Amino acid dipepetide frequency for Globicatella sp. HMSC072A10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.97AlaAla: 4.97 ± 0.129
0.412AlaCys: 0.412 ± 0.026
3.736AlaAsp: 3.736 ± 0.078
4.742AlaGlu: 4.742 ± 0.105
3.033AlaPhe: 3.033 ± 0.074
4.588AlaGly: 4.588 ± 0.093
1.267AlaHis: 1.267 ± 0.037
6.24AlaIle: 6.24 ± 0.115
4.606AlaLys: 4.606 ± 0.085
7.087AlaLeu: 7.087 ± 0.114
1.984AlaMet: 1.984 ± 0.06
3.476AlaAsn: 3.476 ± 0.071
2.006AlaPro: 2.006 ± 0.062
2.947AlaGln: 2.947 ± 0.069
2.501AlaArg: 2.501 ± 0.066
3.835AlaSer: 3.835 ± 0.073
4.151AlaThr: 4.151 ± 0.086
4.656AlaVal: 4.656 ± 0.089
0.534AlaTrp: 0.534 ± 0.028
2.565AlaTyr: 2.565 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.336CysAla: 0.336 ± 0.025
0.056CysCys: 0.056 ± 0.01
0.313CysAsp: 0.313 ± 0.022
0.322CysGlu: 0.322 ± 0.021
0.262CysPhe: 0.262 ± 0.019
0.476CysGly: 0.476 ± 0.026
0.201CysHis: 0.201 ± 0.022
0.361CysIle: 0.361 ± 0.025
0.196CysLys: 0.196 ± 0.018
0.542CysLeu: 0.542 ± 0.028
0.099CysMet: 0.099 ± 0.012
0.196CysAsn: 0.196 ± 0.015
0.23CysPro: 0.23 ± 0.021
0.298CysGln: 0.298 ± 0.024
0.199CysArg: 0.199 ± 0.02
0.33CysSer: 0.33 ± 0.022
0.234CysThr: 0.234 ± 0.018
0.322CysVal: 0.322 ± 0.024
0.05CysTrp: 0.05 ± 0.009
0.218CysTyr: 0.218 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.573AspAla: 3.573 ± 0.089
0.288AspCys: 0.288 ± 0.023
2.763AspAsp: 2.763 ± 0.076
4.856AspGlu: 4.856 ± 0.089
2.807AspPhe: 2.807 ± 0.06
3.409AspGly: 3.409 ± 0.078
1.1AspHis: 1.1 ± 0.041
4.32AspIle: 4.32 ± 0.087
3.225AspLys: 3.225 ± 0.085
5.35AspLeu: 5.35 ± 0.099
1.244AspMet: 1.244 ± 0.044
2.568AspAsn: 2.568 ± 0.075
1.786AspPro: 1.786 ± 0.054
2.37AspGln: 2.37 ± 0.06
2.058AspArg: 2.058 ± 0.06
3.027AspSer: 3.027 ± 0.08
2.798AspThr: 2.798 ± 0.057
3.567AspVal: 3.567 ± 0.078
0.694AspTrp: 0.694 ± 0.033
2.925AspTyr: 2.925 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
5.905GluAla: 5.905 ± 0.113
0.33GluCys: 0.33 ± 0.023
3.838GluAsp: 3.838 ± 0.089
6.464GluGlu: 6.464 ± 0.127
2.706GluPhe: 2.706 ± 0.062
4.039GluGly: 4.039 ± 0.095
1.436GluHis: 1.436 ± 0.044
5.73GluIle: 5.73 ± 0.109
5.504GluLys: 5.504 ± 0.111
7.422GluLeu: 7.422 ± 0.13
2.276GluMet: 2.276 ± 0.065
4.018GluAsn: 4.018 ± 0.086
2.057GluPro: 2.057 ± 0.049
3.499GluGln: 3.499 ± 0.089
3.094GluArg: 3.094 ± 0.079
3.718GluSer: 3.718 ± 0.085
4.291GluThr: 4.291 ± 0.101
5.224GluVal: 5.224 ± 0.094
0.767GluTrp: 0.767 ± 0.037
2.582GluTyr: 2.582 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
2.828PheAla: 2.828 ± 0.073
0.281PheCys: 0.281 ± 0.022
3.015PheAsp: 3.015 ± 0.067
3.246PheGlu: 3.246 ± 0.071
2.057PhePhe: 2.057 ± 0.059
3.117PheGly: 3.117 ± 0.073
0.712PheHis: 0.712 ± 0.029
3.713PheIle: 3.713 ± 0.085
2.886PheLys: 2.886 ± 0.074
3.907PheLeu: 3.907 ± 0.095
1.176PheMet: 1.176 ± 0.047
2.72PheAsn: 2.72 ± 0.059
1.395PhePro: 1.395 ± 0.045
1.485PheGln: 1.485 ± 0.049
1.333PheArg: 1.333 ± 0.045
2.909PheSer: 2.909 ± 0.077
2.385PheThr: 2.385 ± 0.061
2.992PheVal: 2.992 ± 0.073
0.449PheTrp: 0.449 ± 0.025
1.856PheTyr: 1.856 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.229GlyAla: 4.229 ± 0.099
0.42GlyCys: 0.42 ± 0.025
3.122GlyAsp: 3.122 ± 0.087
4.063GlyGlu: 4.063 ± 0.091
3.067GlyPhe: 3.067 ± 0.074
4.176GlyGly: 4.176 ± 0.108
1.375GlyHis: 1.375 ± 0.05
5.49GlyIle: 5.49 ± 0.114
3.87GlyLys: 3.87 ± 0.075
6.345GlyLeu: 6.345 ± 0.132
1.816GlyMet: 1.816 ± 0.059
2.76GlyAsn: 2.76 ± 0.058
1.463GlyPro: 1.463 ± 0.054
2.559GlyGln: 2.559 ± 0.069
2.378GlyArg: 2.378 ± 0.056
3.487GlySer: 3.487 ± 0.083
3.551GlyThr: 3.551 ± 0.077
4.577GlyVal: 4.577 ± 0.088
0.657GlyTrp: 0.657 ± 0.037
2.906GlyTyr: 2.906 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.118HisAla: 1.118 ± 0.045
0.146HisCys: 0.146 ± 0.015
1.065HisAsp: 1.065 ± 0.039
1.327HisGlu: 1.327 ± 0.05
1.147HisPhe: 1.147 ± 0.043
1.214HisGly: 1.214 ± 0.051
0.779HisHis: 0.779 ± 0.043
1.354HisIle: 1.354 ± 0.049
0.802HisLys: 0.802 ± 0.036
2.171HisLeu: 2.171 ± 0.066
0.361HisMet: 0.361 ± 0.025
0.856HisAsn: 0.856 ± 0.034
1.033HisPro: 1.033 ± 0.039
1.319HisGln: 1.319 ± 0.051
0.888HisArg: 0.888 ± 0.038
1.095HisSer: 1.095 ± 0.036
1.048HisThr: 1.048 ± 0.039
1.089HisVal: 1.089 ± 0.045
0.216HisTrp: 0.216 ± 0.017
1.156HisTyr: 1.156 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.204IleAla: 6.204 ± 0.112
0.558IleCys: 0.558 ± 0.029
5.111IleAsp: 5.111 ± 0.094
6.604IleGlu: 6.604 ± 0.102
3.478IlePhe: 3.478 ± 0.079
5.294IleGly: 5.294 ± 0.101
1.538IleHis: 1.538 ± 0.052
6.637IleIle: 6.637 ± 0.123
5.028IleLys: 5.028 ± 0.086
7.437IleLeu: 7.437 ± 0.133
1.889IleMet: 1.889 ± 0.054
4.188IleAsn: 4.188 ± 0.087
3.231IlePro: 3.231 ± 0.075
2.992IleGln: 2.992 ± 0.073
2.807IleArg: 2.807 ± 0.069
4.76IleSer: 4.76 ± 0.095
4.127IleThr: 4.127 ± 0.085
5.492IleVal: 5.492 ± 0.099
0.639IleTrp: 0.639 ± 0.034
2.788IleTyr: 2.788 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.343LysAla: 4.343 ± 0.095
0.213LysCys: 0.213 ± 0.023
3.5LysAsp: 3.5 ± 0.08
5.86LysGlu: 5.86 ± 0.098
2.084LysPhe: 2.084 ± 0.055
3.592LysGly: 3.592 ± 0.07
1.118LysHis: 1.118 ± 0.04
4.863LysIle: 4.863 ± 0.091
4.22LysLys: 4.22 ± 0.09
5.522LysLeu: 5.522 ± 0.113
1.99LysMet: 1.99 ± 0.051
3.37LysAsn: 3.37 ± 0.085
1.959LysPro: 1.959 ± 0.064
3.004LysGln: 3.004 ± 0.075
2.662LysArg: 2.662 ± 0.073
3.085LysSer: 3.085 ± 0.075
3.391LysThr: 3.391 ± 0.071
4.447LysVal: 4.447 ± 0.081
0.624LysTrp: 0.624 ± 0.031
2.37LysTyr: 2.37 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
7.675LeuAla: 7.675 ± 0.128
0.484LeuCys: 0.484 ± 0.023
5.227LeuAsp: 5.227 ± 0.089
6.569LeuGlu: 6.569 ± 0.113
4.469LeuPhe: 4.469 ± 0.1
6.105LeuGly: 6.105 ± 0.108
1.476LeuHis: 1.476 ± 0.053
7.901LeuIle: 7.901 ± 0.128
6.134LeuLys: 6.134 ± 0.118
9.812LeuLeu: 9.812 ± 0.179
2.915LeuMet: 2.915 ± 0.056
5.411LeuAsn: 5.411 ± 0.079
3.97LeuPro: 3.97 ± 0.073
3.269LeuGln: 3.269 ± 0.076
3.388LeuArg: 3.388 ± 0.085
6.996LeuSer: 6.996 ± 0.097
6.29LeuThr: 6.29 ± 0.114
6.552LeuVal: 6.552 ± 0.096
0.812LeuTrp: 0.812 ± 0.038
3.283LeuTyr: 3.283 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
2.034MetAla: 2.034 ± 0.059
0.11MetCys: 0.11 ± 0.01
1.532MetAsp: 1.532 ± 0.054
1.631MetGlu: 1.631 ± 0.053
0.888MetPhe: 0.888 ± 0.037
1.649MetGly: 1.649 ± 0.047
0.403MetHis: 0.403 ± 0.022
2.327MetIle: 2.327 ± 0.066
2.168MetLys: 2.168 ± 0.057
2.274MetLeu: 2.274 ± 0.059
0.902MetMet: 0.902 ± 0.043
1.511MetAsn: 1.511 ± 0.055
0.999MetPro: 0.999 ± 0.041
0.929MetGln: 0.929 ± 0.037
1.077MetArg: 1.077 ± 0.04
1.755MetSer: 1.755 ± 0.045
1.88MetThr: 1.88 ± 0.063
1.903MetVal: 1.903 ± 0.057
0.196MetTrp: 0.196 ± 0.02
0.724MetTyr: 0.724 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.052AsnAla: 3.052 ± 0.07
0.248AsnCys: 0.248 ± 0.02
2.677AsnAsp: 2.677 ± 0.063
3.981AsnGlu: 3.981 ± 0.084
2.201AsnPhe: 2.201 ± 0.057
3.149AsnGly: 3.149 ± 0.069
1.357AsnHis: 1.357 ± 0.049
4.018AsnIle: 4.018 ± 0.088
3.196AsnLys: 3.196 ± 0.078
4.746AsnLeu: 4.746 ± 0.086
1.18AsnMet: 1.18 ± 0.045
2.766AsnAsn: 2.766 ± 0.08
2.341AsnPro: 2.341 ± 0.064
3.225AsnGln: 3.225 ± 0.082
2.27AsnArg: 2.27 ± 0.069
2.536AsnSer: 2.536 ± 0.063
2.563AsnThr: 2.563 ± 0.079
3.05AsnVal: 3.05 ± 0.063
0.595AsnTrp: 0.595 ± 0.031
2.197AsnTyr: 2.197 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.064ProAla: 2.064 ± 0.058
0.154ProCys: 0.154 ± 0.015
1.879ProAsp: 1.879 ± 0.057
2.977ProGlu: 2.977 ± 0.077
1.654ProPhe: 1.654 ± 0.044
2.089ProGly: 2.089 ± 0.054
0.732ProHis: 0.732 ± 0.03
2.901ProIle: 2.901 ± 0.065
1.994ProLys: 1.994 ± 0.058
3.318ProLeu: 3.318 ± 0.066
0.881ProMet: 0.881 ± 0.034
1.987ProAsn: 1.987 ± 0.055
0.71ProPro: 0.71 ± 0.039
1.365ProGln: 1.365 ± 0.052
1.056ProArg: 1.056 ± 0.04
2.09ProSer: 2.09 ± 0.06
2.302ProThr: 2.302 ± 0.068
2.607ProVal: 2.607 ± 0.07
0.326ProTrp: 0.326 ± 0.024
1.457ProTyr: 1.457 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
3.417GlnAla: 3.417 ± 0.082
0.148GlnCys: 0.148 ± 0.018
1.985GlnAsp: 1.985 ± 0.061
2.892GlnGlu: 2.892 ± 0.072
2.104GlnPhe: 2.104 ± 0.068
1.993GlnGly: 1.993 ± 0.056
0.92GlnHis: 0.92 ± 0.041
3.433GlnIle: 3.433 ± 0.074
2.705GlnLys: 2.705 ± 0.062
5.183GlnLeu: 5.183 ± 0.108
1.25GlnMet: 1.25 ± 0.048
2.115GlnAsn: 2.115 ± 0.062
1.485GlnPro: 1.485 ± 0.053
2.309GlnGln: 2.309 ± 0.072
1.79GlnArg: 1.79 ± 0.057
2.487GlnSer: 2.487 ± 0.072
2.572GlnThr: 2.572 ± 0.067
2.995GlnVal: 2.995 ± 0.08
0.514GlnTrp: 0.514 ± 0.031
1.946GlnTyr: 1.946 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
2.218ArgAla: 2.218 ± 0.064
0.192ArgCys: 0.192 ± 0.018
1.941ArgAsp: 1.941 ± 0.063
2.861ArgGlu: 2.861 ± 0.077
1.812ArgPhe: 1.812 ± 0.063
2.005ArgGly: 2.005 ± 0.054
0.805ArgHis: 0.805 ± 0.036
2.948ArgIle: 2.948 ± 0.073
2.451ArgLys: 2.451 ± 0.063
3.96ArgLeu: 3.96 ± 0.076
1.089ArgMet: 1.089 ± 0.043
1.88ArgAsn: 1.88 ± 0.055
1.275ArgPro: 1.275 ± 0.047
2.069ArgGln: 2.069 ± 0.056
1.851ArgArg: 1.851 ± 0.066
1.862ArgSer: 1.862 ± 0.056
1.882ArgThr: 1.882 ± 0.049
2.513ArgVal: 2.513 ± 0.061
0.353ArgTrp: 0.353 ± 0.024
1.787ArgTyr: 1.787 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.481SerAla: 3.481 ± 0.078
0.246SerCys: 0.246 ± 0.02
3.042SerAsp: 3.042 ± 0.07
4.156SerGlu: 4.156 ± 0.091
2.785SerPhe: 2.785 ± 0.071
3.964SerGly: 3.964 ± 0.083
1.197SerHis: 1.197 ± 0.046
4.754SerIle: 4.754 ± 0.093
3.506SerLys: 3.506 ± 0.072
5.87SerLeu: 5.87 ± 0.103
1.559SerMet: 1.559 ± 0.051
2.884SerAsn: 2.884 ± 0.078
1.888SerPro: 1.888 ± 0.054
2.615SerGln: 2.615 ± 0.069
2.162SerArg: 2.162 ± 0.066
3.503SerSer: 3.503 ± 0.086
3.233SerThr: 3.233 ± 0.091
3.847SerVal: 3.847 ± 0.072
0.558SerTrp: 0.558 ± 0.034
2.32SerTyr: 2.32 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.922ThrAla: 3.922 ± 0.09
0.254ThrCys: 0.254 ± 0.019
3.03ThrAsp: 3.03 ± 0.064
3.931ThrGlu: 3.931 ± 0.103
2.373ThrPhe: 2.373 ± 0.065
3.868ThrGly: 3.868 ± 0.082
1.285ThrHis: 1.285 ± 0.047
4.952ThrIle: 4.952 ± 0.091
3.345ThrLys: 3.345 ± 0.081
5.743ThrLeu: 5.743 ± 0.092
1.325ThrMet: 1.325 ± 0.045
2.79ThrAsn: 2.79 ± 0.069
2.326ThrPro: 2.326 ± 0.069
2.262ThrGln: 2.262 ± 0.065
1.816ThrArg: 1.816 ± 0.057
3.068ThrSer: 3.068 ± 0.075
3.783ThrThr: 3.783 ± 0.147
4.261ThrVal: 4.261 ± 0.098
0.552ThrTrp: 0.552 ± 0.027
2.146ThrTyr: 2.146 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
5.057ValAla: 5.057 ± 0.1
0.383ValCys: 0.383 ± 0.023
4.068ValAsp: 4.068 ± 0.082
5.207ValGlu: 5.207 ± 0.111
2.791ValPhe: 2.791 ± 0.069
4.494ValGly: 4.494 ± 0.091
1.149ValHis: 1.149 ± 0.042
5.514ValIle: 5.514 ± 0.111
4.224ValLys: 4.224 ± 0.085
6.374ValLeu: 6.374 ± 0.105
1.9ValMet: 1.9 ± 0.053
3.385ValAsn: 3.385 ± 0.076
2.454ValPro: 2.454 ± 0.068
2.352ValGln: 2.352 ± 0.057
2.262ValArg: 2.262 ± 0.059
4.276ValSer: 4.276 ± 0.085
4.104ValThr: 4.104 ± 0.078
5.017ValVal: 5.017 ± 0.106
0.564ValTrp: 0.564 ± 0.027
2.423ValTyr: 2.423 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.569TrpAla: 0.569 ± 0.028
0.046TrpCys: 0.046 ± 0.008
0.516TrpAsp: 0.516 ± 0.028
0.59TrpGlu: 0.59 ± 0.03
0.469TrpPhe: 0.469 ± 0.027
0.575TrpGly: 0.575 ± 0.035
0.254TrpHis: 0.254 ± 0.022
0.686TrpIle: 0.686 ± 0.032
0.443TrpLys: 0.443 ± 0.026
1.25TrpLeu: 1.25 ± 0.042
0.297TrpMet: 0.297 ± 0.02
0.546TrpAsn: 0.546 ± 0.032
0.309TrpPro: 0.309 ± 0.023
0.593TrpGln: 0.593 ± 0.03
0.347TrpArg: 0.347 ± 0.024
0.548TrpSer: 0.548 ± 0.032
0.482TrpThr: 0.482 ± 0.031
0.625TrpVal: 0.625 ± 0.031
0.134TrpTrp: 0.134 ± 0.015
0.37TrpTyr: 0.37 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.344TyrAla: 2.344 ± 0.059
0.274TyrCys: 0.274 ± 0.021
2.367TyrAsp: 2.367 ± 0.06
2.623TyrGlu: 2.623 ± 0.061
2.274TyrPhe: 2.274 ± 0.06
2.515TyrGly: 2.515 ± 0.06
1.08TyrHis: 1.08 ± 0.038
2.658TyrIle: 2.658 ± 0.062
1.714TyrLys: 1.714 ± 0.055
4.424TyrLeu: 4.424 ± 0.091
0.759TyrMet: 0.759 ± 0.035
1.923TyrAsn: 1.923 ± 0.058
1.623TyrPro: 1.623 ± 0.046
2.782TyrGln: 2.782 ± 0.089
1.815TyrArg: 1.815 ± 0.061
2.204TyrSer: 2.204 ± 0.069
1.965TyrThr: 1.965 ± 0.062
2.261TyrVal: 2.261 ± 0.054
0.414TyrTrp: 0.414 ± 0.026
2.035TyrTyr: 2.035 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2027 proteins (657366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski