyrArg: 2.3 ± 0.061	2.406TyrSer: 2.406 ± 0.069	2.323TyrThr: 2.323 ± 0.056	2.466TyrVal: 2.466 ± 0.064	0.487TyrTrp: 0.487 ± 0.03	1.917TyrTyr: 1.917 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2080 proteins (716885 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---