Amino acid dipepetide frequency for Nesterenkonia natronophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.759AlaAla: 16.759 ± 0.219	0.801AlaCys: 0.801 ± 0.03	6.892AlaAsp: 6.892 ± 0.105	9.941AlaGlu: 9.941 ± 0.136	3.283AlaPhe: 3.283 ± 0.07	10.655AlaGly: 10.655 ± 0.151	2.628AlaHis: 2.628 ± 0.055	4.353AlaIle: 4.353 ± 0.097	2.898AlaLys: 2.898 ± 0.075	12.051AlaLeu: 12.051 ± 0.152	2.577AlaMet: 2.577 ± 0.06	2.143AlaAsn: 2.143 ± 0.05	5.282AlaPro: 5.282 ± 0.082	4.812AlaGln: 4.812 ± 0.079	7.231AlaArg: 7.231 ± 0.105	6.274AlaSer: 6.274 ± 0.094	5.769AlaThr: 5.769 ± 0.095	10.356AlaVal: 10.356 ± 0.126	1.507AlaTrp: 1.507 ± 0.048	2.132AlaTyr: 2.132 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.8CysAla: 0.8 ± 0.037	0.071CysCys: 0.071 ± 0.009	0.323CysAsp: 0.323 ± 0.022	0.39CysGlu: 0.39 ± 0.027	0.197CysPhe: 0.197 ± 0.015	0.724CysGly: 0.724 ± 0.032	0.148CysHis: 0.148 ± 0.015	0.207CysIle: 0.207 ± 0.016	0.085CysLys: 0.085 ± 0.012	0.587CysLeu: 0.587 ± 0.029	0.133CysMet: 0.133 ± 0.013	0.116CysAsn: 0.116 ± 0.013	0.362CysPro: 0.362 ± 0.024	0.201CysGln: 0.201 ± 0.017	0.451CysArg: 0.451 ± 0.024	0.428CysSer: 0.428 ± 0.023	0.392CysThr: 0.392 ± 0.022	0.431CysVal: 0.431 ± 0.023	0.092CysTrp: 0.092 ± 0.011	0.133CysTyr: 0.133 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.875AspAla: 6.875 ± 0.112	0.294AspCys: 0.294 ± 0.021	3.74AspAsp: 3.74 ± 0.089	4.199AspGlu: 4.199 ± 0.081	1.918AspPhe: 1.918 ± 0.048	4.544AspGly: 4.544 ± 0.094	1.53AspHis: 1.53 ± 0.047	2.513AspIle: 2.513 ± 0.06	1.262AspLys: 1.262 ± 0.042	6.088AspLeu: 6.088 ± 0.094	1.084AspMet: 1.084 ± 0.036	0.975AspAsn: 0.975 ± 0.041	3.867AspPro: 3.867 ± 0.059	2.2AspGln: 2.2 ± 0.054	3.786AspArg: 3.786 ± 0.083	3.411AspSer: 3.411 ± 0.07	2.816AspThr: 2.816 ± 0.06	4.782AspVal: 4.782 ± 0.092	0.872AspTrp: 0.872 ± 0.032	1.452AspTyr: 1.452 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.1GluAla: 8.1 ± 0.11	0.312GluCys: 0.312 ± 0.021	4.331GluAsp: 4.331 ± 0.09	5.039GluGlu: 5.039 ± 0.118	2.0GluPhe: 2.0 ± 0.059	4.658GluGly: 4.658 ± 0.082	1.981GluHis: 1.981 ± 0.048	3.017GluIle: 3.017 ± 0.067	1.802GluLys: 1.802 ± 0.047	7.27GluLeu: 7.27 ± 0.112	1.226GluMet: 1.226 ± 0.041	1.599GluAsn: 1.599 ± 0.044	3.568GluPro: 3.568 ± 0.076	3.088GluGln: 3.088 ± 0.06	4.632GluArg: 4.632 ± 0.083	3.863GluSer: 3.863 ± 0.069	3.785GluThr: 3.785 ± 0.083	5.409GluVal: 5.409 ± 0.089	0.854GluTrp: 0.854 ± 0.039	1.394GluTyr: 1.394 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.751PheAla: 3.751 ± 0.083	0.264PheCys: 0.264 ± 0.019	2.196PheAsp: 2.196 ± 0.053	1.816PheGlu: 1.816 ± 0.052	1.114PhePhe: 1.114 ± 0.042	3.241PheGly: 3.241 ± 0.065	0.673PheHis: 0.673 ± 0.032	1.348PheIle: 1.348 ± 0.052	0.618PheLys: 0.618 ± 0.03	2.883PheLeu: 2.883 ± 0.065	0.574PheMet: 0.574 ± 0.031	0.835PheAsn: 0.835 ± 0.031	1.424PhePro: 1.424 ± 0.041	0.875PheGln: 0.875 ± 0.036	1.783PheArg: 1.783 ± 0.042	2.126PheSer: 2.126 ± 0.061	2.203PheThr: 2.203 ± 0.061	2.355PheVal: 2.355 ± 0.058	0.468PheTrp: 0.468 ± 0.03	0.705PheTyr: 0.705 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.117GlyAla: 9.117 ± 0.127	0.569GlyCys: 0.569 ± 0.027	4.355GlyAsp: 4.355 ± 0.083	5.338GlyGlu: 5.338 ± 0.089	3.14GlyPhe: 3.14 ± 0.08	6.738GlyGly: 6.738 ± 0.109	2.064GlyHis: 2.064 ± 0.056	4.242GlyIle: 4.242 ± 0.091	2.382GlyLys: 2.382 ± 0.065	8.587GlyLeu: 8.587 ± 0.12	2.094GlyMet: 2.094 ± 0.057	1.786GlyAsn: 1.786 ± 0.056	3.831GlyPro: 3.831 ± 0.08	2.921GlyGln: 2.921 ± 0.067	5.73GlyArg: 5.73 ± 0.082	5.293GlySer: 5.293 ± 0.088	5.143GlyThr: 5.143 ± 0.078	7.269GlyVal: 7.269 ± 0.099	1.447GlyTrp: 1.447 ± 0.048	2.126GlyTyr: 2.126 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.362HisAla: 2.362 ± 0.056	0.191HisCys: 0.191 ± 0.016	1.296HisAsp: 1.296 ± 0.04	1.382HisGlu: 1.382 ± 0.043	0.779HisPhe: 0.779 ± 0.034	2.119HisGly: 2.119 ± 0.056	0.808HisHis: 0.808 ± 0.032	0.999HisIle: 0.999 ± 0.033	0.52HisLys: 0.52 ± 0.025	2.494HisLeu: 2.494 ± 0.058	0.505HisMet: 0.505 ± 0.026	0.499HisAsn: 0.499 ± 0.029	1.628HisPro: 1.628 ± 0.047	1.05HisGln: 1.05 ± 0.04	2.056HisArg: 2.056 ± 0.062	1.377HisSer: 1.377 ± 0.037	1.369HisThr: 1.369 ± 0.043	1.722HisVal: 1.722 ± 0.045	0.383HisTrp: 0.383 ± 0.025	0.509HisTyr: 0.509 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.588IleAla: 5.588 ± 0.101	0.366IleCys: 0.366 ± 0.021	2.891IleAsp: 2.891 ± 0.072	2.708IleGlu: 2.708 ± 0.064	1.418IlePhe: 1.418 ± 0.051	4.193IleGly: 4.193 ± 0.088	0.922IleHis: 0.922 ± 0.036	2.178IleIle: 2.178 ± 0.059	0.936IleLys: 0.936 ± 0.035	3.828IleLeu: 3.828 ± 0.071	0.847IleMet: 0.847 ± 0.037	1.247IleAsn: 1.247 ± 0.043	2.332IlePro: 2.332 ± 0.057	1.167IleGln: 1.167 ± 0.038	2.761IleArg: 2.761 ± 0.064	2.936IleSer: 2.936 ± 0.063	2.968IleThr: 2.968 ± 0.056	3.536IleVal: 3.536 ± 0.077	0.522IleTrp: 0.522 ± 0.027	0.905IleTyr: 0.905 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	2.638LysAla: 2.638 ± 0.062	0.092LysCys: 0.092 ± 0.012	1.388LysAsp: 1.388 ± 0.041	1.483LysGlu: 1.483 ± 0.044	0.617LysPhe: 0.617 ± 0.031	1.683LysGly: 1.683 ± 0.051	0.69LysHis: 0.69 ± 0.029	1.158LysIle: 1.158 ± 0.039	1.08LysLys: 1.08 ± 0.054	2.504LysLeu: 2.504 ± 0.065	0.502LysMet: 0.502 ± 0.027	0.72LysAsn: 0.72 ± 0.03	1.452LysPro: 1.452 ± 0.045	0.893LysGln: 0.893 ± 0.037	1.837LysArg: 1.837 ± 0.055	1.506LysSer: 1.506 ± 0.05	1.534LysThr: 1.534 ± 0.047	2.049LysVal: 2.049 ± 0.056	0.319LysTrp: 0.319 ± 0.019	0.574LysTyr: 0.574 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.124LeuAla: 12.124 ± 0.143	0.707LeuCys: 0.707 ± 0.036	5.786LeuAsp: 5.786 ± 0.1	6.202LeuGlu: 6.202 ± 0.084	2.944LeuPhe: 2.944 ± 0.074	8.912LeuGly: 8.912 ± 0.125	2.241LeuHis: 2.241 ± 0.049	4.714LeuIle: 4.714 ± 0.094	2.432LeuLys: 2.432 ± 0.061	10.189LeuLeu: 10.189 ± 0.156	2.135LeuMet: 2.135 ± 0.063	2.585LeuAsn: 2.585 ± 0.06	5.492LeuPro: 5.492 ± 0.085	3.072LeuGln: 3.072 ± 0.062	7.415LeuArg: 7.415 ± 0.1	6.331LeuSer: 6.331 ± 0.102	6.679LeuThr: 6.679 ± 0.098	8.072LeuVal: 8.072 ± 0.146	1.31LeuTrp: 1.31 ± 0.05	1.747LeuTyr: 1.747 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.43MetAla: 2.43 ± 0.056	0.123MetCys: 0.123 ± 0.011	1.09MetAsp: 1.09 ± 0.039	1.092MetGlu: 1.092 ± 0.042	0.648MetPhe: 0.648 ± 0.031	1.658MetGly: 1.658 ± 0.043	0.414MetHis: 0.414 ± 0.025	1.089MetIle: 1.089 ± 0.041	0.553MetLys: 0.553 ± 0.028	2.226MetLeu: 2.226 ± 0.06	0.514MetMet: 0.514 ± 0.025	0.575MetAsn: 0.575 ± 0.03	1.201MetPro: 1.201 ± 0.041	0.685MetGln: 0.685 ± 0.03	1.484MetArg: 1.484 ± 0.043	1.654MetSer: 1.654 ± 0.046	1.659MetThr: 1.659 ± 0.049	1.775MetVal: 1.775 ± 0.045	0.272MetTrp: 0.272 ± 0.019	0.288MetTyr: 0.288 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.583AsnAla: 2.583 ± 0.056	0.128AsnCys: 0.128 ± 0.013	1.286AsnAsp: 1.286 ± 0.041	1.273AsnGlu: 1.273 ± 0.043	0.735AsnPhe: 0.735 ± 0.033	1.816AsnGly: 1.816 ± 0.058	0.501AsnHis: 0.501 ± 0.023	1.09AsnIle: 1.09 ± 0.042	0.512AsnLys: 0.512 ± 0.027	2.27AsnLeu: 2.27 ± 0.054	0.448AsnMet: 0.448 ± 0.026	0.563AsnAsn: 0.563 ± 0.03	1.68AsnPro: 1.68 ± 0.046	0.812AsnGln: 0.812 ± 0.032	1.505AsnArg: 1.505 ± 0.047	1.286AsnSer: 1.286 ± 0.044	1.381AsnThr: 1.381 ± 0.042	1.757AsnVal: 1.757 ± 0.044	0.337AsnTrp: 0.337 ± 0.02	0.586AsnTyr: 0.586 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.077ProAla: 6.077 ± 0.108	0.204ProCys: 0.204 ± 0.015	3.425ProAsp: 3.425 ± 0.073	5.037ProGlu: 5.037 ± 0.105	1.59ProPhe: 1.59 ± 0.051	4.889ProGly: 4.889 ± 0.089	1.349ProHis: 1.349 ± 0.046	1.8ProIle: 1.8 ± 0.051	1.324ProLys: 1.324 ± 0.043	4.782ProLeu: 4.782 ± 0.098	1.064ProMet: 1.064 ± 0.034	1.188ProAsn: 1.188 ± 0.039	2.386ProPro: 2.386 ± 0.073	2.102ProGln: 2.102 ± 0.06	3.155ProArg: 3.155 ± 0.056	3.011ProSer: 3.011 ± 0.082	3.094ProThr: 3.094 ± 0.079	4.48ProVal: 4.48 ± 0.078	0.803ProTrp: 0.803 ± 0.035	1.06ProTyr: 1.06 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.261GlnAla: 4.261 ± 0.086	0.183GlnCys: 0.183 ± 0.018	1.796GlnAsp: 1.796 ± 0.045	2.301GlnGlu: 2.301 ± 0.056	1.008GlnPhe: 1.008 ± 0.036	2.518GlnGly: 2.518 ± 0.058	0.966GlnHis: 0.966 ± 0.04	1.677GlnIle: 1.677 ± 0.043	0.981GlnLys: 0.981 ± 0.037	4.253GlnLeu: 4.253 ± 0.082	0.814GlnMet: 0.814 ± 0.032	0.786GlnAsn: 0.786 ± 0.032	1.794GlnPro: 1.794 ± 0.045	1.777GlnGln: 1.777 ± 0.045	3.036GlnArg: 3.036 ± 0.074	1.8GlnSer: 1.8 ± 0.044	1.887GlnThr: 1.887 ± 0.047	3.055GlnVal: 3.055 ± 0.065	0.621GlnTrp: 0.621 ± 0.036	0.727GlnTyr: 0.727 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.231ArgAla: 7.231 ± 0.095	0.426ArgCys: 0.426 ± 0.029	3.589ArgAsp: 3.589 ± 0.068	4.425ArgGlu: 4.425 ± 0.075	2.219ArgPhe: 2.219 ± 0.049	4.972ArgGly: 4.972 ± 0.086	1.73ArgHis: 1.73 ± 0.052	3.402ArgIle: 3.402 ± 0.065	1.918ArgLys: 1.918 ± 0.054	6.886ArgLeu: 6.886 ± 0.108	1.692ArgMet: 1.692 ± 0.047	1.536ArgAsn: 1.536 ± 0.046	3.234ArgPro: 3.234 ± 0.068	2.702ArgGln: 2.702 ± 0.07	6.128ArgArg: 6.128 ± 0.115	4.453ArgSer: 4.453 ± 0.082	4.072ArgThr: 4.072 ± 0.073	4.964ArgVal: 4.964 ± 0.08	1.169ArgTrp: 1.169 ± 0.043	1.625ArgTyr: 1.625 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	7.771SerAla: 7.771 ± 0.106	0.348SerCys: 0.348 ± 0.024	3.244SerAsp: 3.244 ± 0.059	3.823SerGlu: 3.823 ± 0.07	1.939SerPhe: 1.939 ± 0.046	5.981SerGly: 5.981 ± 0.104	1.29SerHis: 1.29 ± 0.037	2.424SerIle: 2.424 ± 0.055	1.401SerLys: 1.401 ± 0.05	5.616SerLeu: 5.616 ± 0.079	1.528SerMet: 1.528 ± 0.045	1.259SerAsn: 1.259 ± 0.037	3.461SerPro: 3.461 ± 0.073	2.102SerGln: 2.102 ± 0.049	3.982SerArg: 3.982 ± 0.078	4.254SerSer: 4.254 ± 0.12	3.637SerThr: 3.637 ± 0.079	4.704SerVal: 4.704 ± 0.078	0.924SerTrp: 0.924 ± 0.031	1.251SerTyr: 1.251 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	7.088ThrAla: 7.088 ± 0.103	0.337ThrCys: 0.337 ± 0.02	3.475ThrAsp: 3.475 ± 0.071	3.857ThrGlu: 3.857 ± 0.08	1.885ThrPhe: 1.885 ± 0.05	5.688ThrGly: 5.688 ± 0.081	1.383ThrHis: 1.383 ± 0.043	2.47ThrIle: 2.47 ± 0.059	1.302ThrLys: 1.302 ± 0.043	5.818ThrLeu: 5.818 ± 0.08	1.187ThrMet: 1.187 ± 0.041	1.288ThrAsn: 1.288 ± 0.04	3.572ThrPro: 3.572 ± 0.065	1.849ThrGln: 1.849 ± 0.052	3.493ThrArg: 3.493 ± 0.062	3.638ThrSer: 3.638 ± 0.067	3.514ThrThr: 3.514 ± 0.068	5.41ThrVal: 5.41 ± 0.086	0.791ThrTrp: 0.791 ± 0.033	1.398ThrTyr: 1.398 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	9.019ValAla: 9.019 ± 0.128	0.574ValCys: 0.574 ± 0.031	4.964ValAsp: 4.964 ± 0.078	5.503ValGlu: 5.503 ± 0.087	2.556ValPhe: 2.556 ± 0.071	6.295ValGly: 6.295 ± 0.107	1.932ValHis: 1.932 ± 0.051	4.118ValIle: 4.118 ± 0.078	1.909ValLys: 1.909 ± 0.045	8.976ValLeu: 8.976 ± 0.14	1.839ValMet: 1.839 ± 0.048	1.957ValAsn: 1.957 ± 0.047	4.411ValPro: 4.411 ± 0.078	2.551ValGln: 2.551 ± 0.06	5.282ValArg: 5.282 ± 0.101	5.117ValSer: 5.117 ± 0.073	5.449ValThr: 5.449 ± 0.075	7.72ValVal: 7.72 ± 0.118	1.0ValTrp: 1.0 ± 0.041	1.492ValTyr: 1.492 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.464TrpAla: 1.464 ± 0.045	0.123TrpCys: 0.123 ± 0.011	0.848TrpAsp: 0.848 ± 0.039	0.843TrpGlu: 0.843 ± 0.034	0.532TrpPhe: 0.532 ± 0.03	0.91TrpGly: 0.91 ± 0.037	0.371TrpHis: 0.371 ± 0.021	0.693TrpIle: 0.693 ± 0.031	0.363TrpLys: 0.363 ± 0.018	1.607TrpLeu: 1.607 ± 0.052	0.341TrpMet: 0.341 ± 0.022	0.448TrpAsn: 0.448 ± 0.027	0.688TrpPro: 0.688 ± 0.033	0.566TrpGln: 0.566 ± 0.026	1.065TrpArg: 1.065 ± 0.037	0.862TrpSer: 0.862 ± 0.037	0.847TrpThr: 0.847 ± 0.033	1.132TrpVal: 1.132 ± 0.04	0.367TrpTrp: 0.367 ± 0.025	0.311TrpTyr: 0.311 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.305TyrAla: 2.305 ± 0.052	0.158TyrCys: 0.158 ± 0.015	1.293TyrAsp: 1.293 ± 0.044	1.277TyrGlu: 1.277 ± 0.044	0.728TyrPhe: 0.728 ± 0.03	1.978TyrGly: 1.978 ± 0.048	0.426TyrHis: 0.426 ± 0.027	0.756TyrIle: 0.756 ± 0.035	0.439TyrLys: 0.439 ± 0.027	2.175TyrLeu: 2.175 ± 0.052	0.324TyrMet: 0.324 ± 0.02	0.443TyrAsn: 0.443 ± 0.028	1.158TyrPro: 1.158 ± 0.039	0.814TyrGln: 0.814 ± 0.034	1.56TyrArg: 1.56 ± 0.049	1.319TyrSer: 1.319 ± 0.041	1.245TyrThr: 1.245 ± 0.046	1.688TyrVal: 1.688 ± 0.047	0.326TyrTrp: 0.326 ± 0.02	0.46TyrTyr: 0.46 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2262 proteins (764907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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