Amino acid dipepetide frequency for Notechis scutatus (mainland tiger snake)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.886AlaAla: 5.886 ± 0.044	1.213AlaCys: 1.213 ± 0.011	2.725AlaAsp: 2.725 ± 0.014	4.79AlaGlu: 4.79 ± 0.03	2.407AlaPhe: 2.407 ± 0.021	4.111AlaGly: 4.111 ± 0.039	1.31AlaHis: 1.31 ± 0.012	2.999AlaIle: 2.999 ± 0.015	3.866AlaLys: 3.866 ± 0.032	5.984AlaLeu: 5.984 ± 0.055	1.42AlaMet: 1.42 ± 0.014	2.224AlaAsn: 2.224 ± 0.014	3.228AlaPro: 3.228 ± 0.02	2.718AlaGln: 2.718 ± 0.023	2.936AlaArg: 2.936 ± 0.017	5.35AlaSer: 5.35 ± 0.028	3.658AlaThr: 3.658 ± 0.032	4.398AlaVal: 4.398 ± 0.022	0.747AlaTrp: 0.747 ± 0.012	1.481AlaTyr: 1.481 ± 0.012	0.001AlaXaa: 0.001 ± 0.0
Cys	1.07CysAla: 1.07 ± 0.01	0.541CysCys: 0.541 ± 0.011	0.968CysAsp: 0.968 ± 0.011	1.314CysGlu: 1.314 ± 0.018	0.843CysPhe: 0.843 ± 0.011	1.584CysGly: 1.584 ± 0.023	0.639CysHis: 0.639 ± 0.008	1.068CysIle: 1.068 ± 0.014	1.319CysLys: 1.319 ± 0.018	2.062CysLeu: 2.062 ± 0.028	0.447CysMet: 0.447 ± 0.008	0.931CysAsn: 0.931 ± 0.01	1.208CysPro: 1.208 ± 0.021	1.062CysGln: 1.062 ± 0.01	1.109CysArg: 1.109 ± 0.012	1.96CysSer: 1.96 ± 0.015	1.147CysThr: 1.147 ± 0.011	1.112CysVal: 1.112 ± 0.011	0.256CysTrp: 0.256 ± 0.005	0.599CysTyr: 0.599 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	2.799AspAla: 2.799 ± 0.016	1.113AspCys: 1.113 ± 0.012	2.691AspAsp: 2.691 ± 0.018	3.439AspGlu: 3.439 ± 0.023	2.065AspPhe: 2.065 ± 0.019	3.414AspGly: 3.414 ± 0.048	1.126AspHis: 1.126 ± 0.01	2.931AspIle: 2.931 ± 0.019	2.786AspLys: 2.786 ± 0.018	4.812AspLeu: 4.812 ± 0.03	1.076AspMet: 1.076 ± 0.013	1.908AspAsn: 1.908 ± 0.014	2.686AspPro: 2.686 ± 0.014	1.857AspGln: 1.857 ± 0.012	2.341AspArg: 2.341 ± 0.016	4.226AspSer: 4.226 ± 0.019	2.478AspThr: 2.478 ± 0.016	3.005AspVal: 3.005 ± 0.024	0.568AspTrp: 0.568 ± 0.007	1.548AspTyr: 1.548 ± 0.011	0.001AspXaa: 0.001 ± 0.0
Glu	4.967GluAla: 4.967 ± 0.028	1.576GluCys: 1.576 ± 0.02	4.414GluAsp: 4.414 ± 0.022	8.552GluGlu: 8.552 ± 0.052	2.12GluPhe: 2.12 ± 0.01	4.164GluGly: 4.164 ± 0.031	1.517GluHis: 1.517 ± 0.011	3.996GluIle: 3.996 ± 0.045	6.358GluLys: 6.358 ± 0.04	6.237GluLeu: 6.237 ± 0.037	1.833GluMet: 1.833 ± 0.014	3.686GluAsn: 3.686 ± 0.024	3.312GluPro: 3.312 ± 0.071	3.1GluGln: 3.1 ± 0.033	3.963GluArg: 3.963 ± 0.028	4.613GluSer: 4.613 ± 0.027	3.735GluThr: 3.735 ± 0.022	4.366GluVal: 4.366 ± 0.048	0.727GluTrp: 0.727 ± 0.007	2.025GluTyr: 2.025 ± 0.049	0.001GluXaa: 0.001 ± 0.0
Phe	1.994PheAla: 1.994 ± 0.018	0.929PheCys: 0.929 ± 0.013	1.712PheAsp: 1.712 ± 0.011	2.145PheGlu: 2.145 ± 0.014	1.531PhePhe: 1.531 ± 0.02	2.116PheGly: 2.116 ± 0.017	1.026PheHis: 1.026 ± 0.011	1.931PheIle: 1.931 ± 0.016	2.015PheLys: 2.015 ± 0.017	3.841PheLeu: 3.841 ± 0.051	0.751PheMet: 0.751 ± 0.013	1.394PheAsn: 1.394 ± 0.017	1.903PhePro: 1.903 ± 0.025	1.779PheGln: 1.779 ± 0.021	2.124PheArg: 2.124 ± 0.036	3.428PheSer: 3.428 ± 0.027	2.051PheThr: 2.051 ± 0.013	2.174PheVal: 2.174 ± 0.015	0.459PheTrp: 0.459 ± 0.007	1.153PheTyr: 1.153 ± 0.014	0.001PheXaa: 0.001 ± 0.0
Gly	3.42GlyAla: 3.42 ± 0.024	1.105GlyCys: 1.105 ± 0.012	2.82GlyAsp: 2.82 ± 0.018	4.23GlyGlu: 4.23 ± 0.036	2.221GlyPhe: 2.221 ± 0.028	4.577GlyGly: 4.577 ± 0.037	1.444GlyHis: 1.444 ± 0.014	3.007GlyIle: 3.007 ± 0.016	4.333GlyLys: 4.333 ± 0.038	5.096GlyLeu: 5.096 ± 0.029	1.271GlyMet: 1.271 ± 0.016	2.506GlyAsn: 2.506 ± 0.023	3.208GlyPro: 3.208 ± 0.04	2.575GlyGln: 2.575 ± 0.015	3.18GlyArg: 3.18 ± 0.019	5.517GlySer: 5.517 ± 0.033	3.436GlyThr: 3.436 ± 0.022	3.128GlyVal: 3.128 ± 0.019	0.692GlyTrp: 0.692 ± 0.009	1.831GlyTyr: 1.831 ± 0.019	0.001GlyXaa: 0.001 ± 0.0
His	1.246HisAla: 1.246 ± 0.011	0.656HisCys: 0.656 ± 0.009	0.933HisAsp: 0.933 ± 0.008	1.388HisGlu: 1.388 ± 0.011	1.084HisPhe: 1.084 ± 0.009	1.34HisGly: 1.34 ± 0.015	0.854HisHis: 0.854 ± 0.014	1.356HisIle: 1.356 ± 0.01	1.462HisLys: 1.462 ± 0.013	2.786HisLeu: 2.786 ± 0.022	0.556HisMet: 0.556 ± 0.007	0.974HisAsn: 0.974 ± 0.012	1.519HisPro: 1.519 ± 0.014	1.362HisGln: 1.362 ± 0.018	1.394HisArg: 1.394 ± 0.014	2.2HisSer: 2.2 ± 0.023	1.473HisThr: 1.473 ± 0.02	1.356HisVal: 1.356 ± 0.008	0.314HisTrp: 0.314 ± 0.005	0.861HisTyr: 0.861 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.896IleAla: 2.896 ± 0.015	1.209IleCys: 1.209 ± 0.01	2.295IleAsp: 2.295 ± 0.014	3.255IleGlu: 3.255 ± 0.046	2.072IlePhe: 2.072 ± 0.018	2.489IleGly: 2.489 ± 0.014	1.57IleHis: 1.57 ± 0.015	2.919IleIle: 2.919 ± 0.024	3.305IleLys: 3.305 ± 0.042	4.973IleLeu: 4.973 ± 0.023	1.1IleMet: 1.1 ± 0.009	2.165IleAsn: 2.165 ± 0.015	3.0IlePro: 3.0 ± 0.016	2.522IleGln: 2.522 ± 0.017	2.498IleArg: 2.498 ± 0.017	4.451IleSer: 4.451 ± 0.028	3.27IleThr: 3.27 ± 0.065	3.001IleVal: 3.001 ± 0.032	0.535IleTrp: 0.535 ± 0.008	1.482IleTyr: 1.482 ± 0.012	0.001IleXaa: 0.001 ± 0.0
Lys	4.16LysAla: 4.16 ± 0.029	1.396LysCys: 1.396 ± 0.013	3.761LysAsp: 3.761 ± 0.054	6.043LysGlu: 6.043 ± 0.042	1.773LysPhe: 1.773 ± 0.011	3.47LysGly: 3.47 ± 0.022	1.518LysHis: 1.518 ± 0.014	3.469LysIle: 3.469 ± 0.032	5.558LysLys: 5.558 ± 0.039	5.56LysLeu: 5.56 ± 0.026	1.606LysMet: 1.606 ± 0.013	2.915LysAsn: 2.915 ± 0.017	3.743LysPro: 3.743 ± 0.061	2.879LysGln: 2.879 ± 0.027	3.719LysArg: 3.719 ± 0.019	4.433LysSer: 4.433 ± 0.025	3.505LysThr: 3.505 ± 0.02	4.128LysVal: 4.128 ± 0.086	0.773LysTrp: 0.773 ± 0.016	1.902LysTyr: 1.902 ± 0.023	0.002LysXaa: 0.002 ± 0.0
Leu	6.036LeuAla: 6.036 ± 0.046	1.901LeuCys: 1.901 ± 0.028	4.636LeuAsp: 4.636 ± 0.022	7.284LeuGlu: 7.284 ± 0.037	3.248LeuPhe: 3.248 ± 0.038	4.863LeuGly: 4.863 ± 0.05	2.64LeuHis: 2.64 ± 0.022	4.146LeuIle: 4.146 ± 0.024	6.325LeuLys: 6.325 ± 0.025	9.47LeuLeu: 9.47 ± 0.103	1.971LeuMet: 1.971 ± 0.022	3.781LeuAsn: 3.781 ± 0.031	5.427LeuPro: 5.427 ± 0.045	5.523LeuGln: 5.523 ± 0.046	5.06LeuArg: 5.06 ± 0.029	7.564LeuSer: 7.564 ± 0.053	4.92LeuThr: 4.92 ± 0.028	5.014LeuVal: 5.014 ± 0.029	0.988LeuTrp: 0.988 ± 0.009	2.408LeuTyr: 2.408 ± 0.022	0.003LeuXaa: 0.003 ± 0.0
Met	1.788MetAla: 1.788 ± 0.015	0.371MetCys: 0.371 ± 0.006	1.312MetAsp: 1.312 ± 0.013	2.008MetGlu: 2.008 ± 0.024	0.754MetPhe: 0.754 ± 0.01	1.196MetGly: 1.196 ± 0.015	0.499MetHis: 0.499 ± 0.007	1.001MetIle: 1.001 ± 0.007	1.618MetLys: 1.618 ± 0.01	1.915MetLeu: 1.915 ± 0.021	0.578MetMet: 0.578 ± 0.008	0.975MetAsn: 0.975 ± 0.012	1.111MetPro: 1.111 ± 0.011	1.0MetGln: 1.0 ± 0.014	1.002MetArg: 1.002 ± 0.009	1.565MetSer: 1.565 ± 0.013	1.157MetThr: 1.157 ± 0.009	1.367MetVal: 1.367 ± 0.013	0.229MetTrp: 0.229 ± 0.003	0.583MetTyr: 0.583 ± 0.007	0.001MetXaa: 0.001 ± 0.0
Asn	2.321AsnAla: 2.321 ± 0.012	0.927AsnCys: 0.927 ± 0.011	1.771AsnAsp: 1.771 ± 0.015	2.68AsnGlu: 2.68 ± 0.014	1.527AsnPhe: 1.527 ± 0.019	2.631AsnGly: 2.631 ± 0.025	1.011AsnHis: 1.011 ± 0.012	2.564AsnIle: 2.564 ± 0.014	2.607AsnLys: 2.607 ± 0.013	3.989AsnLeu: 3.989 ± 0.029	1.001AsnMet: 1.001 ± 0.012	1.875AsnAsn: 1.875 ± 0.019	2.299AsnPro: 2.299 ± 0.019	1.837AsnGln: 1.837 ± 0.02	1.988AsnArg: 1.988 ± 0.014	3.633AsnSer: 3.633 ± 0.029	2.191AsnThr: 2.191 ± 0.014	2.545AsnVal: 2.545 ± 0.027	0.496AsnTrp: 0.496 ± 0.006	1.333AsnTyr: 1.333 ± 0.012	0.001AsnXaa: 0.001 ± 0.0
Pro	3.935ProAla: 3.935 ± 0.024	0.983ProCys: 0.983 ± 0.011	2.655ProAsp: 2.655 ± 0.016	4.395ProGlu: 4.395 ± 0.059	2.003ProPhe: 2.003 ± 0.015	4.121ProGly: 4.121 ± 0.049	1.283ProHis: 1.283 ± 0.016	2.435ProIle: 2.435 ± 0.041	3.218ProLys: 3.218 ± 0.044	4.889ProLeu: 4.889 ± 0.025	1.0ProMet: 1.0 ± 0.012	1.986ProAsn: 1.986 ± 0.018	5.913ProPro: 5.913 ± 0.091	2.445ProGln: 2.445 ± 0.026	2.61ProArg: 2.61 ± 0.016	5.469ProSer: 5.469 ± 0.029	2.965ProThr: 2.965 ± 0.019	3.925ProVal: 3.925 ± 0.048	0.53ProTrp: 0.53 ± 0.009	1.573ProTyr: 1.573 ± 0.02	0.002ProXaa: 0.002 ± 0.0
Gln	3.07GlnAla: 3.07 ± 0.024	0.941GlnCys: 0.941 ± 0.011	2.147GlnAsp: 2.147 ± 0.02	3.824GlnGlu: 3.824 ± 0.03	1.456GlnPhe: 1.456 ± 0.01	2.44GlnGly: 2.44 ± 0.023	1.246GlnHis: 1.246 ± 0.017	2.283GlnIle: 2.283 ± 0.014	3.193GlnLys: 3.193 ± 0.026	4.504GlnLeu: 4.504 ± 0.043	1.155GlnMet: 1.155 ± 0.014	2.18GlnAsn: 2.18 ± 0.02	2.532GlnPro: 2.532 ± 0.025	3.271GlnGln: 3.271 ± 0.057	2.687GlnArg: 2.687 ± 0.03	3.182GlnSer: 3.182 ± 0.034	2.331GlnThr: 2.331 ± 0.017	2.615GlnVal: 2.615 ± 0.016	0.555GlnTrp: 0.555 ± 0.007	1.224GlnTyr: 1.224 ± 0.008	0.001GlnXaa: 0.001 ± 0.0
Arg	2.944ArgAla: 2.944 ± 0.016	1.041ArgCys: 1.041 ± 0.011	2.563ArgAsp: 2.563 ± 0.016	3.73ArgGlu: 3.73 ± 0.022	1.833ArgPhe: 1.833 ± 0.012	2.823ArgGly: 2.823 ± 0.03	1.402ArgHis: 1.402 ± 0.013	2.791ArgIle: 2.791 ± 0.018	3.85ArgLys: 3.85 ± 0.019	4.679ArgLeu: 4.679 ± 0.028	1.173ArgMet: 1.173 ± 0.009	2.259ArgAsn: 2.259 ± 0.013	2.759ArgPro: 2.759 ± 0.02	2.405ArgGln: 2.405 ± 0.023	3.669ArgArg: 3.669 ± 0.032	3.945ArgSer: 3.945 ± 0.035	2.701ArgThr: 2.701 ± 0.016	2.984ArgVal: 2.984 ± 0.054	0.649ArgTrp: 0.649 ± 0.008	1.465ArgTyr: 1.465 ± 0.01	0.003ArgXaa: 0.003 ± 0.0
Ser	5.085SerAla: 5.085 ± 0.021	1.848SerCys: 1.848 ± 0.015	4.099SerAsp: 4.099 ± 0.023	5.437SerGlu: 5.437 ± 0.025	3.287SerPhe: 3.287 ± 0.02	5.187SerGly: 5.187 ± 0.022	2.114SerHis: 2.114 ± 0.022	3.722SerIle: 3.722 ± 0.015	4.599SerLys: 4.599 ± 0.023	7.846SerLeu: 7.846 ± 0.059	1.704SerMet: 1.704 ± 0.012	3.146SerAsn: 3.146 ± 0.027	5.612SerPro: 5.612 ± 0.04	3.808SerGln: 3.808 ± 0.034	4.207SerArg: 4.207 ± 0.029	9.702SerSer: 9.702 ± 0.078	4.635SerThr: 4.635 ± 0.025	4.855SerVal: 4.855 ± 0.018	1.086SerTrp: 1.086 ± 0.017	2.185SerTyr: 2.185 ± 0.017	0.002SerXaa: 0.002 ± 0.0
Thr	3.768ThrAla: 3.768 ± 0.036	1.302ThrCys: 1.302 ± 0.017	2.599ThrAsp: 2.599 ± 0.016	3.867ThrGlu: 3.867 ± 0.024	2.235ThrPhe: 2.235 ± 0.014	3.665ThrGly: 3.665 ± 0.027	1.32ThrHis: 1.32 ± 0.011	2.857ThrIle: 2.857 ± 0.023	3.145ThrLys: 3.145 ± 0.04	5.139ThrLeu: 5.139 ± 0.02	1.152ThrMet: 1.152 ± 0.008	2.079ThrAsn: 2.079 ± 0.016	3.33ThrPro: 3.33 ± 0.022	2.17ThrGln: 2.17 ± 0.015	2.321ThrArg: 2.321 ± 0.017	4.889ThrSer: 4.889 ± 0.024	3.248ThrThr: 3.248 ± 0.029	4.049ThrVal: 4.049 ± 0.062	0.775ThrTrp: 0.775 ± 0.019	1.461ThrTyr: 1.461 ± 0.011	0.001ThrXaa: 0.001 ± 0.0
Val	4.027ValAla: 4.027 ± 0.022	1.308ValCys: 1.308 ± 0.012	2.812ValAsp: 2.812 ± 0.016	4.186ValGlu: 4.186 ± 0.051	2.25ValPhe: 2.25 ± 0.019	3.137ValGly: 3.137 ± 0.017	1.499ValHis: 1.499 ± 0.01	3.223ValIle: 3.223 ± 0.035	4.048ValLys: 4.048 ± 0.07	5.641ValLeu: 5.641 ± 0.022	1.29ValMet: 1.29 ± 0.012	2.485ValAsn: 2.485 ± 0.022	3.84ValPro: 3.84 ± 0.075	2.676ValGln: 2.676 ± 0.014	2.691ValArg: 2.691 ± 0.019	4.927ValSer: 4.927 ± 0.039	4.004ValThr: 4.004 ± 0.082	3.948ValVal: 3.948 ± 0.044	0.648ValTrp: 0.648 ± 0.007	1.538ValTyr: 1.538 ± 0.011	0.002ValXaa: 0.002 ± 0.0
Trp	0.636TrpAla: 0.636 ± 0.007	0.222TrpCys: 0.222 ± 0.004	0.595TrpAsp: 0.595 ± 0.007	0.828TrpGlu: 0.828 ± 0.01	0.495TrpPhe: 0.495 ± 0.01	0.582TrpGly: 0.582 ± 0.008	0.295TrpHis: 0.295 ± 0.004	0.598TrpIle: 0.598 ± 0.007	0.89TrpLys: 0.89 ± 0.01	1.16TrpLeu: 1.16 ± 0.01	0.33TrpMet: 0.33 ± 0.004	0.57TrpAsn: 0.57 ± 0.008	0.428TrpPro: 0.428 ± 0.007	0.511TrpGln: 0.511 ± 0.006	0.616TrpArg: 0.616 ± 0.006	0.864TrpSer: 0.864 ± 0.009	0.724TrpThr: 0.724 ± 0.018	0.61TrpVal: 0.61 ± 0.006	0.169TrpTrp: 0.169 ± 0.004	0.422TrpTyr: 0.422 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.404TyrAla: 1.404 ± 0.01	0.655TyrCys: 0.655 ± 0.011	1.357TyrAsp: 1.357 ± 0.012	1.866TyrGlu: 1.866 ± 0.018	1.253TyrPhe: 1.253 ± 0.009	1.684TyrGly: 1.684 ± 0.014	0.804TyrHis: 0.804 ± 0.007	1.71TyrIle: 1.71 ± 0.021	1.817TyrLys: 1.817 ± 0.021	2.621TyrLeu: 2.621 ± 0.022	0.615TyrMet: 0.615 ± 0.007	1.191TyrAsn: 1.191 ± 0.014	1.275TyrPro: 1.275 ± 0.011	1.336TyrGln: 1.336 ± 0.009	1.552TyrArg: 1.552 ± 0.011	2.246TyrSer: 2.246 ± 0.016	1.742TyrThr: 1.742 ± 0.031	1.598TyrVal: 1.598 ± 0.016	0.348TyrTrp: 0.348 ± 0.005	0.999TyrTyr: 0.999 ± 0.009	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.003XaaGlu: 0.003 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.003XaaGly: 0.003 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.002XaaSer: 0.002 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.017XaaXaa: 0.017 ± 0.004

Statistics based on 26729 proteins (17436458 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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