Amino acid dipepetide frequency for Natrarchaeobaculum sulfurireducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.971AlaAla: 11.971 ± 0.152	0.781AlaCys: 0.781 ± 0.032	9.931AlaAsp: 9.931 ± 0.135	8.306AlaGlu: 8.306 ± 0.103	3.821AlaPhe: 3.821 ± 0.062	8.708AlaGly: 8.708 ± 0.103	1.891AlaHis: 1.891 ± 0.04	5.683AlaIle: 5.683 ± 0.086	1.8AlaLys: 1.8 ± 0.048	9.881AlaLeu: 9.881 ± 0.111	1.994AlaMet: 1.994 ± 0.043	2.376AlaAsn: 2.376 ± 0.038	3.47AlaPro: 3.47 ± 0.062	2.108AlaGln: 2.108 ± 0.044	5.727AlaArg: 5.727 ± 0.076	5.514AlaSer: 5.514 ± 0.076	6.989AlaThr: 6.989 ± 0.086	9.997AlaVal: 9.997 ± 0.132	0.997AlaTrp: 0.997 ± 0.03	2.601AlaTyr: 2.601 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.648CysAla: 0.648 ± 0.028	0.108CysCys: 0.108 ± 0.01	0.65CysAsp: 0.65 ± 0.024	0.614CysGlu: 0.614 ± 0.027	0.219CysPhe: 0.219 ± 0.014	0.817CysGly: 0.817 ± 0.031	0.223CysHis: 0.223 ± 0.015	0.276CysIle: 0.276 ± 0.015	0.143CysLys: 0.143 ± 0.012	0.618CysLeu: 0.618 ± 0.025	0.122CysMet: 0.122 ± 0.012	0.19CysAsn: 0.19 ± 0.014	0.522CysPro: 0.522 ± 0.025	0.186CysGln: 0.186 ± 0.013	0.556CysArg: 0.556 ± 0.023	0.488CysSer: 0.488 ± 0.024	0.416CysThr: 0.416 ± 0.018	0.522CysVal: 0.522 ± 0.026	0.103CysTrp: 0.103 ± 0.01	0.239CysTyr: 0.239 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	9.531AspAla: 9.531 ± 0.106	0.666AspCys: 0.666 ± 0.026	9.755AspAsp: 9.755 ± 0.194	9.352AspGlu: 9.352 ± 0.146	1.76AspPhe: 1.76 ± 0.043	8.408AspGly: 8.408 ± 0.11	1.99AspHis: 1.99 ± 0.055	2.633AspIle: 2.633 ± 0.064	0.882AspLys: 0.882 ± 0.029	7.535AspLeu: 7.535 ± 0.106	1.167AspMet: 1.167 ± 0.036	1.3AspAsn: 1.3 ± 0.034	4.655AspPro: 4.655 ± 0.063	1.797AspGln: 1.797 ± 0.046	6.953AspArg: 6.953 ± 0.097	3.86AspSer: 3.86 ± 0.088	3.872AspThr: 3.872 ± 0.062	8.626AspVal: 8.626 ± 0.101	0.998AspTrp: 0.998 ± 0.025	1.761AspTyr: 1.761 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	9.619GluAla: 9.619 ± 0.129	0.623GluCys: 0.623 ± 0.026	6.566GluAsp: 6.566 ± 0.115	7.127GluGlu: 7.127 ± 0.118	3.19GluPhe: 3.19 ± 0.057	5.518GluGly: 5.518 ± 0.08	2.144GluHis: 2.144 ± 0.05	4.488GluIle: 4.488 ± 0.083	1.857GluLys: 1.857 ± 0.05	8.057GluLeu: 8.057 ± 0.102	1.902GluMet: 1.902 ± 0.045	2.39GluAsn: 2.39 ± 0.053	4.798GluPro: 4.798 ± 0.077	2.827GluGln: 2.827 ± 0.067	7.858GluArg: 7.858 ± 0.108	5.786GluSer: 5.786 ± 0.097	7.466GluThr: 7.466 ± 0.107	6.031GluVal: 6.031 ± 0.087	1.218GluTrp: 1.218 ± 0.032	2.968GluTyr: 2.968 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.431PheAla: 3.431 ± 0.068	0.276PheCys: 0.276 ± 0.016	3.405PheAsp: 3.405 ± 0.061	3.337PheGlu: 3.337 ± 0.056	1.022PhePhe: 1.022 ± 0.031	3.08PheGly: 3.08 ± 0.055	0.59PheHis: 0.59 ± 0.023	1.03PheIle: 1.03 ± 0.033	0.423PheLys: 0.423 ± 0.021	2.672PheLeu: 2.672 ± 0.058	0.507PheMet: 0.507 ± 0.024	0.65PheAsn: 0.65 ± 0.022	1.293PhePro: 1.293 ± 0.038	0.752PheGln: 0.752 ± 0.025	1.702PheArg: 1.702 ± 0.038	1.629PheSer: 1.629 ± 0.035	1.798PheThr: 1.798 ± 0.039	3.454PheVal: 3.454 ± 0.07	0.399PheTrp: 0.399 ± 0.021	0.827PheTyr: 0.827 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.331GlyAla: 7.331 ± 0.102	0.739GlyCys: 0.739 ± 0.028	6.708GlyAsp: 6.708 ± 0.091	7.049GlyGlu: 7.049 ± 0.091	2.951GlyPhe: 2.951 ± 0.062	6.591GlyGly: 6.591 ± 0.111	1.665GlyHis: 1.665 ± 0.043	4.307GlyIle: 4.307 ± 0.077	1.716GlyLys: 1.716 ± 0.048	7.331GlyLeu: 7.331 ± 0.115	1.596GlyMet: 1.596 ± 0.047	1.748GlyAsn: 1.748 ± 0.045	3.227GlyPro: 3.227 ± 0.06	2.077GlyGln: 2.077 ± 0.052	4.703GlyArg: 4.703 ± 0.073	4.939GlySer: 4.939 ± 0.072	5.814GlyThr: 5.814 ± 0.083	7.172GlyVal: 7.172 ± 0.094	1.099GlyTrp: 1.099 ± 0.034	2.603GlyTyr: 2.603 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.006HisAla: 2.006 ± 0.043	0.223HisCys: 0.223 ± 0.014	1.954HisAsp: 1.954 ± 0.041	1.849HisGlu: 1.849 ± 0.041	0.511HisPhe: 0.511 ± 0.022	1.995HisGly: 1.995 ± 0.042	0.558HisHis: 0.558 ± 0.026	0.68HisIle: 0.68 ± 0.024	0.294HisLys: 0.294 ± 0.019	1.701HisLeu: 1.701 ± 0.041	0.304HisMet: 0.304 ± 0.017	0.449HisAsn: 0.449 ± 0.022	1.21HisPro: 1.21 ± 0.035	0.497HisGln: 0.497 ± 0.022	1.361HisArg: 1.361 ± 0.039	0.912HisSer: 0.912 ± 0.032	1.064HisThr: 1.064 ± 0.031	1.939HisVal: 1.939 ± 0.043	0.254HisTrp: 0.254 ± 0.016	0.57HisTyr: 0.57 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.158IleAla: 5.158 ± 0.077	0.284IleCys: 0.284 ± 0.016	4.801IleAsp: 4.801 ± 0.076	4.495IleGlu: 4.495 ± 0.075	1.029IlePhe: 1.029 ± 0.031	4.052IleGly: 4.052 ± 0.068	0.866IleHis: 0.866 ± 0.026	1.346IleIle: 1.346 ± 0.048	0.722IleLys: 0.722 ± 0.028	3.168IleLeu: 3.168 ± 0.068	0.514IleMet: 0.514 ± 0.02	1.059IleAsn: 1.059 ± 0.032	1.968IlePro: 1.968 ± 0.044	1.134IleGln: 1.134 ± 0.036	2.511IleArg: 2.511 ± 0.051	2.26IleSer: 2.26 ± 0.04	2.666IleThr: 2.666 ± 0.054	4.418IleVal: 4.418 ± 0.08	0.371IleTrp: 0.371 ± 0.021	1.03IleTyr: 1.03 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	1.836LysAla: 1.836 ± 0.042	0.135LysCys: 0.135 ± 0.013	1.003LysAsp: 1.003 ± 0.035	1.162LysGlu: 1.162 ± 0.04	0.448LysPhe: 0.448 ± 0.02	1.238LysGly: 1.238 ± 0.038	0.488LysHis: 0.488 ± 0.021	0.794LysIle: 0.794 ± 0.03	0.575LysLys: 0.575 ± 0.03	1.624LysLeu: 1.624 ± 0.039	0.356LysMet: 0.356 ± 0.021	0.591LysAsn: 0.591 ± 0.024	0.918LysPro: 0.918 ± 0.034	0.686LysGln: 0.686 ± 0.028	1.686LysArg: 1.686 ± 0.039	1.111LysSer: 1.111 ± 0.038	1.333LysThr: 1.333 ± 0.036	1.079LysVal: 1.079 ± 0.035	0.198LysTrp: 0.198 ± 0.014	0.527LysTyr: 0.527 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	10.445LeuAla: 10.445 ± 0.139	0.651LeuCys: 0.651 ± 0.022	5.748LeuAsp: 5.748 ± 0.092	12.907LeuGlu: 12.907 ± 0.134	3.051LeuPhe: 3.051 ± 0.066	7.148LeuGly: 7.148 ± 0.103	1.449LeuHis: 1.449 ± 0.038	3.256LeuIle: 3.256 ± 0.06	1.407LeuLys: 1.407 ± 0.039	8.236LeuLeu: 8.236 ± 0.132	1.177LeuMet: 1.177 ± 0.039	1.657LeuAsn: 1.657 ± 0.038	3.764LeuPro: 3.764 ± 0.063	1.91LeuGln: 1.91 ± 0.043	4.805LeuArg: 4.805 ± 0.072	5.443LeuSer: 5.443 ± 0.071	5.17LeuThr: 5.17 ± 0.068	8.13LeuVal: 8.13 ± 0.115	0.881LeuTrp: 0.881 ± 0.028	2.064LeuTyr: 2.064 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.866MetAla: 1.866 ± 0.049	0.134MetCys: 0.134 ± 0.011	1.268MetAsp: 1.268 ± 0.036	1.071MetGlu: 1.071 ± 0.031	0.509MetPhe: 0.509 ± 0.022	1.376MetGly: 1.376 ± 0.04	0.336MetHis: 0.336 ± 0.018	0.826MetIle: 0.826 ± 0.031	0.451MetLys: 0.451 ± 0.023	1.582MetLeu: 1.582 ± 0.037	0.327MetMet: 0.327 ± 0.018	0.625MetAsn: 0.625 ± 0.025	0.73MetPro: 0.73 ± 0.025	0.491MetGln: 0.491 ± 0.023	0.954MetArg: 0.954 ± 0.026	1.396MetSer: 1.396 ± 0.038	1.532MetThr: 1.532 ± 0.035	1.253MetVal: 1.253 ± 0.034	0.155MetTrp: 0.155 ± 0.012	0.409MetTyr: 0.409 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.582AsnAla: 2.582 ± 0.048	0.213AsnCys: 0.213 ± 0.015	1.742AsnAsp: 1.742 ± 0.045	1.959AsnGlu: 1.959 ± 0.048	0.616AsnPhe: 0.616 ± 0.023	1.874AsnGly: 1.874 ± 0.045	0.487AsnHis: 0.487 ± 0.021	0.781AsnIle: 0.781 ± 0.027	0.425AsnLys: 0.425 ± 0.02	1.767AsnLeu: 1.767 ± 0.037	0.409AsnMet: 0.409 ± 0.019	0.486AsnAsn: 0.486 ± 0.028	1.422AsnPro: 1.422 ± 0.037	0.609AsnGln: 0.609 ± 0.024	1.688AsnArg: 1.688 ± 0.043	0.961AsnSer: 0.961 ± 0.032	1.173AsnThr: 1.173 ± 0.033	2.321AsnVal: 2.321 ± 0.05	0.296AsnTrp: 0.296 ± 0.017	0.621AsnTyr: 0.621 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.35ProAla: 4.35 ± 0.063	0.267ProCys: 0.267 ± 0.015	4.845ProAsp: 4.845 ± 0.075	4.538ProGlu: 4.538 ± 0.065	1.508ProPhe: 1.508 ± 0.038	3.608ProGly: 3.608 ± 0.059	0.86ProHis: 0.86 ± 0.032	2.253ProIle: 2.253 ± 0.046	0.841ProLys: 0.841 ± 0.028	3.595ProLeu: 3.595 ± 0.068	0.852ProMet: 0.852 ± 0.026	1.102ProAsn: 1.102 ± 0.032	2.125ProPro: 2.125 ± 0.044	0.952ProGln: 0.952 ± 0.032	2.283ProArg: 2.283 ± 0.049	2.637ProSer: 2.637 ± 0.051	3.28ProThr: 3.28 ± 0.051	4.058ProVal: 4.058 ± 0.072	0.503ProTrp: 0.503 ± 0.024	1.117ProTyr: 1.117 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.389GlnAla: 2.389 ± 0.048	0.18GlnCys: 0.18 ± 0.013	1.365GlnAsp: 1.365 ± 0.034	1.74GlnGlu: 1.74 ± 0.054	0.994GlnPhe: 0.994 ± 0.028	1.538GlnGly: 1.538 ± 0.042	0.554GlnHis: 0.554 ± 0.025	1.15GlnIle: 1.15 ± 0.034	0.604GlnLys: 0.604 ± 0.025	2.551GlnLeu: 2.551 ± 0.05	0.516GlnMet: 0.516 ± 0.023	0.644GlnAsn: 0.644 ± 0.025	1.207GlnPro: 1.207 ± 0.033	1.022GlnGln: 1.022 ± 0.063	1.916GlnArg: 1.916 ± 0.052	1.506GlnSer: 1.506 ± 0.038	1.633GlnThr: 1.633 ± 0.047	1.842GlnVal: 1.842 ± 0.043	0.35GlnTrp: 0.35 ± 0.017	0.861GlnTyr: 0.861 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.073ArgAla: 6.073 ± 0.093	0.525ArgCys: 0.525 ± 0.024	4.756ArgAsp: 4.756 ± 0.082	6.415ArgGlu: 6.415 ± 0.096	2.315ArgPhe: 2.315 ± 0.052	4.232ArgGly: 4.232 ± 0.066	1.26ArgHis: 1.26 ± 0.034	3.148ArgIle: 3.148 ± 0.056	1.429ArgLys: 1.429 ± 0.039	6.139ArgLeu: 6.139 ± 0.092	1.287ArgMet: 1.287 ± 0.032	1.581ArgAsn: 1.581 ± 0.04	2.601ArgPro: 2.601 ± 0.048	1.775ArgGln: 1.775 ± 0.042	5.011ArgArg: 5.011 ± 0.085	3.713ArgSer: 3.713 ± 0.07	4.298ArgThr: 4.298 ± 0.077	4.907ArgVal: 4.907 ± 0.069	0.775ArgTrp: 0.775 ± 0.029	1.957ArgTyr: 1.957 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.146SerAla: 5.146 ± 0.063	0.348SerCys: 0.348 ± 0.019	4.652SerAsp: 4.652 ± 0.108	4.482SerGlu: 4.482 ± 0.096	1.937SerPhe: 1.937 ± 0.044	4.862SerGly: 4.862 ± 0.072	1.08SerHis: 1.08 ± 0.034	2.827SerIle: 2.827 ± 0.052	1.165SerLys: 1.165 ± 0.036	4.909SerLeu: 4.909 ± 0.069	1.212SerMet: 1.212 ± 0.033	1.341SerAsn: 1.341 ± 0.041	2.597SerPro: 2.597 ± 0.044	1.411SerGln: 1.411 ± 0.038	3.397SerArg: 3.397 ± 0.052	3.746SerSer: 3.746 ± 0.084	3.667SerThr: 3.667 ± 0.065	5.11SerVal: 5.11 ± 0.074	0.585SerTrp: 0.585 ± 0.023	1.488SerTyr: 1.488 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.806ThrAla: 6.806 ± 0.088	0.455ThrCys: 0.455 ± 0.021	6.157ThrAsp: 6.157 ± 0.08	4.771ThrGlu: 4.771 ± 0.081	2.121ThrPhe: 2.121 ± 0.047	5.555ThrGly: 5.555 ± 0.059	1.222ThrHis: 1.222 ± 0.034	3.512ThrIle: 3.512 ± 0.055	1.083ThrLys: 1.083 ± 0.033	5.904ThrLeu: 5.904 ± 0.076	1.109ThrMet: 1.109 ± 0.031	1.493ThrAsn: 1.493 ± 0.042	3.236ThrPro: 3.236 ± 0.05	1.403ThrGln: 1.403 ± 0.044	3.308ThrArg: 3.308 ± 0.058	3.099ThrSer: 3.099 ± 0.049	4.326ThrThr: 4.326 ± 0.071	7.001ThrVal: 7.001 ± 0.102	0.641ThrTrp: 0.641 ± 0.025	1.709ThrTyr: 1.709 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.678ValAla: 9.678 ± 0.121	0.697ValCys: 0.697 ± 0.031	8.545ValAsp: 8.545 ± 0.112	7.824ValGlu: 7.824 ± 0.093	2.98ValPhe: 2.98 ± 0.06	7.678ValGly: 7.678 ± 0.09	1.779ValHis: 1.779 ± 0.041	3.595ValIle: 3.595 ± 0.062	1.275ValLys: 1.275 ± 0.033	8.246ValLeu: 8.246 ± 0.112	1.353ValMet: 1.353 ± 0.039	1.821ValAsn: 1.821 ± 0.042	4.217ValPro: 4.217 ± 0.058	1.899ValGln: 1.899 ± 0.047	5.174ValArg: 5.174 ± 0.079	5.213ValSer: 5.213 ± 0.081	6.246ValThr: 6.246 ± 0.085	9.134ValVal: 9.134 ± 0.115	0.788ValTrp: 0.788 ± 0.026	2.113ValTyr: 2.113 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.928TrpAla: 0.928 ± 0.03	0.116TrpCys: 0.116 ± 0.01	0.798TrpAsp: 0.798 ± 0.03	0.852TrpGlu: 0.852 ± 0.027	0.446TrpPhe: 0.446 ± 0.02	0.838TrpGly: 0.838 ± 0.031	0.259TrpHis: 0.259 ± 0.016	0.548TrpIle: 0.548 ± 0.024	0.271TrpLys: 0.271 ± 0.018	1.317TrpLeu: 1.317 ± 0.039	0.235TrpMet: 0.235 ± 0.015	0.356TrpAsn: 0.356 ± 0.019	0.418TrpPro: 0.418 ± 0.02	0.331TrpGln: 0.331 ± 0.019	0.775TrpArg: 0.775 ± 0.03	0.595TrpSer: 0.595 ± 0.025	0.7TrpThr: 0.7 ± 0.026	0.775TrpVal: 0.775 ± 0.028	0.188TrpTrp: 0.188 ± 0.015	0.378TrpTyr: 0.378 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.752TyrAla: 2.752 ± 0.054	0.24TyrCys: 0.24 ± 0.016	2.851TyrAsp: 2.851 ± 0.059	2.584TyrGlu: 2.584 ± 0.048	0.85TyrPhe: 0.85 ± 0.031	2.25TyrGly: 2.25 ± 0.043	0.631TyrHis: 0.631 ± 0.027	0.718TyrIle: 0.718 ± 0.024	0.426TyrLys: 0.426 ± 0.022	2.465TyrLeu: 2.465 ± 0.056	0.351TyrMet: 0.351 ± 0.017	0.574TyrAsn: 0.574 ± 0.021	1.195TyrPro: 1.195 ± 0.033	0.693TyrGln: 0.693 ± 0.026	1.829TyrArg: 1.829 ± 0.039	1.155TyrSer: 1.155 ± 0.034	1.467TyrThr: 1.467 ± 0.04	2.485TyrVal: 2.485 ± 0.046	0.325TyrTrp: 0.325 ± 0.017	0.803TyrTyr: 0.803 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3734 proteins (1078029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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