Amino acid dipepetide frequency for Maverick-related virus strain Spezl

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.432AlaAla: 4.432 ± 1.166
0.17AlaCys: 0.17 ± 0.14
3.239AlaAsp: 3.239 ± 0.81
2.728AlaGlu: 2.728 ± 0.816
0.682AlaPhe: 0.682 ± 0.284
3.921AlaGly: 3.921 ± 1.496
0.852AlaHis: 0.852 ± 0.324
2.557AlaIle: 2.557 ± 0.826
2.216AlaLys: 2.216 ± 1.045
3.921AlaLeu: 3.921 ± 0.871
1.193AlaMet: 1.193 ± 0.381
2.387AlaAsn: 2.387 ± 0.785
3.069AlaPro: 3.069 ± 1.212
2.216AlaGln: 2.216 ± 0.763
0.852AlaArg: 0.852 ± 0.351
2.216AlaSer: 2.216 ± 0.556
1.875AlaThr: 1.875 ± 0.559
3.069AlaVal: 3.069 ± 0.691
0.341AlaTrp: 0.341 ± 0.265
1.534AlaTyr: 1.534 ± 0.462
0.0AlaXaa: 0.0 ± 0.0
Cys
1.023CysAla: 1.023 ± 0.401
0.0CysCys: 0.0 ± 0.0
0.852CysAsp: 0.852 ± 0.344
0.852CysGlu: 0.852 ± 0.365
0.852CysPhe: 0.852 ± 0.506
0.341CysGly: 0.341 ± 0.24
0.0CysHis: 0.0 ± 0.0
0.341CysIle: 0.341 ± 0.352
1.193CysLys: 1.193 ± 0.408
1.364CysLeu: 1.364 ± 0.601
0.0CysMet: 0.0 ± 0.0
0.341CysAsn: 0.341 ± 0.209
0.511CysPro: 0.511 ± 0.233
0.17CysGln: 0.17 ± 0.186
0.341CysArg: 0.341 ± 0.22
0.17CysSer: 0.17 ± 0.152
0.511CysThr: 0.511 ± 0.35
0.341CysVal: 0.341 ± 0.304
0.0CysTrp: 0.0 ± 0.0
0.511CysTyr: 0.511 ± 0.327
0.0CysXaa: 0.0 ± 0.0
Asp
2.387AspAla: 2.387 ± 0.625
0.511AspCys: 0.511 ± 0.236
6.648AspAsp: 6.648 ± 1.126
6.137AspGlu: 6.137 ± 1.109
3.409AspPhe: 3.409 ± 0.636
4.262AspGly: 4.262 ± 1.214
1.534AspHis: 1.534 ± 0.402
5.626AspIle: 5.626 ± 1.206
5.114AspLys: 5.114 ± 1.203
5.626AspLeu: 5.626 ± 0.748
1.023AspMet: 1.023 ± 0.347
2.728AspAsn: 2.728 ± 0.716
3.409AspPro: 3.409 ± 0.805
2.216AspGln: 2.216 ± 0.509
1.534AspArg: 1.534 ± 0.5
4.091AspSer: 4.091 ± 0.717
2.216AspThr: 2.216 ± 0.762
3.58AspVal: 3.58 ± 0.539
0.17AspTrp: 0.17 ± 0.15
4.091AspTyr: 4.091 ± 0.926
0.0AspXaa: 0.0 ± 0.0
Glu
4.432GluAla: 4.432 ± 1.305
0.17GluCys: 0.17 ± 0.161
3.921GluAsp: 3.921 ± 0.717
8.012GluGlu: 8.012 ± 1.5
3.409GluPhe: 3.409 ± 0.798
3.069GluGly: 3.069 ± 0.715
0.682GluHis: 0.682 ± 0.28
5.114GluIle: 5.114 ± 0.734
6.648GluLys: 6.648 ± 1.387
7.33GluLeu: 7.33 ± 0.741
0.852GluMet: 0.852 ± 0.389
3.921GluAsn: 3.921 ± 1.056
2.216GluPro: 2.216 ± 0.692
1.875GluGln: 1.875 ± 0.589
2.898GluArg: 2.898 ± 0.839
3.58GluSer: 3.58 ± 1.059
3.239GluThr: 3.239 ± 0.824
3.409GluVal: 3.409 ± 0.81
0.341GluTrp: 0.341 ± 0.205
3.239GluTyr: 3.239 ± 0.615
0.0GluXaa: 0.0 ± 0.0
Phe
0.852PheAla: 0.852 ± 0.319
0.0PheCys: 0.0 ± 0.0
2.216PheAsp: 2.216 ± 0.502
2.557PheGlu: 2.557 ± 0.656
1.534PhePhe: 1.534 ± 0.533
1.875PheGly: 1.875 ± 0.479
0.682PheHis: 0.682 ± 0.356
2.898PheIle: 2.898 ± 0.988
7.33PheLys: 7.33 ± 1.009
4.773PheLeu: 4.773 ± 0.924
1.364PheMet: 1.364 ± 0.561
5.796PheAsn: 5.796 ± 1.522
1.193PhePro: 1.193 ± 0.584
0.852PheGln: 0.852 ± 0.355
2.728PheArg: 2.728 ± 0.672
3.239PheSer: 3.239 ± 0.491
2.046PheThr: 2.046 ± 0.634
2.216PheVal: 2.216 ± 0.575
0.17PheTrp: 0.17 ± 0.14
1.364PheTyr: 1.364 ± 0.739
0.0PheXaa: 0.0 ± 0.0
Gly
2.216GlyAla: 2.216 ± 0.658
0.852GlyCys: 0.852 ± 0.389
3.409GlyAsp: 3.409 ± 0.939
2.898GlyGlu: 2.898 ± 0.819
2.728GlyPhe: 2.728 ± 0.595
3.58GlyGly: 3.58 ± 0.814
0.852GlyHis: 0.852 ± 0.378
3.75GlyIle: 3.75 ± 0.813
5.796GlyLys: 5.796 ± 0.598
4.091GlyLeu: 4.091 ± 1.108
0.511GlyMet: 0.511 ± 0.235
2.898GlyAsn: 2.898 ± 1.181
1.023GlyPro: 1.023 ± 0.415
1.705GlyGln: 1.705 ± 0.545
2.216GlyArg: 2.216 ± 0.612
2.557GlySer: 2.557 ± 0.972
4.773GlyThr: 4.773 ± 0.94
2.046GlyVal: 2.046 ± 0.653
0.682GlyTrp: 0.682 ± 0.384
2.728GlyTyr: 2.728 ± 0.583
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.682HisCys: 0.682 ± 0.49
1.193HisAsp: 1.193 ± 0.494
0.682HisGlu: 0.682 ± 0.397
0.852HisPhe: 0.852 ± 0.43
0.341HisGly: 0.341 ± 0.244
0.341HisHis: 0.341 ± 0.24
0.682HisIle: 0.682 ± 0.25
1.875HisLys: 1.875 ± 0.578
1.875HisLeu: 1.875 ± 0.642
0.682HisMet: 0.682 ± 0.357
0.852HisAsn: 0.852 ± 0.396
1.364HisPro: 1.364 ± 0.568
0.852HisGln: 0.852 ± 0.284
0.341HisArg: 0.341 ± 0.255
1.364HisSer: 1.364 ± 0.423
0.682HisThr: 0.682 ± 0.315
0.17HisVal: 0.17 ± 0.14
0.0HisTrp: 0.0 ± 0.0
1.364HisTyr: 1.364 ± 0.554
0.0HisXaa: 0.0 ± 0.0
Ile
2.046IleAla: 2.046 ± 0.683
0.341IleCys: 0.341 ± 0.275
4.262IleAsp: 4.262 ± 0.838
5.285IleGlu: 5.285 ± 1.156
3.921IlePhe: 3.921 ± 0.677
3.069IleGly: 3.069 ± 0.86
0.511IleHis: 0.511 ± 0.337
5.285IleIle: 5.285 ± 0.845
10.569IleLys: 10.569 ± 1.456
5.285IleLeu: 5.285 ± 1.02
0.682IleMet: 0.682 ± 0.356
5.285IleAsn: 5.285 ± 0.86
3.069IlePro: 3.069 ± 0.645
2.387IleGln: 2.387 ± 0.666
2.898IleArg: 2.898 ± 0.891
4.603IleSer: 4.603 ± 0.714
3.239IleThr: 3.239 ± 0.599
2.216IleVal: 2.216 ± 0.926
0.341IleTrp: 0.341 ± 0.201
2.557IleTyr: 2.557 ± 0.491
0.0IleXaa: 0.0 ± 0.0
Lys
5.626LysAla: 5.626 ± 1.052
1.705LysCys: 1.705 ± 0.596
5.455LysAsp: 5.455 ± 0.883
7.33LysGlu: 7.33 ± 1.455
4.091LysPhe: 4.091 ± 0.866
4.944LysGly: 4.944 ± 0.719
2.387LysHis: 2.387 ± 0.821
7.842LysIle: 7.842 ± 1.397
13.467LysLys: 13.467 ± 1.856
12.445LysLeu: 12.445 ± 1.991
2.387LysMet: 2.387 ± 0.546
7.842LysAsn: 7.842 ± 0.908
4.603LysPro: 4.603 ± 0.971
5.796LysGln: 5.796 ± 1.083
4.944LysArg: 4.944 ± 0.943
5.285LysSer: 5.285 ± 1.014
6.819LysThr: 6.819 ± 0.81
4.432LysVal: 4.432 ± 0.867
0.852LysTrp: 0.852 ± 0.657
3.58LysTyr: 3.58 ± 0.992
0.0LysXaa: 0.0 ± 0.0
Leu
3.239LeuAla: 3.239 ± 0.726
0.511LeuCys: 0.511 ± 0.301
3.58LeuAsp: 3.58 ± 0.741
6.989LeuGlu: 6.989 ± 0.809
3.58LeuPhe: 3.58 ± 0.746
3.75LeuGly: 3.75 ± 0.897
1.193LeuHis: 1.193 ± 0.506
5.285LeuIle: 5.285 ± 0.866
14.49LeuLys: 14.49 ± 2.209
8.012LeuLeu: 8.012 ± 1.059
1.534LeuMet: 1.534 ± 0.529
9.376LeuAsn: 9.376 ± 1.516
3.239LeuPro: 3.239 ± 0.944
2.046LeuGln: 2.046 ± 0.983
3.921LeuArg: 3.921 ± 1.072
6.308LeuSer: 6.308 ± 1.156
8.183LeuThr: 8.183 ± 0.817
3.75LeuVal: 3.75 ± 0.862
1.023LeuTrp: 1.023 ± 0.36
3.58LeuTyr: 3.58 ± 0.744
0.0LeuXaa: 0.0 ± 0.0
Met
1.023MetAla: 1.023 ± 0.458
0.17MetCys: 0.17 ± 0.152
0.682MetAsp: 0.682 ± 0.308
1.705MetGlu: 1.705 ± 0.532
0.511MetPhe: 0.511 ± 0.254
1.534MetGly: 1.534 ± 0.533
0.0MetHis: 0.0 ± 0.0
2.898MetIle: 2.898 ± 0.698
1.364MetLys: 1.364 ± 0.539
1.023MetLeu: 1.023 ± 0.505
0.341MetMet: 0.341 ± 0.208
1.875MetAsn: 1.875 ± 0.608
0.341MetPro: 0.341 ± 0.238
0.511MetGln: 0.511 ± 0.366
1.193MetArg: 1.193 ± 0.345
1.193MetSer: 1.193 ± 0.388
1.193MetThr: 1.193 ± 0.521
0.852MetVal: 0.852 ± 0.397
0.0MetTrp: 0.0 ± 0.0
0.682MetTyr: 0.682 ± 0.35
0.0MetXaa: 0.0 ± 0.0
Asn
2.898AsnAla: 2.898 ± 0.847
1.023AsnCys: 1.023 ± 0.594
5.114AsnAsp: 5.114 ± 0.752
3.239AsnGlu: 3.239 ± 0.903
3.58AsnPhe: 3.58 ± 0.647
4.091AsnGly: 4.091 ± 0.991
1.534AsnHis: 1.534 ± 0.476
6.819AsnIle: 6.819 ± 0.854
9.376AsnLys: 9.376 ± 1.35
5.114AsnLeu: 5.114 ± 0.974
2.216AsnMet: 2.216 ± 0.698
6.308AsnAsn: 6.308 ± 0.987
1.705AsnPro: 1.705 ± 0.545
3.239AsnGln: 3.239 ± 0.887
2.898AsnArg: 2.898 ± 0.76
3.58AsnSer: 3.58 ± 0.764
4.091AsnThr: 4.091 ± 1.051
3.58AsnVal: 3.58 ± 0.835
0.511AsnTrp: 0.511 ± 0.325
2.557AsnTyr: 2.557 ± 0.679
0.0AsnXaa: 0.0 ± 0.0
Pro
2.728ProAla: 2.728 ± 1.35
0.341ProCys: 0.341 ± 0.206
3.58ProAsp: 3.58 ± 0.543
3.921ProGlu: 3.921 ± 0.783
0.852ProPhe: 0.852 ± 0.455
1.364ProGly: 1.364 ± 0.542
0.511ProHis: 0.511 ± 0.387
1.534ProIle: 1.534 ± 0.522
3.239ProLys: 3.239 ± 0.677
4.944ProLeu: 4.944 ± 1.05
0.17ProMet: 0.17 ± 0.151
2.557ProAsn: 2.557 ± 0.828
2.387ProPro: 2.387 ± 0.993
1.364ProGln: 1.364 ± 0.374
1.875ProArg: 1.875 ± 0.554
2.387ProSer: 2.387 ± 0.733
3.069ProThr: 3.069 ± 0.733
4.262ProVal: 4.262 ± 0.811
0.17ProTrp: 0.17 ± 0.186
1.705ProTyr: 1.705 ± 0.616
0.0ProXaa: 0.0 ± 0.0
Gln
2.046GlnAla: 2.046 ± 0.421
0.17GlnCys: 0.17 ± 0.161
2.728GlnAsp: 2.728 ± 0.824
2.728GlnGlu: 2.728 ± 0.54
1.023GlnPhe: 1.023 ± 0.51
1.364GlnGly: 1.364 ± 0.437
0.341GlnHis: 0.341 ± 0.254
2.387GlnIle: 2.387 ± 0.77
3.069GlnLys: 3.069 ± 0.525
4.773GlnLeu: 4.773 ± 0.89
0.341GlnMet: 0.341 ± 0.225
2.728GlnAsn: 2.728 ± 0.729
1.534GlnPro: 1.534 ± 0.565
1.193GlnGln: 1.193 ± 0.45
2.387GlnArg: 2.387 ± 0.777
1.875GlnSer: 1.875 ± 0.577
2.387GlnThr: 2.387 ± 0.54
1.534GlnVal: 1.534 ± 0.371
0.17GlnTrp: 0.17 ± 0.198
1.875GlnTyr: 1.875 ± 0.458
0.0GlnXaa: 0.0 ± 0.0
Arg
1.364ArgAla: 1.364 ± 0.356
0.511ArgCys: 0.511 ± 0.338
1.875ArgAsp: 1.875 ± 0.496
2.728ArgGlu: 2.728 ± 0.607
2.728ArgPhe: 2.728 ± 0.684
1.875ArgGly: 1.875 ± 0.836
0.341ArgHis: 0.341 ± 0.235
1.534ArgIle: 1.534 ± 0.311
3.58ArgLys: 3.58 ± 0.812
4.432ArgLeu: 4.432 ± 1.08
0.511ArgMet: 0.511 ± 0.323
2.898ArgAsn: 2.898 ± 0.823
1.534ArgPro: 1.534 ± 0.501
0.852ArgGln: 0.852 ± 0.297
1.364ArgArg: 1.364 ± 0.418
2.898ArgSer: 2.898 ± 0.646
1.875ArgThr: 1.875 ± 0.404
3.58ArgVal: 3.58 ± 0.704
0.682ArgTrp: 0.682 ± 0.318
2.557ArgTyr: 2.557 ± 0.633
0.0ArgXaa: 0.0 ± 0.0
Ser
1.023SerAla: 1.023 ± 0.464
0.511SerCys: 0.511 ± 0.378
5.626SerAsp: 5.626 ± 0.848
2.387SerGlu: 2.387 ± 0.998
4.262SerPhe: 4.262 ± 0.755
3.409SerGly: 3.409 ± 1.093
1.193SerHis: 1.193 ± 0.364
3.409SerIle: 3.409 ± 0.744
5.455SerLys: 5.455 ± 1.021
5.455SerLeu: 5.455 ± 0.921
1.875SerMet: 1.875 ± 0.628
4.432SerAsn: 4.432 ± 0.834
2.557SerPro: 2.557 ± 0.852
2.216SerGln: 2.216 ± 0.546
2.046SerArg: 2.046 ± 0.53
5.285SerSer: 5.285 ± 1.154
3.409SerThr: 3.409 ± 0.809
3.069SerVal: 3.069 ± 0.614
0.341SerTrp: 0.341 ± 0.229
2.216SerTyr: 2.216 ± 0.634
0.0SerXaa: 0.0 ± 0.0
Thr
1.875ThrAla: 1.875 ± 0.628
0.511ThrCys: 0.511 ± 0.279
3.921ThrAsp: 3.921 ± 0.809
2.387ThrGlu: 2.387 ± 0.544
3.58ThrPhe: 3.58 ± 0.799
3.58ThrGly: 3.58 ± 0.711
1.023ThrHis: 1.023 ± 0.343
4.603ThrIle: 4.603 ± 1.018
5.626ThrLys: 5.626 ± 0.897
5.626ThrLeu: 5.626 ± 0.897
1.023ThrMet: 1.023 ± 0.279
3.239ThrAsn: 3.239 ± 0.827
4.262ThrPro: 4.262 ± 1.069
2.046ThrGln: 2.046 ± 0.547
2.728ThrArg: 2.728 ± 0.902
3.239ThrSer: 3.239 ± 0.734
3.409ThrThr: 3.409 ± 0.635
1.875ThrVal: 1.875 ± 0.598
0.17ThrTrp: 0.17 ± 0.176
1.875ThrTyr: 1.875 ± 0.681
0.0ThrXaa: 0.0 ± 0.0
Val
2.046ValAla: 2.046 ± 0.953
0.682ValCys: 0.682 ± 0.393
4.944ValAsp: 4.944 ± 0.805
3.239ValGlu: 3.239 ± 0.744
2.387ValPhe: 2.387 ± 0.492
2.216ValGly: 2.216 ± 0.888
1.193ValHis: 1.193 ± 0.329
3.58ValIle: 3.58 ± 0.845
6.648ValLys: 6.648 ± 1.083
3.409ValLeu: 3.409 ± 0.825
1.023ValMet: 1.023 ± 0.628
2.216ValAsn: 2.216 ± 0.538
2.387ValPro: 2.387 ± 0.593
2.898ValGln: 2.898 ± 0.366
1.875ValArg: 1.875 ± 0.52
2.898ValSer: 2.898 ± 0.579
1.023ValThr: 1.023 ± 0.462
2.557ValVal: 2.557 ± 0.744
0.0ValTrp: 0.0 ± 0.0
2.216ValTyr: 2.216 ± 0.65
0.0ValXaa: 0.0 ± 0.0
Trp
0.511TrpAla: 0.511 ± 0.284
0.17TrpCys: 0.17 ± 0.146
0.17TrpAsp: 0.17 ± 0.186
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.341TrpGly: 0.341 ± 0.261
0.341TrpHis: 0.341 ± 0.252
0.17TrpIle: 0.17 ± 0.186
0.682TrpLys: 0.682 ± 0.336
1.023TrpLeu: 1.023 ± 0.362
0.17TrpMet: 0.17 ± 0.153
0.852TrpAsn: 0.852 ± 0.344
0.511TrpPro: 0.511 ± 0.424
0.341TrpGln: 0.341 ± 0.208
0.0TrpArg: 0.0 ± 0.0
0.341TrpSer: 0.341 ± 0.212
0.0TrpThr: 0.0 ± 0.0
0.511TrpVal: 0.511 ± 0.259
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.705TyrAla: 1.705 ± 0.653
0.682TyrCys: 0.682 ± 0.357
2.898TyrAsp: 2.898 ± 0.941
2.557TyrGlu: 2.557 ± 0.675
1.705TyrPhe: 1.705 ± 0.653
2.387TyrGly: 2.387 ± 0.572
0.682TyrHis: 0.682 ± 0.404
1.534TyrIle: 1.534 ± 0.6
4.091TyrLys: 4.091 ± 0.791
3.069TyrLeu: 3.069 ± 0.78
1.023TyrMet: 1.023 ± 0.429
4.944TyrAsn: 4.944 ± 0.841
2.046TyrPro: 2.046 ± 0.437
1.875TyrGln: 1.875 ± 0.526
0.682TyrArg: 0.682 ± 0.313
3.069TyrSer: 3.069 ± 0.821
2.557TyrThr: 2.557 ± 0.418
2.387TyrVal: 2.387 ± 0.85
0.17TyrTrp: 0.17 ± 0.178
1.364TyrTyr: 1.364 ± 0.672
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (5867 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski