Amino acid dipepetide frequency for Streptococcus satellite phage Javan259

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.287AlaCys: 0.287 ± 0.292
4.309AlaAsp: 4.309 ± 1.21
4.596AlaGlu: 4.596 ± 1.359
4.022AlaPhe: 4.022 ± 0.94
3.16AlaGly: 3.16 ± 0.796
0.575AlaHis: 0.575 ± 0.423
3.447AlaIle: 3.447 ± 1.029
5.745AlaLys: 5.745 ± 1.16
5.171AlaLeu: 5.171 ± 0.926
2.585AlaMet: 2.585 ± 0.954
2.011AlaAsn: 2.011 ± 0.778
1.436AlaPro: 1.436 ± 0.513
4.309AlaGln: 4.309 ± 1.015
2.011AlaArg: 2.011 ± 0.685
4.596AlaSer: 4.596 ± 0.807
3.447AlaThr: 3.447 ± 0.903
3.16AlaVal: 3.16 ± 0.738
1.436AlaTrp: 1.436 ± 0.712
2.011AlaTyr: 2.011 ± 0.66
0.0AlaXaa: 0.0 ± 0.0
Cys
0.287CysAla: 0.287 ± 0.306
0.0CysCys: 0.0 ± 0.0
0.862CysAsp: 0.862 ± 0.496
0.575CysGlu: 0.575 ± 0.384
0.287CysPhe: 0.287 ± 0.292
0.0CysGly: 0.0 ± 0.0
0.287CysHis: 0.287 ± 0.285
0.575CysIle: 0.575 ± 0.385
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.287CysMet: 0.287 ± 0.227
0.287CysAsn: 0.287 ± 0.292
0.0CysPro: 0.0 ± 0.0
0.287CysGln: 0.287 ± 0.239
0.287CysArg: 0.287 ± 0.227
0.575CysSer: 0.575 ± 0.369
0.0CysThr: 0.0 ± 0.0
0.287CysVal: 0.287 ± 0.292
0.287CysTrp: 0.287 ± 0.292
0.575CysTyr: 0.575 ± 0.571
0.0CysXaa: 0.0 ± 0.0
Asp
1.724AspAla: 1.724 ± 0.702
0.575AspCys: 0.575 ± 0.399
4.309AspAsp: 4.309 ± 1.576
6.033AspGlu: 6.033 ± 1.216
5.171AspPhe: 5.171 ± 1.221
2.873AspGly: 2.873 ± 1.057
0.287AspHis: 0.287 ± 0.285
5.745AspIle: 5.745 ± 0.952
6.32AspLys: 6.32 ± 1.106
5.458AspLeu: 5.458 ± 1.359
2.298AspMet: 2.298 ± 0.747
4.309AspAsn: 4.309 ± 1.159
0.575AspPro: 0.575 ± 0.416
2.011AspGln: 2.011 ± 0.722
2.873AspArg: 2.873 ± 0.845
2.585AspSer: 2.585 ± 0.86
3.447AspThr: 3.447 ± 0.73
2.585AspVal: 2.585 ± 0.93
0.575AspTrp: 0.575 ± 0.339
3.447AspTyr: 3.447 ± 1.128
0.0AspXaa: 0.0 ± 0.0
Glu
7.756GluAla: 7.756 ± 1.118
0.0GluCys: 0.0 ± 0.0
5.458GluAsp: 5.458 ± 1.325
9.193GluGlu: 9.193 ± 2.08
3.447GluPhe: 3.447 ± 1.035
4.309GluGly: 4.309 ± 1.162
2.011GluHis: 2.011 ± 0.968
6.607GluIle: 6.607 ± 1.529
6.033GluLys: 6.033 ± 1.942
9.767GluLeu: 9.767 ± 1.942
2.011GluMet: 2.011 ± 0.9
3.735GluAsn: 3.735 ± 0.844
2.873GluPro: 2.873 ± 0.688
2.011GluGln: 2.011 ± 0.713
5.171GluArg: 5.171 ± 1.902
3.735GluSer: 3.735 ± 0.852
2.585GluThr: 2.585 ± 0.952
4.022GluVal: 4.022 ± 0.809
2.873GluTrp: 2.873 ± 1.0
3.16GluTyr: 3.16 ± 0.883
0.0GluXaa: 0.0 ± 0.0
Phe
2.011PheAla: 2.011 ± 0.954
0.287PheCys: 0.287 ± 0.285
2.873PheAsp: 2.873 ± 0.844
3.447PheGlu: 3.447 ± 0.956
1.724PhePhe: 1.724 ± 0.594
1.724PheGly: 1.724 ± 0.773
1.149PheHis: 1.149 ± 0.647
2.873PheIle: 2.873 ± 0.877
6.033PheLys: 6.033 ± 1.746
3.735PheLeu: 3.735 ± 0.975
0.862PheMet: 0.862 ± 0.542
4.309PheAsn: 4.309 ± 1.125
0.575PhePro: 0.575 ± 0.404
1.149PheGln: 1.149 ± 0.609
2.011PheArg: 2.011 ± 0.616
2.585PheSer: 2.585 ± 0.717
2.585PheThr: 2.585 ± 0.734
2.585PheVal: 2.585 ± 0.717
0.575PheTrp: 0.575 ± 0.404
1.149PheTyr: 1.149 ± 0.525
0.0PheXaa: 0.0 ± 0.0
Gly
1.436GlyAla: 1.436 ± 0.513
0.575GlyCys: 0.575 ± 0.314
2.298GlyAsp: 2.298 ± 0.865
4.309GlyGlu: 4.309 ± 0.763
3.16GlyPhe: 3.16 ± 0.851
1.436GlyGly: 1.436 ± 0.67
2.011GlyHis: 2.011 ± 0.908
4.309GlyIle: 4.309 ± 1.143
4.596GlyLys: 4.596 ± 1.153
4.884GlyLeu: 4.884 ± 1.009
1.724GlyMet: 1.724 ± 0.637
2.011GlyAsn: 2.011 ± 1.026
0.0GlyPro: 0.0 ± 0.0
2.298GlyGln: 2.298 ± 0.731
0.862GlyArg: 0.862 ± 0.499
2.873GlySer: 2.873 ± 1.38
2.873GlyThr: 2.873 ± 0.97
4.596GlyVal: 4.596 ± 0.777
0.287GlyTrp: 0.287 ± 0.28
3.16GlyTyr: 3.16 ± 1.315
0.0GlyXaa: 0.0 ± 0.0
His
0.862HisAla: 0.862 ± 0.537
0.0HisCys: 0.0 ± 0.0
0.575HisAsp: 0.575 ± 0.459
0.862HisGlu: 0.862 ± 0.502
1.149HisPhe: 1.149 ± 0.461
1.724HisGly: 1.724 ± 0.753
0.575HisHis: 0.575 ± 0.416
1.436HisIle: 1.436 ± 0.608
0.862HisLys: 0.862 ± 0.717
2.585HisLeu: 2.585 ± 0.75
0.287HisMet: 0.287 ± 0.227
1.149HisAsn: 1.149 ± 0.49
0.575HisPro: 0.575 ± 0.416
0.575HisGln: 0.575 ± 0.376
0.862HisArg: 0.862 ± 0.479
0.862HisSer: 0.862 ± 0.457
1.724HisThr: 1.724 ± 0.678
0.575HisVal: 0.575 ± 0.367
0.287HisTrp: 0.287 ± 0.292
1.436HisTyr: 1.436 ± 0.646
0.0HisXaa: 0.0 ± 0.0
Ile
6.033IleAla: 6.033 ± 1.47
0.862IleCys: 0.862 ± 0.496
5.458IleAsp: 5.458 ± 1.011
5.745IleGlu: 5.745 ± 1.224
2.585IlePhe: 2.585 ± 0.726
2.585IleGly: 2.585 ± 0.722
1.436IleHis: 1.436 ± 0.518
2.585IleIle: 2.585 ± 1.061
5.745IleLys: 5.745 ± 1.25
2.298IleLeu: 2.298 ± 0.575
2.298IleMet: 2.298 ± 0.605
2.873IleAsn: 2.873 ± 1.106
1.724IlePro: 1.724 ± 0.566
4.309IleGln: 4.309 ± 1.104
2.873IleArg: 2.873 ± 0.75
5.745IleSer: 5.745 ± 1.233
4.596IleThr: 4.596 ± 1.226
3.735IleVal: 3.735 ± 0.783
0.0IleTrp: 0.0 ± 0.0
3.735IleTyr: 3.735 ± 1.2
0.0IleXaa: 0.0 ± 0.0
Lys
5.171LysAla: 5.171 ± 1.064
0.0LysCys: 0.0 ± 0.0
4.022LysAsp: 4.022 ± 1.012
5.171LysGlu: 5.171 ± 1.521
2.585LysPhe: 2.585 ± 0.915
4.309LysGly: 4.309 ± 1.236
1.436LysHis: 1.436 ± 0.443
6.895LysIle: 6.895 ± 1.764
9.193LysLys: 9.193 ± 1.592
7.469LysLeu: 7.469 ± 1.41
2.585LysMet: 2.585 ± 0.947
5.171LysAsn: 5.171 ± 0.825
2.298LysPro: 2.298 ± 1.006
5.458LysGln: 5.458 ± 1.446
4.884LysArg: 4.884 ± 1.287
5.171LysSer: 5.171 ± 1.248
7.182LysThr: 7.182 ± 1.09
6.607LysVal: 6.607 ± 1.553
0.287LysTrp: 0.287 ± 0.292
2.585LysTyr: 2.585 ± 0.954
0.0LysXaa: 0.0 ± 0.0
Leu
4.884LeuAla: 4.884 ± 1.403
0.862LeuCys: 0.862 ± 0.316
6.32LeuAsp: 6.32 ± 0.984
8.331LeuGlu: 8.331 ± 1.642
4.022LeuPhe: 4.022 ± 1.117
4.309LeuGly: 4.309 ± 0.89
0.575LeuHis: 0.575 ± 0.368
5.171LeuIle: 5.171 ± 1.345
9.48LeuLys: 9.48 ± 1.369
8.905LeuLeu: 8.905 ± 1.64
0.862LeuMet: 0.862 ± 0.577
6.033LeuAsn: 6.033 ± 0.94
2.298LeuPro: 2.298 ± 0.882
2.873LeuGln: 2.873 ± 0.885
3.447LeuArg: 3.447 ± 0.717
5.171LeuSer: 5.171 ± 0.972
6.033LeuThr: 6.033 ± 1.591
5.171LeuVal: 5.171 ± 0.987
1.149LeuTrp: 1.149 ± 0.513
4.884LeuTyr: 4.884 ± 1.019
0.0LeuXaa: 0.0 ± 0.0
Met
3.16MetAla: 3.16 ± 1.031
0.0MetCys: 0.0 ± 0.0
1.724MetAsp: 1.724 ± 0.761
1.724MetGlu: 1.724 ± 0.752
0.862MetPhe: 0.862 ± 0.395
0.575MetGly: 0.575 ± 0.376
0.0MetHis: 0.0 ± 0.0
2.011MetIle: 2.011 ± 0.543
1.724MetLys: 1.724 ± 0.613
2.011MetLeu: 2.011 ± 0.754
0.287MetMet: 0.287 ± 0.227
1.724MetAsn: 1.724 ± 0.615
0.575MetPro: 0.575 ± 0.401
1.724MetGln: 1.724 ± 0.717
0.862MetArg: 0.862 ± 0.515
0.287MetSer: 0.287 ± 0.302
4.309MetThr: 4.309 ± 1.337
0.575MetVal: 0.575 ± 0.403
0.0MetTrp: 0.0 ± 0.0
1.436MetTyr: 1.436 ± 0.649
0.0MetXaa: 0.0 ± 0.0
Asn
3.735AsnAla: 3.735 ± 0.667
0.287AsnCys: 0.287 ± 0.321
3.16AsnAsp: 3.16 ± 1.062
7.182AsnGlu: 7.182 ± 1.417
2.298AsnPhe: 2.298 ± 0.656
4.022AsnGly: 4.022 ± 1.103
2.298AsnHis: 2.298 ± 0.704
3.735AsnIle: 3.735 ± 0.904
4.309AsnLys: 4.309 ± 1.054
3.735AsnLeu: 3.735 ± 0.925
0.575AsnMet: 0.575 ± 0.452
2.585AsnAsn: 2.585 ± 0.715
2.011AsnPro: 2.011 ± 0.611
1.724AsnGln: 1.724 ± 0.7
2.873AsnArg: 2.873 ± 0.748
1.436AsnSer: 1.436 ± 0.62
1.724AsnThr: 1.724 ± 0.59
1.724AsnVal: 1.724 ± 0.825
0.862AsnTrp: 0.862 ± 0.499
2.011AsnTyr: 2.011 ± 0.722
0.0AsnXaa: 0.0 ± 0.0
Pro
0.862ProAla: 0.862 ± 0.491
0.287ProCys: 0.287 ± 0.301
2.873ProAsp: 2.873 ± 0.961
2.011ProGlu: 2.011 ± 0.598
0.862ProPhe: 0.862 ± 0.435
0.0ProGly: 0.0 ± 0.0
0.575ProHis: 0.575 ± 0.37
0.862ProIle: 0.862 ± 0.398
3.16ProLys: 3.16 ± 0.935
0.575ProLeu: 0.575 ± 0.348
0.575ProMet: 0.575 ± 0.413
1.149ProAsn: 1.149 ± 0.495
0.575ProPro: 0.575 ± 0.405
0.575ProGln: 0.575 ± 0.446
1.436ProArg: 1.436 ± 0.631
0.862ProSer: 0.862 ± 0.461
2.873ProThr: 2.873 ± 0.725
1.149ProVal: 1.149 ± 0.651
0.287ProTrp: 0.287 ± 0.292
1.436ProTyr: 1.436 ± 0.57
0.0ProXaa: 0.0 ± 0.0
Gln
3.16GlnAla: 3.16 ± 1.201
0.287GlnCys: 0.287 ± 0.285
3.447GlnAsp: 3.447 ± 0.653
3.735GlnGlu: 3.735 ± 1.383
1.436GlnPhe: 1.436 ± 0.637
2.873GlnGly: 2.873 ± 0.979
1.149GlnHis: 1.149 ± 0.646
2.873GlnIle: 2.873 ± 0.843
3.447GlnLys: 3.447 ± 0.888
2.585GlnLeu: 2.585 ± 0.882
1.149GlnMet: 1.149 ± 0.509
0.862GlnAsn: 0.862 ± 0.408
1.149GlnPro: 1.149 ± 0.736
1.436GlnGln: 1.436 ± 0.723
3.16GlnArg: 3.16 ± 1.101
1.436GlnSer: 1.436 ± 0.798
3.16GlnThr: 3.16 ± 1.411
3.447GlnVal: 3.447 ± 0.75
0.0GlnTrp: 0.0 ± 0.0
1.149GlnTyr: 1.149 ± 0.471
0.0GlnXaa: 0.0 ± 0.0
Arg
2.298ArgAla: 2.298 ± 0.927
0.0ArgCys: 0.0 ± 0.0
2.011ArgAsp: 2.011 ± 0.702
4.309ArgGlu: 4.309 ± 1.448
0.575ArgPhe: 0.575 ± 0.37
2.298ArgGly: 2.298 ± 0.997
0.862ArgHis: 0.862 ± 0.494
4.596ArgIle: 4.596 ± 0.857
4.022ArgLys: 4.022 ± 0.994
7.182ArgLeu: 7.182 ± 1.219
1.149ArgMet: 1.149 ± 0.607
2.011ArgAsn: 2.011 ± 0.659
0.287ArgPro: 0.287 ± 0.239
3.447ArgGln: 3.447 ± 1.124
2.585ArgArg: 2.585 ± 1.257
2.011ArgSer: 2.011 ± 0.726
2.585ArgThr: 2.585 ± 0.824
3.735ArgVal: 3.735 ± 0.868
0.287ArgTrp: 0.287 ± 0.306
3.16ArgTyr: 3.16 ± 0.941
0.0ArgXaa: 0.0 ± 0.0
Ser
2.873SerAla: 2.873 ± 0.679
0.862SerCys: 0.862 ± 0.395
5.171SerAsp: 5.171 ± 0.764
3.447SerGlu: 3.447 ± 1.156
2.873SerPhe: 2.873 ± 0.974
2.585SerGly: 2.585 ± 1.056
0.575SerHis: 0.575 ± 0.426
2.873SerIle: 2.873 ± 0.805
4.596SerLys: 4.596 ± 0.994
6.32SerLeu: 6.32 ± 1.652
1.436SerMet: 1.436 ± 0.474
2.298SerAsn: 2.298 ± 0.489
2.011SerPro: 2.011 ± 0.643
1.436SerGln: 1.436 ± 0.725
2.585SerArg: 2.585 ± 0.526
3.735SerSer: 3.735 ± 2.339
2.585SerThr: 2.585 ± 0.617
2.585SerVal: 2.585 ± 0.706
0.287SerTrp: 0.287 ± 0.331
2.011SerTyr: 2.011 ± 0.643
0.0SerXaa: 0.0 ± 0.0
Thr
4.596ThrAla: 4.596 ± 1.078
0.0ThrCys: 0.0 ± 0.0
3.735ThrAsp: 3.735 ± 0.845
7.182ThrGlu: 7.182 ± 1.58
2.011ThrPhe: 2.011 ± 0.933
4.022ThrGly: 4.022 ± 1.022
1.149ThrHis: 1.149 ± 0.36
4.022ThrIle: 4.022 ± 0.992
2.873ThrLys: 2.873 ± 0.755
5.745ThrLeu: 5.745 ± 1.153
1.149ThrMet: 1.149 ± 0.452
4.022ThrAsn: 4.022 ± 0.937
2.011ThrPro: 2.011 ± 1.024
1.149ThrGln: 1.149 ± 0.676
3.16ThrArg: 3.16 ± 0.78
2.585ThrSer: 2.585 ± 0.695
5.171ThrThr: 5.171 ± 1.681
4.596ThrVal: 4.596 ± 1.253
0.575ThrTrp: 0.575 ± 0.412
5.458ThrTyr: 5.458 ± 1.529
0.0ThrXaa: 0.0 ± 0.0
Val
4.022ValAla: 4.022 ± 0.907
0.287ValCys: 0.287 ± 0.292
2.873ValAsp: 2.873 ± 0.936
6.32ValGlu: 6.32 ± 1.179
2.585ValPhe: 2.585 ± 0.713
2.298ValGly: 2.298 ± 0.761
0.575ValHis: 0.575 ± 0.378
3.447ValIle: 3.447 ± 1.026
5.171ValLys: 5.171 ± 1.529
4.884ValLeu: 4.884 ± 2.018
2.298ValMet: 2.298 ± 0.8
3.447ValAsn: 3.447 ± 0.747
0.862ValPro: 0.862 ± 0.476
0.862ValGln: 0.862 ± 0.528
3.16ValArg: 3.16 ± 1.028
2.873ValSer: 2.873 ± 0.736
5.458ValThr: 5.458 ± 1.141
4.309ValVal: 4.309 ± 1.017
0.287ValTrp: 0.287 ± 0.323
1.724ValTyr: 1.724 ± 0.474
0.0ValXaa: 0.0 ± 0.0
Trp
1.724TrpAla: 1.724 ± 0.816
0.0TrpCys: 0.0 ± 0.0
0.287TrpAsp: 0.287 ± 0.227
0.575TrpGlu: 0.575 ± 0.334
0.287TrpPhe: 0.287 ± 0.292
0.575TrpGly: 0.575 ± 0.583
0.287TrpHis: 0.287 ± 0.322
0.575TrpIle: 0.575 ± 0.387
0.862TrpLys: 0.862 ± 0.441
2.011TrpLeu: 2.011 ± 1.356
0.0TrpMet: 0.0 ± 0.0
0.287TrpAsn: 0.287 ± 0.292
0.287TrpPro: 0.287 ± 0.301
0.287TrpGln: 0.287 ± 0.285
0.575TrpArg: 0.575 ± 0.462
1.436TrpSer: 1.436 ± 0.574
0.287TrpThr: 0.287 ± 0.301
0.862TrpVal: 0.862 ± 0.515
0.287TrpTrp: 0.287 ± 0.227
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.724TyrAla: 1.724 ± 0.763
0.287TyrCys: 0.287 ± 0.285
1.436TyrAsp: 1.436 ± 0.561
2.298TyrGlu: 2.298 ± 0.798
2.298TyrPhe: 2.298 ± 0.874
4.022TyrGly: 4.022 ± 0.845
1.149TyrHis: 1.149 ± 0.553
2.585TyrIle: 2.585 ± 0.77
4.309TyrLys: 4.309 ± 1.104
5.458TyrLeu: 5.458 ± 1.226
0.862TyrMet: 0.862 ± 0.467
2.011TyrAsn: 2.011 ± 0.713
0.862TyrPro: 0.862 ± 0.389
4.022TyrGln: 4.022 ± 0.791
3.735TyrArg: 3.735 ± 1.099
2.585TyrSer: 2.585 ± 0.872
2.585TyrThr: 2.585 ± 0.839
1.436TyrVal: 1.436 ± 0.527
0.862TyrTrp: 0.862 ± 0.449
2.298TyrTyr: 2.298 ± 0.825
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 22 proteins (3482 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski