Amino acid dipepetide frequency for Haloterrigena limicola JCM 13563

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.028AlaAla: 13.028 ± 0.179	0.737AlaCys: 0.737 ± 0.029	10.157AlaAsp: 10.157 ± 0.133	7.971AlaGlu: 7.971 ± 0.106	3.764AlaPhe: 3.764 ± 0.061	8.958AlaGly: 8.958 ± 0.119	1.907AlaHis: 1.907 ± 0.041	5.648AlaIle: 5.648 ± 0.081	1.916AlaLys: 1.916 ± 0.049	10.123AlaLeu: 10.123 ± 0.147	2.168AlaMet: 2.168 ± 0.05	2.472AlaAsn: 2.472 ± 0.047	3.499AlaPro: 3.499 ± 0.073	2.399AlaGln: 2.399 ± 0.043	5.834AlaArg: 5.834 ± 0.09	5.268AlaSer: 5.268 ± 0.089	7.416AlaThr: 7.416 ± 0.092	9.947AlaVal: 9.947 ± 0.136	1.039AlaTrp: 1.039 ± 0.036	2.644AlaTyr: 2.644 ± 0.049	0.003AlaXaa: 0.003 ± 0.002
Cys	0.635CysAla: 0.635 ± 0.031	0.098CysCys: 0.098 ± 0.009	0.68CysAsp: 0.68 ± 0.032	0.674CysGlu: 0.674 ± 0.026	0.2CysPhe: 0.2 ± 0.014	0.881CysGly: 0.881 ± 0.042	0.212CysHis: 0.212 ± 0.016	0.268CysIle: 0.268 ± 0.013	0.134CysLys: 0.134 ± 0.011	0.596CysLeu: 0.596 ± 0.026	0.124CysMet: 0.124 ± 0.011	0.195CysAsn: 0.195 ± 0.015	0.542CysPro: 0.542 ± 0.029	0.218CysGln: 0.218 ± 0.018	0.508CysArg: 0.508 ± 0.028	0.435CysSer: 0.435 ± 0.021	0.428CysThr: 0.428 ± 0.024	0.459CysVal: 0.459 ± 0.023	0.111CysTrp: 0.111 ± 0.012	0.22CysTyr: 0.22 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	9.723AspAla: 9.723 ± 0.118	0.682AspCys: 0.682 ± 0.029	8.747AspAsp: 8.747 ± 0.154	8.782AspGlu: 8.782 ± 0.121	1.932AspPhe: 1.932 ± 0.047	7.628AspGly: 7.628 ± 0.108	2.014AspHis: 2.014 ± 0.047	3.355AspIle: 3.355 ± 0.067	1.066AspLys: 1.066 ± 0.038	7.342AspLeu: 7.342 ± 0.096	1.248AspMet: 1.248 ± 0.038	1.415AspAsn: 1.415 ± 0.044	4.346AspPro: 4.346 ± 0.068	1.856AspGln: 1.856 ± 0.044	6.566AspArg: 6.566 ± 0.095	3.956AspSer: 3.956 ± 0.077	4.337AspThr: 4.337 ± 0.071	7.586AspVal: 7.586 ± 0.096	0.996AspTrp: 0.996 ± 0.035	1.984AspTyr: 1.984 ± 0.049	0.001AspXaa: 0.001 ± 0.001
Glu	8.532GluAla: 8.532 ± 0.113	0.578GluCys: 0.578 ± 0.03	5.984GluAsp: 5.984 ± 0.103	6.356GluGlu: 6.356 ± 0.129	2.903GluPhe: 2.903 ± 0.056	5.263GluGly: 5.263 ± 0.083	2.03GluHis: 2.03 ± 0.05	4.462GluIle: 4.462 ± 0.081	1.904GluLys: 1.904 ± 0.049	7.894GluLeu: 7.894 ± 0.103	1.8GluMet: 1.8 ± 0.044	2.532GluAsn: 2.532 ± 0.055	4.505GluPro: 4.505 ± 0.079	3.094GluGln: 3.094 ± 0.063	7.388GluArg: 7.388 ± 0.104	5.087GluSer: 5.087 ± 0.067	7.478GluThr: 7.478 ± 0.101	5.272GluVal: 5.272 ± 0.085	1.135GluTrp: 1.135 ± 0.037	2.869GluTyr: 2.869 ± 0.068	0.006GluXaa: 0.006 ± 0.003
Phe	3.498PheAla: 3.498 ± 0.064	0.306PheCys: 0.306 ± 0.018	3.3PheAsp: 3.3 ± 0.054	3.055PheGlu: 3.055 ± 0.056	0.986PhePhe: 0.986 ± 0.037	3.054PheGly: 3.054 ± 0.065	0.604PheHis: 0.604 ± 0.027	1.187PheIle: 1.187 ± 0.042	0.443PheLys: 0.443 ± 0.022	2.822PheLeu: 2.822 ± 0.065	0.513PheMet: 0.513 ± 0.025	0.687PheAsn: 0.687 ± 0.027	1.247PhePro: 1.247 ± 0.037	0.85PheGln: 0.85 ± 0.027	1.674PheArg: 1.674 ± 0.044	1.589PheSer: 1.589 ± 0.047	1.815PheThr: 1.815 ± 0.044	3.239PheVal: 3.239 ± 0.066	0.414PheTrp: 0.414 ± 0.02	0.858PheTyr: 0.858 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.288GlyAla: 7.288 ± 0.106	0.706GlyCys: 0.706 ± 0.03	6.43GlyAsp: 6.43 ± 0.094	6.372GlyGlu: 6.372 ± 0.088	3.065GlyPhe: 3.065 ± 0.065	6.554GlyGly: 6.554 ± 0.115	1.659GlyHis: 1.659 ± 0.042	4.542GlyIle: 4.542 ± 0.083	1.867GlyLys: 1.867 ± 0.048	7.35GlyLeu: 7.35 ± 0.109	1.681GlyMet: 1.681 ± 0.051	1.939GlyAsn: 1.939 ± 0.05	3.16GlyPro: 3.16 ± 0.059	2.149GlyGln: 2.149 ± 0.044	4.513GlyArg: 4.513 ± 0.066	4.903GlySer: 4.903 ± 0.078	5.881GlyThr: 5.881 ± 0.086	6.947GlyVal: 6.947 ± 0.114	1.009GlyTrp: 1.009 ± 0.03	2.636GlyTyr: 2.636 ± 0.053	0.002GlyXaa: 0.002 ± 0.001
His	2.039HisAla: 2.039 ± 0.051	0.228HisCys: 0.228 ± 0.016	1.964HisAsp: 1.964 ± 0.05	1.79HisGlu: 1.79 ± 0.04	0.514HisPhe: 0.514 ± 0.024	1.996HisGly: 1.996 ± 0.044	0.561HisHis: 0.561 ± 0.027	0.782HisIle: 0.782 ± 0.03	0.322HisLys: 0.322 ± 0.02	1.726HisLeu: 1.726 ± 0.039	0.321HisMet: 0.321 ± 0.018	0.455HisAsn: 0.455 ± 0.02	1.188HisPro: 1.188 ± 0.035	0.478HisGln: 0.478 ± 0.023	1.307HisArg: 1.307 ± 0.047	0.904HisSer: 0.904 ± 0.033	1.137HisThr: 1.137 ± 0.038	1.887HisVal: 1.887 ± 0.041	0.223HisTrp: 0.223 ± 0.016	0.568HisTyr: 0.568 ± 0.023	0.003HisXaa: 0.003 ± 0.002
Ile	5.495IleAla: 5.495 ± 0.086	0.34IleCys: 0.34 ± 0.019	4.959IleAsp: 4.959 ± 0.084	4.542IleGlu: 4.542 ± 0.073	1.047IlePhe: 1.047 ± 0.043	4.385IleGly: 4.385 ± 0.081	0.894IleHis: 0.894 ± 0.027	1.576IleIle: 1.576 ± 0.049	0.825IleLys: 0.825 ± 0.034	3.204IleLeu: 3.204 ± 0.064	0.537IleMet: 0.537 ± 0.023	1.082IleAsn: 1.082 ± 0.035	2.187IlePro: 2.187 ± 0.045	1.184IleGln: 1.184 ± 0.037	2.623IleArg: 2.623 ± 0.054	2.415IleSer: 2.415 ± 0.053	2.832IleThr: 2.832 ± 0.06	4.403IleVal: 4.403 ± 0.069	0.383IleTrp: 0.383 ± 0.022	1.068IleTyr: 1.068 ± 0.034	0.002IleXaa: 0.002 ± 0.001
Lys	1.838LysAla: 1.838 ± 0.047	0.137LysCys: 0.137 ± 0.013	1.161LysAsp: 1.161 ± 0.038	1.383LysGlu: 1.383 ± 0.043	0.492LysPhe: 0.492 ± 0.024	1.393LysGly: 1.393 ± 0.043	0.509LysHis: 0.509 ± 0.026	0.86LysIle: 0.86 ± 0.029	0.566LysLys: 0.566 ± 0.03	1.709LysLeu: 1.709 ± 0.043	0.374LysMet: 0.374 ± 0.019	0.546LysAsn: 0.546 ± 0.025	0.93LysPro: 0.93 ± 0.033	0.78LysGln: 0.78 ± 0.032	1.727LysArg: 1.727 ± 0.042	1.179LysSer: 1.179 ± 0.04	1.391LysThr: 1.391 ± 0.04	1.131LysVal: 1.131 ± 0.044	0.231LysTrp: 0.231 ± 0.013	0.61LysTyr: 0.61 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.854LeuAla: 10.854 ± 0.145	0.655LeuCys: 0.655 ± 0.025	5.789LeuAsp: 5.789 ± 0.085	11.364LeuGlu: 11.364 ± 0.131	3.149LeuPhe: 3.149 ± 0.071	7.124LeuGly: 7.124 ± 0.114	1.5LeuHis: 1.5 ± 0.037	3.417LeuIle: 3.417 ± 0.068	1.571LeuLys: 1.571 ± 0.04	8.418LeuLeu: 8.418 ± 0.117	1.232LeuMet: 1.232 ± 0.031	1.743LeuAsn: 1.743 ± 0.045	3.977LeuPro: 3.977 ± 0.064	2.141LeuGln: 2.141 ± 0.052	4.932LeuArg: 4.932 ± 0.078	5.509LeuSer: 5.509 ± 0.078	5.534LeuThr: 5.534 ± 0.071	8.187LeuVal: 8.187 ± 0.111	0.866LeuTrp: 0.866 ± 0.033	2.171LeuTyr: 2.171 ± 0.055	0.004LeuXaa: 0.004 ± 0.002
Met	1.936MetAla: 1.936 ± 0.047	0.141MetCys: 0.141 ± 0.014	1.194MetAsp: 1.194 ± 0.034	1.089MetGlu: 1.089 ± 0.037	0.5MetPhe: 0.5 ± 0.024	1.455MetGly: 1.455 ± 0.045	0.341MetHis: 0.341 ± 0.018	0.76MetIle: 0.76 ± 0.031	0.435MetLys: 0.435 ± 0.021	1.577MetLeu: 1.577 ± 0.041	0.326MetMet: 0.326 ± 0.02	0.604MetAsn: 0.604 ± 0.025	0.839MetPro: 0.839 ± 0.03	0.524MetGln: 0.524 ± 0.024	1.071MetArg: 1.071 ± 0.032	1.466MetSer: 1.466 ± 0.041	1.668MetThr: 1.668 ± 0.042	1.287MetVal: 1.287 ± 0.037	0.179MetTrp: 0.179 ± 0.012	0.4MetTyr: 0.4 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.688AsnAla: 2.688 ± 0.058	0.251AsnCys: 0.251 ± 0.02	1.812AsnAsp: 1.812 ± 0.051	1.969AsnGlu: 1.969 ± 0.056	0.616AsnPhe: 0.616 ± 0.028	2.087AsnGly: 2.087 ± 0.047	0.524AsnHis: 0.524 ± 0.021	0.974AsnIle: 0.974 ± 0.037	0.481AsnLys: 0.481 ± 0.026	1.908AsnLeu: 1.908 ± 0.047	0.469AsnMet: 0.469 ± 0.024	0.579AsnAsn: 0.579 ± 0.025	1.538AsnPro: 1.538 ± 0.043	0.692AsnGln: 0.692 ± 0.026	1.676AsnArg: 1.676 ± 0.045	1.04AsnSer: 1.04 ± 0.035	1.326AsnThr: 1.326 ± 0.041	2.199AsnVal: 2.199 ± 0.055	0.345AsnTrp: 0.345 ± 0.019	0.652AsnTyr: 0.652 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.715ProAla: 4.715 ± 0.079	0.228ProCys: 0.228 ± 0.018	4.957ProAsp: 4.957 ± 0.077	4.178ProGlu: 4.178 ± 0.065	1.548ProPhe: 1.548 ± 0.042	3.338ProGly: 3.338 ± 0.063	0.879ProHis: 0.879 ± 0.029	2.191ProIle: 2.191 ± 0.05	0.871ProLys: 0.871 ± 0.033	3.688ProLeu: 3.688 ± 0.058	0.846ProMet: 0.846 ± 0.026	1.205ProAsn: 1.205 ± 0.038	2.168ProPro: 2.168 ± 0.055	1.07ProGln: 1.07 ± 0.031	2.217ProArg: 2.217 ± 0.042	2.633ProSer: 2.633 ± 0.056	3.332ProThr: 3.332 ± 0.061	4.011ProVal: 4.011 ± 0.069	0.488ProTrp: 0.488 ± 0.023	1.111ProTyr: 1.111 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.675GlnAla: 2.675 ± 0.059	0.185GlnCys: 0.185 ± 0.014	1.459GlnAsp: 1.459 ± 0.039	1.86GlnGlu: 1.86 ± 0.045	1.113GlnPhe: 1.113 ± 0.034	1.674GlnGly: 1.674 ± 0.043	0.565GlnHis: 0.565 ± 0.023	1.158GlnIle: 1.158 ± 0.034	0.648GlnLys: 0.648 ± 0.027	2.709GlnLeu: 2.709 ± 0.057	0.561GlnMet: 0.561 ± 0.028	0.755GlnAsn: 0.755 ± 0.032	1.388GlnPro: 1.388 ± 0.041	1.275GlnGln: 1.275 ± 0.054	2.145GlnArg: 2.145 ± 0.052	1.804GlnSer: 1.804 ± 0.045	1.831GlnThr: 1.831 ± 0.045	1.865GlnVal: 1.865 ± 0.041	0.371GlnTrp: 0.371 ± 0.022	0.942GlnTyr: 0.942 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.977ArgAla: 5.977 ± 0.096	0.466ArgCys: 0.466 ± 0.024	4.983ArgAsp: 4.983 ± 0.078	6.319ArgGlu: 6.319 ± 0.097	2.228ArgPhe: 2.228 ± 0.056	4.021ArgGly: 4.021 ± 0.067	1.22ArgHis: 1.22 ± 0.037	3.011ArgIle: 3.011 ± 0.058	1.451ArgLys: 1.451 ± 0.044	6.309ArgLeu: 6.309 ± 0.087	1.274ArgMet: 1.274 ± 0.034	1.622ArgAsn: 1.622 ± 0.044	2.56ArgPro: 2.56 ± 0.047	2.0ArgGln: 2.0 ± 0.047	4.528ArgArg: 4.528 ± 0.089	3.622ArgSer: 3.622 ± 0.06	4.225ArgThr: 4.225 ± 0.069	4.741ArgVal: 4.741 ± 0.072	0.704ArgTrp: 0.704 ± 0.032	1.842ArgTyr: 1.842 ± 0.048	0.003ArgXaa: 0.003 ± 0.002
Ser	5.157SerAla: 5.157 ± 0.083	0.366SerCys: 0.366 ± 0.021	4.604SerAsp: 4.604 ± 0.071	4.357SerGlu: 4.357 ± 0.078	1.805SerPhe: 1.805 ± 0.045	4.867SerGly: 4.867 ± 0.071	1.115SerHis: 1.115 ± 0.037	2.779SerIle: 2.779 ± 0.054	1.248SerLys: 1.248 ± 0.04	5.041SerLeu: 5.041 ± 0.074	1.204SerMet: 1.204 ± 0.037	1.449SerAsn: 1.449 ± 0.044	2.482SerPro: 2.482 ± 0.048	1.534SerGln: 1.534 ± 0.046	3.29SerArg: 3.29 ± 0.06	3.46SerSer: 3.46 ± 0.076	3.612SerThr: 3.612 ± 0.061	4.71SerVal: 4.71 ± 0.074	0.607SerTrp: 0.607 ± 0.023	1.437SerTyr: 1.437 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	7.678ThrAla: 7.678 ± 0.105	0.459ThrCys: 0.459 ± 0.026	6.318ThrAsp: 6.318 ± 0.099	4.812ThrGlu: 4.812 ± 0.077	2.106ThrPhe: 2.106 ± 0.04	5.787ThrGly: 5.787 ± 0.08	1.309ThrHis: 1.309 ± 0.032	3.77ThrIle: 3.77 ± 0.061	1.153ThrLys: 1.153 ± 0.036	6.034ThrLeu: 6.034 ± 0.078	1.126ThrMet: 1.126 ± 0.032	1.664ThrAsn: 1.664 ± 0.042	3.283ThrPro: 3.283 ± 0.062	1.619ThrGln: 1.619 ± 0.041	3.336ThrArg: 3.336 ± 0.059	3.165ThrSer: 3.165 ± 0.056	4.645ThrThr: 4.645 ± 0.082	7.026ThrVal: 7.026 ± 0.105	0.621ThrTrp: 0.621 ± 0.028	1.733ThrTyr: 1.733 ± 0.046	0.003ThrXaa: 0.003 ± 0.001
Val	9.495ValAla: 9.495 ± 0.131	0.687ValCys: 0.687 ± 0.03	7.508ValAsp: 7.508 ± 0.099	6.804ValGlu: 6.804 ± 0.09	2.851ValPhe: 2.851 ± 0.063	7.169ValGly: 7.169 ± 0.107	1.652ValHis: 1.652 ± 0.04	3.838ValIle: 3.838 ± 0.066	1.334ValLys: 1.334 ± 0.038	7.956ValLeu: 7.956 ± 0.106	1.362ValMet: 1.362 ± 0.037	1.844ValAsn: 1.844 ± 0.05	4.186ValPro: 4.186 ± 0.069	1.964ValGln: 1.964 ± 0.053	5.002ValArg: 5.002 ± 0.087	4.952ValSer: 4.952 ± 0.076	6.434ValThr: 6.434 ± 0.101	8.252ValVal: 8.252 ± 0.127	0.81ValTrp: 0.81 ± 0.03	2.132ValTyr: 2.132 ± 0.044	0.002ValXaa: 0.002 ± 0.001
Trp	0.878TrpAla: 0.878 ± 0.03	0.094TrpCys: 0.094 ± 0.01	0.812TrpAsp: 0.812 ± 0.026	0.814TrpGlu: 0.814 ± 0.036	0.476TrpPhe: 0.476 ± 0.025	0.765TrpGly: 0.765 ± 0.029	0.256TrpHis: 0.256 ± 0.02	0.583TrpIle: 0.583 ± 0.023	0.274TrpLys: 0.274 ± 0.018	1.268TrpLeu: 1.268 ± 0.037	0.22TrpMet: 0.22 ± 0.017	0.357TrpAsn: 0.357 ± 0.022	0.442TrpPro: 0.442 ± 0.025	0.411TrpGln: 0.411 ± 0.02	0.776TrpArg: 0.776 ± 0.032	0.552TrpSer: 0.552 ± 0.022	0.791TrpThr: 0.791 ± 0.027	0.744TrpVal: 0.744 ± 0.03	0.185TrpTrp: 0.185 ± 0.014	0.372TrpTyr: 0.372 ± 0.02	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.766TyrAla: 2.766 ± 0.061	0.272TyrCys: 0.272 ± 0.016	2.739TyrAsp: 2.739 ± 0.057	2.58TyrGlu: 2.58 ± 0.052	0.845TyrPhe: 0.845 ± 0.034	2.246TyrGly: 2.246 ± 0.049	0.646TyrHis: 0.646 ± 0.024	0.822TyrIle: 0.822 ± 0.028	0.438TyrLys: 0.438 ± 0.022	2.458TyrLeu: 2.458 ± 0.049	0.404TyrMet: 0.404 ± 0.018	0.682TyrAsn: 0.682 ± 0.029	1.206TyrPro: 1.206 ± 0.037	0.744TyrGln: 0.744 ± 0.033	1.99TyrArg: 1.99 ± 0.05	1.186TyrSer: 1.186 ± 0.035	1.533TyrThr: 1.533 ± 0.047	2.341TyrVal: 2.341 ± 0.051	0.352TyrTrp: 0.352 ± 0.022	0.852TyrTyr: 0.852 ± 0.029	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.005XaaAsp: 0.005 ± 0.003	0.002XaaGlu: 0.002 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.004XaaGly: 0.004 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.005XaaLeu: 0.005 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.003XaaSer: 0.003 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3519 proteins (958682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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