Amino acid dipepetide frequency for Pseudoalteromonas phage AL

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.374AlaAla: 10.374 ± 2.155
0.391AlaCys: 0.391 ± 0.203
4.698AlaAsp: 4.698 ± 0.843
5.872AlaGlu: 5.872 ± 0.775
3.523AlaPhe: 3.523 ± 0.533
5.774AlaGly: 5.774 ± 0.793
0.783AlaHis: 0.783 ± 0.259
6.851AlaIle: 6.851 ± 0.733
6.753AlaLys: 6.753 ± 0.875
7.242AlaLeu: 7.242 ± 0.804
3.23AlaMet: 3.23 ± 0.778
3.915AlaAsn: 3.915 ± 0.81
3.132AlaPro: 3.132 ± 0.447
2.349AlaGln: 2.349 ± 0.411
2.447AlaArg: 2.447 ± 0.648
5.383AlaSer: 5.383 ± 0.696
5.383AlaThr: 5.383 ± 0.892
5.97AlaVal: 5.97 ± 0.769
0.685AlaTrp: 0.685 ± 0.214
3.034AlaTyr: 3.034 ± 0.606
0.0AlaXaa: 0.0 ± 0.0
Cys
0.489CysAla: 0.489 ± 0.298
0.098CysCys: 0.098 ± 0.119
0.098CysAsp: 0.098 ± 0.084
0.979CysGlu: 0.979 ± 0.342
0.587CysPhe: 0.587 ± 0.244
0.685CysGly: 0.685 ± 0.292
0.0CysHis: 0.0 ± 0.0
0.685CysIle: 0.685 ± 0.228
0.587CysLys: 0.587 ± 0.279
1.077CysLeu: 1.077 ± 0.255
0.294CysMet: 0.294 ± 0.148
0.391CysAsn: 0.391 ± 0.187
0.196CysPro: 0.196 ± 0.121
0.391CysGln: 0.391 ± 0.187
0.783CysArg: 0.783 ± 0.246
0.391CysSer: 0.391 ± 0.187
0.294CysThr: 0.294 ± 0.173
0.881CysVal: 0.881 ± 0.29
0.294CysTrp: 0.294 ± 0.2
0.391CysTyr: 0.391 ± 0.175
0.0CysXaa: 0.0 ± 0.0
Asp
4.502AspAla: 4.502 ± 0.541
1.174AspCys: 1.174 ± 0.398
4.11AspAsp: 4.11 ± 0.596
4.991AspGlu: 4.991 ± 0.945
3.327AspPhe: 3.327 ± 0.548
4.6AspGly: 4.6 ± 0.675
1.37AspHis: 1.37 ± 0.253
4.893AspIle: 4.893 ± 0.812
4.306AspLys: 4.306 ± 0.646
7.046AspLeu: 7.046 ± 1.288
1.174AspMet: 1.174 ± 0.338
3.23AspAsn: 3.23 ± 0.543
1.566AspPro: 1.566 ± 0.457
0.979AspGln: 0.979 ± 0.339
1.957AspArg: 1.957 ± 0.406
3.817AspSer: 3.817 ± 0.634
3.034AspThr: 3.034 ± 0.597
3.23AspVal: 3.23 ± 0.577
0.783AspTrp: 0.783 ± 0.312
3.132AspTyr: 3.132 ± 0.495
0.0AspXaa: 0.0 ± 0.0
Glu
4.991GluAla: 4.991 ± 0.789
0.587GluCys: 0.587 ± 0.249
2.838GluAsp: 2.838 ± 0.592
2.74GluGlu: 2.74 ± 0.458
3.034GluPhe: 3.034 ± 0.626
4.502GluGly: 4.502 ± 0.65
1.664GluHis: 1.664 ± 0.53
5.578GluIle: 5.578 ± 0.622
6.068GluLys: 6.068 ± 0.908
9.297GluLeu: 9.297 ± 1.158
1.762GluMet: 1.762 ± 0.398
2.642GluAsn: 2.642 ± 0.514
0.783GluPro: 0.783 ± 0.29
3.523GluGln: 3.523 ± 0.705
2.642GluArg: 2.642 ± 0.577
4.698GluSer: 4.698 ± 0.745
3.523GluThr: 3.523 ± 0.47
4.306GluVal: 4.306 ± 0.59
1.077GluTrp: 1.077 ± 0.314
2.349GluTyr: 2.349 ± 0.551
0.0GluXaa: 0.0 ± 0.0
Phe
3.523PheAla: 3.523 ± 0.626
0.685PheCys: 0.685 ± 0.198
2.545PheAsp: 2.545 ± 0.403
2.838PheGlu: 2.838 ± 0.491
1.37PhePhe: 1.37 ± 0.379
3.621PheGly: 3.621 ± 0.502
0.489PheHis: 0.489 ± 0.193
2.447PheIle: 2.447 ± 0.406
3.719PheLys: 3.719 ± 0.796
2.349PheLeu: 2.349 ± 0.34
1.37PheMet: 1.37 ± 0.388
2.447PheAsn: 2.447 ± 0.486
0.685PhePro: 0.685 ± 0.226
1.077PheGln: 1.077 ± 0.228
0.979PheArg: 0.979 ± 0.271
3.034PheSer: 3.034 ± 0.53
3.034PheThr: 3.034 ± 0.604
1.37PheVal: 1.37 ± 0.32
0.294PheTrp: 0.294 ± 0.145
1.468PheTyr: 1.468 ± 0.31
0.0PheXaa: 0.0 ± 0.0
Gly
7.731GlyAla: 7.731 ± 1.252
0.391GlyCys: 0.391 ± 0.193
5.187GlyAsp: 5.187 ± 0.783
5.383GlyGlu: 5.383 ± 0.708
2.545GlyPhe: 2.545 ± 0.471
7.046GlyGly: 7.046 ± 1.66
1.174GlyHis: 1.174 ± 0.324
4.013GlyIle: 4.013 ± 0.754
5.285GlyLys: 5.285 ± 0.704
6.655GlyLeu: 6.655 ± 0.844
1.272GlyMet: 1.272 ± 0.321
2.936GlyAsn: 2.936 ± 0.427
0.098GlyPro: 0.098 ± 0.084
2.838GlyGln: 2.838 ± 0.703
2.349GlyArg: 2.349 ± 0.412
4.013GlySer: 4.013 ± 0.622
3.23GlyThr: 3.23 ± 0.653
4.795GlyVal: 4.795 ± 0.652
0.587GlyTrp: 0.587 ± 0.223
3.719GlyTyr: 3.719 ± 0.798
0.0GlyXaa: 0.0 ± 0.0
His
1.37HisAla: 1.37 ± 0.293
0.0HisCys: 0.0 ± 0.0
0.783HisAsp: 0.783 ± 0.332
0.587HisGlu: 0.587 ± 0.209
0.489HisPhe: 0.489 ± 0.201
1.468HisGly: 1.468 ± 0.386
0.196HisHis: 0.196 ± 0.135
0.881HisIle: 0.881 ± 0.284
1.664HisLys: 1.664 ± 0.513
1.174HisLeu: 1.174 ± 0.303
0.294HisMet: 0.294 ± 0.133
0.979HisAsn: 0.979 ± 0.313
0.196HisPro: 0.196 ± 0.158
0.685HisGln: 0.685 ± 0.235
0.881HisArg: 0.881 ± 0.25
0.685HisSer: 0.685 ± 0.25
0.685HisThr: 0.685 ± 0.214
0.881HisVal: 0.881 ± 0.261
0.294HisTrp: 0.294 ± 0.157
1.077HisTyr: 1.077 ± 0.348
0.0HisXaa: 0.0 ± 0.0
Ile
4.991IleAla: 4.991 ± 0.667
0.685IleCys: 0.685 ± 0.246
5.774IleAsp: 5.774 ± 0.93
5.872IleGlu: 5.872 ± 0.721
1.859IlePhe: 1.859 ± 0.499
3.719IleGly: 3.719 ± 0.664
0.979IleHis: 0.979 ± 0.337
4.013IleIle: 4.013 ± 0.682
5.97IleLys: 5.97 ± 1.052
4.306IleLeu: 4.306 ± 0.661
1.566IleMet: 1.566 ± 0.353
5.089IleAsn: 5.089 ± 0.752
1.272IlePro: 1.272 ± 0.38
1.762IleGln: 1.762 ± 0.358
3.523IleArg: 3.523 ± 0.609
4.306IleSer: 4.306 ± 0.738
4.502IleThr: 4.502 ± 0.692
3.034IleVal: 3.034 ± 0.634
0.587IleTrp: 0.587 ± 0.243
2.545IleTyr: 2.545 ± 0.412
0.0IleXaa: 0.0 ± 0.0
Lys
7.536LysAla: 7.536 ± 0.998
0.685LysCys: 0.685 ± 0.24
4.893LysAsp: 4.893 ± 0.724
5.187LysGlu: 5.187 ± 0.879
1.859LysPhe: 1.859 ± 0.432
4.698LysGly: 4.698 ± 0.76
1.37LysHis: 1.37 ± 0.341
3.915LysIle: 3.915 ± 0.639
4.208LysLys: 4.208 ± 0.783
7.34LysLeu: 7.34 ± 0.873
2.349LysMet: 2.349 ± 0.654
3.719LysAsn: 3.719 ± 0.616
2.838LysPro: 2.838 ± 0.525
3.425LysGln: 3.425 ± 0.553
2.838LysArg: 2.838 ± 0.647
4.795LysSer: 4.795 ± 0.764
5.089LysThr: 5.089 ± 0.526
4.306LysVal: 4.306 ± 0.58
1.468LysTrp: 1.468 ± 0.375
2.447LysTyr: 2.447 ± 0.489
0.0LysXaa: 0.0 ± 0.0
Leu
7.34LeuAla: 7.34 ± 0.963
0.979LeuCys: 0.979 ± 0.286
5.187LeuAsp: 5.187 ± 0.728
5.774LeuGlu: 5.774 ± 0.77
2.936LeuPhe: 2.936 ± 0.39
4.893LeuGly: 4.893 ± 0.668
1.174LeuHis: 1.174 ± 0.437
5.481LeuIle: 5.481 ± 0.698
7.046LeuLys: 7.046 ± 0.599
5.578LeuLeu: 5.578 ± 0.828
2.447LeuMet: 2.447 ± 0.496
4.404LeuAsn: 4.404 ± 0.477
3.425LeuPro: 3.425 ± 0.668
4.013LeuGln: 4.013 ± 0.546
3.523LeuArg: 3.523 ± 0.597
5.285LeuSer: 5.285 ± 0.736
6.068LeuThr: 6.068 ± 0.738
4.795LeuVal: 4.795 ± 0.808
0.587LeuTrp: 0.587 ± 0.234
3.915LeuTyr: 3.915 ± 0.635
0.0LeuXaa: 0.0 ± 0.0
Met
2.055MetAla: 2.055 ± 0.522
0.098MetCys: 0.098 ± 0.096
0.979MetAsp: 0.979 ± 0.287
1.174MetGlu: 1.174 ± 0.332
0.783MetPhe: 0.783 ± 0.29
1.957MetGly: 1.957 ± 0.421
0.0MetHis: 0.0 ± 0.0
2.251MetIle: 2.251 ± 0.464
2.153MetLys: 2.153 ± 0.462
2.349MetLeu: 2.349 ± 0.44
0.489MetMet: 0.489 ± 0.259
2.251MetAsn: 2.251 ± 0.515
0.881MetPro: 0.881 ± 0.213
1.272MetGln: 1.272 ± 0.346
1.37MetArg: 1.37 ± 0.302
1.859MetSer: 1.859 ± 0.548
1.859MetThr: 1.859 ± 0.442
1.468MetVal: 1.468 ± 0.329
0.391MetTrp: 0.391 ± 0.181
0.587MetTyr: 0.587 ± 0.27
0.0MetXaa: 0.0 ± 0.0
Asn
4.306AsnAla: 4.306 ± 0.728
0.783AsnCys: 0.783 ± 0.377
3.817AsnAsp: 3.817 ± 0.652
4.013AsnGlu: 4.013 ± 0.556
1.957AsnPhe: 1.957 ± 0.335
5.676AsnGly: 5.676 ± 0.691
0.979AsnHis: 0.979 ± 0.328
3.425AsnIle: 3.425 ± 0.573
3.817AsnLys: 3.817 ± 0.524
4.698AsnLeu: 4.698 ± 0.667
1.37AsnMet: 1.37 ± 0.338
3.327AsnAsn: 3.327 ± 0.519
2.055AsnPro: 2.055 ± 0.372
1.762AsnGln: 1.762 ± 0.547
1.957AsnArg: 1.957 ± 0.342
2.545AsnSer: 2.545 ± 0.405
3.132AsnThr: 3.132 ± 0.655
2.349AsnVal: 2.349 ± 0.519
0.783AsnTrp: 0.783 ± 0.261
1.468AsnTyr: 1.468 ± 0.325
0.0AsnXaa: 0.0 ± 0.0
Pro
1.566ProAla: 1.566 ± 0.399
0.0ProCys: 0.0 ± 0.0
1.957ProAsp: 1.957 ± 0.431
1.566ProGlu: 1.566 ± 0.305
1.272ProPhe: 1.272 ± 0.494
0.881ProGly: 0.881 ± 0.331
0.196ProHis: 0.196 ± 0.122
1.468ProIle: 1.468 ± 0.358
2.251ProLys: 2.251 ± 0.527
3.132ProLeu: 3.132 ± 0.494
1.174ProMet: 1.174 ± 0.312
1.566ProAsn: 1.566 ± 0.534
0.489ProPro: 0.489 ± 0.252
1.37ProGln: 1.37 ± 0.34
1.664ProArg: 1.664 ± 0.402
2.349ProSer: 2.349 ± 0.394
2.251ProThr: 2.251 ± 0.495
2.447ProVal: 2.447 ± 0.413
0.294ProTrp: 0.294 ± 0.162
0.979ProTyr: 0.979 ± 0.259
0.0ProXaa: 0.0 ± 0.0
Gln
4.795GlnAla: 4.795 ± 0.751
0.294GlnCys: 0.294 ± 0.171
2.055GlnAsp: 2.055 ± 0.43
2.251GlnGlu: 2.251 ± 0.4
1.468GlnPhe: 1.468 ± 0.354
2.055GlnGly: 2.055 ± 0.453
0.979GlnHis: 0.979 ± 0.346
2.74GlnIle: 2.74 ± 0.568
2.447GlnLys: 2.447 ± 0.576
3.132GlnLeu: 3.132 ± 0.716
1.37GlnMet: 1.37 ± 0.345
1.859GlnAsn: 1.859 ± 0.365
1.174GlnPro: 1.174 ± 0.266
0.979GlnGln: 0.979 ± 0.32
1.37GlnArg: 1.37 ± 0.312
2.642GlnSer: 2.642 ± 0.6
2.251GlnThr: 2.251 ± 0.471
1.957GlnVal: 1.957 ± 0.356
0.489GlnTrp: 0.489 ± 0.273
0.881GlnTyr: 0.881 ± 0.269
0.0GlnXaa: 0.0 ± 0.0
Arg
3.327ArgAla: 3.327 ± 0.523
0.196ArgCys: 0.196 ± 0.155
2.055ArgAsp: 2.055 ± 0.391
3.132ArgGlu: 3.132 ± 0.67
2.251ArgPhe: 2.251 ± 0.468
2.74ArgGly: 2.74 ± 0.629
0.489ArgHis: 0.489 ± 0.241
2.349ArgIle: 2.349 ± 0.46
3.034ArgLys: 3.034 ± 0.631
3.523ArgLeu: 3.523 ± 0.679
0.587ArgMet: 0.587 ± 0.284
1.957ArgAsn: 1.957 ± 0.508
1.37ArgPro: 1.37 ± 0.647
1.468ArgGln: 1.468 ± 0.409
1.762ArgArg: 1.762 ± 0.526
2.251ArgSer: 2.251 ± 0.362
1.762ArgThr: 1.762 ± 0.302
3.621ArgVal: 3.621 ± 0.562
0.783ArgTrp: 0.783 ± 0.234
1.37ArgTyr: 1.37 ± 0.395
0.0ArgXaa: 0.0 ± 0.0
Ser
5.578SerAla: 5.578 ± 0.725
0.489SerCys: 0.489 ± 0.239
4.502SerAsp: 4.502 ± 0.646
4.6SerGlu: 4.6 ± 0.748
2.936SerPhe: 2.936 ± 0.472
4.893SerGly: 4.893 ± 0.812
1.468SerHis: 1.468 ± 0.45
4.502SerIle: 4.502 ± 0.662
4.013SerLys: 4.013 ± 0.723
4.698SerLeu: 4.698 ± 0.727
1.468SerMet: 1.468 ± 0.381
3.425SerAsn: 3.425 ± 0.471
2.447SerPro: 2.447 ± 0.507
3.132SerGln: 3.132 ± 0.588
3.034SerArg: 3.034 ± 0.628
4.013SerSer: 4.013 ± 1.035
2.153SerThr: 2.153 ± 0.509
4.013SerVal: 4.013 ± 0.608
0.979SerTrp: 0.979 ± 0.317
1.566SerTyr: 1.566 ± 0.344
0.0SerXaa: 0.0 ± 0.0
Thr
4.893ThrAla: 4.893 ± 0.853
0.587ThrCys: 0.587 ± 0.261
4.208ThrAsp: 4.208 ± 0.731
4.11ThrGlu: 4.11 ± 0.552
3.23ThrPhe: 3.23 ± 0.549
5.089ThrGly: 5.089 ± 0.75
0.391ThrHis: 0.391 ± 0.201
3.523ThrIle: 3.523 ± 0.479
3.817ThrLys: 3.817 ± 0.549
3.425ThrLeu: 3.425 ± 0.474
1.174ThrMet: 1.174 ± 0.381
3.719ThrAsn: 3.719 ± 0.631
2.251ThrPro: 2.251 ± 0.459
2.74ThrGln: 2.74 ± 0.466
2.153ThrArg: 2.153 ± 0.504
3.523ThrSer: 3.523 ± 0.52
3.523ThrThr: 3.523 ± 0.52
4.404ThrVal: 4.404 ± 0.742
1.077ThrTrp: 1.077 ± 0.311
2.153ThrTyr: 2.153 ± 0.458
0.0ThrXaa: 0.0 ± 0.0
Val
5.089ValAla: 5.089 ± 0.764
0.783ValCys: 0.783 ± 0.271
4.6ValAsp: 4.6 ± 0.596
4.502ValGlu: 4.502 ± 0.696
2.251ValPhe: 2.251 ± 0.42
3.132ValGly: 3.132 ± 0.795
0.979ValHis: 0.979 ± 0.319
3.327ValIle: 3.327 ± 0.434
4.795ValLys: 4.795 ± 0.891
3.915ValLeu: 3.915 ± 0.601
1.664ValMet: 1.664 ± 0.482
3.523ValAsn: 3.523 ± 0.496
2.349ValPro: 2.349 ± 0.542
1.664ValGln: 1.664 ± 0.525
2.349ValArg: 2.349 ± 0.393
4.893ValSer: 4.893 ± 0.603
4.698ValThr: 4.698 ± 0.693
3.915ValVal: 3.915 ± 0.571
0.489ValTrp: 0.489 ± 0.199
1.468ValTyr: 1.468 ± 0.352
0.0ValXaa: 0.0 ± 0.0
Trp
0.587TrpAla: 0.587 ± 0.265
0.098TrpCys: 0.098 ± 0.105
0.881TrpAsp: 0.881 ± 0.287
0.685TrpGlu: 0.685 ± 0.239
0.489TrpPhe: 0.489 ± 0.211
1.272TrpGly: 1.272 ± 0.415
0.391TrpHis: 0.391 ± 0.174
1.174TrpIle: 1.174 ± 0.337
0.489TrpLys: 0.489 ± 0.193
0.979TrpLeu: 0.979 ± 0.287
0.294TrpMet: 0.294 ± 0.172
0.685TrpAsn: 0.685 ± 0.28
0.587TrpPro: 0.587 ± 0.253
0.294TrpGln: 0.294 ± 0.204
0.881TrpArg: 0.881 ± 0.295
0.489TrpSer: 0.489 ± 0.155
0.685TrpThr: 0.685 ± 0.275
0.881TrpVal: 0.881 ± 0.29
0.0TrpTrp: 0.0 ± 0.0
0.294TrpTyr: 0.294 ± 0.161
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.74TyrAla: 2.74 ± 0.361
0.587TyrCys: 0.587 ± 0.243
2.055TyrAsp: 2.055 ± 0.429
2.349TyrGlu: 2.349 ± 0.426
1.174TyrPhe: 1.174 ± 0.396
2.545TyrGly: 2.545 ± 0.444
0.196TyrHis: 0.196 ± 0.137
2.838TyrIle: 2.838 ± 0.584
2.545TyrLys: 2.545 ± 0.576
3.034TyrLeu: 3.034 ± 0.472
0.783TyrMet: 0.783 ± 0.209
2.153TyrAsn: 2.153 ± 0.45
1.077TyrPro: 1.077 ± 0.294
1.468TyrGln: 1.468 ± 0.316
1.566TyrArg: 1.566 ± 0.365
2.936TyrSer: 2.936 ± 0.416
2.838TyrThr: 2.838 ± 0.441
1.762TyrVal: 1.762 ± 0.322
0.196TyrTrp: 0.196 ± 0.139
0.979TyrTyr: 0.979 ± 0.271
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (10219 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski